| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J P Carson, G Kulik, M J Webe. Antiapoptotic signaling in LNCaP prostate cancer cells: a survival signaling pathway independent of phosphatidylinositol 3'-kinase and Akt/protein kinase B. Cancer research. vol 59. issue 7. 1999-04-21. PMID:10197612. |
in lncap prostate cancer cells, the pten phosphoinositide phosphatase is inactivated, leading to constitutive activation of akt/pkb and resistance to apoptosis. |
1999-04-21 |
2023-08-12 |
Not clear |
| K Podsypanina, L H Ellenson, A Nemes, J Gu, M Tamura, K M Yamada, C Cordon-Cardo, G Catoretti, P E Fisher, R Parson. Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 4. 1999-03-25. PMID:9990064. |
taken together, these data suggest that pten is a regulator of apoptosis and proliferation that behaves as a "landscaper" tumor suppressor in the gut and a "gatekeeper" tumor suppressor in other organs. |
1999-03-25 |
2023-08-12 |
mouse |
| P L Dahia, R C Aguiar, J Alberta, J B Kum, S Caron, H Sill, D J Marsh, J Ritz, A Freedman, C Stiles, C En. PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies. Human molecular genetics. vol 8. issue 2. 1999-03-18. PMID:9931326. |
the finding that pten levels inversely correlate with phosphorylated akt supports the hypothesis that pten regulates ptdins(3,4,5)p3and suggests a role for pten in apoptosis. |
1999-03-18 |
2023-08-12 |
human |
| V Stambolic, A Suzuki, J L de la Pompa, G M Brothers, C Mirtsos, T Sasaki, J Ruland, J M Penninger, D P Siderovski, T W Ma. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell. vol 95. issue 1. 1998-11-02. PMID:9778245. |
expression of exogenous pten in mutant cells restores both their sensitivity to agonist-induced apoptosis and normal pattern of pkb/akt phosphorylation. |
1998-11-02 |
2023-08-12 |
mouse |