| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiang Zhang, Bin Zhang, Leina Sun, Qingna Yan, Yu Zhang, Zhenfa Zhang, Yanjun Su, Changli Wan. MicroRNA-130b targets PTEN to induce resistance to cisplatin in lung cancer cells by activating Wnt/β-catenin pathway. Cell biochemistry and function. vol 36. issue 4. 2018-07-10. PMID:29653464. |
these findings suggest that mir-130b targets pten to mediate chemoresistance, proliferation, and apoptosis via wnt/β-catenin pathway. |
2018-07-10 |
2023-08-13 |
mouse |
| Qiang Zhang, Bin Zhang, Leina Sun, Qingna Yan, Yu Zhang, Zhenfa Zhang, Yanjun Su, Changli Wan. MicroRNA-130b targets PTEN to induce resistance to cisplatin in lung cancer cells by activating Wnt/β-catenin pathway. Cell biochemistry and function. vol 36. issue 4. 2018-07-10. PMID:29653464. |
these findings suggest that mir-130b targets pten to mediate chemoresistance, proliferation, and apoptosis via wnt/β-catenin pathway. |
2018-07-10 |
2023-08-13 |
mouse |
| Minghui Jia, Xiaoyun Chen, Jili Liu, Jun Che. PTEN promotes apoptosis of H2O2‑injured rat nasal epithelial cells through PI3K/Akt and other pathways. Molecular medicine reports. vol 17. issue 1. 2018-07-09. PMID:29115519. |
pten promotes apoptosis of h2o2‑injured rat nasal epithelial cells through pi3k/akt and other pathways. |
2018-07-09 |
2023-08-13 |
rat |
| Minghui Jia, Xiaoyun Chen, Jili Liu, Jun Che. PTEN promotes apoptosis of H2O2‑injured rat nasal epithelial cells through PI3K/Akt and other pathways. Molecular medicine reports. vol 17. issue 1. 2018-07-09. PMID:29115519. |
in h2o2‑injured cells, oxidative stress, due to increased ros levels and apoptosis rates, was induced, and pten aggravated the injury. |
2018-07-09 |
2023-08-13 |
rat |
| Jing Wu, Zhihui Sun, Huijie Sun, Yanhua L. MicroRNA‑27a promotes tumorigenesis via targeting AKT in triple negative breast cancer. Molecular medicine reports. vol 17. issue 1. 2018-07-09. PMID:29115608. |
a luciferase assay was performed to evaluate the effect of mir‑27a on phosphatase and tensin homolog (pten) and b cell lymphoma (bcl)‑2 associated x, apoptosis regulator (bax) expression. |
2018-07-09 |
2023-08-13 |
mouse |
| Ling-Juan Lao, Xin-Jiang Song, Jia X. [Effect of resveratrol in regulating proliferation and apoptosis of rectal cancer cells via up-regulating PTEN]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 9. 2018-06-28. PMID:29082697. |
[effect of resveratrol in regulating proliferation and apoptosis of rectal cancer cells via up-regulating pten]. |
2018-06-28 |
2023-08-13 |
human |
| Ling-Juan Lao, Xin-Jiang Song, Jia X. [Effect of resveratrol in regulating proliferation and apoptosis of rectal cancer cells via up-regulating PTEN]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 9. 2018-06-28. PMID:29082697. |
to analysis the relative expression of pten(phosphatase and tensin homology deleted on chromosome ten) in rectal cancer cell lines and the effects of resveratrol on cell proliferation and apoptosis of rectal cancer cells in vitro. |
2018-06-28 |
2023-08-13 |
human |
| Ling-Juan Lao, Xin-Jiang Song, Jia X. [Effect of resveratrol in regulating proliferation and apoptosis of rectal cancer cells via up-regulating PTEN]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 9. 2018-06-28. PMID:29082697. |
shrna(short hairpin rna) was built to down-regulate pten expression in sw480 cells, and detect whether the own-regulated pten expression impact resveratrol's effect in growth inhibition and apoptosis induction of in vitro rectal cancer cells. |
2018-06-28 |
2023-08-13 |
human |
| Ling-Juan Lao, Xin-Jiang Song, Jia X. [Effect of resveratrol in regulating proliferation and apoptosis of rectal cancer cells via up-regulating PTEN]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 9. 2018-06-28. PMID:29082697. |
