| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianjun Shen, Weina Niu, Hongbo Zhang, Ma Jun, Hongyan Zhan. Downregulation of MicroRNA-147 Inhibits Cell Proliferation and Increases the Chemosensitivity of Gastric Cancer Cells to 5-Fluorouracil by Directly Targeting PTEN. Oncology research. vol 26. issue 6. 2019-02-05. PMID:28950928. |
pten knockdown reversed the effects of mir-147 downregulation on the proliferation, chemosensitivity, and 5-fu-induced apoptosis of gastric cancer cells. |
2019-02-05 |
2023-08-13 |
Not clear |
| Jianjun Shen, Weina Niu, Hongbo Zhang, Ma Jun, Hongyan Zhan. Downregulation of MicroRNA-147 Inhibits Cell Proliferation and Increases the Chemosensitivity of Gastric Cancer Cells to 5-Fluorouracil by Directly Targeting PTEN. Oncology research. vol 26. issue 6. 2019-02-05. PMID:28950928. |
in conclusion, mir-147 suppressed the proliferation and enhanced the chemosensitivity of gastric cancer cells to 5-fu by promoting cell apoptosis through directly targeting pten and regulating the pi3k/akt signaling pathway. |
2019-02-05 |
2023-08-13 |
Not clear |
| Raj Pranap Arun, Divya Sivanesan, Prasanna Vidyasekar, Rama Shanker Verm. PTEN/FOXO3/AKT pathway regulates cell death and mediates morphogenetic differentiation of Colorectal Cancer Cells under Simulated Microgravity. Scientific reports. vol 7. issue 1. 2019-02-04. PMID:28729699. |
gene expression analysis on dld1 cells showed upregulation of tumor suppressors pten and foxo3; leading to akt downregulation and further induction of apoptosis, through upregulation of cdk inhibitors cdkn2b, cdkn2d. |
2019-02-04 |
2023-08-13 |
Not clear |
| Feng He, Ning Ma, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Zhe Zhang, Guangwu Huang, Kazuhiko Takeuchi, Mariko Murat. Taurine exhibits an apoptosis-inducing effect on human nasopharyngeal carcinoma cells through PTEN/Akt pathways in vitro. Amino acids. vol 50. issue 12. 2019-02-04. PMID:30225664. |
in conclusion, taurine may inhibit cell proliferation and induce apoptosis in npc through pten activation with concomitant akt inactivation. |
2019-02-04 |
2023-08-13 |
human |
| Guangfa Zhu, Wenmei Zhang, Yan Liu, Shenghao Wan. miR‑371b‑5p inhibits endothelial cell apoptosis in monocrotaline‑induced pulmonary arterial hypertension via PTEN/PI3K/Akt signaling pathways. Molecular medicine reports. vol 18. issue 6. 2019-01-29. PMID:30387816. |
in addition, vo‑ohpic, a pten inhibitor, reduced the protein expression levels of pten in the paecs and inhibited the effects of anti‑mir‑371b‑5p on cell apoptosis. |
2019-01-29 |
2023-08-13 |
rat |
| Kun Han, Zhao Jian Li, Peng Su. MicroRNA‑494 promotes the proliferation and migration of human glioma cancer cells through the protein kinase B/mechanistic target of rapamycin pathway by phosphatase and tensin homolog expression. Oncology reports. vol 41. issue 1. 2019-01-22. PMID:30365133. |
by contrast, overexpression of mir‑494 by mir‑494 mimics promoted cell growth and migration, and suppressed the apoptosis of glioma cancer via the akt/mtor pathway by pten expression. |
2019-01-22 |
2023-08-13 |
human |
| Tonglei Liu, Shuang Liu, Yu Xu, Ruo Shu, Feng Wang, Cheng Chen, Yujian Zeng, Huayou Lu. Circular RNA-ZFR Inhibited Cell Proliferation and Promoted Apoptosis in Gastric Cancer by Sponging miR-130a/miR-107 and Modulating PTEN. Cancer research and treatment. vol 50. issue 4. 2019-01-17. PMID:29361817. |
