| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dapeng Chen, Zhengjun Zhang, Xiaorui Lu, Xinbin Yan. Long non-coding RNA SNHG15 regulates cardiomyocyte apoptosis after hypoxia/reperfusion injury via modulating miR-188-5p/PTEN axis. Archives of physiology and biochemistry. 2021-05-06. PMID:32970504. |
mir-188-5p could combine with snhg15 and pten, and form a snhg15-mir-188-5p-pten axis, which regulated the apoptosis of mcs. |
2021-05-06 |
2023-08-13 |
mouse |
| Jun Dong, Xiqiang Xu, Qingyu Zhang, Zenong Yuan, Bingyi Ta. Critical implication of the PTEN/PI3K/AKT pathway during BMP2-induced heterotopic ossification. Molecular medicine reports. vol 23. issue 4. 2021-05-04. PMID:33537834. |
it was shown that overexpression of pten inhibited proliferation but stimulated apoptosis in mesenchymal pluripotent c3h10t1/2 cells. |
2021-05-04 |
2023-08-13 |
Not clear |
| Yifei Shen, Yin Zhu, Fei Ron. miR‑200c‑3p regulates the proliferation and apoptosis of human trabecular meshwork cells by targeting PTEN. Molecular medicine reports. vol 22. issue 2. 2021-05-03. PMID:32626945. |
mir‑200c‑3p regulates the proliferation and apoptosis of human trabecular meshwork cells by targeting pten. |
2021-05-03 |
2023-08-13 |
human |
| Yifei Shen, Yin Zhu, Fei Ron. miR‑200c‑3p regulates the proliferation and apoptosis of human trabecular meshwork cells by targeting PTEN. Molecular medicine reports. vol 22. issue 2. 2021-05-03. PMID:32626945. |
the results demonstrated that the overexpression of mir‑200c‑3p enhanced cell proliferation and inhibited cell apoptosis, while pten reversed the effects of mir‑200c‑3p. |
2021-05-03 |
2023-08-13 |
human |
| Yifei Shen, Yin Zhu, Fei Ron. miR‑200c‑3p regulates the proliferation and apoptosis of human trabecular meshwork cells by targeting PTEN. Molecular medicine reports. vol 22. issue 2. 2021-05-03. PMID:32626945. |
taken together, these data suggested that overexpression of mir‑200c‑3p targets pten to suppress cleaved caspase‑3 and bax expression and activate the pten/akt/mtor signaling pathway, thereby resulting in the promotion of cell proliferation and the inhibition of cell apoptosis. |
2021-05-03 |
2023-08-13 |
human |
| Yuan-Ming He, Xiu-Min Zhou, Shuo-Yi Jiang, Zu-Bin Zhang, Bi-Yin Cao, Jin-Bao Liu, Yuan-Ying Zeng, Jun Zhao, Xin-Liang Ma. TRIM25 activates AKT/mTOR by inhibiting PTEN via K63-linked polyubiquitination in non-small cell lung cancer. Acta pharmacologica Sinica. 2021-05-01. PMID:33931764. |
moreover, we found that the antibacterial nitroxoline can activate pten by reducing its k63-linked polyubiquitination and sensitizes nsclc to cisplatin-induced apoptosis. |
2021-05-01 |
2023-08-13 |
Not clear |
| Javid Sadri Nahand, Layla Shojaie, Seyed Amirreza Akhlagh, Mohammad Saeid Ebrahimi, Hamid Reza Mirzaei, Hossein Bannazadeh Baghi, Maryam Mahjoubin-Tehran, Nima Rezaei, Michael R Hamblin, Vida Tajiknia, Neda Rahimian, Hamed Mirzae. Cell death pathways and viruses: Role of microRNAs. Molecular therapy. Nucleic acids. vol 24. 2021-04-28. PMID:33898103. |
mir-21 is regulated by several viruses and can affect both apoptosis and anoikis via modulating various targets, such as pdcd4, pten, interleukin (il)-12, maspin, and fas-l. mir-34 can be downregulated by viral infection and has different effects on apoptosis, depending on the type of virus and/or host cell. |
2021-04-28 |
2023-08-13 |
human |
| Li Zhu, Xueying Zhou, Shanshan Li, Jianmeng Liu, Jingyan Yang, Xiangyun Fan, Shengnian Zho. miR‑183‑5p attenuates cerebral ischemia injury by negatively regulating PTEN. Molecular medicine reports. vol 22. issue 5. 2021-04-26. PMID:32901892. |
overexpression of pten reversed the mir‑183‑5p‑induced n2a cell apoptosis inhibition and survival after ogd. |
2021-04-26 |
2023-08-13 |
mouse |
| Hanyu Deng, Bo Yu, Yang Yu, Ge Tian, Liu Yan. NO66 overexpression rescues ethanol-induced cell apoptosis in human AC16 cardiomyocytes by suppressing PTEN and activating the PI3K/Akt signaling. Acta biochimica et biophysica Sinica. vol 52. issue 10. 2021-04-26. PMID:33085743. |
no66 overexpression rescues ethanol-induced cell apoptosis in human ac16 cardiomyocytes by suppressing pten and activating the pi3k/akt signaling. |
2021-04-26 |
2023-08-13 |
human |
| Hanyu Deng, Bo Yu, Yang Yu, Ge Tian, Liu Yan. NO66 overexpression rescues ethanol-induced cell apoptosis in human AC16 cardiomyocytes by suppressing PTEN and activating the PI3K/Akt signaling. Acta biochimica et biophysica Sinica. vol 52. issue 10. 2021-04-26. PMID:33085743. |
meanwhile, the application of pi3k inhibitor (ly294002) and pten overexpression attenuated the inhibition efficiency of no66 on cell apoptosis. |
2021-04-26 |
2023-08-13 |
human |
