| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhong-Zhao Zhang, Chang-Hui Wen, Min Jia, Hong-Qiang Zhang, Shao-Qin Su. Alkannin exerts antitumor properties in cutaneous squamous cell carcinoma by inducing apoptosis and shifting the M1/M2 polarization of tumor-associated macrophages by upregulating PTEN. The Kaohsiung journal of medical sciences. 2022-11-11. PMID:36367154. |
alkannin exerts antitumor properties in cutaneous squamous cell carcinoma by inducing apoptosis and shifting the m1/m2 polarization of tumor-associated macrophages by upregulating pten. |
2022-11-11 |
2023-08-14 |
mouse |
| Zhong-Zhao Zhang, Chang-Hui Wen, Min Jia, Hong-Qiang Zhang, Shao-Qin Su. Alkannin exerts antitumor properties in cutaneous squamous cell carcinoma by inducing apoptosis and shifting the M1/M2 polarization of tumor-associated macrophages by upregulating PTEN. The Kaohsiung journal of medical sciences. 2022-11-11. PMID:36367154. |
downregulation of pten reversed the effects of alkannin on apoptosis of cscc cells and m1/m2 polarization of macrophages. |
2022-11-11 |
2023-08-14 |
mouse |
| Zhong-Zhao Zhang, Chang-Hui Wen, Min Jia, Hong-Qiang Zhang, Shao-Qin Su. Alkannin exerts antitumor properties in cutaneous squamous cell carcinoma by inducing apoptosis and shifting the M1/M2 polarization of tumor-associated macrophages by upregulating PTEN. The Kaohsiung journal of medical sciences. 2022-11-11. PMID:36367154. |
in conclusion, alkannin curbed the advancement of cscc by expediting apoptosis and facilitating m1 polarization of macrophages by upregulating pten. |
2022-11-11 |
2023-08-14 |
mouse |
| Mahtab Yadollahi-Farsani, Zeinab Amini-Farsani, Fatemeh Moayedi, Niusha Khazaei, Hajar Yaghoob. MiR-548k suppresses apoptosis in breast cancer cells by affecting PTEN/PI3K/AKT signaling pathway. IUBMB life. 2022-10-30. PMID:36309967. |
in brief, suppression of pten partly mediated by mir-548k diminished apoptosis and promoted cell proliferation through pi3k/akt pathway in breast cancer, suggesting a novel therapeutic axis, mir-548k/pten/ pi3k/akt, for treatment of breast cancer in the future. |
2022-10-30 |
2023-08-14 |
Not clear |
| Yuan Cheng, Qing He, Na Li, Mengdi Lu. Activation of PTEN/P13K/AKT Signaling Pathway by miRNA-124-3p-Loaded Nanoparticles to Regulate Oxidative Stress Attenuates Cardiomyocyte Regulation and Myocardial Injury. Oxidative medicine and cellular longevity. vol 2022. 2022-10-21. PMID:36267811. |
the expression of cleaved caspase 3 and the apoptosis rate in the nano-mir-124-3p and pten cotransfection group was also significantly increased. |
2022-10-21 |
2023-08-14 |
rat |
| Xiaohong Li, Peng An, Fang Han, Meihong Yu, Zhenfei Yu, Ying L. Silencing of YTHDF1 Attenuates Cerebral Stroke by Inducing PTEN Degradation and Activating the PTEN/AKT/mTOR Pathway. Molecular biotechnology. 2022-10-19. PMID:36261761. |
overexpressing pten rescued the effects of ythdf1 depletion on cell viability and apoptosis. |
2022-10-19 |
2023-08-14 |
mouse |
| Maheshkumar Kannan, Sridharan Jayamohan, Rajesh Kannan Moorthy, Siva Chander Chabattula, Mathan Ganeshan, Antony Joseph Velanganni Arockia. Dysregulation of miRISC Regulatory Network Promotes Hepatocellular Carcinoma by Targeting PI3K/Akt Signaling Pathway. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232606. |
the mir-221/aeg-1 axis silencing induces apoptosis and g2/m phase arrest and inhibits cellular proliferation and angiogenesis by upregulating p57, p53, rb, and pten and downregulating lsf, lc3a, bcl-2, opn, mmp9, pi3k, and akt in hcc cells. |
