| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jin Woo Shin, Se-Hee Kim, Jin Young Yoo. PTEN downregulation induces apoptosis and cell cycle arrest in uterine cervical cancer cells. Experimental and therapeutic medicine. vol 22. issue 4. 2021-09-11. PMID:34504554. |
p53 silencing did not affect the ability of pten knockdown to induce apoptosis in cervical cancer cells. |
2021-09-11 |
2023-08-13 |
human |
| Jin Woo Shin, Se-Hee Kim, Jin Young Yoo. PTEN downregulation induces apoptosis and cell cycle arrest in uterine cervical cancer cells. Experimental and therapeutic medicine. vol 22. issue 4. 2021-09-11. PMID:34504554. |
taken together, the present study results imply that pten silencing induces apoptosis and decreases proliferation in cervical cancer cells; hence, pten inhibition may represent a promising strategy for the treatment of cervical cancer. |
2021-09-11 |
2023-08-13 |
human |
| Lingyan Zhang, Zibin Bu, Juan Shen, Liping Shang, Yuanyuan Chen, Ping Zhang, Yan Wan. MicroRNA-221 regulates cell activity and apoptosis in acute lymphoblastic leukemia via regulating PTEN. Experimental and therapeutic medicine. vol 22. issue 4. 2021-09-11. PMID:34504582. |
microrna-221 regulates cell activity and apoptosis in acute lymphoblastic leukemia via regulating pten. |
2021-09-11 |
2023-08-13 |
human |
| Alison F Bartolucci, Tracy Uliasz, John J Pelus. MicroRNA-21 as a regulator of human cumulus cell viability and its potential influence on the developmental potential of the oocyte. Biology of reproduction. vol 103. issue 1. 2021-09-10. PMID:32333014. |
furthermore, cultured cumulus cells treated with a mir-21-5p inhibitor had an increase in apoptosis and a corresponding increase in the expression of pten, a gene known to inhibit the akt-dependent survival pathway in cumulus cells. |
2021-09-10 |
2023-08-13 |
human |
| Qin Zhou, Yujie Zhang, Xiaoxiang Lu, Chang Wang, Xinxin Pei, Yafang Lu, Cheng Cao, Changzhi Xu, Buchang Zhan. Stable overexpression of mutated PTEN in Chinese hamster ovary cells enhances their performance and therapeutic antibody production. Biotechnology journal. vol 16. issue 9. 2021-09-09. PMID:34053183. |
our results showed that cho-k1 cells stably expressing pten c124s or g129e exhibited enhanced proliferation, reduced apoptosis rate, and increased transient expression of therapeutic antibodies compared to the control cells. |
2021-09-09 |
2023-08-13 |
Not clear |
| Ata Abbas, Roshan Padmanabhan, Charis En. Metabolic stress regulates genome-wide transcription in a PTEN-dependent manner. Human molecular genetics. vol 29. issue 16. 2021-08-27. PMID:32744308. |
our findings provide a new insight in understanding tumor pathology and how pten loss of function, whether by genetic or non-genetic mechanisms, can contribute to a favorable transcriptional program employed by tumor cells to escape apoptosis, hence developing more aggressive and metastatic phenotypes. |
2021-08-27 |
2023-08-13 |
Not clear |
| G A Puzanov, V N Senchenk. [SCP Phosphatases and Oncogenesis]. Molekuliarnaia biologiia. vol 55. issue 4. 2021-08-27. PMID:34432772. |
in addition, the substrates of scp phosphatases include smad transcription modulators; akt1 protein kinase, which regulates the cell cycle, apoptosis, and angiogenesis; the twist1 and c-myc transcription factors; ras family proteins, which are involved in signaling pathways regulating the cell growth and apoptosis; cdca3, which is associated with cell division; the cyclin-dependent kinase inhibitor p21; and the promyelocytic leukemia protein (pml), which is involved in regulation of the tumor suppressors p53, pten, and mtor. |
