| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianfeng Yao, Ming Li, Liqing Lin, Youzhu Li, Jianlong Zhuang, Yanfang Huang, Weilin Peng, Jianfeng Lian, Rongfu Huang, Xiaoyu Yan. Zygote (Cambridge, England). 2022-04-04. PMID:35369894. |
pten (phosphatase and tensin homolog) is a well known tumour suppressor gene that functions as a mediator of apoptosis and is crucial for mammalian reproduction. |
2022-04-04 |
2023-08-13 |
human |
| Huijie Chen, Yue Zhang, Mengmeng Zou, Xiaowei Sun, Xiaodan Huang, Shiwen X. Dibutyl phthalate-induced oxidative stress and apoptosis in swine testis cells and therapy of naringenin via PTEN/PI3K/AKT signaling pathway. Environmental toxicology. 2022-04-01. PMID:35363423. |
herein, swine testis (st) cells were treated with 1.8 μm of dbp or/and 25.39 nm of nrg for 24 h, we described the discovery path of nrg inhibition on apoptosis in dbp-exposed st cells through targeting phosphatase and tensin homologue deleted on chromosome 10 (pten). |
2022-04-01 |
2023-08-13 |
Not clear |
| Huijie Chen, Yue Zhang, Mengmeng Zou, Xiaowei Sun, Xiaodan Huang, Shiwen X. Dibutyl phthalate-induced oxidative stress and apoptosis in swine testis cells and therapy of naringenin via PTEN/PI3K/AKT signaling pathway. Environmental toxicology. 2022-04-01. PMID:35363423. |
we found that nrg specifically binds to three basic residues (his93, lys125, lys128) of p loop in pten, as well as phosphatase domains (asp92, his93, cys124, lys125, ala126, lys128, and arg130) in active dephosphorylation pockets, thereby reducing pten level and activating pi3k/akt signaling pathway, and further inhibiting oxidative stress and mitochondrial pathway apoptosis. |
2022-04-01 |
2023-08-13 |
Not clear |
| Dezhi Li, Hongying Lv, Huijiang Gao, Zizong Wang, Dongfei Wang, Kaihua Tian, Lin L. Circular RNA hsa_circ_0077837 is upregulated in non-small cell lung cancer to downregulate phosphatase and tensin homolog through methylation. Bioengineered. vol 13. issue 3. 2022-03-05. PMID:35246018. |
the roles of hsa_circ_0077837 and pten in nsclc cell proliferation were evaluated using cell apoptosis assay. |
2022-03-05 |
2023-08-13 |
Not clear |
| Dezhi Li, Hongying Lv, Huijiang Gao, Zizong Wang, Dongfei Wang, Kaihua Tian, Lin L. Circular RNA hsa_circ_0077837 is upregulated in non-small cell lung cancer to downregulate phosphatase and tensin homolog through methylation. Bioengineered. vol 13. issue 3. 2022-03-05. PMID:35246018. |
in nsclc cells, hsa_circ_0077837 overexpression decreased pten expression, increased pten gene methylation, and reduced hcc827 cell apoptosis via pten. |
2022-03-05 |
2023-08-13 |
Not clear |
| Xiao Han, Yun-Long Zhang, Qiu-Yue Lin, Hui-Hua Li, Shu-Bin Gu. ATGL deficiency aggravates pressure overload-triggered myocardial hypertrophic remodeling associated with the proteasome-PTEN-mTOR-autophagy pathway. Cell biology and toxicology. 2022-02-26. PMID:35218467. |
tac in wt mice significantly reduced cardiac function and autophagy while enhancing left ventricular hypertrophy, interstitial fibrosis, inflammatory response, superoxide generation, and cardiomyocyte apoptosis, accompanied with upregulation of the proteasome activity, reduction of pten level and activation of akt-mtor signaling, and these effects were further aggravated in atgl ko mice. |
2022-02-26 |
2023-08-13 |
mouse |
| Jun Jiang, Guannan Gao, Qiang Pan, Jing Liu, Yu Tian, Xiaoji Zhan. Circular RNA circHIPK3 is downregulated in diabetic cardiomyopathy and overexpression of circHIPK3 suppresses PTEN to protect cardiomyocytes from high glucose-induced cell apoptosis. Bioengineered. vol 13. issue 3. 2022-02-24. PMID:35200097. |
