| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qinyi Wang, Junmin Wang, Hongjiao Xiang, Peilun Ding, Tao Wu, Guang J. The biochemical and clinical implications of phosphatase and tensin homolog deleted on chromosome ten in different cancers. American journal of cancer research. vol 11. issue 12. 2022-01-12. PMID:35018228. |
to a large extent, the tumor suppressive function of pten is realized through its inhibition of the pi3k/akt signaling pathway which controls cells apoptosis and development. |
2022-01-12 |
2023-08-13 |
Not clear |
| Hong Chen, Chao Zhou, Jianfeng Zheng, Zhaosi Zhang, Yongbing Deng, Chongjie Cheng, Zongduo Guo, Gang Huo, Cheng Yin, Xiaochuan Su. PTEN and AKT/GSK-3β/CRMP-2 signaling pathway are involved in neuronal apoptosis and axonal injury in early brain injury after SAH in rats. Genes & diseases. vol 9. issue 1. 2022-01-10. PMID:35005122. |
pten and akt/gsk-3β/crmp-2 signaling pathway are involved in neuronal apoptosis and axonal injury in early brain injury after sah in rats. |
2022-01-10 |
2023-08-13 |
rat |
| Hong Chen, Chao Zhou, Jianfeng Zheng, Zhaosi Zhang, Yongbing Deng, Chongjie Cheng, Zongduo Guo, Gang Huo, Cheng Yin, Xiaochuan Su. PTEN and AKT/GSK-3β/CRMP-2 signaling pathway are involved in neuronal apoptosis and axonal injury in early brain injury after SAH in rats. Genes & diseases. vol 9. issue 1. 2022-01-10. PMID:35005122. |
the purpose of this study was to investigate the effects of phosphatase and tensin homolog deleted on chromosome ten (pten) on axonal injury and neuronal apoptosis post-sah in rats and to find its underlying mechanism. |
2022-01-10 |
2023-08-13 |
rat |
| Hong Chen, Chao Zhou, Jianfeng Zheng, Zhaosi Zhang, Yongbing Deng, Chongjie Cheng, Zongduo Guo, Gang Huo, Cheng Yin, Xiaochuan Su. PTEN and AKT/GSK-3β/CRMP-2 signaling pathway are involved in neuronal apoptosis and axonal injury in early brain injury after SAH in rats. Genes & diseases. vol 9. issue 1. 2022-01-10. PMID:35005122. |
after knocking down pten, neuronal apoptosis and axonal injury were alleviated, and nerve function and blood-brain barrier were protected; accordingly, after overexpression of pten, neuronal apoptosis and axon damage were aggravated, and nerve function damage and blood-brain barrier damage were increased. |
2022-01-10 |
2023-08-13 |
rat |
| Hong Chen, Chao Zhou, Jianfeng Zheng, Zhaosi Zhang, Yongbing Deng, Chongjie Cheng, Zongduo Guo, Gang Huo, Cheng Yin, Xiaochuan Su. PTEN and AKT/GSK-3β/CRMP-2 signaling pathway are involved in neuronal apoptosis and axonal injury in early brain injury after SAH in rats. Genes & diseases. vol 9. issue 1. 2022-01-10. PMID:35005122. |
pten and akt/gsk-3β/crmp-2 pathway were jointly involved in regulating neuronal apoptosis and wm axon injury after sah. |
2022-01-10 |
2023-08-13 |
rat |
| Hong Chen, Chao Zhou, Jianfeng Zheng, Zhaosi Zhang, Yongbing Deng, Chongjie Cheng, Zongduo Guo, Gang Huo, Cheng Yin, Xiaochuan Su. PTEN and AKT/GSK-3β/CRMP-2 signaling pathway are involved in neuronal apoptosis and axonal injury in early brain injury after SAH in rats. Genes & diseases. vol 9. issue 1. 2022-01-10. PMID:35005122. |
according to our research, pten was a negative factor of ebi, and together with the akt/gsk-3β/crmp-2 signaling pathway aggravates neuronal apoptosis and wm axon damage after sah. |
2022-01-10 |
2023-08-13 |
rat |
