| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Reem Ali, Muslim Alabdullah, Islam Miligy, Makhliyo Normatova, Roya Babaei-Jadidi, Abdolrahman S Nateri, Emad A Rakha, Srinivasan Madhusuda. ATM Regulated PTEN Degradation Is XIAP E3 Ubiquitin Ligase Mediated in p85α Deficient Cancer Cells and Influence Platinum Sensitivity. Cells. vol 8. issue 10. 2020-07-06. PMID:31635307. |
the clinicopathological significance of atm, pten, p85α, and xiap (x-linked inhibitor of apoptosis protein) was evaluated in 525 human ovarian cancers using immunohistochemistry. |
2020-07-06 |
2023-08-13 |
human |
| Li-Ping Yin, Huan Zhu, Ru-Yuan Zhu, Li Huan. A novel SCNN1G mutation in a PHA I infant patient correlates with nephropathy. Biochemical and biophysical research communications. vol 519. issue 2. 2020-06-29. PMID:31522814. |
in addition, it was demonstrated that the scnn1g defects triggered programmed cell death via inhibiting mir-21 and upregulating pten, which then orchestrated the key downstream regulators, including bcl2, bax2, and cleaved caspse-3 in a way that favors cell apoptosis. |
2020-06-29 |
2023-08-13 |
Not clear |
| Po-Han Lin, Yen-Ting Tung, Hsin-Yuan Chen, Yi-Fen Chiang, Hui-Chih Hong, Ko-Chieh Huang, Sung-Po Hsu, Tsui-Chin Huang, Shih-Min Hsi. Melatonin activates cell death programs for the suppression of uterine leiomyoma cell proliferation. Journal of pineal research. vol 68. issue 1. 2020-06-11. PMID:31710386. |
the utsmc cell cycle was arrested by melatonin treatment through up-regulation of p21, p27, and pten protein expression, but melatonin did not further promote apoptosis program activation. |
2020-06-11 |
2023-08-13 |
mouse |
| Jia-Qi He, Min-Xia Zheng, Hua-Zhong Ying, Yu-Sen Zhong, Huan-Huan Zhang, Min Xu, Chen-Huan Y. PRP1, a heteropolysaccharide from Platycodonis Radix, induced apoptosis of HepG2 cells via regulating miR-21-mediated PI3K/AKT pathway. International journal of biological macromolecules. vol 158. 2020-05-23. PMID:32380108. |
prp1 repressed the expression of mir-21, which directly targeted and suppressed pten (a negative regulator of the pi3k/akt signaling cascade), and subsequently upregulated the expression of pten but downregulated the pi3k/akt pathway, thereby promoting liver cancer cell apoptosis. |
2020-05-23 |
2023-08-13 |
human |
| Xin Chen, Yue Li, Meng Feng, Xiaoyu Hu, Hai Zhang, Ruijie Zhang, Xiaoqing Dong, Chunxiao Liu, Zhao Zhang, Shanxiang Jiang, Shile Huang, Long Che. Maduramicin induces cardiac muscle cell death by the ROS-dependent PTEN/Akt-Erk1/2 signaling pathway. Journal of cellular physiology. vol 234. issue 7. 2020-05-20. PMID:30511398. |
moreover, we found that both phosphatase and tensin homolog on chromosome 10 (pten) and protein kinase b (akt) were implicated in the regulation of erk1/2 inactivation and apoptosis in the cells and tissues exposed to mad. |
2020-05-20 |
2023-08-13 |
Not clear |
| Ying Xu, Guohua Zhang, Chen Zou, Zhigang Gong, Sijia Wang, Jun Liu, Gui Ma, Xiaogu Liu, Wenbo Zhang, Pengcheng Jian. Long noncoding RNA DGCR5 suppresses gastric cancer progression by acting as a competing endogenous RNA of PTEN and BTG1. Journal of cellular physiology. vol 234. issue 7. 2020-05-11. PMID:30515803. |
gain- and loss-of-function of dgcr5 revealed that dgcr5 functioned as a competing endogenous rna for mir-23b to suppress gc cell proliferation, invasion and migration, and facilitate apoptosis by regulating pten and btg1 in vitro. |
2020-05-11 |
2023-08-13 |
Not clear |
