| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhi Zhou, Xiaopo Zhang, Guohui Yi, Yong Zhang, Juan Zhang, Can Tan, Bangbei Wan, Yejuan Li, Hui Lu, Weiying L. LINC00092 derived from follicular fluid alleviated the symptoms of PCOS through inactivation of phosphatase and tensin homolog by recruiting KDM5A. Reproductive biology. vol 23. issue 2. 2023-04-21. PMID:37084543. |
taken together, ff-evs delivered linc00092 repressed the transcriptional activity of pten by binding to kdm5a to enhance demethylation of h3k4me3, thereby reducing apoptosis in ovarian cells and alleviating pcos symptoms. |
2023-04-21 |
2023-08-14 |
rat |
| Hong-Beom Park, Yosuk Min, Sohyun Hwang, Kwang-Hyun Bae. Suppression of USP7 negatively regulates the stability of ETS proto-oncogene 2 protein. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 162. 2023-04-16. PMID:37062218. |
moreover, it also known that usp7 functions in the cell cycle, apoptosis, dna repair, chromatin remodeling, and epigenetic regulation through deubiquitination of several substrates including p53, mouse double minute 2 homolog (mdm2), myc, and phosphatase and tensin homolog (pten). |
2023-04-16 |
2023-08-14 |
mouse |
| Shantanu Gupta, Pritam Kumar Panda, Daner A Silveira, Rajeev Ahuja, Ronaldo F Hashimot. Quadra-Stable Dynamics of p53 and PTEN in the DNA Damage Response. Cells. vol 12. issue 7. 2023-04-13. PMID:37048159. |
our network's wild-type system shows that ddr activates the g2/m checkpoint, and this triggers a cascade of events, involving p53 and pten, that ultimately lead to the four potential phenotypes: cell cycle arrest, senescence, autophagy, and apoptosis (quadra-stable dynamics). |
2023-04-13 |
2023-08-14 |
Not clear |
| Yu Fu, Yangyue Fang, Shuai Gong, Tao Xue, Peng Wang, Li She, Jianping Huan. Deep learning-based network pharmacology for exploring the mechanism of licorice for the treatment of COVID-19. Scientific reports. vol 13. issue 1. 2023-04-10. PMID:37037848. |
overall, in this study, glabrone and vestitol from licorice were found to inhibit viral replication by inhibiting the activation of mpro, s-protein and ace2; related compounds in licorice may reduce the inflammatory response and inhibit apoptosis by acting on pten and map3k8. |
2023-04-10 |
2023-08-14 |
Not clear |
| Miao Song, Jian Zhang, Siming Huo, Xuliang Zhang, Yilong Cui, Yanfei L. Mitophagy alleviates AIF-mediated spleen apoptosis induced by AlCl Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-04-07. PMID:37028746. |
phosphatase and tensin homolog (pten)-induced putative kinase1 (pink1)/e3 ubiquitin ligase park2 (parkin)-mediated mitophagy maintains mitochondrial homeostasis by removing damaged mitochondria, but its function in aif-mediated spleen apoptosis induced by al is not clear. |
2023-04-07 |
2023-08-14 |
Not clear |
| Xingang Cui, Xiaoyang Liu, Peng Kong, Ting Du, Tao Li, Guihe Yang, Weimin Zhang, Xingzhi Jing, Wenchao Wan. PTEN inhibitor VO-OHpic protects endplate chondrocytes against apoptosis and calcification via activating Nrf-2 signaling pathway. Aging. vol 15. 2023-03-27. PMID:36971687. |
pten inhibitor vo-ohpic protects endplate chondrocytes against apoptosis and calcification via activating nrf-2 signaling pathway. |
2023-03-27 |
2023-08-14 |
Not clear |
