| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kathrin Zitzmann, George Vlotides, Burkhard Göke, Christoph J Auernhamme. PI(3)K-Akt-mTOR pathway as a potential therapeutic target in neuroendocrine tumors. Expert review of endocrinology & metabolism. vol 3. issue 2. 2019-11-20. PMID:30764093. |
molecular analysis of nets suggests, that in addition to mutations in certain tumor-suppressor genes (e.g., pten), multiple autocrine growth factor loops contribute to hyperactive pi(3)k-akt-mtor signaling, thus promoting unrestricted proliferation and resistance to apoptosis. |
2019-11-20 |
2023-08-13 |
human |
| L-L Yuan, L Li, J-N Liu, J Mei, C-J Le. Down-regulation of miR-29a facilitates apoptosis of colorectal carcinoma cell SW480 and suppresses its Paclitaxel resistance. European review for medical and pharmacological sciences. vol 22. issue 17. 2019-11-14. PMID:30229821. |
pten can suppress pi3k/akt activity, and regulate cell proliferation, apoptosis, and drug resistance. |
2019-11-14 |
2023-08-13 |
Not clear |
| N-N An, J Shawn, J-P Peng, M-D Wu, L-G Huan. Up-regulation of miR-190b promoted growth, invasion, migration and inhibited apoptosis of Wilms' tumor cells by repressing the PTEN expression. European review for medical and pharmacological sciences. vol 22. issue 4. 2019-11-06. PMID:29509256. |
up-regulation of mir-190b promoted growth, invasion, migration and inhibited apoptosis of wilms' tumor cells by repressing the pten expression. |
2019-11-06 |
2023-08-13 |
Not clear |
| Rong Zhang, Guobing Li, Qian Zhang, Qin Tang, Jingbin Huang, Changpeng Hu, Yali Liu, Qing Wang, Wuyi Liu, Ning Gao, Shiwen Zho. Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells. Cell death & disease. vol 9. issue 6. 2019-11-05. PMID:29789524. |
collectively, these findings suggest a hierarchical model in which induction of apoptosis by hirsutine stems primarily from activation of rock1 and pten, inactivation of pi3k/akt, leading in turn to gsk3β dephosphorylation and mptp opening, and culminating in caspase-3 activation and apoptosis. |
2019-11-05 |
2023-08-13 |
mouse |
| R Yao, W-T Feng, L-J Xu, X-M Zhong, H Liu, Y Sun, L-L Zho. DUXAP10 regulates proliferation and apoptosis of chronic myeloid leukemia via PTEN pathway. European review for medical and pharmacological sciences. vol 22. issue 15. 2019-11-04. PMID:30070329. |
duxap10 regulates proliferation and apoptosis of chronic myeloid leukemia via pten pathway. |
2019-11-04 |
2023-08-13 |
Not clear |
| Sanjay Singh, Raghu Asal, Stuti Bhaga. Multifunctional antioxidant nanoliposome-mediated delivery of PTEN plasmids restore the expression of tumor suppressor protein and induce apoptosis in prostate cancer cells. Journal of biomedical materials research. Part A. vol 106. issue 12. 2019-10-24. PMID:30194716. |
multifunctional antioxidant nanoliposome-mediated delivery of pten plasmids restore the expression of tumor suppressor protein and induce apoptosis in prostate cancer cells. |
2019-10-24 |
2023-08-13 |
human |
| Sanjay Singh, Raghu Asal, Stuti Bhaga. Multifunctional antioxidant nanoliposome-mediated delivery of PTEN plasmids restore the expression of tumor suppressor protein and induce apoptosis in prostate cancer cells. Journal of biomedical materials research. Part A. vol 106. issue 12. 2019-10-24. PMID:30194716. |
the mrna expression pattern of other relevant proteins predominantly involved in cancer cell proliferation and apoptosis suggested that the high pten expression could control the synthesis of oncogenic proteins. |
2019-10-24 |
2023-08-13 |
