| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Duy N Do, Ran Li, Pier-Luc Dudemaine, Eveline M Ibeagha-Awem. MicroRNA roles in signalling during lactation: an insight from differential expression, time course and pathway analyses of deep sequence data. Scientific reports. vol 7. 2018-11-12. PMID:28317898. |
relevant signalling pathways for transition between lactation stages are involved in apoptosis (pten and sapk/jnk), intracellular signalling (protein kinase a, tgf-β and erk5), cell cycle regulation (stat3), cytokines, hormones and growth factors (prolactin, growth hormone and glucocorticoid receptor). |
2018-11-12 |
2023-08-13 |
cattle |
| Meng Li, Xiang Yang, Shouchuan Wan. PTEN enhances nasal epithelial cell resistance to TNFα‑induced inflammatory injury by limiting mitophagy via repression of the TLR4‑JNK‑Bnip3 pathway. Molecular medicine reports. vol 18. issue 3. 2018-11-08. PMID:30015897. |
the results demonstrated that tnfα treatment induced nasal epithelial cell apoptosis, proliferation arrest and migration inhibition via downregulating phosphatase and tensin homolog (pten) levels. |
2018-11-08 |
2023-08-13 |
Not clear |
| Meng Li, Xiang Yang, Shouchuan Wan. PTEN enhances nasal epithelial cell resistance to TNFα‑induced inflammatory injury by limiting mitophagy via repression of the TLR4‑JNK‑Bnip3 pathway. Molecular medicine reports. vol 18. issue 3. 2018-11-08. PMID:30015897. |
by contrast, pten overexpression in nasal epithelial cells alleviated the mitochondrial damage and cellular apoptosis via inhibiting the tlr4‑jnk‑bnip3 pathway, favoring the survival of nasal epithelial cells under inflammatory injury. |
2018-11-08 |
2023-08-13 |
Not clear |
| Meng Li, Xiang Yang, Shouchuan Wan. PTEN enhances nasal epithelial cell resistance to TNFα‑induced inflammatory injury by limiting mitophagy via repression of the TLR4‑JNK‑Bnip3 pathway. Molecular medicine reports. vol 18. issue 3. 2018-11-08. PMID:30015897. |
therefore, this data uncovered a potential molecular basis for nasal epithelial cell apoptosis in response to inflammatory injury, and pten was identified as the endogenous defender of nasal epithelial cell survival via controlling lethal mitophagy by inhibiting the tlr4‑jnk‑bnip3 pathway, suggesting that this pathway may be a potential target for clinically treating chronic nasal and sinus inflammatory injury. |
2018-11-08 |
2023-08-13 |
Not clear |
| Shohei Miyata, Li-Yan Wang, Susumu Kitanak. 3EZ, 20Ac-ingenol induces cell-specific apoptosis in cyclin D1 over-expression through the activation of ATR and downregulation of p-Akt. Leukemia research. vol 64. 2018-11-05. PMID:29179029. |
we have previously used western blot analysis to show that the catalytic topoisomerase (topo) inhibitor, 3ez, 20ac-ingenol, induced dna damage response (ddr), which activated atr, downregulated p-akt through upregulation of pten level, and led to cell cycle arrest or apoptosis. |
2018-11-05 |
2023-08-13 |
Not clear |
| Shohei Miyata, Li-Yan Wang, Susumu Kitanak. 3EZ, 20Ac-ingenol induces cell-specific apoptosis in cyclin D1 over-expression through the activation of ATR and downregulation of p-Akt. Leukemia research. vol 64. 2018-11-05. PMID:29179029. |
in this study, we used atr or pten sirna and observed that the specific cell arrest and apoptosis of ball-1 cells in ddr caused by 3ez, 20ac-ingenol was dependant on activation of atr and downregulation of nuclear p-akt through upregulation of pten. |
2018-11-05 |
2023-08-13 |