| Jianzhong Ai, Jia Li, Qin Su, Hong Ma, Qiang Wei, Hong Li, Guangping Ga. rAAV-delivered PTEN therapeutics for prostate cancer. Molecular therapy. Nucleic acids. vol 27. 2022-01-03. PMID:34976432. |
the effect of pten on pca cell migration, apoptosis, and the cell cycle was analyzed |
2022-01-03 |
2023-08-13 |
mouse |
| Ke Li, Xujie Ya, Xiujuan Duan, Yang Li, Xuefeng Li. miRNA-19b-3p Stimulates Cardiomyocyte Apoptosis Induced by Myocardial Ischemia Reperfusion via Downregulating PTEN. Disease markers. vol 2021. 2021-12-27. PMID:34956421. |
mirna-19b-3p stimulates cardiomyocyte apoptosis induced by myocardial ischemia reperfusion via downregulating pten. |
2021-12-27 |
2023-08-13 |
Not clear |
| Ke Li, Xujie Ya, Xiujuan Duan, Yang Li, Xuefeng Li. miRNA-19b-3p Stimulates Cardiomyocyte Apoptosis Induced by Myocardial Ischemia Reperfusion via Downregulating PTEN. Disease markers. vol 2021. 2021-12-27. PMID:34956421. |
to clarify the function of mirna-19b-3p in accelerating myocardial ischemia-reperfusion injury- (miri-) induced cardiomyocyte apoptosis by downregulating gene of phosphate and tension homology deleted on chromsome ten (pten), thus influencing the progression of acute myocardial infarction. |
2021-12-27 |
2023-08-13 |
Not clear |
| Alveiro Erira, Fernando Velandia, José Penagos, Camilo Zubieta, Gonzalo Arboled. Differential Regulation of the EGFR/PI3K/AKT/PTEN Pathway between Low- and High-Grade Gliomas. Brain sciences. vol 11. issue 12. 2021-12-24. PMID:34942957. |
the permanent activation of the egfr/pi3k/akt pathway by various genetic or post-translational alterations of egfr, pi3kca, and pten has been associated with increased proliferation and resistance to apoptosis. |
2021-12-24 |
2023-08-13 |
Not clear |
| Bing Lu, Hong Lv, Zhiqiang Yang, Jun Shu, Hao Zhan. LncRNA PCAT29 Up-Regulates the Expression of PTEN by Down-Regulating miR-494 in Non-Small-Cell Lung Cancer to Suppress Tumor Progression. Critical reviews in eukaryotic gene expression. vol 31. issue 6. 2021-12-22. PMID:34936288. |
cell apoptosis and proliferation analyses were formed to study the effects of overexpression of pcat29, mir-494, and pten on apoptosis and proliferation of h23 cells. |
2021-12-22 |
2023-08-13 |
Not clear |
| RongXin Xiao, Hong Wang, Biao Yan. MicroRNA-98-5p modulates cervical cancer progression via controlling PI3K/AKT pathway. Bioengineered. vol 12. issue 2. 2021-12-13. PMID:34895048. |
reverse transcription quantitative polymerase chain reaction was applied to detect mir-98-5p expression in cc tissues and cell lines; cell counting kit-8 and edu analysis were performed for checking cell proliferation, flow cytometry for cell apoptosis, transwell for cell invasion and migration, western blot for proliferation-related proteins ki67 and proliferating cell nuclear antigen expression, apoptosis-related proteins bcl-2 and bax expression, epithelial-mesenchymal transition (emt)-related proteins snail, matrix metalloproteinase-3, e-cadherin and n-cadherin expression, as well as pi3k/akt pathway-related proteins pten, pi3k as well as akt expression levels, and the nude mouse tumor xenograft experiment was applied to verify |
2021-12-13 |
2023-08-13 |
mouse |
| Rehab E Abdelrahman, Abdel Azeim A Khalaf, Mohamed A Elhady, Marwa A Ibrahim, Eman I Hassanen, Peter A Nosh. Quercetin ameliorates ochratoxin A-Induced immunotoxicity in broiler chickens by modulation of PI3K/AKT pathway. Chemico-biological interactions. vol 351. 2021-12-10. PMID:34717913. |
