| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Sui, Youyi Dong, Yasuo Watanabe, Fuminori Yamaguchi, Katsuyoshi Sugimoto, Masaaki Tokud. Alteration and clinical relevance of PTEN expression and its correlation with survivin expression in epithelial ovarian tumors. Oncology reports. vol 15. issue 4. 2006-07-27. PMID:16525657. |
both pten and survivin proteins can regulate cell cycle and apoptosis, but their biological effects are adverse. |
2006-07-27 |
2023-08-12 |
human |
| C P Gomes, L A L A Andrad. PTEN and p53 expression in primary ovarian carcinomas: immunohistochemical study and discussion of pathogenetic mechanisms. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 16 Suppl 1. 2006-07-26. PMID:16515600. |
pten and p53 are proteins that have many different regulatory functions, including apoptosis. |
2006-07-26 |
2023-08-12 |
Not clear |
| Zhen Qiu, Ying-hao Sun, Chuan-liang Xu, Yuan-tian Wang, Zheng-qin Gu, Yi Li. [PTEN and p27Kip1 have a cooperative role on inhibition proliferation, modulation of cell cycle and inducing apoptosis in prostate cancer PC-3 cell]. Zhonghua wai ke za zhi [Chinese journal of surgery]. vol 42. issue 10. 2006-07-07. PMID:15265403. |
[pten and p27kip1 have a cooperative role on inhibition proliferation, modulation of cell cycle and inducing apoptosis in prostate cancer pc-3 cell]. |
2006-07-07 |
2023-08-12 |
human |
| Zhen Qiu, Ying-hao Sun, Chuan-liang Xu, Yuan-tian Wang, Zheng-qin Gu, Yi Li. [PTEN and p27Kip1 have a cooperative role on inhibition proliferation, modulation of cell cycle and inducing apoptosis in prostate cancer PC-3 cell]. Zhonghua wai ke za zhi [Chinese journal of surgery]. vol 42. issue 10. 2006-07-07. PMID:15265403. |
to investigate whether the human pc-3 cell infected with recombinant ad-pten and ad-p27kip1 can steadily produce pten and p27kip1 protein and change the biologic behaviors such as cell proliferation, cell cycle and apoptosis. |
2006-07-07 |
2023-08-12 |
human |
| Jerod Bertram, James W Peacock, Clara Tan, Alice L-F Mui, Stephen W Chung, Martin E Gleave, Shoukat Dedhar, Michael E Cox, Christopher J On. Inhibition of the phosphatidylinositol 3'-kinase pathway promotes autocrine Fas-induced death of phosphatase and tensin homologue-deficient prostate cancer cells. Cancer research. vol 66. issue 9. 2006-07-05. PMID:16651432. |
furthermore, we find that apoptosis induced by expression of wild-type pten, driven by a tetracycline-inducible expression system in lncap cells, can be inhibited by blocking fas/fasl interaction using fas:fc or nok-1. |
2006-07-05 |
2023-08-12 |
Not clear |
| Vicente Andrés, Marisol Gascón-Irún, Pier Paolo Pandolfi, Herminia González-Navarr. Atheroma development in apolipoprotein E-null mice is not affected by partial inactivation of PTEN. Frontiers in bioscience : a journal and virtual library. vol 11. 2006-06-27. PMID:16720346. |
likewise, the atheroma of pten(+/-)apoe-/- and apoe-/- mice displayed similar vsmc content, cellularity and rates of proliferation and apoptosis. |
2006-06-27 |
2023-08-12 |
mouse |
| Jose R Bayascas, Nick R Leslie, Ramon Parsons, Stewart Fleming, Dario R Aless. Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice. Current biology : CB. vol 15. issue 20. 2006-06-26. PMID:16243031. |
knockout of pkbalpha in pten-deficient cells reduces aggressive growth and promotes apoptosis, whereas treatment of pten(+/-) mice with rapamycin, an inhibitor of the activation of s6k, reduces neoplasia. |