| Xingang Cui, Xiaoyang Liu, Peng Kong, Ting Du, Tao Li, Guihe Yang, Weimin Zhang, Xingzhi Jing, Wenchao Wan. PTEN inhibitor VO-OHpic protects endplate chondrocytes against apoptosis and calcification via activating Nrf-2 signaling pathway. Aging. vol 15. 2023-03-27. PMID:36971687. |
phosphatase and tensin homolog (pten) is a tumor suppressor gene that promotes cell apoptosis, and recent studies indicated that pten is overexpressed in degenerated intervertebral disc. |
2023-03-27 |
2023-08-14 |
Not clear |
| Ayushi Srivastava, Dinender K Singl. PTEN-AKT pathway attenuates apoptosis and adverse remodeling in ponatinib-induced skeletal muscle toxicity following BMP-7 treatment. Physiological reports. vol 11. issue 6. 2023-03-22. PMID:36945866. |
furthermore, bmp-7 treatment significantly (p < 0.05) attenuated ponatinib-induced apoptosis, bax/bcl2 ratio, decreased pten, and increased cell survival protein akt, decreased adverse muscle remodeling, and improved muscle function. |
2023-03-22 |
2023-08-14 |
mouse |
| Yan Jiang, Xiahao Zhao, Jin Chen, Stanley Aniagu, Tao Che. PM2.5 induces cardiac malformations via PI3K/akt2/mTORC1 signaling pathway in zebrafish larvae. Environmental pollution (Barking, Essex : 1987). 2023-02-22. PMID:36804889. |
in conclusion, our results indicate that pm2.5 activates pi3k/akt2/mtorc1 signaling via ahr/ros-induced pten suppression, which leads to mitochondrial-mediated intrinsic apoptosis and wnt signaling suppression, resulting in cardiac defects in zebrafish larvae. |
2023-02-22 |
2023-08-14 |
zebrafish |
| Fangmin Xie, Yuanyuan Cheng, Xin Gao, Sixin Song, Xu Zhao, Xianbing Meng, Zhende Shang, Mingfeng Yan. CircRNA circ_POLA2 overexpression suppresses cell apoptosis by downregulating PTEN in glioblastoma. Anti-cancer drugs. 2023-02-02. PMID:36730613. |
circrna circ_pola2 overexpression suppresses cell apoptosis by downregulating pten in glioblastoma. |
2023-02-02 |
2023-08-14 |
Not clear |
| Fangmin Xie, Yuanyuan Cheng, Xin Gao, Sixin Song, Xu Zhao, Xianbing Meng, Zhende Shang, Mingfeng Yan. CircRNA circ_POLA2 overexpression suppresses cell apoptosis by downregulating PTEN in glioblastoma. Anti-cancer drugs. 2023-02-02. PMID:36730613. |
the roles of circ_pola2 and pten in regulating gbm cell apoptosis were explored using cell apoptosis assay. |
2023-02-02 |
2023-08-14 |
Not clear |
| Fangmin Xie, Yuanyuan Cheng, Xin Gao, Sixin Song, Xu Zhao, Xianbing Meng, Zhende Shang, Mingfeng Yan. CircRNA circ_POLA2 overexpression suppresses cell apoptosis by downregulating PTEN in glioblastoma. Anti-cancer drugs. 2023-02-02. PMID:36730613. |
moreover, pten reduced the inhibitory effects of circ_pola2 on gbm cell apoptosis. |
2023-02-02 |
2023-08-14 |
Not clear |
| Fangmin Xie, Yuanyuan Cheng, Xin Gao, Sixin Song, Xu Zhao, Xianbing Meng, Zhende Shang, Mingfeng Yan. CircRNA circ_POLA2 overexpression suppresses cell apoptosis by downregulating PTEN in glioblastoma. Anti-cancer drugs. 2023-02-02. PMID:36730613. |
circ_pola2 is overexpressed in mcl and might promote gbm cell apoptosis through downregulating pten. |
2023-02-02 |
2023-08-14 |
Not clear |
| Hui Wang, HaiTang Re. Circular RNA SMARCA5 Modulates Epithelial-Mesenchymal Transformation, Proliferation, and Metastasis of Nasopharyngeal Carcinoma Cells via microRNA-582-3p/Phosphatase and Tensin Homolog Axis. Evidence-based complementary and alternative medicine : eCAM. vol 2023. 2023-01-23. PMID:36686977. |
