| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jinfeng Wu, Hong Gao, Wanyu Ge, Jie H. Over expression of PTEN induces apoptosis and prevents cell proliferation in breast cancer cells. Acta biochimica Polonica. vol 67. issue 4. 2021-08-02. PMID:33332075. |
over expression of pten induces apoptosis and prevents cell proliferation in breast cancer cells. |
2021-08-02 |
2023-08-13 |
Not clear |
| Jinfeng Wu, Hong Gao, Wanyu Ge, Jie H. Over expression of PTEN induces apoptosis and prevents cell proliferation in breast cancer cells. Acta biochimica Polonica. vol 67. issue 4. 2021-08-02. PMID:33332075. |
in the present study, we have determined the effect of pten over expression in apoptosis induction and cell proliferation in breast cancer cells. |
2021-08-02 |
2023-08-13 |
Not clear |
| Jinfeng Wu, Hong Gao, Wanyu Ge, Jie H. Over expression of PTEN induces apoptosis and prevents cell proliferation in breast cancer cells. Acta biochimica Polonica. vol 67. issue 4. 2021-08-02. PMID:33332075. |
furthermore, the pten over expression leads to the activation of mitochondrial based intrinsic apoptosis pathways, which is confirmed by the activation and over expression of caspases 9 and caspases 3. |
2021-08-02 |
2023-08-13 |
Not clear |
| Jianfeng Yao, Rongfu Huang, Ming Li, Yi Jiang, Peiya Wu, Youzhu Li, Weilin Peng, Chengzhou Hua, Yanfang Huang, Huifang You, Yuanyuan Chen, Dianliang Lin, Xiaoyu Yan. PTEN Expression in Human Granulosa Cells Is Associated with Ovarian Responses and Clinical Outcomes in IVF. Reproductive sciences (Thousand Oaks, Calif.). vol 28. issue 7. 2021-07-30. PMID:33439476. |
pten (encoding phosphatase and tensin homolog) is a well-known tumor suppressor gene that functions as a mediator of apoptosis and is crucial for mammal reproduction. |
2021-07-30 |
2023-08-13 |
human |
| Jianfeng Yao, Rongfu Huang, Ming Li, Yi Jiang, Peiya Wu, Youzhu Li, Weilin Peng, Chengzhou Hua, Yanfang Huang, Huifang You, Yuanyuan Chen, Dianliang Lin, Xiaoyu Yan. PTEN Expression in Human Granulosa Cells Is Associated with Ovarian Responses and Clinical Outcomes in IVF. Reproductive sciences (Thousand Oaks, Calif.). vol 28. issue 7. 2021-07-30. PMID:33439476. |
apoptosis in granulosa cells were analyzed using annexin v-allophycocyanin staining after pten short hairpin rna lentivirus transfection. |
2021-07-30 |
2023-08-13 |
human |
| Zhihui Huang, Wenming Ma, Jinhuai Xiao, Xiaoyu Dai, Weiqi Lin. CircRNA_0092516 regulates chondrocyte proliferation and apoptosis in osteoarthritis through the miR-337-3p/PTEN axis. Journal of biochemistry. vol 169. issue 4. 2021-07-29. PMID:33135071. |
the potential mechanism analysis expounded that circrna_0092516 bound to mir-337-3p, and the interference with circrna_0092516 boosted chondrocyte proliferation and restrained cell apoptosis through the mir-337-3p/phosphatase and tensin homolog (pten) axis, thereby improving oa. |
2021-07-29 |
2023-08-13 |
human |
| Jiangyan Li, Xiaoru Chang, Mengting Shang, Shuyan Niu, Wenli Zhang, Yunjing Li, Zuoyi Sun, Tianshu Wu, Lu Kong, Ting Zhang, Meng Tang, Yuying Xu. The crosstalk between DRP1-dependent mitochondrial fission and oxidative stress triggers hepatocyte apoptosis induced by silver nanoparticles. Nanoscale. vol 13. issue 28. 2021-07-26. PMID:34254625. |
phosphatase and tensin homolog (pten)-induced putative kinase 1 (pink1) gene silencing contributed to the aggravation of mitochondrial damage, oxidative stress, and apoptosis. |
2021-07-26 |
2023-08-13 |
mouse |
| Chen-Jun Zhang, Yu Huang, Ji-De Lu, Jie Lin, Zhi-Ru Ge, Hui Huan. Upregulated microRNA-132 rescues cardiac fibrosis and restores cardiocyte proliferation in dilated cardiomyopathy through the phosphatase and tensin homolog-mediated PI3K/Akt signal transduction pathway. Journal of cellular biochemistry. 2021-07-21. PMID:30216493. |
