| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yaowei Ai, Qiaohui Zhou, Ling Li, Zhihong Pan, Mingwen Guo, Jingbo Ha. Interference of P-REX2a may inhibit proliferation and reverse the resistance of SGC7901 cells to doxorubicin. Oncology letters. vol 15. issue 3. 2020-10-01. PMID:29435055. |
when the cells were treated with 0.3 µm doxorubicin for 24 h, the rate of apoptosis in the sirna-transfected groups significantly increased and no marked changes in of pten and akt expression were observed. |
2020-10-01 |
2023-08-13 |
Not clear |
| Dawei Mu, Gaobiao Zhou, Jianye Li, Bin Su, Heqing Gu. Ursolic acid activates the apoptosis of prostate cancer via ROCK/PTEN mediated mitochondrial translocation of cofilin-1. Oncology letters. vol 15. issue 3. 2020-10-01. PMID:29435058. |
the aim of the present study was to assess whether ursolic acid activates the apoptosis of prostate cancer and to investigate the mechanism by which the rho-associated protein kinase 1 (rock1)/phosphatase and tensin homolog (pten) signaling pathway performs a role in ursolic acid-mediated cofilin-1 to induce apoptosis in human prostate cancer. |
2020-10-01 |
2023-08-13 |
human |
| Xiaofeng Han, Jianwei Zheng, Yunlei Wang, Zhigang Ga. miRNA-29a inhibits colon cancer growth by regulation of the PTEN/Akt/GSK3β and Wnt/β-catenin signaling pathways. Oncology letters. vol 16. issue 2. 2020-10-01. PMID:30013659. |
furthermore, upregulation of mirna-29a suppressed cell viability, increased lactate dehydrogenase levels and apoptosis, and promoted caspase-3/9 activities and b-cell lymphoma 2-associated x protein and phosphatase and tensin homolog (pten) protein expression in colon cancer cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yan-Wei Wu, Chiou-Feng Lin, Yee-Shin Lin, Wu-Chou Su, Wei-Hsin Chi. Autophagy regulates vinorelbine sensitivity due to continued Keap1-mediated ROS generation in lung adenocarcinoma cells. Cell death discovery. vol 4. 2020-10-01. PMID:30245856. |
we modified as2 cells with pten overexpression, mtor knockdown, keap1 knockdown, and revealed amplified p62 and lc3 expression accompanied with decreased akt, keap1, ros, and vinorelbine-induced apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yan-Wei Wu, Chiou-Feng Lin, Yee-Shin Lin, Wu-Chou Su, Wei-Hsin Chi. Autophagy regulates vinorelbine sensitivity due to continued Keap1-mediated ROS generation in lung adenocarcinoma cells. Cell death discovery. vol 4. 2020-10-01. PMID:30245856. |
declined p62, lc3 expression were accompanied with increased akt, keap1, ros, and vinorelbine-induced apoptosis after modification of a549 cells with pten knockdown, atg5 knockdown, and keap1 overexpression. |
2020-10-01 |
2023-08-13 |
Not clear |
| Weiyun Wu, Wenkai Tan, Shicai Ye, Yu Zhou, Juanhua Qua. Analysis of the promoter region of the human miR-32 gene in colorectal cancer. Oncology letters. vol 17. issue 4. 2020-10-01. PMID:30881496. |
microrna (mir)-32 upregulation in crc tissues was previously reported, where it increased the proliferation, migration and invasion, and reduced apoptosis of crc cells by inhibiting the expression of phosphatase and tensin homolog (pten). |
2020-10-01 |
2023-08-13 |
human |
| Yugang Yin, Lei Lv, Wenni Wan. Expression of miRNA-214 in the sera of elderly patients with acute myocardial infarction and its effect on cardiomyocyte apoptosis. Experimental and therapeutic medicine. vol 17. issue 6. 2020-10-01. PMID:31086597. |