2022-10-14 |
2023-08-14 |
Not clear |
| Sara Julietta Lozano-Herrera, Gabriel Luna-Bárcenas, Ramón Gerardo Guevara-González, Rocio Campos-Vega, Juan Carlos Solís-Sáinz, Ana Gabriela Hernández-Puga, Haydé Azeneth Vergara-Castañed. Fermentation Extract of Naringenin Increases the Expression of Estrogenic Receptor β and Modulates Genes Related to the p53 Signalling Pathway, miR-200c and miR-141 in Human Colon Cancer Cells Exposed to BPA. Molecules (Basel, Switzerland). vol 27. issue 19. 2022-10-14. PMID:36235125. |
as an important result, naringenin (ic50 250 µm) and fen (ic50 37%) promoted intrinsic pathways of apoptosis through phosphatase and tensin homolog (pten) (+2.70, +1.72-fold, respectively) and casp9 (+3.99, +2.03-fold, respectively) expression. |
2022-10-14 |
2023-08-14 |
human |
| Chengpeng Yu, Dean Rao, Tiantian Wang, Jia Song, Lei Zhang, Wenjie Huan. Emerging roles of TRIM27 in cancer and other human diseases. Frontiers in cell and developmental biology. vol 10. 2022-10-06. PMID:36200036. |
its ubiquitination targets include pten, iκbα and p53, which allows it to regulate many signaling pathways to exert its functions under both physiological and pathological conditions, such as cell proliferation, differentiation and apoptosis. |
2022-10-06 |
2023-08-14 |
human |
| Junbin Wang, Xinyi Lai, Xuxing Pen. CircLIFR Inhibits Non-small Cell Lung Cancer Progression by Acting as a miR-429 Sponge to Enhance CELF2 Expression. Biochemical genetics. 2022-09-14. PMID:36104590. |
importantly, overexpression of circlifr impeded cell proliferation, migration, invasion, and inactivated protein kinase b (akt)/phosphatase and tensin homolog (pten)-signaling pathways while enhanced apoptosis and cell-cycle arrest in nsclc cells, which was overturned by upregulation of mir-429 or silencing of celf2. |
2022-09-14 |
2023-08-14 |
human |
| Liqing Lu, Tian Fang, Tuo Pang, Ziyi Chen, Longhuai Cheng, Dejun Ma, Zhen X. The potential application of branch-PCR assembled PTEN gene nanovector in lung cancer gene therapy. Chembiochem : a European journal of chemical biology. 2022-09-08. PMID:36073901. |
when transfected into nci-h1299 cancer cells, np-pten could overexpress pten protein to restore pten function through the deactivation of pi3k-akt-mtor signaling pathway to inhibit cell proliferation and induce cell apoptosis. |
2022-09-08 |
2023-08-14 |
mouse |
| Yakun Fang, Wenjun Ji, Chao Ya. Research Progress of PI3K/PTEN/AKT Signaling Pathway Associated with Renal Cell Carcinoma. Disease markers. vol 2022. 2022-09-01. PMID:36046376. |
the product encoded by pten was found to negatively regulate the pi3k/akt signaling pathway, thereby inhibiting cell proliferation and promoting apoptosis. |
2022-09-01 |
2023-08-14 |
Not clear |
| Reem Sabry, Makenna Williams, Nicholas Werry, Jonathan LaMarre, Laura A Favett. BPA Decreases PDCD4 in Bovine Granulosa Cells Independently of miR-21 Inhibition. International journal of molecular sciences. vol 23. issue 15. 2022-08-12. PMID:35955412. |
before measuring apoptosis and quantifying mir-21 apoptotic targets pdcd4 and pten, transfection was optimized and validated. |
2022-08-12 |
2023-08-14 |
cattle |
| Chunhua Tian, Jing Su, Zhao Ma, Yang Wu, Hongyun M. lncRNA NBAT1 Inhibits Cell Metastasis and Promotes Apoptosis in Endometrial Cancer by Sponging miR-21-5p to Regulate PTEN. Computational and mathematical methods in medicine. vol 2022. 2022-08-01. PMID:35912140. |