the aim of our study is to investigate the expression of microrna-132 (mir-132) and its effect on cardiocyte proliferation, apoptosis, and cardiac fibrosis by binding to phosphatase and tensin homolog (pten) through the phosphateidylinositol 3-kinase (pi3k)/protein kinase (akt) signal transduction pathway in dcm rats. |
2021-07-21 |
2023-08-13 |
rat |
| Chen-Jun Zhang, Yu Huang, Ji-De Lu, Jie Lin, Zhi-Ru Ge, Hui Huan. Upregulated microRNA-132 rescues cardiac fibrosis and restores cardiocyte proliferation in dilated cardiomyopathy through the phosphatase and tensin homolog-mediated PI3K/Akt signal transduction pathway. Journal of cellular biochemistry. 2021-07-21. PMID:30216493. |
rat models of dcm exhibited a lower level of mir-132, pi3k, akt, b-cell lymphoma 2, collagen i, and collagen iii, but a higher level of pten, bcl-2-associated x protein, and proliferating cell nuclear antigen as well as inflammatory response (ang ii and ald), accompanied by declined cardiocyte proliferation and elevated apoptosis and cardiac fibrosis. |
2021-07-21 |
2023-08-13 |
rat |
| Chen-Jun Zhang, Yu Huang, Ji-De Lu, Jie Lin, Zhi-Ru Ge, Hui Huan. Upregulated microRNA-132 rescues cardiac fibrosis and restores cardiocyte proliferation in dilated cardiomyopathy through the phosphatase and tensin homolog-mediated PI3K/Akt signal transduction pathway. Journal of cellular biochemistry. 2021-07-21. PMID:30216493. |
upregulated mir-132 or silenced pten activated the pi3k/akt pathway, thus facilitating cardiocyte proliferation and repressing cardiocyte apoptosis and cardiac fibrosis, as well as inflammatory responses. |
2021-07-21 |
2023-08-13 |
rat |
| Chen-Jun Zhang, Yu Huang, Ji-De Lu, Jie Lin, Zhi-Ru Ge, Hui Huan. Upregulated microRNA-132 rescues cardiac fibrosis and restores cardiocyte proliferation in dilated cardiomyopathy through the phosphatase and tensin homolog-mediated PI3K/Akt signal transduction pathway. Journal of cellular biochemistry. 2021-07-21. PMID:30216493. |
these findings indicate that mir-132 activates the pi3k/akt pathway by inhibiting pten expression, thus facilitating cardiocyte proliferation and inhibiting apoptosis and cardiac fibrosis in dcm rats. |
2021-07-21 |
2023-08-13 |
rat |
| Xiao-Heng Xu, Si-Jin Zhang, Qi-Bo Hu, Xing-Yu Song, Wei Pa. Effects of microRNA-494 on proliferation, migration, invasion, and apoptosis of medulloblastoma cells by mediating c-myc through the p38 MAPK signaling pathway. Journal of cellular biochemistry. 2021-07-21. PMID:30304554. |
in response to mir-494 mimic, mb cells were found to have increased bax and pten expressions, as well as cell number in g1 phase and cell apoptosis and decreased c-myc, p38 mapk, bcl-2, mtdh, il-6, and survivin expression and cell number count in the s phase, cell proliferation, migration, and invasion. |
2021-07-21 |
2023-08-13 |
Not clear |
| Haitao Niu, Yang Liu, Yanzhou Wang, Yong Tian, Hongsheng Jiang, Shuanzhu Cao, Ming Yang, Shaoquan L. MiR-130b can suppress proliferation of glioma cells through targeting PTEN to regulate AKT pathway. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. vol 25. issue 4. 2021-07-21. PMID:33099953. |
to study the mechanism of action of micro ribonucleic acid (mir)-130b in the proliferation and apoptosis of glioma cells, and to determine whether it regulates the target gene phosphatase and tensin homolog deleted on chromosome ten (pten). |
2021-07-21 |
2023-08-13 |
Not clear |