when compared with normal hcms, the expressions of p53-upregulated modulator of apoptosis (puma), phosphatase and tensin homolog (pten), b-cell lymphoma-2-associated x protein (bax) and caspase 7 proteins was decreased in hcms overexpressing mirna-214 following h |
2020-10-01 |
2023-08-13 |
human |
| Yingying Zhang, Jinfeng Liu, Yan Lv, Chao Zhang, Shuai Gu. LncRNA meg3 suppresses hepatocellular carcinoma in vitro and vivo studies. American journal of translational research. vol 11. issue 7. 2020-10-01. PMID:31396320. |
furthermore, overexpression of meg3 (a) decreased proliferation, migration, and invasion of hepg2 cells; (b) enhanced apoptosis and the proportion of hepg2 cells in g1 of the cell cycle; (c) increased the expression of phosphatase and tensin homolog (pten), bcl2-associated x (bax), and p53 proteins; and (d) decreased the expression of mirna-10a-5p, akt, p-akt, bcl-2, and the matrix metalloproteinases (mmps)-2 and -9. |
2020-10-01 |
2023-08-13 |
Not clear |
| Fei Wang, Yi Li, Zhe Zhang, Jingxin Wang, Jinghao Wan. SHCBP1 regulates apoptosis in lung cancer cells through phosphatase and tensin homolog. Oncology letters. vol 18. issue 2. 2020-10-01. PMID:31423258. |
furthermore, inhibition of pten by sirna reversed the increase in apoptosis induced by shcbp1 sirna. |
2020-10-01 |
2023-08-13 |
Not clear |
| Fei Wang, Yi Li, Zhe Zhang, Jingxin Wang, Jinghao Wan. SHCBP1 regulates apoptosis in lung cancer cells through phosphatase and tensin homolog. Oncology letters. vol 18. issue 2. 2020-10-01. PMID:31423258. |
these results suggested that shcbp1 may be upregulated in lung cancer and it may serve a key role in the apoptosis of lung cancer cells; this effect was associated with the expression of pten. |
2020-10-01 |
2023-08-13 |
Not clear |
| Wu Chen, Yuan Ruan, Sheng Zhao, Jinzhuo Ning, Ting Rao, Weimin Yu, Xiangjun Zhou, Cong Liu, Yucheng Qi, Fan Chen. MicroRNA-205 inhibits the apoptosis of renal tubular epithelial cells via the PTEN/Akt pathway in renal ischemia-reperfusion injury. American journal of translational research. vol 11. issue 12. 2020-10-01. PMID:31934284. |
mir-205 exerted its protective effect by inhibiting hk-2 cell apoptosis and promoting hk-2 cell proliferation by inhibiting the expression of pten during hri, and this protective effect was blocked by silencing pten. |
2020-10-01 |
2023-08-13 |
rat |
| Shiny S R Jasphin, Dinkar Desai, Siddharth Pandit, Nithin M Gonsalves, Preethi B Nayak, Amal Iyp. Immunohistochemical expression of phosphatase and tensin homolog in histologic gradings of oral squamous cell carcinoma. Contemporary clinical dentistry. vol 7. issue 4. 2020-09-30. PMID:27994422. |
pten has its major function in the regulation of cell adhesion, cell cycle arrest, migration, apoptosis programming, and differentiation. |
2020-09-30 |
2023-08-13 |
human |
| Zheng Liu, Feng Wang, Zhi-Wei Zhou, He-Chun Xia, Xin-Yu Wang, Yin-Xue Yang, Zhi-Xu He, Tao Sun, Shu-Feng Zho. Alisertib induces G American journal of translational research. vol 9. issue 3. 2020-09-30. PMID:28386317. |
als also bound key regulating proteins of cell cycle, apoptosis and autophagy, such as cyclin-dependent kinase 1 (cdk1/cdc2), cdk2, cyclin b1, p27 kip1, p53, cytochrome c, cleaved caspase 3, bax, bcl-2, bcl-xl, phosphatidylinositol 3-kinase (pi3k), protein kinase b (akt), mammalian target of rapamycin (mtor), 5'-adenosine monophosphate-activated protein kinase (ampk), p38 mitogen-activated protein kinase (mapk), beclin 1, phosphatase and tensin homolog (pten), and microtubule-associated protein light chain 3 (lc3). |
