| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hemat El-Sayed El-Horany, Hanaa Hibishy Gaballah, Duaa Samir Hela. Berberine ameliorates renal injury in a rat model of D-galactose-induced aging through a PTEN/Akt-dependent mechanism. Archives of physiology and biochemistry. vol 126. issue 2. 2020-03-23. PMID:30145915. |
this study aimed to investigate the protective effects of berberine (bbr) against d-galactose (d-gal)-induced renal aging in rats, pointing to its ability to modulate phosphatase and tensin homolog deleted on chromosome ten (pten)/akt signalling, and to attenuate oxidative stress, inflammation and apoptosis. |
2020-03-23 |
2023-08-13 |
rat |
| Yanxian Lai, Jianyong Li, Lintao Zhong, Xiang He, Xiaoyun Si, Yili Sun, Yanmei Chen, Jiayuan Zhong, Yinlan Hu, Bing Li, Wangjun Liao, Cheng Liu, Yulin Liao, Jiancheng Xiu, Jianping Bi. The pseudogene PTENP1 regulates smooth muscle cells as a competing endogenous RNA. Clinical science (London, England : 1979). vol 133. issue 13. 2020-03-23. PMID:31235554. |
the long non-coding rna (lncrna) ptenp1 is a pseudogene of phosphatase and tensin homologue deleted on chromosome ten (pten), has been implicated in smooth muscle cell (smc) proliferation and apoptosis. |
2020-03-23 |
2023-08-13 |
human |
| Yanxian Lai, Jianyong Li, Lintao Zhong, Xiang He, Xiaoyun Si, Yili Sun, Yanmei Chen, Jiayuan Zhong, Yinlan Hu, Bing Li, Wangjun Liao, Cheng Liu, Yulin Liao, Jiancheng Xiu, Jianping Bi. The pseudogene PTENP1 regulates smooth muscle cells as a competing endogenous RNA. Clinical science (London, England : 1979). vol 133. issue 13. 2020-03-23. PMID:31235554. |
here, we hypothesised that ptenp1 inhibits hasmc proliferation and enhances apoptosis by promoting pten expression. |
2020-03-23 |
2023-08-13 |
human |
| Yanxian Lai, Jianyong Li, Lintao Zhong, Xiang He, Xiaoyun Si, Yili Sun, Yanmei Chen, Jiayuan Zhong, Yinlan Hu, Bing Li, Wangjun Liao, Cheng Liu, Yulin Liao, Jiancheng Xiu, Jianping Bi. The pseudogene PTENP1 regulates smooth muscle cells as a competing endogenous RNA. Clinical science (London, England : 1979). vol 133. issue 13. 2020-03-23. PMID:31235554. |
ptenp1 overexpression significantly increased the protein expression of pten, promoted apoptosis and inhibited the proliferation of hasmcs. |
2020-03-23 |
2023-08-13 |
human |
| Laurence Booth, Jane Lisa Roberts, Andrew Poklepovic, Paul Den. Prior exposure of pancreatic tumors to [sorafenib + vorinostat] enhances the efficacy of an anti-PD-1 antibody. Cancer biology & therapy. vol 20. issue 1. 2020-02-26. PMID:30142009. |
abbreviations: erk: extracellular regulated kinase; pi3k: phosphatidyl inositol 3 kinase; ca: constitutively active; dn: dominant negative; er: endoplasmic reticulum; aif: apoptosis inducing factor; ampk: amp-dependent protein kinase; mtor: mammalian target of rapamycin; jak: janus kinase; stat: signal transducers and activators of transcription; mapk: mitogen activated protein kinase; pten: phosphatase and tensin homologue on chromosome ten; ros: reactive oxygen species; cmv: empty vector plasmid or virus; si: small interfering; scr: scrambled; ip: immunoprecipitation; veh: vehicle; hdac: histone deacetylase. |
2020-02-26 |
2023-08-13 |
mouse |
| Lakshminarasimhan Harini, Sweta Srivastava, George Peter Gnanakumar, Bose Karthikeyan, Cecil Ross, Vaithilingam Krishnakumar, Velu Rajesh Kannan, Krishnan Sundar, Thandavarayan Kathiresa. An ingenious non-spherical mesoporous silica nanoparticle cargo with curcumin induces mitochondria-mediated apoptosis in breast cancer (MCF-7) cells. Oncotarget. vol 10. issue 11. 2020-02-25. PMID:30838091. |