circular rna-zfr inhibited cell proliferation and promoted apoptosis in gastric cancer by sponging mir-130a/mir-107 and modulating pten. |
2019-01-17 |
2023-08-13 |
Not clear |
| Xukeng Guo, Minghua Cheng, Weiqi Ke, Yuting Wang, Xuan J. MicroRNA‑214 suppresses propofol‑induced neuroapoptosis through activation of phosphoinositide 3‑kinase/protein kinase B signaling by targeting phosphatase and tensin homolog expression. International journal of molecular medicine. vol 42. issue 5. 2019-01-02. PMID:30106086. |
treatment with a pten inhibitor successfully suppressed the pten protein expression and decreased the apoptosis of propofol‑treated nerve cells subsequent to mir‑214 overexpression through pi3k/akt signaling. |
2019-01-02 |
2023-08-13 |
rat |
| Junhong Tian, Leilei Yua. Sirtuin 6 inhibits colon cancer progression by modulating PTEN/AKT signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 106. 2018-12-18. PMID:29957460. |
in addition, compared with cells over-expressed sirt6, cell apoptosis was repressed and cell proliferation and tumorigenesis were enhanced in cells with sirt6 over-expression and pten knockdown. |
2018-12-18 |
2023-08-13 |
Not clear |
| Ying Xing, Man-Man Wang, Ya-Shuo Feng, Fang Dong, Feng Zhan. Possible Involvement of PTEN Signaling Pathway in the Anti-apoptotic Effect of Electroacupuncture Following Ischemic Stroke in Rats. Cellular and molecular neurobiology. vol 38. issue 8. 2018-12-17. PMID:30136167. |
here, we aimed to evaluate whether ea therapy at points of quchi (li11) and zusanli (st36) alleviated neuronal apoptosis by pten signaling pathway after ischemic stroke. |
2018-12-17 |
2023-08-13 |
rat |
| Ying Xing, Man-Man Wang, Ya-Shuo Feng, Fang Dong, Feng Zhan. Possible Involvement of PTEN Signaling Pathway in the Anti-apoptotic Effect of Electroacupuncture Following Ischemic Stroke in Rats. Cellular and molecular neurobiology. vol 38. issue 8. 2018-12-17. PMID:30136167. |
these findings suggest that ea treatment at points of quchi (li11)- and zusanli (st36)-induced neuroprotection might involve inhibition of apoptosis via pten pathway. |
2018-12-17 |
2023-08-13 |
rat |
| Takahiro Kodama, Jing Yi, Justin Y Newberg, Jean C Tien, Hao Wu, Milton J Finegold, Michiko Kodama, Zhubo Wei, Takeshi Tamura, Tetsuo Takehara, Randy L Johnson, Nancy A Jenkins, Neal G Copelan. Molecular profiling of nonalcoholic fatty liver disease-associated hepatocellular carcinoma using SB transposon mutagenesis. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 44. 2018-12-12. PMID:30327349. |
liver-specific deletion of sav1 was found to promote hepatic lipid accumulation, apoptosis, and fibrogenesis, leading to the acceleration of hepatocarcinogenesis in liver-specific pten mutant mice. |
2018-12-12 |
2023-08-13 |
mouse |
| Bing-Gang Zhou, Chang-Sheng Wei, Song Zhang, Zhi Zhang, Huan-Min Ga. Matrine reversed multidrug resistance of breast cancer MCF-7/ADR cells through PI3K/AKT signaling pathway. Journal of cellular biochemistry. vol 119. issue 5. 2018-12-11. PMID:29130495. |