2020-09-30 |
2023-08-13 |
Not clear |
| Yang Zhai, Yanjun Zhang, Kejun Nan, Xuan Lian. Reduced expression levels of PTEN are associated with decreased sensitivity of HCC827 cells to icotinib. Oncology letters. vol 13. issue 5. 2020-09-30. PMID:28521430. |
the present study demonstrated that icotinib significantly inhibited the proliferation and increased the apoptosis rate of hcc827 cells; the cellular mrna and protein expression levels of phosphatase and tensin homolog (pten) were also significantly downregulated. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yang Zhai, Yanjun Zhang, Kejun Nan, Xuan Lian. Reduced expression levels of PTEN are associated with decreased sensitivity of HCC827 cells to icotinib. Oncology letters. vol 13. issue 5. 2020-09-30. PMID:28521430. |
the current study identified that the downregulation of pten expression levels may promote cellular proliferation in addition to decreasing the apoptosis of hcc827 cells, and may reduce the sensitivity of hcc827 cells to icotinib. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yu Gan, Qing Chen, Yan Le. Regulation of paclitaxel sensitivity in prostate cancer cells by PTEN/maspin signaling. Oncology letters. vol 14. issue 4. 2020-09-30. PMID:29085510. |
in the present study, it was found that paclitaxel induced more apoptosis and maspin expression in phosphatase and tensin homolog (pten)-positive 22rv1 cells than pten-negative lncap cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jing Liu, Weiyan Chen, Haiyan Zhang, Ting Liu, Lin Zha. miR-214 targets the PTEN-mediated PI3K/Akt signaling pathway and regulates cell proliferation and apoptosis in ovarian cancer. Oncology letters. vol 14. issue 5. 2020-09-30. PMID:29113199. |
mir-214 may activate the pi3k/akt signaling pathway by downregulating the targeted pten, which may promote oc cell proliferation and inhibit apoptosis. |
2020-09-30 |
2023-08-13 |
human |
| Xingyue Li, Ziyi Wu, Yi Zhang, Ying Xu, Guang Han, Ping Zha. Activation of Autophagy Contributes to Sevoflurane-Induced Neurotoxicity in Fetal Rats. Frontiers in molecular neuroscience. vol 10. 2020-09-30. PMID:29311820. |
changes in neural stem cell (nsc) apoptosis, neurogenesis, neuron quantity and learning and memory function were examined after administration of an autophagy or pten inhibitor. |
2020-09-30 |
2023-08-13 |
rat |
| Yanfang He, Jie Bai, Ping Liu, Jianxin Dong, Yajuan Tang, Jianli Zhou, Ping Han, Jun Xing, Yan Chen, Xiangyang Y. miR-494 protects pancreatic β-cell function by targeting PTEN in gestational diabetes mellitus. EXCLI journal. vol 16. 2020-09-30. PMID:29333131. |
in addition, phosphatase and tensin homolog (pten) which has been shown to play a pivotal role in apoptosis, was proved to be a direct target of mir-494 in pancreatic β-cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yanfang He, Jie Bai, Ping Liu, Jianxin Dong, Yajuan Tang, Jianli Zhou, Ping Han, Jun Xing, Yan Chen, Xiangyang Y. miR-494 protects pancreatic β-cell function by targeting PTEN in gestational diabetes mellitus. EXCLI journal. vol 16. 2020-09-30. PMID:29333131. |
more importantly, sirna-induced downregulation of pten reversed the effects of mir-494 knockdown on insulin secretion, cell proliferation, and apoptosis of pancreatic β-cells. |
2020-09-30 |
2023-08-13 |
Not clear |