the experimental results suggested that resveratrol can be used as an anti-proliferative and apoptosis induction agent in rectal cancer through up-regulation of pten. |
2018-06-28 |
2023-08-13 |
human |
| Weigang Cui, Songtao Wang, Zhongping Wang, Zhiyong Wang, Chunli Sun, Yinghua Zhan. Inhibition of PTEN Attenuates Endoplasmic Reticulum Stress and Apoptosis via Activation of PI3K/AKT Pathway in Alzheimer's Disease. Neurochemical research. vol 42. issue 11. 2018-06-26. PMID:28819903. |
inhibition of pten attenuates endoplasmic reticulum stress and apoptosis via activation of pi3k/akt pathway in alzheimer's disease. |
2018-06-26 |
2023-08-13 |
mouse |
| Weigang Cui, Songtao Wang, Zhongping Wang, Zhiyong Wang, Chunli Sun, Yinghua Zhan. Inhibition of PTEN Attenuates Endoplasmic Reticulum Stress and Apoptosis via Activation of PI3K/AKT Pathway in Alzheimer's Disease. Neurochemical research. vol 42. issue 11. 2018-06-26. PMID:28819903. |
however, the direct effects of the pten on er stress and apoptosis in ad have not been elucidated. |
2018-06-26 |
2023-08-13 |
mouse |
| Weigang Cui, Songtao Wang, Zhongping Wang, Zhiyong Wang, Chunli Sun, Yinghua Zhan. Inhibition of PTEN Attenuates Endoplasmic Reticulum Stress and Apoptosis via Activation of PI3K/AKT Pathway in Alzheimer's Disease. Neurochemical research. vol 42. issue 11. 2018-06-26. PMID:28819903. |
a pten inhibitor, dipotassium bisperoxo-(5-hydroxypyridine-2-carboxyl)-oxovanadate (bpv) could decrease apoptosis, induce akt phosphorylation and inhibit the er stress response proteins in hippocampus in app/ps1 transgenic ad model mice. |
2018-06-26 |
2023-08-13 |
mouse |
| Jianping Xiao, Tao Tao, Yongxiang Yin, Li Zhao, Lan Yang, Lingqing H. miR-144 may regulate the proliferation, migration and invasion of trophoblastic cells through targeting PTEN in preeclampsia. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 94. 2018-05-18. PMID:28772212. |
the expression of mir-144 and pten in 30 placentas of patients with pe and 30 normal placentas was compared; next, htr8/svneo cells were transfected with mir-144 mimics and mir-144 inhibitors and cultured for 48h, and the proliferation and apoptosis, cell migration and invasion of the cells were examined; furthermore, the expression pten, caspase-3 and bcl-2 was examined; next, dual luciferase reporter assay has been performed to confirm that pten is a direct target of mir-144; finally, htr-8/svneo cells were transfected with either pten overexpression plasmid or pten rnai to determine whether knockdown or overexpression of pten can mimic the effect of mir-144 we have observed that the expression of mir-144 was significantly decreased and the expression of pten was markedly increased in placentas of patients with pe compared with normal placentas; moreover, transfection of mir-144 mimics in trophoblastic cells induced significant increase in cell proliferation, migration, invasion, and decrease in cell apoptosis, and also affected the cell cycles; on the other hand, transfection of mir-144 inhibitors has shown the opposite effects; furthermore, transient overexpression of mir-144 induced marked decrease in the expression of pten, caspase-3 and increase in expression of bcl-2 (p<0.01), while transfection of mir-144 inhibitors showed the opposite effects; finally, pten has been confirmed as a direct target of mir-144; finally, transfection of pten overexpression plasmid or pten rnai can mimic the results of mir-144 inhibitor or mir-144 mimics, respectively. |
2018-05-18 |
2023-08-13 |
Not clear |
| Duy Luong, Prashant Kesharwani, Hashem O Alsaab, Samaresh Sau, Subhash Padhye, Fazlul H Sarkar, Arun K Iye. Folic acid conjugated polymeric micelles loaded with a curcumin difluorinated analog for targeting cervical and ovarian cancers. Colloids and surfaces. B, Biointerfaces. vol 157. 2018-04-30. PMID:28658642. |