| Yishuang Sun, Mengxue Yu, Mengmeng Qu, Yuhong Ma, Dandan Zheng, Yanan Yue, Shuting Guo, Li Tang, Guorui Li, Weishuai Zheng, Min Wang, Deyin Guo, Changyong L. Hepatitis B virus-triggered PTEN/β-catenin/c-Myc signaling enhances PD-L1 expression to promote immune evasion. American journal of physiology. Gastrointestinal and liver physiology. vol 318. issue 1. 2020-05-04. PMID:31604033. |
mechanistically, decrease in pten enhanced β-catenin/c-myc signaling and pd-l1 expression in hbv-expressing hepatoma cells, which in turn augmented pd-1 expression, lowered il-2 secretion, and induced t cell apoptosis. |
2020-05-04 |
2023-08-13 |
mouse |
| Wanfen Zhang, Cheng Chen, Ran Jing, Tongqiang Liu, Bicheng Li. Remote Ischemic Preconditioning Protects Cisplatin-Induced Acute Kidney Injury through the PTEN/AKT Signaling Pathway. Oxidative medicine and cellular longevity. vol 2019. 2020-04-20. PMID:31781349. |
furthermore, ripc substantially reversed the downregulation of mir-144 and upregulation of pten in renal tissues of cis-induced aki mice and alleviated tubular cell apoptosis via activating pten/akt signaling. |
2020-04-20 |
2023-08-13 |
mouse |
| Petek Ballar Kirmizibayrak, Burcu Erbaykent-Tepedelen, Oguz Gozen, Yalcin Erzuruml. Divergent Modulation of Proteostasis in Prostate Cancer. Advances in experimental medicine and biology. vol 1233. 2020-04-20. PMID:32274755. |
alterations in various complex signaling pathways and cellular processes including cell cycle control, transcription, dna repair, apoptosis, cell adhesion, epithelial-mesenchymal transition (emt), and angiogenesis are critical factors influencing pca development through key molecular changes mainly by posttranslational modifications in pca-related proteins, including ar, nkx3.1, pten, p53, cyclin d1, and p27. |
2020-04-20 |
2023-08-13 |
Not clear |
| Jianguang Jia, Dankai Zhan, Jing Li, Zhixiang Li, Hongbo Li, Jun Qia. The contrary functions of lncRNA HOTAIR/miR-17-5p/PTEN axis and Shenqifuzheng injection on chemosensitivity of gastric cancer cells. Journal of cellular and molecular medicine. vol 23. issue 1. 2020-04-15. PMID:30338929. |
in addition, hotair was also found to directly target mir-17-5p, and pten appeared to be subject to the modification of hotair and mir-17-5p in its acting on the viability, proliferation, emt process, and apoptosis of gastric cancer cells. |
2020-04-15 |
2023-08-13 |
human |
| Maheshkumar Kannan, Sridharan Jayamohan, Rajesh Kannan Moorthy, Siva Chander Chabattula, Mathan Ganeshan, Antony Joseph Velanganni Arockia. AEG-1/miR-221 Axis Cooperatively Regulates the Progression of Hepatocellular Carcinoma by Targeting PTEN/PI3K/AKT Signaling Pathway. International journal of molecular sciences. vol 20. issue 22. 2020-04-13. PMID:31698701. |
on the other hand, there were no significant expression changes of aeg-1 in mir-221 mimic and mir-221 inhibitor transfected hcc cells and inhibition of mir-221/aeg-1 axis decreased cell proliferation, invasion, migration, and angiogenesis and induced apoptosis, cell cycle arrest by upregulating p57, p53, pten, and rb and downregulating lsf, mmp9, opn, bcl-2, pi3k, akt, and lc3a in hcc cells. |
2020-04-13 |
2023-08-13 |
Not clear |
| Eszter Molná. [vestigation of molecular factors determining BRAF-inhibitor sensitivity in solid tumors]. Magyar onkologia. vol 64. issue 1. 2020-04-10. PMID:32181767. |
in v600 braf mutant melanoma cells that did not or slightly express pten protein, prenylation inhibitor zoledronic acid inhibited cell proliferation and induced apoptosis more profoundly than in melanoma cells expressing pten. |
2020-04-10 |
2023-08-13 |
Not clear |
