| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M V Chuenkova, F B Furnari, W K Cavenee, M A Pereir. Trypanosoma cruzi trans-sialidase: a potent and specific survival factor for human Schwann cells by means of phosphatidylinositol 3-kinase/Akt signaling. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 17. 2001-09-20. PMID:11481434. |
in contrast, the cys-rich domain of ts did not block apoptosis in schwann cells overexpressing dominant-negative akt or constitutively active pten, a negative regulator of pi3k/akt signaling. |
2001-09-20 |
2023-08-12 |
human |
| N R Leslie, D Bennett, A Gray, I Pass, K Hoang-Xuan, C P Downe. Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions. The Biochemical journal. vol 357. issue Pt 2. 2001-08-23. PMID:11439092. |
the tumour suppressor protein pten (phosphatase and tensin homolog deleted on chromosome 10) is a lipid phosphatase which can antagonize the phosphoinositide 3-kinase (pi 3-kinase) signalling pathway, promoting apoptosis and inhibiting cell-cycle progression and cell motility. |
2001-08-23 |
2023-08-12 |
Not clear |
| A Suzuki, M T Yamaguchi, T Ohteki, T Sasaki, T Kaisho, Y Kimura, R Yoshida, A Wakeham, T Higuchi, M Fukumoto, T Tsubata, P S Ohashi, S Koyasu, J M Penninger, T Nakano, T W Ma. T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity. vol 14. issue 5. 2001-07-19. PMID:11371355. |
pten(flox/-) t cells hyperproliferate, are autoreactive, secrete increased levels of th1/th2 cytokines, resist apoptosis, and show increased phosphorylation of pkb/akt and erk. |
2001-07-19 |
2023-08-12 |
mouse |
| P Li, S V Nicosia, W Ba. Antagonism between PTEN/MMAC1/TEP-1 and androgen receptor in growth and apoptosis of prostatic cancer cells. The Journal of biological chemistry. vol 276. issue 23. 2001-07-12. PMID:11278645. |
here, we describe a mutual repression and selective dominance between pten and the androgen receptor (ar) in the growth and the apoptosis of prostatic cancer cells. |
2001-07-12 |
2023-08-12 |
Not clear |
| P Li, S V Nicosia, W Ba. Antagonism between PTEN/MMAC1/TEP-1 and androgen receptor in growth and apoptosis of prostatic cancer cells. The Journal of biological chemistry. vol 276. issue 23. 2001-07-12. PMID:11278645. |
whereas the repression of the transcriptional activity of the ar by pten is likely to involve the down-regulation of akt, androgens protected prostate cancer cells from pten-induced apoptosis without an effect on akt activity, demonstrating a differential involvement of akt in the interaction between pten and the ar. |
2001-07-12 |
2023-08-12 |
Not clear |
| L Patel, I Pass, P Coxon, C P Downes, S A Smith, C H Macphe. Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN. Current biology : CB. vol 11. issue 10. 2001-07-12. PMID:11378386. |
antisense-mediated disruption of ppargamma expression prevented the upregulation of pten that normally accompanies monocyte differentiation and reduced the proportion of macrophages undergoing apoptosis, while electrophoretic mobility shift assays showed that ppargamma is able to bind two response elements in the genomic sequence upstream of pten. |
2001-07-12 |
2023-08-12 |
human |
| L P Weng, J L Brown, C En. PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model. Human molecular genetics. vol 10. issue 6. 2001-06-28. PMID:11230179. |
we have shown previously that over-expression of pten in a tetracycline-controlled inducible system blocks cell cycle progression and induces apoptosis in mcf-7 breast cancer cells. |
2001-06-28 |
2023-08-12 |
Not clear |
| L Simpson, J Li, D Liaw, I Hennessy, J Oliner, F Christians, R Parson. PTEN expression causes feedback upregulation of insulin receptor substrate 2. Molecular and cellular biology. vol 21. issue 12. 2001-06-28. PMID:11359902. |
pten expression rapidly reduced the activity of akt, which was followed by a g(1) arrest and eventually apoptosis. |
2001-06-28 |
2023-08-12 |
Not clear |
| J Hisatake, J O'Kelly, M R Uskokovic, S Tomoyasu, H P Koeffle. Novel vitamin D(3) analog, 21-(3-methyl-3-hydroxy-butyl)-19-nor D(3), that modulates cell growth, differentiation, apoptosis, cell cycle, and induction of PTEN in leukemic cells. Blood. vol 97. issue 8. 2001-05-24. PMID:11290607. |
novel vitamin d(3) analog, 21-(3-methyl-3-hydroxy-butyl)-19-nor d(3), that modulates cell growth, differentiation, apoptosis, cell cycle, and induction of pten in leukemic cells. |
2001-05-24 |
2023-08-12 |
Not clear |