circular rna circhipk3 is downregulated in diabetic cardiomyopathy and overexpression of circhipk3 suppresses pten to protect cardiomyocytes from high glucose-induced cell apoptosis. |
2022-02-24 |
2023-08-13 |
human |
| Jun Jiang, Guannan Gao, Qiang Pan, Jing Liu, Yu Tian, Xiaoji Zhan. Circular RNA circHIPK3 is downregulated in diabetic cardiomyopathy and overexpression of circHIPK3 suppresses PTEN to protect cardiomyocytes from high glucose-induced cell apoptosis. Bioengineered. vol 13. issue 3. 2022-02-24. PMID:35200097. |
the role of circhipk3 and pten in regulating the apoptosis of ac16 cells was analyzed by cell apoptosis assay. |
2022-02-24 |
2023-08-13 |
human |
| Jun Jiang, Guannan Gao, Qiang Pan, Jing Liu, Yu Tian, Xiaoji Zhan. Circular RNA circHIPK3 is downregulated in diabetic cardiomyopathy and overexpression of circHIPK3 suppresses PTEN to protect cardiomyocytes from high glucose-induced cell apoptosis. Bioengineered. vol 13. issue 3. 2022-02-24. PMID:35200097. |
circhipk3 may suppress ac16 cell apoptosis induced by high glucose and inhibited the role of pten in cell apoptosis. |
2022-02-24 |
2023-08-13 |
human |
| Jun Jiang, Guannan Gao, Qiang Pan, Jing Liu, Yu Tian, Xiaoji Zhan. Circular RNA circHIPK3 is downregulated in diabetic cardiomyopathy and overexpression of circHIPK3 suppresses PTEN to protect cardiomyocytes from high glucose-induced cell apoptosis. Bioengineered. vol 13. issue 3. 2022-02-24. PMID:35200097. |
therefore, circhipk3 may downregulate pten to protect cardiomyocytes from high glucose-induced cell apoptosis. |
2022-02-24 |
2023-08-13 |
human |
| Statement of Retraction: Silencing of PTEN inhibits the oxidative stress damage and hippocampal cell apoptosis induced by Sevoflurane through activating MEK1/ERK signaling pathway in infant rats. Cell cycle (Georgetown, Tex.). 2022-02-22. PMID:35191822. |
statement of retraction: silencing of pten inhibits the oxidative stress damage and hippocampal cell apoptosis induced by sevoflurane through activating mek1/erk signaling pathway in infant rats. |
2022-02-22 |
2023-08-13 |
rat |
| Michaela Plamper, Bettina Gohlke, Joachim Woelfl. PTEN hamartoma tumor syndrome in childhood and adolescence-a comprehensive review and presentation of the German pediatric guideline. Molecular and cellular pediatrics. vol 9. issue 1. 2022-02-21. PMID:35187600. |
loss of pten activity leads to an increased phosphorylation of different cell proteins, which may have an influence on growth, migration, and apoptosis. |
2022-02-21 |
2023-08-13 |
Not clear |
| Yuxia Fan, Xin Fan, Hao Yan, Zheng Liu, Xiaoming Wang, Qingling Yuan, Jie Xie, Xiubo Lu, Yang Yan. Long non-coding ROR promotes the progression of papillary thyroid carcinoma through regulation of the TESC/ALDH1A1/TUBB3/PTEN axis. Cell death & disease. vol 13. issue 2. 2022-02-17. PMID:35173149. |
overexpression of lncrna ror, tesc, aldh1a1 or tubb3 and silencing of pten promoted ptc cell viability, colony formation, migration, and invasion while suppressing apoptosis. |
2022-02-17 |
2023-08-13 |
mouse |
| Song Guo, Raymond M Moore, M Cristine Charlesworth, Kenneth L Johnson, Robert J Spinner, Anthony J Windebank, Huan Wan. The proteome of distal nerves: implication in delayed repair and poor functional recovery. Neural regeneration research. vol 17. issue 9. 2022-02-10. PMID:35142689. |
ipa revealed that protective pathways such as lxr/rxr, acute phase response, rac, erk/mapk, cntf, il-6, and fgf signaling were inhibited in the delayed repair group, whereas three detrimental pathways, including the complement system, pten, and apoptosis signaling, were activated. |
