| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richard Seonghun Nho, Hong Xia, Deanna Diebold, Judy Kahm, Jill Kleidon, Eric White, Craig A Henk. PTEN regulates fibroblast elimination during collagen matrix contraction. The Journal of biological chemistry. vol 281. issue 44. 2006-12-11. PMID:16963781. |
consistent with this, knockdown of pten in pten(+/+) embryonic fibroblasts by small interfering rna augmented akt activity and suppressed apoptosis in contractile collagen matrices. |
2006-12-11 |
2023-08-12 |
Not clear |
| Richard Seonghun Nho, Hong Xia, Deanna Diebold, Judy Kahm, Jill Kleidon, Eric White, Craig A Henk. PTEN regulates fibroblast elimination during collagen matrix contraction. The Journal of biological chemistry. vol 281. issue 44. 2006-12-11. PMID:16963781. |
furthermore, inhibition of akt activity restored the sensitivity of pten null cells to collagen contraction-induced apoptosis, indicating that the mechanism by which pten alters fibroblast viability is through modulation of phosphorylated akt levels. |
2006-12-11 |
2023-08-12 |
Not clear |
| Dimpy Koul, Yasunari Takada, Ruijun Shen, Bharat B Aggarwal, W K Alfred Yun. PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells. Biochemical and biophysical research communications. vol 350. issue 2. 2006-12-04. PMID:17011514. |
pten enhances tnf-induced apoptosis through modulation of nuclear factor-kappab signaling pathway in human glioma cells. |
2006-12-04 |
2023-08-12 |
human |
| Dimpy Koul, Yasunari Takada, Ruijun Shen, Bharat B Aggarwal, W K Alfred Yun. PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells. Biochemical and biophysical research communications. vol 350. issue 2. 2006-12-04. PMID:17011514. |
downregulation of the antiapoptotic genes by pten increased tnf-induced apoptosis, as indicated by caspase activation, tunel, annexin staining, and esterase assay. |
2006-12-04 |
2023-08-12 |
human |
| Dimpy Koul, Yasunari Takada, Ruijun Shen, Bharat B Aggarwal, W K Alfred Yun. PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells. Biochemical and biophysical research communications. vol 350. issue 2. 2006-12-04. PMID:17011514. |
we conclude that the ectopic expression of pten enhances tnf-induced apoptosis and downregulates the proliferation of glioma cells through the suppression of various molecules including nfkappab, and various mediators of cellular survival and proliferation, and that this targets might be essential for its central role in the growth and survival of glioma cancer cells. |
2006-12-04 |
2023-08-12 |
human |
| Meng Shyan Choy, Boon Huat Bay, Heung-Chin Cheng, Nam Sang Cheun. PTEN is recruited to specific microdomains of the plasma membrane during lactacystin-induced neuronal apoptosis. Neuroscience letters. vol 405. issue 1-2. 2006-10-24. PMID:16857313. |
pten is recruited to specific microdomains of the plasma membrane during lactacystin-induced neuronal apoptosis. |
2006-10-24 |
2023-08-12 |
Not clear |
| Meng Shyan Choy, Boon Huat Bay, Heung-Chin Cheng, Nam Sang Cheun. PTEN is recruited to specific microdomains of the plasma membrane during lactacystin-induced neuronal apoptosis. Neuroscience letters. vol 405. issue 1-2. 2006-10-24. PMID:16857313. |
we previously demonstrated that lactacystin-induced apoptosis of culture cortical neuron is associated with: (i) cleavage of pten (55 kda) to a 50 kda truncated form and (ii) accumulation of pten and all the truncated pten in a detergent-insoluble membrane fraction of the neuronal cells. |
2006-10-24 |
2023-08-12 |
Not clear |
| Meng Shyan Choy, Boon Huat Bay, Heung-Chin Cheng, Nam Sang Cheun. PTEN is recruited to specific microdomains of the plasma membrane during lactacystin-induced neuronal apoptosis. Neuroscience letters. vol 405. issue 1-2. 2006-10-24. PMID:16857313. |
taken together, our data suggest that caspase-3-like proteases are involved in the conversion of pten to a 50-kda truncated form and that pten and its truncated form accumulate at specific microdomains of the plasma membrane in neuronal cells undergoing apoptosis. |
2006-10-24 |
2023-08-12 |
Not clear |
| Zhi-Fang Yang, Ji-Lin Yi, Xing-Rui Li, Da-Xing Xie, Xiao-Feng Liao, Xin M. [PTEN induces apoptosis and up-regulates p53 expression in HepG2 cells]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology. vol 12. issue 12. 2006-10-20. PMID:15619344. |
[pten induces apoptosis and up-regulates p53 expression in hepg2 cells]. |
2006-10-20 |
2023-08-12 |
Not clear |
| Zhi-Fang Yang, Ji-Lin Yi, Xing-Rui Li, Da-Xing Xie, Xiao-Feng Liao, Xin M. [PTEN induces apoptosis and up-regulates p53 expression in HepG2 cells]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology. vol 12. issue 12. 2006-10-20. PMID:15619344. |
to investigate the effects of tumor suppressor gene pten on apoptosis and protein expression of p53 in hepg2 cells, as well as to explore its mechanisms. |
2006-10-20 |
2023-08-12 |
Not clear |