Not clear |
| Chensi Zeng, Xingxin Li, Anmao Li, Bei Yi, Xi Peng, Xi Huang, Jianbin Che. Knockdown of NUPR1 inhibits the growth of U266 and RPMI8226 multiple myeloma cell lines via activating PTEN and caspase activation‑dependent apoptosis. Oncology reports. vol 40. issue 3. 2018-11-02. PMID:30015974. |
knockdown of nupr1 inhibits the growth of u266 and rpmi8226 multiple myeloma cell lines via activating pten and caspase activation‑dependent apoptosis. |
2018-11-02 |
2023-08-13 |
human |
| Chensi Zeng, Xingxin Li, Anmao Li, Bei Yi, Xi Peng, Xi Huang, Jianbin Che. Knockdown of NUPR1 inhibits the growth of U266 and RPMI8226 multiple myeloma cell lines via activating PTEN and caspase activation‑dependent apoptosis. Oncology reports. vol 40. issue 3. 2018-11-02. PMID:30015974. |
these findings showed that nupr1 may be involved in the proliferation and apoptosis of mm cells by adjusting caspase proteins and pten, suggesting that nupr1 may be a novel therapeutic target for mm. |
2018-11-02 |
2023-08-13 |
human |
| Dong Guo, Ye-Wei Wang, Lei Yan, Ji Ma, Xin-Wei Han, Shao-Feng Shu. Dysregulation of microRNA‑23b‑3p contributes to the development of intracranial aneurysms by targeting phosphatase and tensin homolog. International journal of molecular medicine. vol 42. issue 3. 2018-10-29. PMID:29845190. |
experiments were then performed to investigate the effect of mir‑23b‑3p and pten on the viability and apoptosis of pulmonary artery smcs (pasmcs). |
2018-10-29 |
2023-08-13 |
Not clear |
| Dong Guo, Ye-Wei Wang, Lei Yan, Ji Ma, Xin-Wei Han, Shao-Feng Shu. Dysregulation of microRNA‑23b‑3p contributes to the development of intracranial aneurysms by targeting phosphatase and tensin homolog. International journal of molecular medicine. vol 42. issue 3. 2018-10-29. PMID:29845190. |
the results showed that cells transfected with mir‑23b‑3p inhibitors suppressed the viability of smcs by promoting the apoptosis of the cells compared with that of the scramble controls, while cells transfected with mir‑23b‑3p mimics and pten sirna enhanced the viability of vsmcs by inducing apoptosis. |
2018-10-29 |
2023-08-13 |
Not clear |
| Dong Guo, Ye-Wei Wang, Lei Yan, Ji Ma, Xin-Wei Han, Shao-Feng Shu. Dysregulation of microRNA‑23b‑3p contributes to the development of intracranial aneurysms by targeting phosphatase and tensin homolog. International journal of molecular medicine. vol 42. issue 3. 2018-10-29. PMID:29845190. |
mir‑23b‑3p and pten interfered with the viability and apoptosis of smcs. |
2018-10-29 |
2023-08-13 |
Not clear |
| Guang Li, Yanping Song, Gangcan Li, Jingjing Ren, Jia Xie, Yunjie Zhang, Fei Gao, Jiao Mu, Jinqian Da. Downregulation of microRNA‑21 expression inhibits proliferation, and induces G1 arrest and apoptosis via the PTEN/AKT pathway in SKM‑1 cells. Molecular medicine reports. vol 18. issue 3. 2018-10-26. PMID:30015844. |
in addition, the expression levels of apoptosis regulator bcl‑2 (bcl2), cyclind1 and phosphorylated‑protein kinase b (akt) were significantly decreased in skm‑1 cells transfected with the mir‑21 inhibitor, whilst the expression levels of phosphatase and tensin homolog (pten), bcl‑associated protein x (bax) and cleaved caspase 3 were significantly elevated. |
2018-10-26 |
2023-08-13 |
Not clear |
| Yan Ping Wei, Xiang Hua Wang, Gang Liu, Jin Feng Zhang, Yong Xian Yang, Juan Zhang, Xiao Li Song, Zhong Dong Li, Lin Dong Zha. Matrine exerts inhibitory effects in melanoma through the regulation of miR-19b-3p/PTEN. International journal of oncology. vol 53. issue 2. 2018-10-22. PMID:29845233. |