the action mechanism in which circular rna (circ) smarca5 targeted nasopharyngeal carcinoma (npc) cell proliferation, migration, invasion, and apoptosis via microrna (mir)-582-3p/phosphatase and tensin homolog (pten) axis was explored. |
2023-01-23 |
2023-08-14 |
Not clear |
| Peyman Amini, Reza Moazamiyanfar, Mohammad Sedigh Dakkali, Emad Jafarzadeh, Maryam Ganjizadeh, Nima Rastegar-Pouyani, Kave Mouludi, Ehsan Khodamoradi, Shahram Taeb, Masoud Najaf. Induction of Cancer Cell Death by Apigenin: A Review on Different Cell Death Pathways. Mini reviews in medicinal chemistry. 2023-01-20. PMID:36658710. |
it seems that apigenin enhances apoptosis by inducing anticancer immunity and tumor suppressor genes, like p53 and pten, and also by inhibiting stat3 and nf-κb signaling pathways. |
2023-01-20 |
2023-08-14 |
Not clear |
| Buket Altinok Gunes, Yalda Hekmatshoar, Tulin Ozkan, Sureyya Bozkurt, O Sena Erdogan Aydos, Yahya Buyukasik, Elifcan Aladag, Asuman Sungurogl. Downregulation of Stearoyl-CoA Desaturase 1 (SCD-1) Promotes Resistance to Imatinib in Chronic Myeloid Leukemia. Mediterranean journal of hematology and infectious diseases. vol 15. issue 1. 2023-01-20. PMID:36660357. |
moreover, we analyzed the mrna expression levels of genes responsible for apoptosis, such as bcl-2, p53, and other genes (scd-1, pten). |
2023-01-20 |
2023-08-14 |
Not clear |
| Yueli Zhang, Xinchun Wang, Shuyun Wang, Jia Liu, Ruijia Li, Xiaoxia Li, Rui Zhan. Circ-ERBB2 knockdown sensitized colorectal cancer cells to 5-FU via miR-181a-5p/PTEN/Akt pathway. Journal of biochemical and molecular toxicology. 2023-01-14. PMID:36639866. |
in addition, phosphatase and tensin homolog (pten) was verified as mir-181a-5p's downstream target, circ-erbb2 activates the akt pathway and inhibits cell apoptosis through modulating mir-181a-5p/pten. |
2023-01-14 |
2023-08-14 |
Not clear |
| b' H Gbelcov\\xc3\\xa1, L Gergely, V \\xc5\\xa0i\\xc5\\xa1ovsk\\xc3\\xbd, \\xc4\\xbd Straka, D B\\xc3\\xb6hmer, A Pastor\\xc3\\xa1kov\\xc3\\xa1, K Su\\xc5\\xa1ienkov\\xc3\\xa1, V Repisk\\xc3\\xa1, M Korbe\\xc4\\xbe, \\xc4\\xbd Danihel, P Pri\\xc5\\xa1\\xc4\\x8d\\xc3\\xa1kov\\xc3\\xa. PTEN mutations as predictive marker for the high-grade endometrial cancer development in slovak women. Physiological research. vol 71. issue Suppl 1. 2023-01-02. PMID:36592448.' |
pten encodes a phosphatase, a key regulatory enzyme involved in a signal transduction pathway that regulates cell growth, migration and apoptosis. |
2023-01-02 |
2023-08-14 |
human |
| Bei Yu, Yuan Huang, Yue Yang, Haifeng Hu, Jin Yan. Effect of CTP-mediated PTEN on 5637 bladder cancer cells and the underlying molecular mechanism. BMC urology. vol 22. issue 1. 2022-12-10. PMID:36496361. |
the aim of the present study was to explore the effect of cytoplasmic transduction peptide (ctp)-phosphatase and tensin homolog (pten) on the proliferation, cell cycle, apoptosis, migration and invasion of bladder cancer cells and the underlying molecular mechanism. |
2022-12-10 |
2023-08-14 |
Not clear |
| Fatemeh Yarmohammadi, Zainab Ebrahimian, Gholamreza Karim. MicroRNAs target the PI3K/Akt/p53 and the Sirt1/Nrf2 signaling pathways in doxorubicin-induced cardiotoxicity. Journal of biochemical and molecular toxicology. 2022-11-23. PMID:36416353. |
studies have demonstrated that mirnas by modifying the expression of proteins such as pten, akt, and survivin can affect dox-induced cardiac apoptosis. |
2022-11-23 |
2023-08-14 |
Not clear |