western blot analysis suggest, curcumin induce apoptosis through the activation of caspase 9, 6, 12, parp, chop and pten. |
2020-02-25 |
2023-08-13 |
Not clear |
| Xiao-Hui Zhang, Pin Hu, Yang-Qin Xie, Yong-Jun Kang, Min L. Long Noncoding RNA HOTAIR Promotes Endometrial Carcinoma Cell Proliferation by Binding to PTEN via the Activating Phosphatidylinositol 3-Kinase/Akt Signaling Pathway. Molecular and cellular biology. vol 39. issue 23. 2020-02-25. PMID:31527078. |
overexpression of hotair promoted proliferation and inhibited apoptosis of ec cells, similar to pten knockdown. |
2020-02-25 |
2023-08-13 |
Not clear |
| Yan Wang, Zhong He, Qiu Yang, Guangju Zho. XBP1 inhibits mesangial cell apoptosis in response to oxidative stress via the PTEN/AKT pathway in diabetic nephropathy. FEBS open bio. vol 9. issue 7. 2020-02-18. PMID:31077568. |
in addition, xbp1-induced injuries in mc were reversed by overexpression of pten, and xbp1 inhibited apoptosis, which was mediated by the activated pten/akt signaling pathway. |
2020-02-18 |
2023-08-13 |
Not clear |
| Shilpa Katta, Arun Srivastava, Rajesh L Thangapazham, Inger L Rosner, Jennifer Cullen, Hua Li, Shashwat Shara. Curcumin-Gene Expression Response in Hormone Dependent and Independent Metastatic Prostate Cancer Cells. International journal of molecular sciences. vol 20. issue 19. 2020-02-12. PMID:31581661. |
evaluation of significantly regulated top canonical pathways highlighted that transforming growth factor beta (tgf-β), wingless-related integration site (wnt), phosphoinositide 3-kinase/protein kinase b/ mammalian target of rapamycin (pik3/akt(pkb)/mtor), and nuclear factor kappa-light-chain-enhancer of activated b cells (nf-kb) signaling were primarily inhibited, and phosphatase and tensin homolog (pten) dependent cell cycle arrest and apoptosis pathways were elevated with curcumin treatment. |
2020-02-12 |
2023-08-13 |
Not clear |
| Bo Sun, Xudong Zhao, Jianguang Ming, Xing Liu, Daming Liu, Chuanlu Jian. Stepwise detection and evaluation reveal miR-10b and miR-222 as a remarkable prognostic pair for glioblastoma. Oncogene. vol 38. issue 33. 2020-02-05. PMID:31289362. |
inhibition of mir-10b and mir-222 strongly suppress gbm cells growth, invasion, and induce apoptosis by co-targeting pten and leading to activation of p53 ultimately. |
2020-02-05 |
2023-08-13 |
mouse |
| Weilu Li, Yongjun Jiang, Xia Wu, Fucun Yan. Targeted Regulation of miR-26a on PTEN to Affect Proliferation and Apoptosis of Prostate Cancer Cells. Cancer biotherapy & radiopharmaceuticals. vol 34. issue 7. 2020-01-30. PMID:31135180. |
targeted regulation of mir-26a on pten to affect proliferation and apoptosis of prostate cancer cells. |
2020-01-30 |
2023-08-13 |
Not clear |
| Wenrong Zhao, Peng Geng, Yunyun Li, Xiaohe Wei, Jingxin Chen. MicroRNA-21 promotes endometrial carcinoma proliferation and invasion by targeting PTEN. International journal of clinical and experimental pathology. vol 10. issue 12. 2020-01-26. PMID:31966504. |
therefore, we concluded that mir-21 could promote cell proliferation and invasion ability, and inhibite cell apoptosis in endometrial carcinoma partially by regulating its target gene pten on post-transcriptional level. |
2020-01-26 |
2023-08-13 |
Not clear |
| Feng Jiang, Min Yang, Chuyan Wu, Jimei Wan. Potential Roles of miR-374a-5p in Mediating Neuroprotective Effects and Related Molecular Mechanism. Journal of molecular neuroscience : MN. vol 69. issue 1. 2020-01-21. PMID:31127537. |