| Anabel Gil, Amparo Andrés-Pons, Elena Fernández, Miguel Valiente, Josema Torres, Javier Cervera, Rafael Pulid. Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs. Molecular biology of the cell. vol 17. issue 9. 2006-10-17. PMID:16807353. |
nuclear localization of pten by a ran-dependent mechanism enhances apoptosis: involvement of an n-terminal nuclear localization domain and multiple nuclear exclusion motifs. |
2006-10-17 |
2023-08-12 |
Not clear |
| Demetrius M Kokkinakis, Anthony G Brickner, John M Kirkwood, Xiaoyan Liu, Jason E Goldwasser, Anastasiya Kastrama, Cindy Sander, Dora Bocangel, Sunil Chad. Mitotic arrest, apoptosis, and sensitization to chemotherapy of melanomas by methionine deprivation stress. Molecular cancer research : MCR. vol 4. issue 8. 2006-10-12. PMID:16908595. |
although the genes controlling mitotic arrest and/or apoptosis in response to low extracellular methionine levels are unknown, it is likely that such control is exerted via the induction/up-regulation of tumor suppressors/growth inhibitor genes, such as tgfb, pten, gas1, egr3, btg3, mda7, and the proteoglycans (lum, bgn, and dcn), as well as the down-regulation/loss of function of prosurvival genes, such as nfkappab, myc, and erbb2. |
2006-10-12 |
2023-08-12 |
Not clear |
| Joon Ho Lee, Soon Young Shin, Sungyong Kim, Jaebum Choo, Young Han Le. Suppression of PTEN expression during aggregation with retinoic acid in P19 mouse embryonal carcinoma cells. Biochemical and biophysical research communications. vol 347. issue 3. 2006-09-13. PMID:16842746. |
our results suggest that ra attenuates the induction of apoptosis during the aggregation phase of p19 ec cells, probably by suppressing pten expression. |
2006-09-13 |
2023-08-12 |
mouse |
| Xiaojuan Yan, Michael Fraser, Qing Qiu, Benjamin K Tsan. Over-expression of PTEN sensitizes human ovarian cancer cells to cisplatin-induced apoptosis in a p53-dependent manner. Gynecologic oncology. vol 102. issue 2. 2006-08-29. PMID:16545436. |
over-expression of pten sensitizes human ovarian cancer cells to cisplatin-induced apoptosis in a p53-dependent manner. |
2006-08-29 |
2023-08-12 |
human |
| Xiaojuan Yan, Michael Fraser, Qing Qiu, Benjamin K Tsan. Over-expression of PTEN sensitizes human ovarian cancer cells to cisplatin-induced apoptosis in a p53-dependent manner. Gynecologic oncology. vol 102. issue 2. 2006-08-29. PMID:16545436. |
whereas pten, a tumor suppressor gene product, is believed to promote apoptosis primarily via inactivation of the pi3k/akt cell survival pathway, recent evidence suggests that pten may function independently of this pathway. |
2006-08-29 |
2023-08-12 |
human |
| Xiaojuan Yan, Michael Fraser, Qing Qiu, Benjamin K Tsan. Over-expression of PTEN sensitizes human ovarian cancer cells to cisplatin-induced apoptosis in a p53-dependent manner. Gynecologic oncology. vol 102. issue 2. 2006-08-29. PMID:16545436. |
in this study, we determined whether and how pten over-expression sensitizes ovarian cancer cells to cddp-induced apoptosis. |
2006-08-29 |
2023-08-12 |
human |
| S W Han, J Roma. Fibronectin induces cell proliferation and inhibits apoptosis in human bronchial epithelial cells: pro-oncogenic effects mediated by PI3-kinase and NF-kappa B. Oncogene. vol 25. issue 31. 2006-08-23. PMID:16518410. |
taken together, our findings demonstrate that fibronectin stimulates human bronchial epithelial cell growth and inhibits apoptosis through activation of nf-kappab, which, in turn, increases the expression of c-myc and cyclin d1 and decreases p21 and pten via alpha5beta1 integrin-dependent signals that include pi3-k/akt. |
2006-08-23 |
2023-08-12 |
human |
| Y-Y He, J Pi, J-L Huang, B A Diwan, M P Waalkes, C F Chignel. Chronic UVA irradiation of human HaCaT keratinocytes induces malignant transformation associated with acquired apoptotic resistance. Oncogene. vol 25. issue 26. 2006-08-08. PMID:16682958. |
the resistance of ulth cells to uva-induced apoptosis was reversed by either inhibition of phosphatidylinositol 3-kinase (pi-3k) or adenovirus expression of pten or dominant negative akt. |
2006-08-08 |
2023-08-12 |
mouse |
| E Lopez-Sanchez, E Frances-Muñoz, J L Menezo, M D Pinazo-Dura. Optic nerve alterations in PTEN +/- mice. European journal of ophthalmology. vol 16. issue 3. 2006-08-07. PMID:16761247. |
to study the morphologic characteristics of the optic nerve (on) by using an experimental model of knockout mice for the expression of the pten gene, mainly involved in cell cycle arrest, apoptosis control, and cell size regulation. |
2006-08-07 |
2023-08-12 |
mouse |
| Li Sui, Youyi Dong, Yasuo Watanabe, Fuminori Yamaguchi, Katsuyoshi Sugimoto, Masaaki Tokud. Alteration and clinical relevance of PTEN expression and its correlation with survivin expression in epithelial ovarian tumors. Oncology reports. vol 15. issue 4. 2006-07-27. PMID:16525657. |
the tumor suppressor pten, phosphatase and tensin homolog on chromosome 10, plays an essential role in regulating signaling pathways involved in cell growth and apoptosis and is inactivated in a wide variety of tumors. |
2006-07-27 |
2023-08-12 |
human |