methyl thiazolyl tetrazolium (mtt) assay was used to detect the inhibitory action; annexin v to detect apoptosis; fluorospectrophotometry to examine intracellular adriamycin (adr) accumulation; and western blot to label the proteins of p-glycoprotein (p-gp), mrp1, pten, p-akt, bcl-2, bax, and caspase-3. |
2018-12-11 |
2023-08-13 |
Not clear |
| Yulong Yao, Fangyuan Sun, Ming Le. miR-25 inhibits sepsis-induced cardiomyocyte apoptosis by targetting PTEN. Bioscience reports. vol 38. issue 2. 2018-12-11. PMID:29440462. |
mir-25 inhibits sepsis-induced cardiomyocyte apoptosis by targetting pten. |
2018-12-11 |
2023-08-13 |
rat |
| Yanliang Zheng, Jingfang Xie, Fangfang Jiang, Yunyun Li, Guanlin Chang, Haiqing M. Inhibition of miR‑21 promotes cell apoptosis in oral squamous cell carcinoma by upregulating PTEN. Oncology reports. vol 40. issue 5. 2018-11-27. PMID:30132571. |
inhibition of mir‑21 promotes cell apoptosis in oral squamous cell carcinoma by upregulating pten. |
2018-11-27 |
2023-08-13 |
Not clear |
| Yakun Kong, Junjie Yin, Yun Fu, Yufeng Chen, Yanhong Zhou, Xiuqin Gen. Suppression of Elk1 inhibits thyroid cancer progression by mediating PTEN expression. Oncology reports. vol 40. issue 3. 2018-11-15. PMID:30015900. |
we found that loss of elk1 function obviously induced the expression of early growth response‑1 (egr‑1) and pten, promoted apoptosis and constrained the proliferation of thyroid cancer cells. |
2018-11-15 |
2023-08-13 |
Not clear |
| Yuan Miao, Wei Zheng, Nana Li, Zhen Su, Lifen Zhao, Huimin Zhou, Li Ji. MicroRNA-130b targets PTEN to mediate drug resistance and proliferation of breast cancer cells via the PI3K/Akt signaling pathway. Scientific reports. vol 7. 2018-11-13. PMID:28165066. |
altogether, mir-130b targets pten to induce mdr, proliferation, and apoptosis via pi3k/akt signaling pathway. |
2018-11-13 |
2023-08-13 |
Not clear |
| Zi-Wen Long, Jiang-Hong Wu, Cai-Hong, Ya-Nong Wang, Ye Zho. MiR-374b Promotes Proliferation and Inhibits Apoptosis of Human GIST Cells by Inhibiting PTEN through Activation of the PI3K/Akt Pathway. Molecules and cells. vol 41. issue 6. 2018-11-13. PMID:29902839. |
mir-374b promotes proliferation and inhibits apoptosis of human gist cells by inhibiting pten through activation of the pi3k/akt pathway. |
2018-11-13 |
2023-08-13 |
human |
| Zi-Wen Long, Jiang-Hong Wu, Cai-Hong, Ya-Nong Wang, Ye Zho. MiR-374b Promotes Proliferation and Inhibits Apoptosis of Human GIST Cells by Inhibiting PTEN through Activation of the PI3K/Akt Pathway. Molecules and cells. vol 41. issue 6. 2018-11-13. PMID:29902839. |
in order to investigate a new treatment fot gist, we hypothesized the effect of mir-374b targeting pten gene-mediated pi3k/akt signal transduction pathway on proliferation and apoptosis of human gastrointestinal stromal tumor (gist) cells. |
2018-11-13 |
2023-08-13 |
human |
| Zi-Wen Long, Jiang-Hong Wu, Cai-Hong, Ya-Nong Wang, Ye Zho. MiR-374b Promotes Proliferation and Inhibits Apoptosis of Human GIST Cells by Inhibiting PTEN through Activation of the PI3K/Akt Pathway. Molecules and cells. vol 41. issue 6. 2018-11-13. PMID:29902839. |
taken together, the results indicated that mir-374b promotes viability and inhibits apoptosis of human gist cells by targeting pten gene through the pi3k/akt signaling pathway. |
2018-11-13 |
2023-08-13 |
human |