| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Muzi Zhang, Yuwen Fan, Haibo Jiang, Jian Shao, Ming L. Establishment of hyperammonemia mode in yellow catfish and the mitigation of exogenous L-ornithine-L-aspartate. Developmental and comparative immunology. 2022-07-08. PMID:35803415. |
the results showed that ammonia poisoning could induce serum ammonia content elevated, liver damage (serum aminotransferase activity elevated and liver malondialdehyde accumulation), and up-regulation of cytokine (il 1, il 8 and tnfɑ), apoptosis (p53, bax, cytochrome c, caspase 3 and caspase 9) and autophagy (dynein, beclin 1, akt and pten) genes transcription, but lola could mitigate the adverse effect of ammonia poisoning. |
2022-07-08 |
2023-08-14 |
Not clear |
| Tomasz Wenta, Anette Schmidt, Qin Zhang, Raman Devarajan, Prateek Singh, Xiayun Yang, Anne Ahtikoski, Markku Vaarala, Gong-Hong Wei, Aki Mannine. Disassembly of α6β4-mediated hemidesmosomal adhesions promotes tumorigenesis in PTEN-negative prostate cancer by targeting plectin to focal adhesions. Oncogene. 2022-06-30. PMID:35773413. |
using an extensive crispr/cas9-mediated genetic engineering approaches in different prostate cancer cell lines combined with in vivo tumorigenesis studies in mice, bone marrow-on-chip assays and bioinformatics, as well as histological analysis of prostate cancer patient cohorts, we demonstrated that simultaneous loss of pten and hemidesmosomal adhesions induced several tumorigenic properties including proliferation, migration, resistance to anoikis, apoptosis, and drug treatment in vitro, and increased metastatic capacity in vivo. |
2022-06-30 |
2023-08-14 |
mouse |
| Lin Zhang, Bin Li, Wei Li, Jingbo Jiang, Wei Chen, Huayun Yang, Diguang Pa. miR-107 attenuates sepsis-induced myocardial injury by targeting PTEN and activating the PI3K/AKT signaling pathway. Cells, tissues, organs. 2022-06-19. PMID:35717938. |
pten overexpression partially reversed the inhibition of mir-107 mimic on cardiomyocyte apoptosis. |
2022-06-19 |
2023-08-14 |
rat |
| Lin Zhang, Bin Li, Wei Li, Jingbo Jiang, Wei Chen, Huayun Yang, Diguang Pa. miR-107 attenuates sepsis-induced myocardial injury by targeting PTEN and activating the PI3K/AKT signaling pathway. Cells, tissues, organs. 2022-06-19. PMID:35717938. |
to conclude, mir-107 activates the pi3k/akt pathway by inhibiting pten, thus attenuating sepsis-induced myocardial injury and lps-induced cardiomyocyte apoptosis. |
2022-06-19 |
2023-08-14 |
rat |
| Qikai Zhang, Zongsi Zhu, Jiaqiang Guan, Yingying Hu, Wenjin Zhou, Wanchun Ye, Bijing Lin, Shanshan Weng, Yuemiao Chen, Cuiping Zhen. Hes1 Controls Proliferation and Apoptosis in Chronic Lymphoblastic Leukemia Cells by Modulating PTEN Expression. Molecular biotechnology. 2022-06-15. PMID:35704163. |
hes1 controls proliferation and apoptosis in chronic lymphoblastic leukemia cells by modulating pten expression. |
2022-06-15 |
2023-08-14 |
Not clear |
| Qikai Zhang, Zongsi Zhu, Jiaqiang Guan, Yingying Hu, Wenjin Zhou, Wanchun Ye, Bijing Lin, Shanshan Weng, Yuemiao Chen, Cuiping Zhen. Hes1 Controls Proliferation and Apoptosis in Chronic Lymphoblastic Leukemia Cells by Modulating PTEN Expression. Molecular biotechnology. 2022-06-15. PMID:35704163. |
collectively, hes1 can promote activation of the notch1 signaling pathway to cause pten transcription inhibition and the subsequent expression reduction, thereby promoting the proliferation and inhibiting the apoptosis of cll cells. |
2022-06-15 |
2023-08-14 |
Not clear |