in addition, administration of ota resulted in apoptosis, which was evident by the increased expression level of pten, bax and caspase-3 genes and decreased expression level of pi3k, akt and bcl-2 genes. |
2021-12-10 |
2023-08-13 |
cat |
| Congjin Guan, Liyi Luan, Ji Li, Lei Yan. MiR-212-3p improves rat functional recovery and inhibits neurocyte apoptosis in spinal cord injury models via PTEN downregulation-mediated activation of AKT/mTOR pathway. Brain research. vol 1768. 2021-12-09. PMID:34216580. |
mir-212-3p improves rat functional recovery and inhibits neurocyte apoptosis in spinal cord injury models via pten downregulation-mediated activation of akt/mtor pathway. |
2021-12-09 |
2023-08-13 |
rat |
| Yonghua Liu, Bingmu Fang, Xiaoning Feng, Yu Jiang, Yuxiao Zeng, Jinhong Jian. Mechanism of IDH1-R132H mutation in T cell acute lymphoblastic leukemia mouse model via the Notch1 pathway. Tissue & cell. vol 74. 2021-12-09. PMID:34814054. |
cell proliferation, apoptosis, and invasion were evaluated after the intervention of notch1, pten, or pi3k expression. |
2021-12-09 |
2023-08-13 |
mouse |
| Jinhua Yan, Ling Yao, Ping Li, Guohe Wu, Xiaobin L. Long non-coding RNA MIR17HG sponges microRNA-21 to upregulate PTEN and regulate homoharringtonine-based chemoresistance of acute myeloid leukemia cells. Oncology letters. vol 23. issue 1. 2021-12-07. PMID:34868361. |
furthermore, cell apoptosis showed that mir17hg and pten overexpression enhanced cell apoptosis following cell treatment with htt. |
2021-12-07 |
2023-08-13 |
Not clear |
| Jinhua Yan, Ling Yao, Ping Li, Guohe Wu, Xiaobin L. Long non-coding RNA MIR17HG sponges microRNA-21 to upregulate PTEN and regulate homoharringtonine-based chemoresistance of acute myeloid leukemia cells. Oncology letters. vol 23. issue 1. 2021-12-07. PMID:34868361. |
however, mir-21 overexpression exerted the opposite effect, since it reversed the effects of mir17hg and pten overexpression in aml cell apoptosis. |
2021-12-07 |
2023-08-13 |
Not clear |
| Jia Chen, Mingyang Wang, Hanli Wang, Miao Lon. Zearalenone promotes apoptosis of mouse Leydig cells by targeting phosphatase and tensin homolog and thus inhibiting the PI3K/AKT signal pathway. Environmental science and pollution research international. vol 28. issue 47. 2021-12-06. PMID:34264493. |
an adenovirus vector model was constructed to interfere with the pten gene to investigate whether zea promotes the apoptosis of tm3 cells through the pi3k/akt pathway. |
2021-12-06 |
2023-08-13 |
mouse |
| Jia Chen, Mingyang Wang, Hanli Wang, Miao Lon. Zearalenone promotes apoptosis of mouse Leydig cells by targeting phosphatase and tensin homolog and thus inhibiting the PI3K/AKT signal pathway. Environmental science and pollution research international. vol 28. issue 47. 2021-12-06. PMID:34264493. |
apoptosis was detected cytometrically and the protein expression levels of pten, akt, p-akt, bax, and bcl-2 were evaluated via western blot analysis. |
2021-12-06 |
2023-08-13 |
mouse |
| Jia Chen, Mingyang Wang, Hanli Wang, Miao Lon. Zearalenone promotes apoptosis of mouse Leydig cells by targeting phosphatase and tensin homolog and thus inhibiting the PI3K/AKT signal pathway. Environmental science and pollution research international. vol 28. issue 47. 2021-12-06. PMID:34264493. |
this study thus demonstrates that zea promotes apoptosis of tm3 cells by targeting pten and thus inhibiting the pi3k/akt signal pathway. |
2021-12-06 |
2023-08-13 |
mouse |