lncrna nbat1 inhibits cell metastasis and promotes apoptosis in endometrial cancer by sponging mir-21-5p to regulate pten. |
2022-08-01 |
2023-08-14 |
Not clear |
| Yuan Cheng, Qing He, Tao Jin, Na L. miR-214-3p Protects and Restores the Myocardial Tissue of Rat Myocardial Infarction Model by Targeting PTEN. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-07-28. PMID:35899226. |
a cotransfection of mir-214-3p and pten brought about an obvious elevation in the myocardial infarct area, tissue damage, and fibrosis, even in the aspect of cellular apoptosis than a mere transfection of mir-214-3p. |
2022-07-28 |
2023-08-14 |
rat |
| Miyesaier Abudureyimu, Lifang Zhao, Xuanming Luo, Xiang Wang, Haibo Li. Influences of ALDH2 on Cardiomyocyte Apoptosis in Heart Failure Rats Through Regulating PINK1-Parkin Signaling Pathway-Mediated Mitophagy. Cellular and molecular biology (Noisy-le-Grand, France). vol 68. issue 2. 2022-07-23. PMID:35869735. |
the study aimed to investigate the influences of aldehyde dehydrogenase 2 (aldh2) on cardiomyocyte apoptosis in heart failure (hf) rats through regulating the pten induced putative kinase 1 (pink1)-parkin signaling pathway-mediated mitophagy. |
2022-07-23 |
2023-08-14 |
rat |
| Xin Yang, Heling Zhang, Tong Qu, Yi Wang, Yongxian Zhong, Yuchen Yan, Xuefei Ji, Tiayan Chi, Peng Liu, Libo Zo. Tolfenamic acid inhibits ROS-generating oxidase Nox1-regulated p53 activity in intrastriatal injection of malonic acid rats. The journal of physiological sciences : JPS. vol 72. issue 1. 2022-07-19. PMID:35850611. |
tolfenamic acid reduced mouse double minute 2 (mdm2), phosphatase and tensin homologue (pten), p53-upregulated modulator of apoptosis (puma) and bcl2-associated x (bax) at the mrna level to inhibit apoptosis and downregulated sestrin 2 (sesn2) and hypoxia inducible factor 1, alpha subunit (hif-1α) mrna levels to exert antioxidative stress effects. |
2022-07-19 |
2023-08-14 |
mouse |
| Shanshan Zhu, Weiyi Yu, Liwei Bi, Fei Qin, Jie Li, Haiquan Zeng, Lingsong L. [Quercetin induces apoptosis of human breast cancer cells by activiting PTEN and inhibiting PI3K/AKT and JNK signaling pathways]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 8. 2022-07-19. PMID:35851085. |
[quercetin induces apoptosis of human breast cancer cells by activiting pten and inhibiting pi3k/akt and jnk signaling pathways]. |
2022-07-19 |
2023-08-14 |
human |
| Shanshan Zhu, Weiyi Yu, Liwei Bi, Fei Qin, Jie Li, Haiquan Zeng, Lingsong L. [Quercetin induces apoptosis of human breast cancer cells by activiting PTEN and inhibiting PI3K/AKT and JNK signaling pathways]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 8. 2022-07-19. PMID:35851085. |
after adding ly294002 to inhibit pi3k/akt, the apoptosis rate increased for cells treated with both ly294002 and quercetin; the expression of pten protein also showed an increase. |
2022-07-19 |
2023-08-14 |
human |
| Shanshan Zhu, Weiyi Yu, Liwei Bi, Fei Qin, Jie Li, Haiquan Zeng, Lingsong L. [Quercetin induces apoptosis of human breast cancer cells by activiting PTEN and inhibiting PI3K/AKT and JNK signaling pathways]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 8. 2022-07-19. PMID:35851085. |
conclusion quercetin can signeristically inhibit cell viability and induce cell apoptosis on mcf-7 cells, by up-regulating the expression of pten and down-regulating pi3k/akt and jnk pathways. |
2022-07-19 |
2023-08-14 |
human |