| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei-chang Chen, Mao-song Lin, Xia Ba. Induction of apoptosis in colorectal cancer cells by peroxisome proliferators-activated receptor gamma activation up-regulating PTEN and inhibiting PI3K activity. Chinese medical journal. vol 118. issue 17. 2005-10-14. PMID:16157051. |
induction of apoptosis in colorectal cancer cells by peroxisome proliferators-activated receptor gamma activation up-regulating pten and inhibiting pi3k activity. |
2005-10-14 |
2023-08-12 |
Not clear |
| Judit Pallares, Jose Luis Martínez-Guitarte, Xavier Dolcet, David Llobet, Montserrat Rue, José Palacios, Jaime Prat, Xavier Matias-Gui. Survivin expression in endometrial carcinoma: a tissue microarray study with correlation with PTEN and STAT-3. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. vol 24. issue 3. 2005-10-11. PMID:15968200. |
immunohistochemical evaluation included 1) survivin, 2) markers of cell proliferation and apoptosis (ki67-mib1 and m 30-neoepitope cytokeratin 18), and 3) proteins involved in cell signaling pathways (pten, phospho-akt, beta-catenin, p53, and stat-3). |
2005-10-11 |
2023-08-12 |
Not clear |
| Judit Pallares, Jose Luis Martínez-Guitarte, Xavier Dolcet, David Llobet, Montserrat Rue, José Palacios, Jaime Prat, Xavier Matias-Gui. Survivin expression in endometrial carcinoma: a tissue microarray study with correlation with PTEN and STAT-3. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. vol 24. issue 3. 2005-10-11. PMID:15968200. |
because pten abnormalities are very frequent in ecs, the results from this study indicate that pten may interfere with the process of apoptosis and cell proliferation by promoting survivin expression. |
2005-10-11 |
2023-08-12 |
Not clear |
| Hong Zhao, Yongzhi Cui, Joelle Dupont, Hui Sun, Lothar Hennighausen, Shoshana Yaka. Overexpression of the tumor suppressor gene phosphatase and tensin homologue partially inhibits wnt-1-induced mammary tumorigenesis. Cancer research. vol 65. issue 15. 2005-10-04. PMID:16061670. |
the tumor suppressor phosphatase and tensin homologue (pten) is involved in cell proliferation, adhesion, and apoptosis. |
2005-10-04 |
2023-08-12 |
mouse |
| Miguel Valiente, Amparo Andrés-Pons, Beatriz Gomar, Josema Torres, Anabel Gil, Caroline Tapparel, Stylianos E Antonarakis, Rafael Pulid. Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases. The Journal of biological chemistry. vol 280. issue 32. 2005-09-22. PMID:15951562. |
the tumor suppressor phosphatase pten is a key regulator of cell growth and apoptosis that interacts with pdz domains from regulatory proteins, including magi-1/2/3, hdlg, and mast205. |
2005-09-22 |
2023-08-12 |
Not clear |
| b' Hongbo Hu, Cheng Jiang, Guangxun Li, Junxuan L\\xc3\\xb. PKB/AKT and ERK regulation of caspase-mediated apoptosis by methylseleninic acid in LNCaP prostate cancer cells. Carcinogenesis. vol 26. issue 8. 2005-09-20. PMID:15845651.' |
since inactivation of the akt/protein kinase b negative regulator gene pten (phosphatase and tensin homologue deleted on chromosome 10) is common in prostate cancer (pca), we compared pten wild-type du145 pca cells (low basal akt activity) with pten-mutant lncap pca cells (high basal akt activity) for their apoptosis responses to the methylselenol precursor methylseleninic acid (msea) and sodium selenite, an inorganic salt. |
2005-09-20 |
2023-08-12 |
Not clear |
| Lindsey D Mayo, Young Rok Seo, Mark W Jackson, Martin L Smith, Javier Rivera Guzman, Chandrashekhar K Korgaonkar, David B Donne. Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified. The Journal of biological chemistry. vol 280. issue 28. 2005-09-12. PMID:15843377. |
the protection of p53 from mdm2 by pten and the damage-induced activation of pten by phosphorylated p53 leads to the formation of an apoptotic amplification cycle in which p53 and pten coordinately increase cellular apoptosis. |
2005-09-12 |
2023-08-12 |
human |
| Xiaoqian Ma, Angelique C Ziel-van der Made, Binha Autar, Hetty A van der Korput, Marcel Vermeij, Petra van Duijn, Kitty B Cleutjens, Ronald de Krijger, Paul Krimpenfort, Anton Berns, Theo H van der Kwast, Jan Trapma. Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis. Cancer research. vol 65. issue 13. 2005-09-07. PMID:15994948. |
targeted biallelic inactivation of pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis. |
2005-09-07 |
2023-08-12 |
mouse |
| S Hara, M Oya, R Mizuno, A Horiguchi, K Marumo, M Mura. Akt activation in renal cell carcinoma: contribution of a decreased PTEN expression and the induction of apoptosis by an Akt inhibitor. Annals of oncology : official journal of the European Society for Medical Oncology. vol 16. issue 6. 2005-09-01. PMID:15851405. |
akt activation in renal cell carcinoma: contribution of a decreased pten expression and the induction of apoptosis by an akt inhibitor. |
2005-09-01 |
2023-08-12 |
human |