2021-08-27 |
2023-08-13 |
Not clear |
| Tao Liu, Yu Sun, Shengzhuang Yang, Xiangsen Lian. Inhibitory Effect of Selenium on Esophagus Cancer Cells and the Related Mechanism. Journal of nutritional science and vitaminology. vol 66. issue 5. 2021-08-25. PMID:33132349. |
mechanistically, fal1 and pten were found to participate in regulating cell cycle and cell apoptosis process by decreasing cyclind1, cdk2, and promoting caspase-3, caspase-8. |
2021-08-25 |
2023-08-13 |
Not clear |
| Hui Chen, Su-Xiang Guo, Sai Zhang, Xiao-Dan Li, Hao Wang, Xiao-Wei L. MiRNA-620 promotes TGF-β1-induced proliferation of airway smooth muscle cell through controlling PTEN/AKT signaling pathway. The Kaohsiung journal of medical sciences. vol 36. issue 11. 2021-08-20. PMID:32583575. |
moreover, knocking down mir-620 alone efficiently reduced the phosphorylation of protein kinase b (akt), decreased tgf-β1-induced proliferation and promoted apoptosis in asmcs, whereas downregulation of pten in mir-620 inhibitor-transfected cells restored the activation of akt, increased tgf-β1-triggered proliferation, and partially inhibited asmc apoptosis. |
2021-08-20 |
2023-08-13 |
Not clear |
| Hui Chen, Su-Xiang Guo, Sai Zhang, Xiao-Dan Li, Hao Wang, Xiao-Wei L. MiRNA-620 promotes TGF-β1-induced proliferation of airway smooth muscle cell through controlling PTEN/AKT signaling pathway. The Kaohsiung journal of medical sciences. vol 36. issue 11. 2021-08-20. PMID:32583575. |
taken together, the present study provided evidence that mir-620 increased tgf-β1-mediated proliferation and suppressed apoptosis in asmcs via the regulation of pten and akt expression. |
2021-08-20 |
2023-08-13 |
Not clear |
| Huiying Wan, Dingding Zhang, Weimin Hu, Zhen Xie, Qiu Du, Qiongrong Xia, Taishen Wen, Haiping Ji. Aberrant PTEN, PIK3CA, pMAPK, and TP53 expression in human scalp and face angiosarcoma. Medicine. vol 100. issue 30. 2021-08-20. PMID:34397726. |
tumor cell apoptosis was assessed by terminal deoxyribonucleotide transferase-mediated dutp nick end-labeling staining.significantly lower pten but higher pik3ca, pmapk, and tp53 immunostaining were detected in the angiosarcoma specimens than in the benign hemangioma specimens(p < .01). |
2021-08-20 |
2023-08-13 |
human |
| Didi Chen, Huafang Su, Yunhao Li, Xinyi Wu, Yifei Li, Chaoyi Wei, Deli Shi, Ya Gao, Qingyu Zhou, Qiongqiong Wang, Xiance Jin, Congying Xi. miR-20b and miR-125a promote tumorigenesis in radioresistant esophageal carcinoma cells. Aging. vol 13. issue 7. 2021-08-16. PMID:33714953. |
mir-20b-5p upregulation promoted cell proliferation, migration, invasion, and the emt process, and decreased apoptosis by negatively regulating pten. |
2021-08-16 |
2023-08-13 |
Not clear |
| Xian Wu, Ruiying Tong, Xiuli Chen, Xinying Jiang, Xiaoying He, Libing M. The miR-302s/367 Cluster Inhibits the Proliferation and Apoptosis in Sheep Fetal Fibroblasts via the Cell Cycle and PI3K-Akt Pathways. Mammalian genome : official journal of the International Mammalian Genome Society. vol 32. issue 3. 2021-08-16. PMID:33956176. |
the results showed that mir-302s/367 could not reprogram sffs into ipscs; however, they could inhibit both the proliferation and apoptosis of sffs by targeting cdk2, e2f1, e2f2, and pten in the cell cycle and pi3k-akt pathways. |