| Xiaowei Xing, Shuang Guo, Guanghao Zhang, Yusheng Liu, Shaojie Bi, Xin Wang, Qinghua L. miR-26a-5p protects against myocardial ischemia/reperfusion injury by regulating the PTEN/PI3K/AKT signaling pathway. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 53. issue 2. 2020-04-07. PMID:31994603. |
furthermore, mir-26a-5p effectively improved viability and inhibited apoptosis in cardiomyocytes upon i/r injury by inhibiting pten expression to activate the pi3k/akt signaling pathway. |
2020-04-07 |
2023-08-13 |
mouse |
| Yanhua Wang, Na Qin, Caifa Zhao, Jiehua Yuan, Shiqi Lu, Wenjing Li, Huiyao Xiang, Hang Ha. The correlation between the methylation of PTEN gene and the apoptosis of osteosarcoma cells mediated by SeHA nanoparticles. Colloids and surfaces. B, Biointerfaces. vol 184. 2020-04-06. PMID:31541893. |
the correlation between the methylation of pten gene and the apoptosis of osteosarcoma cells mediated by seha nanoparticles. |
2020-04-06 |
2023-08-13 |
human |
| Song Qin, Hongliang Wang, Guoyue Liu, Hong Mei, Miao Che. miR‑21‑5p ameliorates hyperoxic acute lung injury and decreases apoptosis of AEC II cells via PTEN/AKT signaling in rats. Molecular medicine reports. vol 20. issue 6. 2020-04-06. PMID:31702805. |
although mirna‑21‑5p has previously been reported to decrease h2o2‑induced aec ii apoptosis by targeting pten in vitro, whether mir‑21‑5p can decrease hali in vivo and the downstream molecular mechanisms remain unclear. |
2020-04-06 |
2023-08-13 |
rat |
| S L Xie, M Wang, X H Du, Z W Zhao, G Y L. [miR-455 Inhibits HepG2 Cell Proliferation and Promotes Apoptosis by Targeting RhoC]. Molekuliarnaia biologiia. vol 54. issue 1. 2020-04-06. PMID:32163390. |
as pten is a key tumor suppressor gene in hcc, and bcl-2 and caspase 3 are important indication of apoptosis, expression levels of pten, bcl2 and caspase 3 proteins were determined in cells overexpressing rhoc. |
2020-04-06 |
2023-08-13 |
Not clear |
| S L Xie, M Wang, X H Du, Z W Zhao, G Y L. [miR-455 Inhibits HepG2 Cell Proliferation and Promotes Apoptosis by Targeting RhoC]. Molekuliarnaia biologiia. vol 54. issue 1. 2020-04-06. PMID:32163390. |
in addition, we show that rhoc could activate the hcc cells proliferation ability and inhibit apoptosis rate (p < 0.01), and decrease expression of pten and caspase 3 (p < 0.01), while upregulating levels of bcl2. |
2020-04-06 |
2023-08-13 |
Not clear |
| Shen Liu, Jun Jia, Hengxing Zhou, Chi Zhang, Lu Liu, Jun Liu, Lu Lu, Xueying Li, Yi Kang, Yongfu Lou, Zhiwei Cai, Yiming Ren, Xiaohong Kong, Shiqing Fen. PTEN modulates neurites outgrowth and neuron apoptosis involving the PI3K/Akt/mTOR signaling pathway. Molecular medicine reports. vol 20. issue 5. 2020-03-31. PMID:31702028. |
pten modulates neurites outgrowth and neuron apoptosis involving the pi3k/akt/mtor signaling pathway. |
2020-03-31 |
2023-08-13 |
Not clear |
| Shen Liu, Jun Jia, Hengxing Zhou, Chi Zhang, Lu Liu, Jun Liu, Lu Lu, Xueying Li, Yi Kang, Yongfu Lou, Zhiwei Cai, Yiming Ren, Xiaohong Kong, Shiqing Fen. PTEN modulates neurites outgrowth and neuron apoptosis involving the PI3K/Akt/mTOR signaling pathway. Molecular medicine reports. vol 20. issue 5. 2020-03-31. PMID:31702028. |
in addition, pten inhibition is useful for protecting the neuron from apoptosis. |
2020-03-31 |
2023-08-13 |
Not clear |
| Feng Tian, Junhu Wang, Zhanhua Zhang, Jie Yan. miR-107 modulates chondrocyte proliferation, apoptosis, and extracellular matrix synthesis by targeting PTEN. International journal of clinical and experimental pathology. vol 12. issue 2. 2020-03-25. PMID:31933853. |
mir-107 modulates chondrocyte proliferation, apoptosis, and extracellular matrix synthesis by targeting pten. |
2020-03-25 |
2023-08-13 |
Not clear |