upregulation of pten reversed the inhibitory effect of apoptotic markers elevation and pc12 cells apoptosis by the overexpression of mir-374a-5p after ogd treatment. |
2020-01-21 |
2023-08-13 |
human |
| Feng Jiang, Min Yang, Chuyan Wu, Jimei Wan. Potential Roles of miR-374a-5p in Mediating Neuroprotective Effects and Related Molecular Mechanism. Journal of molecular neuroscience : MN. vol 69. issue 1. 2020-01-21. PMID:31127537. |
pi3k pathway was required for the apoptosis effect caused by pten overexpression. |
2020-01-21 |
2023-08-13 |
human |
| Wenbo Li, Juncai Li. Overexpression of the zinc-α2-glycoprotein accelerates apoptosis and inhibits growth via the mTOR/PTEN signaling pathway in gastric carcinoma cells. Life sciences. vol 240. 2020-01-13. PMID:31790689. |
pten inhibition reversed the effects of azgp1 on cell growth and apoptosis in sgc-7901 cells. |
2020-01-13 |
2023-08-13 |
human |
| Lili Zhuang, Hongmei Qu, Jianxiang Cong, Huangguan Dai, Xiaoyan Li. MiR-181c affects estrogen-dependent endometrial carcinoma cell growth by targeting PTEN. Endocrine journal. vol 66. issue 6. 2020-01-09. PMID:30971627. |
besides, overexpression of pten markedly promoted the apoptosis of e2-induced rl95-2 cells through regulating the bax and bcl-2 expression, and modulated the expression of akt pathway, p53 and cyclin d. in conclusion, our findings revealed that mir-181c affected the estrogen-dependent endometrial carcinoma cell growth by targeting pten. |
2020-01-09 |
2023-08-13 |
human |
| Xin Li, Shuilong Guo, Li Min, Qingdong Guo, Shutian Zhan. miR-92a-3p promotes the proliferation, migration and invasion of esophageal squamous cell cancer by regulating PTEN. International journal of molecular medicine. vol 44. issue 3. 2020-01-09. PMID:31257524. |
the overexpression of pten not only inhibited escc proliferation, migration and invasion, but also promoted escc cell apoptosis. |
2020-01-09 |
2023-08-13 |
Not clear |
| Han-Hua Zhu, Xian-Tao Wang, Yu-Han Sun, Wen-Kai He, Jia-Bao Liang, Bing-Hai Mo, Lang L. MicroRNA-486-5p targeting PTEN Protects Against Coronary Microembolization-Induced Cardiomyocyte Apoptosis in Rats by activating the PI3K/AKT pathway. European journal of pharmacology. vol 855. 2019-12-20. PMID:31075240. |
microrna-486-5p targeting pten protects against coronary microembolization-induced cardiomyocyte apoptosis in rats by activating the pi3k/akt pathway. |
2019-12-20 |
2023-08-13 |
rat |
| Han-Hua Zhu, Xian-Tao Wang, Yu-Han Sun, Wen-Kai He, Jia-Bao Liang, Bing-Hai Mo, Lang L. MicroRNA-486-5p targeting PTEN Protects Against Coronary Microembolization-Induced Cardiomyocyte Apoptosis in Rats by activating the PI3K/AKT pathway. European journal of pharmacology. vol 855. 2019-12-20. PMID:31075240. |
overexpression of mir-486-5p reduced cardiomyocyte apoptosis and improved cardiac function through inhibition of pten and activation of the pi3k/akt pathway in rat cme models. |
2019-12-20 |
2023-08-13 |
rat |
| Han-Hua Zhu, Xian-Tao Wang, Yu-Han Sun, Wen-Kai He, Jia-Bao Liang, Bing-Hai Mo, Lang L. MicroRNA-486-5p targeting PTEN Protects Against Coronary Microembolization-Induced Cardiomyocyte Apoptosis in Rats by activating the PI3K/AKT pathway. European journal of pharmacology. vol 855. 2019-12-20. PMID:31075240. |
overexpression of mir-486-5p, which targets pten, protects against cme-induced cardiomyocyte apoptosis and improves cardiac function in rats by activating the pi3k/akt pathway. |
2019-12-20 |
2023-08-13 |
rat |