2021-08-16 |
2023-08-13 |
mouse |
| Tian Liang, Feng Gao, Jinghai Che. Role of PTEN-less in cardiac injury, hypertrophy and regeneration. Cell regeneration (London, England). vol 10. issue 1. 2021-08-13. PMID:34337686. |
downregulation of pten expression or inhibiting its biologic activity improves heart function, promotes cardiomyocytes proliferation, reduces cardiac fibrosis as well as dilation, and inhibits apoptosis following ischemic stress such as myocardial infarction. |
2021-08-13 |
2023-08-13 |
Not clear |
| Roseane Guimarães Ferreira, Luis Eduardo Mosquera Narvaez, Kaio Murilo Monteiro Espíndola, Amanda Caroline R S Rosario, Wenddy Graziela N Lima, Marta Chagas Monteir. Can Nimesulide Nanoparticles Be a Therapeutic Strategy for the Inhibition of the KRAS/PTEN Signaling Pathway in Pancreatic Cancer? Frontiers in oncology. vol 11. 2021-08-07. PMID:34354940. |
this drug works by increasing the levels of pten expression and inhibiting proliferation and apoptosis. |
2021-08-07 |
2023-08-13 |
Not clear |
| Bin Wang, Peiyan Hua, Li Zhang, Jindong Li, Yan Zhan. LncRNA-IUR up-regulates PTEN by sponging miR-21 to regulate cancer cell proliferation and apoptosis in esophageal squamous cell carcinoma. Esophagus : official journal of the Japan Esophageal Society. vol 17. issue 3. 2021-08-05. PMID:32124090. |
lncrna-iur up-regulates pten by sponging mir-21 to regulate cancer cell proliferation and apoptosis in esophageal squamous cell carcinoma. |
2021-08-05 |
2023-08-13 |
Not clear |
| Deyu Xu, Lei Shen, Ling Zhou, Wengang Sha, Jing Yang, Guoyuan L. Upregulation of FABP7 inhibits acute kidney injury-induced TCMK-1 cell apoptosis via activating the PPAR gamma signalling pathway. Molecular omics. vol 16. issue 6. 2021-08-05. PMID:33315023. |
fabp7 overexpression reversed the effects of lps on inhibiting cell viability and proliferation, promoting cell apoptosis, increasing the expression of fabp7, pparγ, pten and p27kip1, and reducing cleaved caspase-3/-9 expression and the phosphorylation of pten, but had no influence on pparα expression. |
2021-08-05 |
2023-08-13 |
Not clear |
| Zubiao Gao, Xiaofeng Ye, Anne Bordeaux, Stanka Hettich, Siyao Lin, Fang Han, Yan Ji. miR-26b regulates cell proliferation and apoptosis of CD117+CD44+ ovarian cancer stem cells by targeting PTEN. European journal of histochemistry : EJH. vol 65. issue 1. 2021-08-05. PMID:33634678. |
mir-26b regulates cell proliferation and apoptosis of cd117+cd44+ ovarian cancer stem cells by targeting pten. |
2021-08-05 |
2023-08-13 |
human |
| Zubiao Gao, Xiaofeng Ye, Anne Bordeaux, Stanka Hettich, Siyao Lin, Fang Han, Yan Ji. miR-26b regulates cell proliferation and apoptosis of CD117+CD44+ ovarian cancer stem cells by targeting PTEN. European journal of histochemistry : EJH. vol 65. issue 1. 2021-08-05. PMID:33634678. |
moreover, pten overexpression reversed the effects of mir-26b on the cell proliferation and apoptosis. |
2021-08-05 |
2023-08-13 |
human |
| Zubiao Gao, Xiaofeng Ye, Anne Bordeaux, Stanka Hettich, Siyao Lin, Fang Han, Yan Ji. miR-26b regulates cell proliferation and apoptosis of CD117+CD44+ ovarian cancer stem cells by targeting PTEN. European journal of histochemistry : EJH. vol 65. issue 1. 2021-08-05. PMID:33634678. |
pten overexpression remarkably accelerated the cell proliferation, and inhibited cell apoptosis. |
2021-08-05 |
2023-08-13 |
human |