| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Maehama, G S Taylor, J E Dixo. PTEN and myotubularin: novel phosphoinositide phosphatases. Annual review of biochemistry. vol 70. 2002-02-27. PMID:11395408. |
recent studies have demonstrated that pten plays an essential role in regulating signaling pathways involved in cell growth and apoptosis, and mutations in the pten gene are now known to cause tumorigenesis in a number of human tissues. |
2002-02-27 |
2023-08-12 |
human |
| T Maehama, G S Taylor, J E Dixo. PTEN and myotubularin: novel phosphoinositide phosphatases. Annual review of biochemistry. vol 70. 2002-02-27. PMID:11395408. |
mutations that impair pten function result in a marked increase in cellular levels of pip3 and constitutive activation of akt survival signaling pathways, leading to inhibition of apoptosis, hyperplasia, and tumor formation. |
2002-02-27 |
2023-08-12 |
human |
| T Maehama, G S Taylor, J E Dixo. PTEN and myotubularin: novel phosphoinositide phosphatases. Annual review of biochemistry. vol 70. 2002-02-27. PMID:11395408. |
certain structural features of pten contribute to its specificity for pip3, as well as its role(s) in regulating cellular proliferation and apoptosis. |
2002-02-27 |
2023-08-12 |
human |
| Xiu-Juan Yuan, Young E Whan. PTEN sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a FADD-dependent pathway. Oncogene. vol 21. issue 2. 2002-02-15. PMID:11803475. |
pten sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a fadd-dependent pathway. |
2002-02-15 |
2023-08-12 |
human |
| Xiu-Juan Yuan, Young E Whan. PTEN sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a FADD-dependent pathway. Oncogene. vol 21. issue 2. 2002-02-15. PMID:11803475. |
therefore, we asked if reconstitution of pten function would lead to the reversal of resistance to apoptosis in prostate cancer cells. |
2002-02-15 |
2023-08-12 |
human |
| Xiu-Juan Yuan, Young E Whan. PTEN sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a FADD-dependent pathway. Oncogene. vol 21. issue 2. 2002-02-15. PMID:11803475. |
adenovirus-mediated expression of pten completely suppressed constitutive akt activation in lncap prostate cancer cells and enhanced apoptosis induced by a broad range of apoptotic stimuli. |
2002-02-15 |
2023-08-12 |
human |
| Xiu-Juan Yuan, Young E Whan. PTEN sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a FADD-dependent pathway. Oncogene. vol 21. issue 2. 2002-02-15. PMID:11803475. |
pten expression sensitized cells to death receptor-mediated apoptosis induced by tumor necrosis factor, anti-fas antibody, and trail. |
2002-02-15 |
2023-08-12 |
human |
| Xiu-Juan Yuan, Young E Whan. PTEN sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a FADD-dependent pathway. Oncogene. vol 21. issue 2. 2002-02-15. PMID:11803475. |
pten also sensitized cells to non-receptor mediated apoptosis induced by a kinase inhibitor staurosporine and chemotherapeutic agents mitoxantrone and etoposide. |
2002-02-15 |
2023-08-12 |
human |
| Xiu-Juan Yuan, Young E Whan. PTEN sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a FADD-dependent pathway. Oncogene. vol 21. issue 2. 2002-02-15. PMID:11803475. |
lipid phosphatase activity of pten is required for apoptosis as the pten g129e mutant selectively deficient in lipid phosphatase activity was unable to sensitize cells to apoptosis. |
2002-02-15 |
2023-08-12 |
human |
| Xiu-Juan Yuan, Young E Whan. PTEN sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a FADD-dependent pathway. Oncogene. vol 21. issue 2. 2002-02-15. PMID:11803475. |
taken together, these data are consistent with the hypothesis that pten promotes drug-induced apoptosis by facilitating caspase-8 activation and bid cleavage through a fadd-dependent pathway. |
2002-02-15 |
2023-08-12 |
human |
