| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nuria Eritja, Isidre Felip, Mari Alba Dosil, Lucia Vigezzi, Cristina Mirantes, Andree Yeramian, Raúl Navaridas, Maria Santacana, David Llobet-Navas, Akihiko Yoshimura, Masatoshi Nomura, Mario Encinas, Xavier Matias-Guiu, Xavi Dolce. A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-β in mouse endometrium. Cell death and differentiation. vol 24. issue 8. 2018-03-27. PMID:28524854. |
likewise smad3 deletion, pten knockout prevents tgf-β-induced apoptosis and increases cell proliferation by increasing pi3k/akt/mtor signaling. |
2018-03-27 |
2023-08-13 |
mouse |
| Giovanna Carrà, Cristina Panuzzo, Davide Torti, Guido Parvis, Sabrina Crivellaro, Ubaldo Familiari, Marco Volante, Deborah Morena, Marcello Francesco Lingua, Mara Brancaccio, Angelo Guerrasio, Pier Paolo Pandolfi, Giuseppe Saglio, Riccardo Taulli, Alessandro Morott. Therapeutic inhibition of USP7-PTEN network in chronic lymphocytic leukemia: a strategy to overcome TP53 mutated/deleted clones. Oncotarget. vol 8. issue 22. 2018-03-26. PMID:28418900. |
treatment of primary cll samples and cell lines with p5091 induces cell growth arrest and apoptosis, through the restoration of pten nuclear pool, both in tp53-wild type and -null environment. |
2018-03-26 |
2023-08-13 |
Not clear |
| Xiaorong Mao, Senrong Du, Zhongxia Yang, Liting Zhang, Xuebin Peng, Ni Jiang, Haiyu Zho. Inhibitors of PARP-1 exert inhibitory effects on the biological characteristics of hepatocellular carcinoma cells in vitro. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28498459. |
flow cytometry was used to detect the apoptosis of hepg2 cells, western blot analysis was used to detect the protein expression of casepase‑3, casepase‑8, b‑cell lymphoma 2 (bcl‑2)‑associated x protein (bax), bcl‑2, phosphatase and tensin homolog (pten), tissue inhibitor of metalloproteinase (timp) 3 and matrix metalloprotease (mmp) 3. |
2018-03-26 |
2023-08-13 |
Not clear |
| Ulkan Kilic, Ahmet Burak Caglayan, Mustafa Caglar Beker, Mehmet Yalcin Gunal, Berrak Caglayan, Esra Yalcin, Taha Kelestemur, Reyhan Zeynep Gundogdu, Burak Yulug, Bayram Yılmaz, Bilal Ersen Kerman, Ertugrul Kili. Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice. Redox biology. vol 12. 2018-03-20. PMID:28395173. |
our data suggest that akt phosphorylation, preferably at the thr308 site of the activation loop via pdk1 and pten, mediates melatonin's neuroprotective activity and increased akt phosphorylation leads to reduced apoptosis. |
2018-03-20 |
2023-08-13 |
mouse |
| Je-Won Ryu, Sung Sik Choe, Seung-Hee Ryu, Eun-Young Park, Byoung Wook Lee, Tae Keun Kim, Chang Hoon Ha, Sang-Wook Le. Paradoxical induction of growth arrest and apoptosis by EGF via the up-regulation of PTEN by activating Redox factor-1/Egr-1 in human lung cancer cells. Oncotarget. vol 8. issue 3. 2018-02-23. PMID:27935858. |
paradoxical induction of growth arrest and apoptosis by egf via the up-regulation of pten by activating redox factor-1/egr-1 in human lung cancer cells. |
2018-02-23 |
2023-08-13 |
human |
| Je-Won Ryu, Sung Sik Choe, Seung-Hee Ryu, Eun-Young Park, Byoung Wook Lee, Tae Keun Kim, Chang Hoon Ha, Sang-Wook Le. Paradoxical induction of growth arrest and apoptosis by EGF via the up-regulation of PTEN by activating Redox factor-1/Egr-1 in human lung cancer cells. Oncotarget. vol 8. issue 3. 2018-02-23. PMID:27935858. |
egf-induced pten upregulation increased apoptosis and autophagy-induced damage in a549 cells, whereas ref-1 knockdown blocked egf-induced pten upregulation in an nadph oxidase p22phox subunit-independent manner. |
2018-02-23 |
2023-08-13 |
human |