taken together, the results indicated that matrine may suppress cell proliferation and invasion and induce cell apoptosis partially via mir-19b-3p targeting of pten. |
2018-10-22 |
2023-08-13 |
human |
| Mingliang Wang, Min Liu, Ting Ni, Qiliang Li. miR‑214 mediates vascular inflammation and apoptosis via PTEN expression. Molecular medicine reports. vol 18. issue 2. 2018-10-19. PMID:29916551. |
mir‑214 mediates vascular inflammation and apoptosis via pten expression. |
2018-10-19 |
2023-08-13 |
Not clear |
| Mingliang Wang, Min Liu, Ting Ni, Qiliang Li. miR‑214 mediates vascular inflammation and apoptosis via PTEN expression. Molecular medicine reports. vol 18. issue 2. 2018-10-19. PMID:29916551. |
the results demonstrated that anti‑mir‑214 mimics inhibited cell proliferation, increased apoptosis and inflammatory factors (tnf‑α, il‑1β, il‑6 and il‑18 levels), inhibited cell proliferation, and induced bax protein expression in tnf‑α‑induced vascular endothelial cells through induction of pten and nf‑κb protein expression and inhibition of akt protein expression. |
2018-10-19 |
2023-08-13 |
Not clear |
| Mingliang Wang, Min Liu, Ting Ni, Qiliang Li. miR‑214 mediates vascular inflammation and apoptosis via PTEN expression. Molecular medicine reports. vol 18. issue 2. 2018-10-19. PMID:29916551. |
the pten inhibitor inhibited the function of anti‑mir‑214 on apoptosis and inflammation in tnf‑α‑induced inflammation vascular endothelial cells through the pten/akt signaling pathway. |
2018-10-19 |
2023-08-13 |
Not clear |
| Mingliang Wang, Min Liu, Ting Ni, Qiliang Li. miR‑214 mediates vascular inflammation and apoptosis via PTEN expression. Molecular medicine reports. vol 18. issue 2. 2018-10-19. PMID:29916551. |
these results suggest that mir‑214 mediates vascular inflammation and apoptosis via pten expression. |
2018-10-19 |
2023-08-13 |
Not clear |
| Yi Tian, Xinqiang Xiao, Xing Gong, Feng Peng, Yun Xu, Yongfang Jiang, Guozhong Gon. HBx promotes cell proliferation by disturbing the cross-talk between miR-181a and PTEN. Scientific reports. vol 7. 2018-10-15. PMID:28053323. |
finally, hbx interrupted the balance between apoptosis and proliferation, which contributed to the development of hepatocellular carcinoma, was also related to the interaction of mir-181a and pten. |
2018-10-15 |
2023-08-13 |
Not clear |
| Maliheh Moradzadeh, Alijan Tabarraei, Hamid Reza Sadeghnia, Ahmad Ghorbani, Ashraf Mohamadkhani, Saiedeh Erfanian, Amirhossein Sahebka. Kaempferol increases apoptosis in human acute promyelocytic leukemia cells and inhibits multidrug resistance genes. Journal of cellular biochemistry. vol 119. issue 2. 2018-10-15. PMID:28865123. |
furthermore, the expression levels of genes involved in apoptosis (pi3 k, akt, bcl2, bax, p53, p21, pten, casp3, casp8, and casp9), differentiation (pml-rar and hdac1), and multi-drug resistance (abcb1 and abcc1) were determined using quantitative real-time pcr. |
2018-10-15 |
2023-08-13 |
human |
| Zhang Li, Zhenfeng Cheng, Yu Haifeng, Mengting Chen, Lifang L. PTEN signaling inhibitor VO-OHpic improves cardiac myocyte survival by mediating apoptosis resistance in vitro. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 103. 2018-10-15. PMID:29864901. |
pten signaling inhibitor vo-ohpic improves cardiac myocyte survival by mediating apoptosis resistance in vitro. |
2018-10-15 |
2023-08-13 |
Not clear |