| Sucharita Bandyopadhyay, Sudha K Pai, Misako Watabe, Steven C Gross, Shigeru Hirota, Sadahiro Hosobe, Taisei Tsukada, Kunio Miura, Ken Saito, Stephen J Markwell, Ying Wang, Jodi Huggenvik, Mary E Pauza, Megumi Iiizumi, Kounosuke Watab. FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis. Oncogene. vol 24. issue 34. 2005-09-01. PMID:15897909. |
fas expression inversely correlates with pten level in prostate cancer and a pi 3-kinase inhibitor synergizes with fas sirna to induce apoptosis. |
2005-09-01 |
2023-08-12 |
human |
| Terence M Williams, Ghada S Hassan, Jiangwei Li, Alex W Cohen, Freddy Medina, Philippe G Frank, Richard G Pestell, Dolores Di Vizio, Massimo Loda, Michael P Lisant. Caveolin-1 promotes tumor progression in an autochthonous mouse model of prostate cancer: genetic ablation of Cav-1 delays advanced prostate tumor development in tramp mice. The Journal of biological chemistry. vol 280. issue 26. 2005-08-16. PMID:15802273. |
mechanistically, we showed that loss or down-regulation of cav-1 expression results in increased apoptosis, with increased prostate apoptosis response factor-4 and pten levels in cav-1(-/-) null prostate tumors. |
2005-08-16 |
2023-08-12 |
mouse |
| Andrew Xiao, Chaoying Yin, Chunyu Yang, Antonio Di Cristofano, Pier Paolo Pandolfi, Terry Van Dyk. Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation. Cancer research. vol 65. issue 12. 2005-08-08. PMID:15958561. |
depletion of pten function in adult astrocytoma cells alleviated the apoptosis evoked by prb family protein inactivation and also induced tumor cell invasion. |
2005-08-08 |
2023-08-12 |
mouse |
| Andrew Xiao, Chaoying Yin, Chunyu Yang, Antonio Di Cristofano, Pier Paolo Pandolfi, Terry Van Dyk. Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation. Cancer research. vol 65. issue 12. 2005-08-08. PMID:15958561. |
thus, we show that pten deficiency in prb-deficient astrocytoma cells contributes to tumor progression via multiple mechanisms, including suppression of apoptosis, increased cell invasion, and angiogenesis, all of which are hallmarks of high-grade astrocytoma. |
2005-08-08 |
2023-08-12 |
mouse |
| Amparo Andrés-Pons, Miguel Valiente, Josema Torres, Anabel Gil, Isabel Roglá, Francisca Ripoll, Javier Cervera, Rafael Pulid. Functional definition of relevant epitopes on the tumor suppressor PTEN protein. Cancer letters. vol 223. issue 2. 2005-07-21. PMID:15896465. |
the binding of pten to pdz-domain-containing proteins appears to play an important role in the control of cell growth, motility and apoptosis. |
2005-07-21 |
2023-08-12 |
Not clear |
| Ji-Hyun Chung, Margaret E Ginn-Pease, Charis En. Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault protein. Cancer research. vol 65. issue 10. 2005-07-07. PMID:15899801. |
pten is a tumor suppressor phosphatase that causes cell cycle arrest and/or apoptosis. |
2005-07-07 |
2023-08-12 |
Not clear |
| Hirohiko Okamura, Kaya Yoshida, Hiroyuki Morimoto, Tatsuji Hanej. PTEN expression elicited by EGR-1 transcription factor in calyculin A-induced apoptotic cells. Journal of cellular biochemistry. vol 94. issue 1. 2005-06-28. PMID:15517593. |
the present results suggest that the level of pten expression and the phosphorylation status of akt were associated with apoptosis induced by calyculin a. |
2005-06-28 |
2023-08-12 |
human |
| Eric C Chu, Andrzej S Tarnawsk. PTEN regulatory functions in tumor suppression and cell biology. Medical science monitor : international medical journal of experimental and clinical research. vol 10. issue 10. 2005-06-24. PMID:15448614. |
pten has been shown to play a pivotal role in apoptosis, cell cycle arrest, and possibly cell migration. |
2005-06-24 |
2023-08-12 |
Not clear |
| Sooyong Lee, Eui-Ju Choi, Changbae Jin, Dong-Hyun Ki. Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line. Gynecologic oncology. vol 97. issue 1. 2005-06-21. PMID:15790433. |
the aim of this study was to understand the role of pik3ca and pten on the resistance of human ovarian cancer cells to cisplatin-induced apoptosis. |
2005-06-21 |
2023-08-12 |
human |
| Nael Shoman, Shannon Klassen, Andrew McFadden, Miķelis G Bickis, Emina Torlakovic, Rajni Chibba. Reduced PTEN expression predicts relapse in patients with breast carcinoma treated by tamoxifen. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. vol 18. issue 2. 2005-05-25. PMID:15475931. |
the pten (phosphatase and tensin homolog deleted on chromosome ten) gene is a novel candidate tumor suppressor that plays an important role in cell cycle regulation and apoptosis by regulating protein kinase-b/akt activity. |
2005-05-25 |
2023-08-12 |
Not clear |
| Nael Shoman, Shannon Klassen, Andrew McFadden, Miķelis G Bickis, Emina Torlakovic, Rajni Chibba. Reduced PTEN expression predicts relapse in patients with breast carcinoma treated by tamoxifen. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. vol 18. issue 2. 2005-05-25. PMID:15475931. |
decreased pten and/or increased protein kinase b/akt activity in breast cancer cells has recently been associated with resistance to tamoxifen-induced apoptosis. |
2005-05-25 |
2023-08-12 |
Not clear |