| Liang Chen, Liu Cao, Mengsi Zhan, Jin Li, Dayuan Wang, Régis Laurent, Serge Mignani, Anne-Marie Caminade, Jean-Pierre Majoral, Xiangyang Sh. Engineered Stable Bioactive Per Se Amphiphilic Phosphorus Dendron Nanomicelles as a Highly Efficient Drug Delivery System To Take Down Breast Cancer In Vivo. Biomacromolecules. 2022-06-13. PMID:35694854. |
strikingly, we show that the drug-free micelles possess good intrinsic anticancer activity and act collectively with dox to take down breast cancer cells in vitro and the xenografted tumor model in vivo through upregulation of bax, pten, and p53 proteins for enhanced cell apoptosis. |
2022-06-13 |
2023-08-14 |
Not clear |
| Gang Yan, Zhangcai Wan, Yechao Zhong, Manling Che. LncRNA MCM3AP-AS1 Regulates miR-21/PTEN Axis to Affect Cervical Squamous Cell Carcinoma Cell Proliferation and Apoptosis. Critical reviews in eukaryotic gene expression. vol 32. issue 4. 2022-06-13. PMID:35695665. |
cck-8 cell proliferation analysis and cell apoptosis analysis were applied to study the roles of mcm3ap-as1, mir-21, and pten in regulating cell proliferation and apoptosis in cscc. |
2022-06-13 |
2023-08-14 |
human |
| Gang Yan, Zhangcai Wan, Yechao Zhong, Manling Che. LncRNA MCM3AP-AS1 Regulates miR-21/PTEN Axis to Affect Cervical Squamous Cell Carcinoma Cell Proliferation and Apoptosis. Critical reviews in eukaryotic gene expression. vol 32. issue 4. 2022-06-13. PMID:35695665. |
cell proliferation and apoptosis analysis showed that mcm3ap-as1 and pten overexpression increased apoptosis but decreased proliferation of cscc cells. |
2022-06-13 |
2023-08-14 |
human |
| Yihan Fu, Hong Su. The molecular mechanism of circRHOBTB3 inhibits the proliferation and invasion of epithelial ovarian cancer by serving as the ceRNA of miR-23a-3p. Journal of ovarian research. vol 15. issue 1. 2022-06-01. PMID:35650643. |
furthermore, it revealed that circrhobtb3 could serve as the cerna of mir‑23a-3p to facilitate pten expression, suppress proliferation, g1/s transition, invasion, and promote apoptosis in eoc. |
2022-06-01 |
2023-08-13 |
Not clear |
| Xue Qi, Zeheng Ren, Yuan Cui, Jinxi Zhang, Yue Zhang, Shengchen Wang, Hongjin Li. Cadmium induces apoptosis by miR-9-5p targeting PTEN and regulates the PI3K/AKT pathway in the piglet adrenal gland. Environmental science and pollution research international. 2022-05-26. PMID:35616841. |
cadmium induces apoptosis by mir-9-5p targeting pten and regulates the pi3k/akt pathway in the piglet adrenal gland. |
2022-05-26 |
2023-08-13 |
Not clear |
| Chunxia Li, Lihui Zhang, Xingpeng Bu, Guofang Chu, Xiaofang Zhao, Yaru Li. LncRNA NORAD promotes the progression of myocardial infarction by targeting the miR-22-3p/PTEN axis. Acta biochimica et biophysica Sinica. vol 54. issue 4. 2022-05-24. PMID:35607965. |
overexpression of mir-22-3p inhibits h/r-induced cell apoptosis and reduces ldh and mda levels, while its effects are abolished by overexpression of pten. |
2022-05-24 |
2023-08-13 |
mouse |
| Qianying Yang, Sha Lv, Huirong Zhu, Liming Zhang, Hua Li, Shengfang Son. A Potential Research Target for Scleral Remodeling: Effect of MiR-29a on Scleral Fibroblasts. Ophthalmic research. 2022-05-23. PMID:35605595. |
the purpose of this study was to determine whether mir-29a rugulates cell survival and apoptosis and the expression of pten, mmp-2, and collagen i on scleral fibroblasts. |
2022-05-23 |
2023-08-13 |
Not clear |