| M Matsushima-Nishiu, M Unoki, K Ono, T Tsunoda, T Minaguchi, H Kuramoto, M Nishida, T Satoh, T Tanaka, Y Nakamur. Growth and gene expression profile analyses of endometrial cancer cells expressing exogenous PTEN. Cancer research. vol 61. issue 9. 2001-05-21. PMID:11325847. |
enforced expression of pten in various cancer cell lines decreases cell proliferation through arrest of the cell cycle, accompanied in some cases by induction of apoptosis. |
2001-05-21 |
2023-08-12 |
Not clear |
| L Simpson, R Parson. PTEN: life as a tumor suppressor. Experimental cell research. vol 264. issue 1. 2001-04-12. PMID:11237521. |
by blocking the activation of akt, pten regulates cellular processes such as cell cycling, translation, and apoptosis. |
2001-04-12 |
2023-08-12 |
Not clear |
| L Weng, J Brown, C En. PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways. Human molecular genetics. vol 10. issue 3. 2001-04-05. PMID:11159942. |
pten induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/akt-dependent and -independent pathways. |
2001-04-05 |
2023-08-12 |
Not clear |
| L P Weng, O Gimm, J B Kum, W M Smith, X P Zhou, D Wynford-Thomas, G Leone, C En. Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death. Human molecular genetics. vol 10. issue 3. 2001-04-05. PMID:11159944. |
we have previously reported that overexpression of pten in mcf-7 breast cancer cells induces cell cycle arrest and apoptosis. |
2001-04-05 |
2023-08-12 |
human |
| R M Sharrard, N J Maitlan. Phenotypic effects of overexpression of the MMAC1 gene in prostate epithelial cells. British journal of cancer. vol 83. issue 8. 2000-11-03. PMID:10993660. |
over-expression of wild type pten protein induced cell shrinkage and rounding, but did not result in increased levels of classical apoptosis. |
2000-11-03 |
2023-08-12 |
human |
| N L Ge, S Rudikof. Expression of PTEN in PTEN-deficient multiple myeloma cells abolishes tumor growth in vivo. Oncogene. vol 19. issue 36. 2000-10-02. PMID:10962569. |
ectopic expression of wild type pten in opm-2 cells inhibited akt phosphorylation which was correlated with an increase in apoptosis. |
2000-10-02 |
2023-08-12 |
mouse |
| G L Mutter, M C Lin, J T Fitzgerald, J B Kum, C En. Changes in endometrial PTEN expression throughout the human menstrual cycle. The Journal of clinical endocrinology and metabolism. vol 85. issue 6. 2000-06-23. PMID:10852473. |
frequent mutation of the pten tumor suppressor gene in endometrial adenocarcinoma has led to the prediction that its product, a phosphatase that regulates the cell cycle, apoptosis, and possibly cell adhesion, is functionally active within normal endometrial tissues. |
2000-06-23 |
2023-08-12 |
human |
| X P Zhou, D J Marsh, H Hampel, J B Mulliken, O Gimm, C En. Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis. Human molecular genetics. vol 9. issue 5. 2000-06-01. PMID:10749983. |
pten is a tumour suppressor and dual-specificity phosphatase which affects apoptosis via its lipid phosphatase activity in the phosphoinositol-3-kinase and akt pathway as well as inhibiting cell spreading via the focal adhesion kinase pathway. |
2000-06-01 |
2023-08-12 |
Not clear |
| J Liliental, S Y Moon, R Lesche, R Mamillapalli, D Li, Y Zheng, H Sun, H W. Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases. Current biology : CB. vol 10. issue 7. 2000-05-16. PMID:10753747. |
pten regulates apoptosis and cell cycle progression through its phosphatase activity on phosphatidylinositol (pi) 3,4,5-trisphosphate (pi(3,4,5)p(3)), a product of pi 3-kinase [2-5]. |
2000-05-16 |
2023-08-12 |
mouse |
| S Persad, S Attwell, V Gray, M Delcommenne, A Troussard, J Sanghera, S Dedha. Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 7. 2000-04-24. PMID:10716737. |
furthermore, dominant-negative ilk or wt pten induces g(1) phase cycle arrest and enhanced apoptosis. |
2000-04-24 |
2023-08-12 |
human |
| X Wang, A Gjörloff-Wingren, M Saxena, N Pathan, J C Reed, T Musteli. The tumor suppressor PTEN regulates T cell survival and antigen receptor signaling by acting as a phosphatidylinositol 3-phosphatase. Journal of immunology (Baltimore, Md. : 1950). vol 164. issue 4. 2000-03-09. PMID:10657643. |
expression of active pten lead to a 50% loss of transfected cells due to increased apoptosis, which was completely prevented by coexpression of a constitutively active, membrane-bound form of protein kinase b. |
2000-03-09 |
2023-08-12 |
Not clear |