| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Saito, X Swanson, A M Mhashilkar, Y Oida, R Schrock, C D Branch, S Chada, L Zumstein, R Rames. Adenovirus-mediated transfer of the PTEN gene inhibits human colorectal cancer growth in vitro and in vivo. Gene therapy. vol 10. issue 23. 2003-12-04. PMID:14528320. |
adenoviral-mediated transfer of pten (ad-pten) suppressed cell growth and induced apoptosis significantly in colorectal cancer cells (dld-1, ht29, and sw480) carrying wtpten than in normal colon fibroblast cells (ccd-18co) carrying wtpten. |
2003-12-04 |
2023-08-12 |
human |
| Muxiang Zhou, Lubing Gu, Harry W Findley, Rong Jiang, William G Wood. PTEN reverses MDM2-mediated chemotherapy resistance by interacting with p53 in acute lymphoblastic leukemia cells. Cancer research. vol 63. issue 19. 2003-12-03. PMID:14559824. |
the tumor suppressor pten has been associated with the cellular localization of mdm2 in regulation of apoptosis through inhibiting pi3k/akt signaling. |
2003-12-03 |
2023-08-12 |
Not clear |
| Muxiang Zhou, Lubing Gu, Harry W Findley, Rong Jiang, William G Wood. PTEN reverses MDM2-mediated chemotherapy resistance by interacting with p53 in acute lymphoblastic leukemia cells. Cancer research. vol 63. issue 19. 2003-12-03. PMID:14559824. |
furthermore, loss of pten can result in resistance to apoptosis by activating mdm2-mediated antiapoptotic mechanism. |
2003-12-03 |
2023-08-12 |
Not clear |
| Ji Shin Lee, Hyung Seok Kim, Young Bok Kim, Min Cheol Lee, Chang Soo Par. Expression of PTEN in renal cell carcinoma and its relation to tumor behavior and growth. Journal of surgical oncology. vol 84. issue 3. 2003-12-02. PMID:14598361. |
the aim of our study was to evaluate pten expression in rcc and its correlation with clinicopathologic features, cell proliferation, and apoptosis. |
2003-12-02 |
2023-08-12 |
Not clear |
| Ozlem Guzeloglu-Kayisli, Umit A Kayisli, Rafat Al-Rejjal, Wenxin Zheng, Guven Luleci, Aydin Aric. Regulation of PTEN (phosphatase and tensin homolog deleted on chromosome 10) expression by estradiol and progesterone in human endometrium. The Journal of clinical endocrinology and metabolism. vol 88. issue 10. 2003-11-12. PMID:14557489. |
pten regulates cell growth, apoptosis, and proliferation. |
2003-11-12 |
2023-08-12 |
human |
| Ozlem Guzeloglu-Kayisli, Umit A Kayisli, Rafat Al-Rejjal, Wenxin Zheng, Guven Luleci, Aydin Aric. Regulation of PTEN (phosphatase and tensin homolog deleted on chromosome 10) expression by estradiol and progesterone in human endometrium. The Journal of clinical endocrinology and metabolism. vol 88. issue 10. 2003-11-12. PMID:14557489. |
we propose that pten might be one of the signaling proteins that estrogen and progesterone are acting to affect endometrial cell proliferation and/or apoptosis. |
2003-11-12 |
2023-08-12 |
human |
| Josema Torres, Joe Rodriguez, Michael P Myers, Miguel Valiente, Jonathan D Graves, Nicholas K Tonks, Rafael Pulid. Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3: implications for the control of protein stability and PTEN-protein interactions. The Journal of biological chemistry. vol 278. issue 33. 2003-11-10. PMID:12788938. |
pten phosphatase is one of the most commonly targeted tumor suppressors in human cancers and a key regulator of cell growth and apoptosis. |
2003-11-10 |
2023-08-12 |
human |
| Josema Torres, Joe Rodriguez, Michael P Myers, Miguel Valiente, Jonathan D Graves, Nicholas K Tonks, Rafael Pulid. Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3: implications for the control of protein stability and PTEN-protein interactions. The Journal of biological chemistry. vol 278. issue 33. 2003-11-10. PMID:12788938. |
our findings suggest the existence of a regulatory mechanism of protein stability and pten-protein interactions during apoptosis, executed by caspase-3 in a pten phosphorylation-regulated manner. |
2003-11-10 |
2023-08-12 |
human |
| Jie Zhang, Yong Choi, Blanche Mavromatis, Alan Lichtenstein, Weiqun L. Preferential killing of PTEN-null myelomas by PI3K inhibitors through Akt pathway. Oncogene. vol 22. issue 40. 2003-10-31. PMID:13679867. |
re-expression of pten induced strong apoptosis and growth inhibition. |
2003-10-31 |
2023-08-12 |
Not clear |
| Jie Zhang, Yong Choi, Blanche Mavromatis, Alan Lichtenstein, Weiqun L. Preferential killing of PTEN-null myelomas by PI3K inhibitors through Akt pathway. Oncogene. vol 22. issue 40. 2003-10-31. PMID:13679867. |