| Shiyong Ling, Xi Luo, Bo Lv, Hua Wang, Mengzhi Xie, Kai Huang, Jingchuan Su. Effect of miR-144-3p-Targeted Regulation of PTEN on Proliferation, Apoptosis, and Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells under Stretch. Emergency medicine international. vol 2022. 2022-05-20. PMID:35592654. |
effect of mir-144-3p-targeted regulation of pten on proliferation, apoptosis, and osteogenic differentiation of bone marrow mesenchymal stem cells under stretch. |
2022-05-20 |
2023-08-13 |
Not clear |
| Shiyong Ling, Xi Luo, Bo Lv, Hua Wang, Mengzhi Xie, Kai Huang, Jingchuan Su. Effect of miR-144-3p-Targeted Regulation of PTEN on Proliferation, Apoptosis, and Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells under Stretch. Emergency medicine international. vol 2022. 2022-05-20. PMID:35592654. |
to investigate the effects of mir-144-3p-targeted regulation of phosphatase and tensin homolog deleted on chromosome ten (pten) gene on proliferation, apoptosis, and osteogenic differentiation of bone marrow mesenchymal stem cells (bmscs) under retraction force. |
2022-05-20 |
2023-08-13 |
Not clear |
| Zohreh Mirzapour Abbas Abadi, Fatemeh Samiee Rad, Dariush Hamedi Asl, Babak Rahmani, Mahmood Soleimani Dodaran, Amir Peiman. Clinicopathological Significance of PTEN Expression and Its Prognostic Effect in Colorectal Adenocarcinoma Patients. Iranian journal of pathology. vol 17. issue 2. 2022-04-25. PMID:35463728. |
pten is a regulator of the pi3k/akt signaling pathway that inhibits cell proliferation and promotes apoptosis. |
2022-04-25 |
2023-08-13 |
Not clear |
| Hongmei Zhao, Lian Shi, Xiaohong Wang, Xiuli Yu, Danfeng Wan. Sp1 transcription factor represses transcription of phosphatase and tensin homolog to aggravate lung injury in mice with type 2 diabetes mellitus-pulmonary tuberculosis. Bioengineered. vol 13. issue 4. 2022-04-14. PMID:35420971. |
overexpression of pten improved mouse survival and reduced bacterial load, inflammatory infiltration, cell apoptosis, and fibrosis in lung tissues. |
2022-04-14 |
2023-08-13 |
mouse |
| Shuyan Sheng, Wenzhuo Su, Deshen Mao, Conghan Li, Xinyang Hu, Wanyu Deng, Yong Yao, Yongsheng J. MicroRNA-21 induces cisplatin resistance in head and neck squamous cell carcinoma. PloS one. vol 17. issue 4. 2022-04-14. PMID:35421166. |
in both the umscc-1 and upci-4b cell lines, the mir-21 mimic enhanced cell proliferation with reduced apoptosis and increased viability, whereas the mir-21 inhibitor resulted in the opposite effects (all p<0.001); additionally, mir-21 directly targeted the tumour suppressor phosphatase and tensin homologue (pten) and inhibited pten expression. |
2022-04-14 |
2023-08-13 |
Not clear |
| Shuyan Sheng, Wenzhuo Su, Deshen Mao, Conghan Li, Xinyang Hu, Wanyu Deng, Yong Yao, Yongsheng J. MicroRNA-21 induces cisplatin resistance in head and neck squamous cell carcinoma. PloS one. vol 17. issue 4. 2022-04-14. PMID:35421166. |
overexpression of mir-21 can enhance cell proliferation, reduce apoptosis, and induce drug resistance by inhibiting pten expression. |
2022-04-14 |
2023-08-13 |
Not clear |
| Christopher J Unterberger, Vilena I Maklakova, Michelle Lazar, Paige D Arneson, Sean J Mcilwain, Philippos K Tsourkas, Rong Hu, John J Kopchick, Steven M Swanson, Paul C Marke. GH action in prostate cancer cells promotes proliferation limits apoptosis and regulates cancer-related gene expression. Endocrinology. 2022-04-06. PMID:35383352. |
when pten mutant cells were grown as xenografts in mice, pegvisomant treatment dramatically reduced xenograft size, and this was accompanied by decreased proliferation and increased apoptosis. |
2022-04-06 |
2023-08-13 |
mouse |