human |
| Taylor A Johnson, Dinender K Singl. PTEN inhibitor VO-OHpic attenuates inflammatory M1 macrophages and cardiac remodeling in doxorubicin-induced cardiomyopathy. American journal of physiology. Heart and circulatory physiology. vol 315. issue 5. 2019-09-24. PMID:30095997. |
the role of phosphatase and tensin homolog (pten) in apoptosis has been documented in doxo-induced cardiomyopathy (dic) and heart failure models. |
2019-09-24 |
2023-08-13 |
Not clear |
| Taylor A Johnson, Dinender K Singl. PTEN inhibitor VO-OHpic attenuates inflammatory M1 macrophages and cardiac remodeling in doxorubicin-induced cardiomyopathy. American journal of physiology. Heart and circulatory physiology. vol 315. issue 5. 2019-09-24. PMID:30095997. |
however, whether direct inhibition of pten attenuates apoptosis, cardiac remodeling, and inflammatory m1 macrophages in the dic model remains elusive. |
2019-09-24 |
2023-08-13 |
Not clear |
| Taylor A Johnson, Dinender K Singl. PTEN inhibitor VO-OHpic attenuates inflammatory M1 macrophages and cardiac remodeling in doxorubicin-induced cardiomyopathy. American journal of physiology. Heart and circulatory physiology. vol 315. issue 5. 2019-09-24. PMID:30095997. |
therefore, the present study was designed to understand the effects of vo-ohpic (vo), a potent inhibitor of pten, in reducing apoptosis and cardiac remodeling. |
2019-09-24 |
2023-08-13 |
Not clear |
| Xiaoyun Zhang, Tong Jin, Xiaoxi Huang, Xinjuan Liu, Zheng Liu, Yanjun Jia, Jianyu Ha. Effects of the tumor suppressor PTEN on biological behaviors of activated pancreatic stellate cells in pancreatic fibrosis. Experimental cell research. vol 373. issue 1-2. 2019-09-24. PMID:30321515. |
in vivo, pten levels gradually decreased during pancreatic fibrosis, which positively correlated with apoptosis of activated pscs, but negatively with psc activation. |
2019-09-24 |
2023-08-13 |
rat |
| Xiaoyun Zhang, Tong Jin, Xiaoxi Huang, Xinjuan Liu, Zheng Liu, Yanjun Jia, Jianyu Ha. Effects of the tumor suppressor PTEN on biological behaviors of activated pancreatic stellate cells in pancreatic fibrosis. Experimental cell research. vol 373. issue 1-2. 2019-09-24. PMID:30321515. |
in vitro, pten appears to prevent pscs from further activation and promotes apoptosis through regulation of the akt and fak/erk pathways. |
2019-09-24 |
2023-08-13 |
rat |
| Kathryn L Garner, Virginie M S Betin, Vanda Pinto, Mark Graham, Emmanuelle Abgueguen, Matt Barnes, David C Bedford, Craig A McArdle, Richard J M Cowar. Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress. Scientific reports. vol 8. issue 1. 2019-09-19. PMID:29500363. |
however, contrary to this, knockdown of the negative regulator of pi3k-akt signalling, phosphatase and tensin homolog deleted from chromosome 10 (pten), sensitizes podocytes to er stress and apoptosis, despite increasing akt phosphorylation. |
2019-09-19 |
2023-08-13 |
Not clear |
| Liyang Dong, Yanan Pu, Lina Zhang, Qianqian Qi, Lei Xu, Wei Li, Chuan Wei, Xiaofan Wang, Sha Zhou, Jifeng Zhu, Xuefeng Wang, Feng Liu, Xiaojun Chen, Chuan S. Human umbilical cord mesenchymal stem cell-derived extracellular vesicles promote lung adenocarcinoma growth by transferring miR-410. Cell death & disease. vol 9. issue 2. 2019-09-06. PMID:29440630. |
furthermore, we showed that hucmsc-ev-mediated luad growth is associated with increased proliferation and decreased apoptosis in luad cells, concomitant with reduced pten expression mediated by the hucmsc-ev-transmitted mir-410. |
2019-09-06 |
2023-08-13 |
human |