| Ding Tian, Yin Xiang, Yong Tang, Zhuowang Ge, Qianhui Li, Yachen Zhan. Circ-ADAM9 targeting PTEN and ATG7 promotes autophagy and apoptosis of diabetic endothelial progenitor cells by sponging mir-20a-5p. Cell death & disease. vol 11. issue 7. 2021-04-15. PMID:32661238. |
circ-adam9 targeting pten and atg7 promotes autophagy and apoptosis of diabetic endothelial progenitor cells by sponging mir-20a-5p. |
2021-04-15 |
2023-08-13 |
mouse |
| Ding Tian, Yin Xiang, Yong Tang, Zhuowang Ge, Qianhui Li, Yachen Zhan. Circ-ADAM9 targeting PTEN and ATG7 promotes autophagy and apoptosis of diabetic endothelial progenitor cells by sponging mir-20a-5p. Cell death & disease. vol 11. issue 7. 2021-04-15. PMID:32661238. |
circ-adam9 upregulated pten and atg7 in interaction with mir-20a-5p, and inhibited the phosphorylation of akt and mtor to aggravate autophagy and apoptosis of epcs under high glucose. |
2021-04-15 |
2023-08-13 |
mouse |
| Liang Zhang, Zhuang Tong, Zhe Sun, Guolian Zhu, Erdong Shen, Yanfeng Huan. MiR-25-3p targets PTEN to regulate the migration, invasion, and apoptosis of esophageal cancer cells via the PI3K/AKT pathway. Bioscience reports. vol 40. issue 10. 2021-04-14. PMID:32985648. |
mir-25-3p targets pten to regulate the migration, invasion, and apoptosis of esophageal cancer cells via the pi3k/akt pathway. |
2021-04-14 |
2023-08-13 |
Not clear |
| Weiyun Wu, Yongze Chen, Shicai Ye, Hui Yang, Jianyun Yang, Juanhua Qua. Transcription factor forkhead box K1 regulates miR-32 expression and enhances cell proliferation in colorectal cancer. Oncology letters. vol 21. issue 5. 2021-04-13. PMID:33841568. |
increased microrna (mir)-32 expression in colorectal cancer (crc) tissues enhances crc cell proliferation, migration, invasion and attenuates crc cell apoptosis by repressing the expression of phosphatase and tensin homolog (pten). |
2021-04-13 |
2023-08-13 |
Not clear |
| Qingxin Zeng, Ziyi Zhu, Lijiang Song, Zhengfu H. Transferred by exosomes-derived MiR-19b-3p targets PTEN to regulate esophageal cancer cell apoptosis, migration and invasion. Bioscience reports. vol 40. issue 11. 2021-04-12. PMID:33146702. |
transferred by exosomes-derived mir-19b-3p targets pten to regulate esophageal cancer cell apoptosis, migration and invasion. |
2021-04-12 |
2023-08-13 |
Not clear |
| Qingxin Zeng, Ziyi Zhu, Lijiang Song, Zhengfu H. Transferred by exosomes-derived MiR-19b-3p targets PTEN to regulate esophageal cancer cell apoptosis, migration and invasion. Bioscience reports. vol 40. issue 11. 2021-04-12. PMID:33146702. |
mir-19b-3p transferred by exosomes could significantly reduce ec9706 cells apoptosis rate, promote cell migration and invasion, and could target the inhibition of pten expression. |
2021-04-12 |
2023-08-13 |
Not clear |
| Qingxin Zeng, Ziyi Zhu, Lijiang Song, Zhengfu H. Transferred by exosomes-derived MiR-19b-3p targets PTEN to regulate esophageal cancer cell apoptosis, migration and invasion. Bioscience reports. vol 40. issue 11. 2021-04-12. PMID:33146702. |
pten overexpression promoted apoptosis, inhibited cell migration and invasion, down-regulated the expression of mmp-2 and vimentin, and up-regulated e-cadherin expression; however, these effects could be partially reversed by mir-19b-3p. |
2021-04-12 |
2023-08-13 |
Not clear |
| Libin Zhang, Jing Hu, Menghui Hao, Liang B. Long noncoding RNA Linc01296 promotes hepatocellular carcinoma development through regulation of the miR-26a/PTEN axis. Biological chemistry. vol 401. issue 3. 2021-04-08. PMID:31318685. |
knockdown of linc01296 suppressed hcc cell processes, such as proliferation, migration and invasion, and enhanced apoptosis in vitro; these effects were reversed by a mir-26a mimic or pten overexpression. |
2021-04-08 |
2023-08-13 |
Not clear |
| Qinjie Weng, Mengting Zhao, Jiahuan Zheng, Lijun Yang, Zijie Xu, Zhikang Zhang, Jincheng Wang, Jiajia Wang, Bo Yang, Q Richard Lu, Meidan Ying, Qiaojun H. STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia. Cell death and differentiation. vol 27. issue 1. 2021-04-02. PMID:31097787. |
stat3 dictates β-cell apoptosis by modulating pten in streptozocin-induced hyperglycemia. |
2021-04-02 |
2023-08-13 |
mouse |
| Qinjie Weng, Mengting Zhao, Jiahuan Zheng, Lijun Yang, Zijie Xu, Zhikang Zhang, Jincheng Wang, Jiajia Wang, Bo Yang, Q Richard Lu, Meidan Ying, Qiaojun H. STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia. Cell death and differentiation. vol 27. issue 1. 2021-04-02. PMID:31097787. |
mechanistically, accumulating pten, induced by stat3 deficiency, directly represses phosphorylation of akt, which negatively modulates transcription factor activation, dysregulates β-cell function, positively promotes apoptotic signaling, and finally induces β-cell apoptosis. |
2021-04-02 |
2023-08-13 |
mouse |