| Longjiang Xu, Hong Leng, Xin Shi, Jiang Ji, Jinxiang Fu, Hong Len. MiR-155 promotes cell proliferation and inhibits apoptosis by PTEN signaling pathway in the psoriasis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 90. 2018-02-23. PMID:28402921. |
mir-155 promotes cell proliferation and inhibits apoptosis by pten signaling pathway in the psoriasis. |
2018-02-23 |
2023-08-13 |
Not clear |
| Longjiang Xu, Hong Leng, Xin Shi, Jiang Ji, Jinxiang Fu, Hong Len. MiR-155 promotes cell proliferation and inhibits apoptosis by PTEN signaling pathway in the psoriasis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 90. 2018-02-23. PMID:28402921. |
the purposes of the study was to evaluated the effects of mirna-155 on cell proliferation, migration and apoptosis in psoriasis development via pten singaling pathway and identify its direct target protein. |
2018-02-23 |
2023-08-13 |
Not clear |
| Yinghan Su, Bin Sun, Xuejing Lin, Xinying Zhao, Weidan Ji, Miaoxia He, Haihua Qian, Xianmin Song, Jianmin Yang, Jianmin Wang, Jie Che. Therapeutic strategy with artificially-designed i-lncRNA targeting multiple oncogenic microRNAs exhibits effective antitumor activity in diffuse large B-cell lymphoma. Oncotarget. vol 7. issue 31. 2018-02-21. PMID:27172795. |
the in vitro experiments confirmed that the i-lncrna expression significantly inhibited cell proliferation, induced cell cycle arrest and apoptosis in dlbcl cell lines, mainly through upregulating the expression of pten, p27kip1, timp3, reck and downregulating the expression of p38/mapk, survivin, cdk4, c-myc. |
2018-02-21 |
2023-08-13 |
mouse |
| Ying Wang, Bingyu Chen, Zhen Wang, Wei Zhang, Ke Hao, Yu Chen, Kaiqiang Li, Tongtong Wang, Yiwei Xie, Zhihui Huang, Xiangmin Ton. Marsdenia tenacissimae extraction (MTE) inhibits the proliferation and induces the apoptosis of human acute T cell leukemia cells through inactivating PI3K/AKT/mTOR signaling pathway via PTEN enhancement. Oncotarget. vol 7. issue 50. 2018-02-21. PMID:27756877. |
marsdenia tenacissimae extraction (mte) inhibits the proliferation and induces the apoptosis of human acute t cell leukemia cells through inactivating pi3k/akt/mtor signaling pathway via pten enhancement. |
2018-02-21 |
2023-08-13 |
human |
| Ying Wang, Bingyu Chen, Zhen Wang, Wei Zhang, Ke Hao, Yu Chen, Kaiqiang Li, Tongtong Wang, Yiwei Xie, Zhihui Huang, Xiangmin Ton. Marsdenia tenacissimae extraction (MTE) inhibits the proliferation and induces the apoptosis of human acute T cell leukemia cells through inactivating PI3K/AKT/mTOR signaling pathway via PTEN enhancement. Oncotarget. vol 7. issue 50. 2018-02-21. PMID:27756877. |
mechanistically, mte enhanced pten (phosphatases and tensin homolog) level and inactivated pi3k/akt/mtor signaling pathway in jurkat cells, which mediated the inhibition of cell proliferation by mte and mte-induced apoptosis. |
2018-02-21 |
2023-08-13 |
human |
| Yongqiang Yue, Ke Ma, Zhen Li, Zhonggao Wan. Angiotensin II type 1 receptor-associated protein regulates carotid intimal hyperplasia through controlling apoptosis of vascular smooth muscle cells. Biochemical and biophysical research communications. vol 495. issue 2. 2018-02-14. PMID:29247644. |
under the condition of angiotensin-ii stimulation, atrap overexpression induced the apoptosis of rat vsmcs by depressing the pi3k-akt signaling; whereas up-regulation of akt by pten inhibitor abolished the apoptotic death. |
2018-02-14 |
2023-08-13 |
rat |
| Zun-Ping Ke, Peng Xu, Yan Shi, Ai-Mei Ga. MicroRNA-93 inhibits ischemia-reperfusion induced cardiomyocyte apoptosis by targeting PTEN. Oncotarget. vol 7. issue 20. 2018-01-08. PMID:27119510. |