2022-02-10 |
2023-08-13 |
rat |
| Maryam Farzaneh Behelgardi, Zahra Gholami Shahvir, S Mohsen Asghar. Apoptosis induction in human lung and colon cancer cells via impeding VEGF signaling pathways. Molecular biology reports. 2022-02-10. PMID:35142981. |
encouragingly, significant downregulation of b-cell lymphoma 2 (bcl2), x-linked inhibitor of apoptosis, procaspase9, and procaspase3, as well as upregulation of pten and p53 tumor suppressors, bcl2 associated x, cytochrome c, cleaved caspase9, and cleaved caspase3 in vgb4-treated a549 and ht29 cells, further confirmed the profound inductive influence of vgb4 on apoptotic pathways. |
2022-02-10 |
2023-08-13 |
human |
| Kang Li, Hongyuan Shen, Minghui Lu, Jiarong Chen, Qingshui Yin, Pingyue L. Formononetin inhibits osteosarcoma cell proliferation and promotes apoptosis by regulating the miR-214-3p/phosphatase and tensin homolog pathway. Translational cancer research. vol 9. issue 8. 2022-02-04. PMID:35117853. |
our study aims to detect the role of fn on mg-63 cell viability and apoptosis through regulating phosphatase and tensin homolog (pten) expression via microrna-214-3p (mir-214-3p). |
2022-02-04 |
2023-08-13 |
Not clear |
| Zhi Zhou, Zhihua Tu, Juan Zhang, Can Tan, Xiaoyong Shen, Bangbei Wan, Yejuan Li, Anguo Wang, Liqiang Zhao, Jiajia Hu, Ning Ma, Jing Zhou, Lin Chen, Yanqin Song, Weiying L. Follicular Fluid-Derived Exosomal MicroRNA-18b-5p Regulates PTEN-Mediated PI3K/Akt/mTOR Signaling Pathway to Inhibit Polycystic Ovary Syndrome Development. Molecular neurobiology. 2022-01-29. PMID:35092573. |
pten knockdown increased kgn cell proliferation and limited apoptosis. |
2022-01-29 |
2023-08-13 |
rat |
| Yihua Bei, Dongchao Lu, Christian Bär, Shambhabi Chatterjee, Alessia Costa, Isabelle Riedel, Frank C Mooren, Yujiao Zhu, Zhenzhen Huang, Meng Wei, Meiyu Hu, Sunyi Liu, Pujiao Yu, Kun Wang, Thomas Thum, Junjie Xia. MiR-486 attenuates cardiac ischemia/reperfusion injury and mediates the beneficial effect of exercise for myocardial protection. Molecular therapy : the journal of the American Society of Gene Therapy. 2022-01-25. PMID:35077859. |
consistently, mir-486 was downregulated in oxygen glucose deprivation/reperfusion (ogdr)-stressed cardiomyocytes, while upregulating mir-486 inhibited cardiomyocyte apoptosis through pten and foxo1 inhibition and akt/mtor activation. |
2022-01-25 |
2023-08-13 |
Not clear |
| Yihua Bei, Dongchao Lu, Christian Bär, Shambhabi Chatterjee, Alessia Costa, Isabelle Riedel, Frank C Mooren, Yujiao Zhu, Zhenzhen Huang, Meng Wei, Meiyu Hu, Sunyi Liu, Pujiao Yu, Kun Wang, Thomas Thum, Junjie Xia. MiR-486 attenuates cardiac ischemia/reperfusion injury and mediates the beneficial effect of exercise for myocardial protection. Molecular therapy : the journal of the American Society of Gene Therapy. 2022-01-25. PMID:35077859. |
in conclusion, mir-486 is protective against cardiac i/r injury and myocardial apoptosis through targeting pten and foxo1 and activation of the akt/mtor pathway, and mediates the beneficial effect of exercise for myocardial protection. |
2022-01-25 |
2023-08-13 |
Not clear |
| Qinyi Wang, Junmin Wang, Hongjiao Xiang, Peilun Ding, Tao Wu, Guang J. The biochemical and clinical implications of phosphatase and tensin homolog deleted on chromosome ten in different cancers. American journal of cancer research. vol 11. issue 12. 2022-01-12. PMID:35018228. |
in addition, as a targeted gene in multiple pathways, pten has a variety of physiological activities, such as those regulating the cell cycle, inducing cell apoptosis, and inhibiting cell invasion, etc. |
2022-01-12 |
2023-08-13 |
Not clear |