| T Virolle, E D Adamson, V Baron, D Birle, D Mercola, T Mustelin, I de Bell. The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling. Nature cell biology. vol 3. issue 12. 2002-02-08. PMID:11781575. |
inducing egr-1 by exposing cells to ultraviolet light upregulates expression of pten messenger rna and protein, and leads to apoptosis. |
2002-02-08 |
2023-08-12 |
mouse |
| T Virolle, E D Adamson, V Baron, D Birle, D Mercola, T Mustelin, I de Bell. The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling. Nature cell biology. vol 3. issue 12. 2002-02-08. PMID:11781575. |
egr-1-/- cells, which cannot upregulate pten expression after irradiation, are resistant to ultraviolet-light-induced apoptosis. |
2002-02-08 |
2023-08-12 |
mouse |
| K M Yamada, M Arak. Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis. Journal of cell science. vol 114. issue Pt 13. 2002-01-17. PMID:11559746. |
tumor suppressor pten: modulator of cell signaling, growth, migration and apoptosis. |
2002-01-17 |
2023-08-12 |
human |
| K M Yamada, M Arak. Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis. Journal of cell science. vol 114. issue Pt 13. 2002-01-17. PMID:11559746. |
functions for pten have been identified in the regulation of many normal cell processes, including growth, adhesion, migration, invasion and apoptosis. |
2002-01-17 |
2023-08-12 |
human |
| K M Yamada, M Arak. Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis. Journal of cell science. vol 114. issue Pt 13. 2002-01-17. PMID:11559746. |
pten appears to play particularly important roles in regulating anoikis (apoptosis of cells after loss of contact with extracellular matrix) and cell migration. |
2002-01-17 |
2023-08-12 |
human |
| G Schwartzbauer, J Robbin. The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival. The Journal of biological chemistry. vol 276. issue 38. 2001-10-25. PMID:11448956. |
increased pten expression by recombinant adenovirus in cultured neonatal rat primary cardiomyocytes caused cardiomyocyte apoptosis as evidenced by increased caspase-3 activity and cleaved poly(a)dp-ribose polymerase. |
2001-10-25 |
2023-08-12 |
rat |
| C M van Golen, T S Schwab, K M Ignatoski, S P Ethier, E L Feldma. PTEN/MMAC1 overexpression decreases insulin-like growth factor-I-mediated protection from apoptosis in neuroblastoma cells. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 12. issue 7. 2001-10-25. PMID:11457734. |
the pten gene product, a protein which dephosphorylates phosphatidylinositol lipids, prevents activation of akt and regulates several cellular functions, including cell cycle progression, cell migration, and survival from apoptosis. |
2001-10-25 |
2023-08-12 |
Not clear |
| C M van Golen, T S Schwab, K M Ignatoski, S P Ethier, E L Feldma. PTEN/MMAC1 overexpression decreases insulin-like growth factor-I-mediated protection from apoptosis in neuroblastoma cells. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 12. issue 7. 2001-10-25. PMID:11457734. |
in this study, pten overexpression decreases igf-i-induced akt activity, enhances serum withdrawal-induced apoptosis, and decreases igf-i protection and cell growth in shep cells. |
2001-10-25 |
2023-08-12 |
Not clear |
| C M van Golen, T S Schwab, K M Ignatoski, S P Ethier, E L Feldma. PTEN/MMAC1 overexpression decreases insulin-like growth factor-I-mediated protection from apoptosis in neuroblastoma cells. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 12. issue 7. 2001-10-25. PMID:11457734. |
the pten lipid phosphatase mutant g129e fails to inhibit igf-i-stimulated akt activity and protection from apoptosis. |
2001-10-25 |
2023-08-12 |
Not clear |
| V Stambolic, D MacPherson, D Sas, Y Lin, B Snow, Y Jang, S Benchimol, T W Ma. Regulation of PTEN transcription by p53. Molecular cell. vol 8. issue 2. 2001-10-18. PMID:11545734. |
pten was required for p53-mediated apoptosis in immortalized mouse embryonic fibroblasts. |
2001-10-18 |
2023-08-12 |
mouse |