| Xin-Jie Hao, Cheng-Zhen Xu, Jin-Tai Wang, Xiao-Jie Li, Ming-Min Wang, Yi-Hai Gu, Zhi-Gang Lian. miR-21 promotes proliferation and inhibits apoptosis of hepatic stellate cells through targeting PTEN/PI3K/AKT pathway. Journal of receptor and signal transduction research. vol 38. issue 5-6. 2019-09-04. PMID:31038023. |
proliferation, apoptosis, and phosphatase and tensin homolog (pten)/phosphoinositide 3-kinase (pi3k)/protein kinase b (akt) signaling pathway related genes and proteins were detected by quantitative real-time polymerase chain reaction (qrt-pcr) and western blot, respectively. |
2019-09-04 |
2023-08-13 |
Not clear |
| Ji Wei Li, Li Wei, Zhijun Han, Zhong Che. Mesenchymal stromal cells-derived exosomes alleviate ischemia/reperfusion injury in mouse lung by transporting anti-apoptotic miR-21-5p. European journal of pharmacology. vol 852. 2019-09-03. PMID:30682335. |
we further demonstrated that msc-exo ameliorated iri in vivo or h/r induced apoptosis in vitro by inhibiting both intrinsic and extrinsic apoptosis pathway via mir-21-5p targeting pten and pdcd4, while artificial overexpressing pten or pdcd4 significantly attenuated the anti-apoptotic effect of msc-exo in vitro. |
2019-09-03 |
2023-08-13 |
mouse |
| Davood Bashash, Mohamad Sayyadi, Ava Safaroghli-Azar, Negar Sheikh-Zeineddini, Niknam Riyahi, Majid Momen. Small molecule inhibitor of c-Myc 10058-F4 inhibits proliferation and induces apoptosis in acute leukemia cells, irrespective of PTEN status. The international journal of biochemistry & cell biology. vol 108. 2019-08-29. PMID:30639430. |
small molecule inhibitor of c-myc 10058-f4 inhibits proliferation and induces apoptosis in acute leukemia cells, irrespective of pten status. |
2019-08-29 |
2023-08-13 |
Not clear |
| Mohammad Ariful Islam, Yingjie Xu, Wei Tao, Jessalyn M Ubellacker, Michael Lim, Daniel Aum, Gha Young Lee, Kun Zhou, Harshal Zope, Mikyung Yu, Wuji Cao, James Trevor Oswald, Meshkat Dinarvand, Morteza Mahmoudi, Robert Langer, Philip W Kantoff, Omid C Farokhzad, Bruce R Zetter, Jinjun Sh. Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA. Nature biomedical engineering. vol 2. issue 11. 2019-08-22. PMID:31015614. |
we also show that the restoration of pten function in pten-null prostate cancer cells inhibits the phosphatidylinositol 3-kinase (pi3k)-akt pathway and enhances apoptosis. |
2019-08-22 |
2023-08-13 |
mouse |
| Jie Yuan, Zhangyao Su, Wenchao Gu, Xianjuan Shen, Qiumin Zhao, Linying Shi, Chunjing Jin, Xudong Wang, Hui Cong, Shaoqing J. MiR-19b and miR-20a suppress apoptosis, promote proliferation and induce tumorigenicity of multiple myeloma cells by targeting PTEN. Cancer biomarkers : section A of Disease markers. vol 24. issue 3. 2019-08-05. PMID:30883341. |
mir-19b and mir-20a suppress apoptosis, promote proliferation and induce tumorigenicity of multiple myeloma cells by targeting pten. |
2019-08-05 |
2023-08-13 |
Not clear |
| Xiaoyuan Wang, Zhijian Li, Jie Bai, Wuqi Song, Fengmin Zhan. miR‑17‑5p regulates the proliferation and apoptosis of human trabecular meshwork cells by targeting phosphatase and tensin homolog. Molecular medicine reports. vol 19. issue 4. 2019-07-30. PMID:30816540. |
furthermore, transient overexpression of mir‑17‑5p induced a significant increase in the proliferation and a significant decrease in the apoptosis of htmcs by affecting the expression of pten, and the apoptosis‑related proteins b‑cell lymphoma‑associated x protein (bax), b‑cell lymphoma‑extra large (bcl‑xl) and b‑cell lymphoma‑2 (bcl‑2). |
2019-07-30 |
2023-08-13 |
human |