| Yanan Shen, Lihai Chen, Yuan Zhang, Jiayue Du, Jing Hu, Hongguang Bao, Yan Xing, Yanna S. Phosphatase and Tensin Homolog Deleted on Chromosome Ten Knockdown Attenuates Cognitive Deficits by Inhibiting Neuroinflammation in a Mouse Model of Perioperative Neurocognitive Disorder. Neuroscience. vol 468. 2021-07-21. PMID:34166762. |
surgically treated mice had increased expression of pten, ampk, bax, il-1β, and tnf-α, as well as increasing number of activated microglia and apoptosis neurons in the hippocampus. |
2021-07-21 |
2023-08-13 |
mouse |
| Anna Yu Korshunova, Mikhail L Blagonravov, Ekaterina V Neborak, Sergey P Syatkin, Anastasia P Sklifasovskaya, Said M Semyatov, Enzo Agostinell. BCL2‑regulated apoptotic process in myocardial ischemia‑reperfusion injury (Review). International journal of molecular medicine. vol 47. issue 1. 2021-07-15. PMID:33155658. |
there are several signaling pathways and compounds regulating bcl2, including pi3k/akt and mek1/erk1/2, jak2/stat3, endothelial nitric oxide synthase, pten, cardiac ankyrin repeat protein and microrna, which can serve as targets for modern methods of cardioprotective therapy inhibiting intrinsic apoptosis and saving viable cardiomyocytes after mi/ri. |
2021-07-15 |
2023-08-13 |
Not clear |
| Jianzhong Wang, Qilong Feng, Dongke Liang, Junfeng Sh. MiRNA-26a inhibits myocardial infarction-induced apoptosis by targeting PTEN via JAK/STAT pathways. Cells & development. vol 165. 2021-07-08. PMID:33993982. |
mirna-26a inhibits myocardial infarction-induced apoptosis by targeting pten via jak/stat pathways. |
2021-07-08 |
2023-08-13 |
Not clear |
| Rongrong Zhang, Haiyan Zhu, Yufang Yuan, Yun Wang, Zhaofang Tia. SPAG6 promotes cell proliferation and inhibits apoptosis through the PTEN/PI3K/AKT pathway in Burkitt lymphoma. Oncology reports. vol 44. issue 5. 2021-07-06. PMID:33000212. |
it was further ascertained whether the phosphoinositide 3‑kinase (pi3k)/pten/protein kinase b (akt) pathway mediates the effects of spag6 on cell proliferation and apoptosis, and the results demonstrated that silencing of spag6 suppressed the viability of daudi and raji cells, whereas pten knockdown using sirna or sf1670 (a specific pten inhibitor) reversed the inhibitory effect on cell proliferation and the promoting effect on cell apoptosis induced by spag6 depletion in vitro as well as in vivo. |
2021-07-06 |
2023-08-13 |
Not clear |
| Xiangjian Zhang, Yingqun Niu, Yibo Huan. Melatonin inhibits cell proliferation in a rat model of breast hyperplasia by mediating the PTEN/AKT pathway. Oncology reports. vol 45. issue 5. 2021-07-02. PMID:34184749. |
melatonin treatment led to a significant reduction in the degree of breast hyperplasia (p<0.05), a significant reduction in pcna, a significant increase in the level of apoptosis (p<0.05), a significant increase in pten (p<0.05), and a significant reduction in akt/p‑akt (p<0.05). |
2021-07-02 |
2023-08-13 |
rat |
| Ji-Bo Han, Mao-Ling Huang, Fen Li, Rui Yang, Shi-Ming Chen, Ze-Zhang Ta. MiR-214 Mediates Cell Proliferation and Apoptosis of Nasopharyngeal Carcinoma Through Targeting Both WWOX and PTEN. Cancer biotherapy & radiopharmaceuticals. vol 35. issue 8. 2021-06-28. PMID:32101017. |
mir-214 mediates cell proliferation and apoptosis of nasopharyngeal carcinoma through targeting both wwox and pten. |
2021-06-28 |
2023-08-13 |
Not clear |
| Gefei Wu, Jiasheng Hu, Hongmin Zhu, Shuhua Wu, Sheng Huang, Zhisheng Li. Treatment with melatonin ameliorates febrile convulsion via modulating the MEG3/miR‑223/PTEN/AKT signaling pathway. International journal of molecular medicine. vol 48. issue 2. 2021-06-24. PMID:34165162. |
in both cell and animal models, mrna levels of meg3 and pten increased in the apoptosis group, while treatment with mt decreased the expression levels of meg3 and pten. |
2021-06-24 |
2023-08-13 |
Not clear |