to understand the biologic importance of the phosphatidylinositol 3 kinase (pi3k)/akt activation affected by pten deletion, we analysed apoptosis and growth inhibition by applying pi3k inhibitors to myeloma lines and by expressing akt constructs. |
2003-10-31 |
2023-08-12 |
Not clear |
| Charis En. PTEN: one gene, many syndromes. Human mutation. vol 22. issue 3. 2003-10-27. PMID:12938083. |
pten, on 10q23.3, encodes a major lipid phosphatase which signals down the phosphoinositol-3-kinase/akt pathway and effects g1 cell cycle arrest and apoptosis. |
2003-10-27 |
2023-08-12 |
Not clear |
| Sue J Sohn, Arvind Rajpal, Astar Winot. Apoptosis during lymphoid development. Current opinion in immunology. vol 15. issue 2. 2003-10-10. PMID:12633672. |
the pten phosphatase and bim, a pro-apoptotic bcl-2 family member, regulate apoptosis in both t and b cells. |
2003-10-10 |
2023-08-12 |
Not clear |
| Jong Eun Yeon, Sophia Califano, Julia Xu, Jack R Wands, Suzanne M De La Mont. Potential role of PTEN phosphatase in ethanol-impaired survival signaling in the liver. Hepatology (Baltimore, Md.). vol 38. issue 3. 2003-10-07. PMID:12939597. |
however, uncoupling of the signaling cascade downstream of pten that mediates apoptosis may account for the relatively modest degrees of ongoing cell loss observed in livers of chronic ethanol-fed rats. |
2003-10-07 |
2023-08-12 |
rat |
| Hua-Chuan Zheng, Yi-Ling Li, Jin-Min Sun, Xue-Fei Yang, Xiao-Han Li, Wei-Guo Jiang, Yin-Chang Zhang, Yan Xi. Growth, invasion, metastasis, differentiation, angiogenesis and apoptosis of gastric cancer regulated by expression of PTEN encoding products. World journal of gastroenterology. vol 9. issue 8. 2003-09-24. PMID:12918097. |
growth, invasion, metastasis, differentiation, angiogenesis and apoptosis of gastric cancer regulated by expression of pten encoding products. |
2003-09-24 |
2023-08-12 |
Not clear |
| M Tanaka, H B Grossma. In vivo gene therapy of human bladder cancer with PTEN suppresses tumor growth, downregulates phosphorylated Akt, and increases sensitivity to doxorubicin. Gene therapy. vol 10. issue 19. 2003-09-17. PMID:12923562. |
direct injection of ad-mmac into established subcutaneous um-uc-3 (pten deleted, upregulation of phosphorylated akt) and um-uc-6dox (wild-type pten, upregulation of phosphorylated akt) tumors in nude mice resulted in pten expression, apoptosis, and significantly decreased growth compared to ad-ctr- or phosphate-buffered saline (pbs)-treated tumors. |
2003-09-17 |
2023-08-12 |
mouse |
| Jill M Stahl, Mitchell Cheung, Arati Sharma, Nishit R Trivedi, Sumathi Shanmugam, Gavin P Robertso. Loss of PTEN promotes tumor development in malignant melanoma. Cancer research. vol 63. issue 11. 2003-07-31. PMID:12782594. |
in summary, loss of pten reduces apoptosis and promotes cell survival, thereby favoring melanoma tumor formation. |
2003-07-31 |
2023-08-12 |
mouse |
| Heng Wu, Vikas Goel, Frank G Halusk. PTEN signaling pathways in melanoma. Oncogene. vol 22. issue 20. 2003-07-07. PMID:12789288. |
in addition, agonist-induced apoptosis is mediated by pten, through the upregulation of proapoptotic machinery involving caspases and bid, and the downregulation of antiapoptotic proteins such as bcl2. |
2003-07-07 |
2023-08-12 |
human |
| Heng Wu, Vikas Goel, Frank G Halusk. PTEN signaling pathways in melanoma. Oncogene. vol 22. issue 20. 2003-07-07. PMID:12789288. |
therefore, the combined effects of the loss of pten lipid and protein phosphatase activity may result in aberrant cell growth and escape from apoptosis, as well as abnormal cell spreading and migration. |
2003-07-07 |
2023-08-12 |
human |
| Li Li, Fenghua Liu, Alonzo H Ros. PTEN regulation of neural development and CNS stem cells. Journal of cellular biochemistry. vol 88. issue 1. 2003-06-13. PMID:12461771. |
we also found that pten haploinsufficiency can protect precursor cells from apoptosis in response to oxidative stress. |
2003-06-13 |
2023-08-12 |
mouse |
| Lynne M Howells, Barbara Gallacher-Horley, Catherine E Houghton, Margaret M Manson, E Ann Hudso. Indole-3-carbinol inhibits protein kinase B/Akt and induces apoptosis in the human breast tumor cell line MDA MB468 but not in the nontumorigenic HBL100 line. Molecular cancer therapeutics. vol 1. issue 13. 2003-05-15. PMID:12479697. |
in corroboration of the results obtained with the breast cell lines, 13c decreased phospho-pkb levels and induced apoptosis in the prostate cell line lncap, which expresses very low levels of pten, but did not do so in pten-positive du145 cells. |
2003-05-15 |
2023-08-12 |
human |