when the nanomicelles were tested in folate-receptor overexpressing ovarian and cervical cancer cells they exhibited high anticancer activity causing significant cell population to undergo apoptosis due to upregulation of tumor suppressor phosphatase and tensin homolog (pten) and inhibition of nuclear factor kappa-b (nfκb), which further confirmed the targeting ability and anticancer potentials of folate-targeted formulations. |
2018-04-30 |
2023-08-13 |
Not clear |
| Xiafei Fu, Yuanli He, Xuefeng Wang, Dongxian Peng, Xiaoying Chen, Xinran Li, Qing Wan. Overexpression of miR-21 in stem cells improves ovarian structure and function in rats with chemotherapy-induced ovarian damage by targeting PDCD4 and PTEN to inhibit granulosa cell apoptosis. Stem cell research & therapy. vol 8. issue 1. 2018-04-30. PMID:28807003. |
overexpression of mir-21 in stem cells improves ovarian structure and function in rats with chemotherapy-induced ovarian damage by targeting pdcd4 and pten to inhibit granulosa cell apoptosis. |
2018-04-30 |
2023-08-13 |
rat |
| Li Yan, Rui Cao, YuanBo Liu, LianZhao Wang, Bo Pan, XiaoYan Lv, Hu Jiao, Qiang Zhuang, XueJian Sun, Ran Xia. MiR-21-5p Links Epithelial-Mesenchymal Transition Phenotype with Stem-Like Cell Signatures via AKT Signaling in Keloid Keratinocytes. Scientific reports. vol 6. 2018-04-24. PMID:27596120. |
to investigate the role of mir-21-5p in keloid pathogenesis, we transfected mir-21-5p mimic or inhibitor in keloid keratinocytes and examined the abilities of cell proliferation, apoptosis, migration and invasion, the expressions of emt-related markers vimentin and e-cadherin and stem-like cells-associated markers cd44 and aldh1, and the involvement of pten and the signaling of akt and erk. |
2018-04-24 |
2023-08-13 |
Not clear |
| HaiTao Liu, Tao Yin, Wenjun Yan, Rui Si, Bo Wang, Mai Chen, Fei Li, Qiong Wang, Ling Ta. Dysregulation of microRNA-214 and PTEN contributes to the pathogenesis of hypoxic pulmonary hypertension. International journal of chronic obstructive pulmonary disease. vol 12. 2018-04-24. PMID:28684904. |
furthermore, the introduction of mir-214 significantly promoted the proliferation of pasmcs by suppressing apoptosis of the cells, which was mediated by the downregulation of pten. |
2018-04-24 |
2023-08-13 |
Not clear |
| Huilong Wen, Zhong Wu, Huidong Hu, Yixiong Wu, Gang Yang, Jiajun Lu, Guang Yang, Gang Guo, Qirong Don. The anti-tumor effect of pachymic acid on osteosarcoma cells by inducing PTEN and Caspase 3/7-dependent apoptosis. Journal of natural medicines. vol 72. issue 1. 2018-04-24. PMID:28856634. |
the anti-tumor effect of pachymic acid on osteosarcoma cells by inducing pten and caspase 3/7-dependent apoptosis. |
2018-04-24 |
2023-08-13 |
human |
| Huilong Wen, Zhong Wu, Huidong Hu, Yixiong Wu, Gang Yang, Jiajun Lu, Guang Yang, Gang Guo, Qirong Don. The anti-tumor effect of pachymic acid on osteosarcoma cells by inducing PTEN and Caspase 3/7-dependent apoptosis. Journal of natural medicines. vol 72. issue 1. 2018-04-24. PMID:28856634. |
moreover, ac-devd-cho (a caspase 3/7 inhibitor) pre-treatment or pten knockdown partially blocked the effects of pa on cell proliferation and apoptosis. |
2018-04-24 |
2023-08-13 |
human |
| R-K Li, J- Gao, L-H Guo, G-Q Huang, W-H Lu. PTENP1 acts as a ceRNA to regulate PTEN by sponging miR-19b and explores the biological role of PTENP1 in breast cancer. Cancer gene therapy. vol 24. issue 7. 2018-04-23. PMID:28731027. |
further, ptenp1 and pten are direct targets of mir-19b, and overexpressed ptenp1 in mda-mb-231 cells could supress cell proliferation, migration and invasion and promote cell apoptosis. |
2018-04-23 |
2023-08-13 |
Not clear |