microrna-93 inhibits ischemia-reperfusion induced cardiomyocyte apoptosis by targeting pten. |
2018-01-08 |
2023-08-13 |
Not clear |
| Ge-Liang Liu, Han-Jie Yang, Bo Liu, Tian Li. Effects of MicroRNA-19b on the Proliferation, Apoptosis, and Migration of Wilms' Tumor Cells Via the PTEN/PI3K/AKT Signaling Pathway. Journal of cellular biochemistry. vol 118. issue 10. 2017-12-21. PMID:28322459. |
mtt assay, propidium iodide (pi) staining, annexin-v/pi double-staining, transwell assay and western blotting were performed to examine cell proliferation, cycle, apoptosis, migration, and invasion, and the protein expressions of pten, p13k, akt, and p-akt. |
2017-12-21 |
2023-08-13 |
human |
| Florian Thuma, Sarah Heiler, Martina Schnölzer, Margot Zölle. Palmitoylated claudin7 captured in glycolipid-enriched membrane microdomains promotes metastasis via associated transmembrane and cytosolic molecules. Oncotarget. vol 7. issue 21. 2017-12-18. PMID:27120791. |
an association of cld7mpalm with the major pten phosphorylating kinases does not restore apoptosis resistance as phosphorylated pten is not guided towards gem to compete with non-phosphorylated pten. |
2017-12-18 |
2023-08-13 |
rat |
| Do Won Hwang, Han Young Kim, Fangyuan Li, Ji Yong Park, Dohyun Kim, Jae Hyung Park, Hwa Seung Han, Jung Woo Byun, Yun-Sang Lee, Jae Min Jeong, Kookheon Char, Dong Soo Le. In vivo visualization of endogenous miR-21 using hyaluronic acid-coated graphene oxide for targeted cancer therapy. Biomaterials. vol 121. 2017-12-12. PMID:28088076. |
knockdown of endogenous mir-21 by hgp21 led to decreased proliferation and reduced migration of cancer cells, as well as the induction of apoptosis, with enhanced pten levels. |
2017-12-12 |
2023-08-13 |
mouse |
| James T Lynch, Robert McEwen, Claire Crafter, Ultan McDermott, Mathew J Garnett, Simon T Barry, Barry R Davie. Identification of differential PI3K pathway target dependencies in T-cell acute lymphoblastic leukemia through a large cancer cell panel screen. Oncotarget. vol 7. issue 16. 2017-12-04. PMID:26989080. |
induction of apoptosis only occurred following akti treatment in cell lines with pten protein loss and high levels of active akt. |
2017-12-04 |
2023-08-13 |
Not clear |
| Hayriye Hızarcıoğlu-Gülşen, Esra Kılıç, Elena Dominguez-Garrido, Yusuf Aydemir, Gülen Eda Utine, İnci Nur Saltık-Temize. Polyposis deserves a perfect physical examination for final diagnosis: Bannayan-Riley-Ruvalcaba syndrome. The Turkish journal of pediatrics. vol 59. issue 1. 2017-12-04. PMID:29168369. |
the mutation of the pten gene that is responsible for controlling cellular proliferation, migration and apoptosis clarifies the reason of tissue overgrowth in brrs. |
2017-12-04 |
2023-08-13 |
Not clear |
| Jiahong Xu, Yu Tang, Yihua Bei, Shengguang Ding, Lin Che, Jianhua Yao, Hongbao Wang, Dongchao Lv, Junjie Xia. miR-19b attenuates H2O2-induced apoptosis in rat H9C2 cardiomyocytes via targeting PTEN. Oncotarget. vol 7. issue 10. 2017-11-30. PMID:26918829. |
mir-19b attenuates h2o2-induced apoptosis in rat h9c2 cardiomyocytes via targeting pten. |
2017-11-30 |
2023-08-13 |
rat |
| Jiahong Xu, Yu Tang, Yihua Bei, Shengguang Ding, Lin Che, Jianhua Yao, Hongbao Wang, Dongchao Lv, Junjie Xia. miR-19b attenuates H2O2-induced apoptosis in rat H9C2 cardiomyocytes via targeting PTEN. Oncotarget. vol 7. issue 10. 2017-11-30. PMID:26918829. |
furthermore, pten was negatively regulated by mir-19b at the protein level while silencing pten could completely block the aggravated impact of mir-19b inhibitor on h2o2-induced apoptosis in h9c2 cardiomyocytes, indicating pten as a downstream target of mir-19b controlling h2o2-induced apoptosis. |
2017-11-30 |
2023-08-13 |
rat |