2006-06-26 |
2023-08-12 |
mouse |
| Y Zhu, P Hoell, B Ahlemeyer, J Krieglstei. PTEN: a crucial mediator of mitochondria-dependent apoptosis. Apoptosis : an international journal on programmed cell death. vol 11. issue 2. 2006-06-15. PMID:16502258. |
pten: a crucial mediator of mitochondria-dependent apoptosis. |
2006-06-15 |
2023-08-12 |
rat |
| Y Zhu, P Hoell, B Ahlemeyer, J Krieglstei. PTEN: a crucial mediator of mitochondria-dependent apoptosis. Apoptosis : an international journal on programmed cell death. vol 11. issue 2. 2006-06-15. PMID:16502258. |
in the present study, we attempted to study the role and the underlying mechanism of pten in neuronal apoptosis. |
2006-06-15 |
2023-08-12 |
rat |
| Y Zhu, P Hoell, B Ahlemeyer, J Krieglstei. PTEN: a crucial mediator of mitochondria-dependent apoptosis. Apoptosis : an international journal on programmed cell death. vol 11. issue 2. 2006-06-15. PMID:16502258. |
however, the expression of pten, and the levels of phospho-pten and phospho-akt were not changed at all time points tested (0.5-24 h) after sts stimulation, suggesting that the protein level as well as the phosphorylation status of pten were not related to the procession of apoptosis. |
2006-06-15 |
2023-08-12 |
rat |
| Y Zhu, P Hoell, B Ahlemeyer, J Krieglstei. PTEN: a crucial mediator of mitochondria-dependent apoptosis. Apoptosis : an international journal on programmed cell death. vol 11. issue 2. 2006-06-15. PMID:16502258. |
these findings demonstrated that pten is a crucial mediator of mitochondria-dependent apoptosis, and thus could become a molecular target for interfering with neurodegenerative diseases. |
2006-06-15 |
2023-08-12 |
rat |
| Anindya Goswami, Padhma Ranganathan, Vivek M Rangneka. The phosphoinositide 3-kinase/Akt1/Par-4 axis: a cancer-selective therapeutic target. Cancer research. vol 66. issue 6. 2006-05-03. PMID:16540633. |
additionally, we found that par-4 participates in mediating apoptosis by pten, the tumor suppressor responsible for blocking pi3k/akt signaling. |
2006-05-03 |
2023-08-12 |
Not clear |
| Atsuo Okamura, Nobuko Iwata, Akira Tamekane, Kimikazu Yakushijin, Shinichiro Nishikawa, Miyuki Hamaguchi, Chie Fukui, Katsuya Yamamoto, Toshimitsu Matsu. Casein kinase Iepsilon down-regulates phospho-Akt via PTEN, following genotoxic stress-induced apoptosis in hematopoietic cells. Life sciences. vol 78. issue 14. 2006-04-14. PMID:16274701. |
casein kinase iepsilon down-regulates phospho-akt via pten, following genotoxic stress-induced apoptosis in hematopoietic cells. |
2006-04-14 |
2023-08-12 |
human |
| Atsuo Okamura, Nobuko Iwata, Akira Tamekane, Kimikazu Yakushijin, Shinichiro Nishikawa, Miyuki Hamaguchi, Chie Fukui, Katsuya Yamamoto, Toshimitsu Matsu. Casein kinase Iepsilon down-regulates phospho-Akt via PTEN, following genotoxic stress-induced apoptosis in hematopoietic cells. Life sciences. vol 78. issue 14. 2006-04-14. PMID:16274701. |
these results suggest that the ckiepsilon-induced down-regulation of pi3k/akt signaling through pten lead to amplified sensitivity to apoptosis. |
2006-04-14 |
2023-08-12 |
human |
| Huajun Yan, Patrick Frost, Yijiang Shi, Bao Hoang, Sanjai Sharma, Myrna Fisher, Joseph Gera, Alan Lichtenstei. Mechanism by which mammalian target of rapamycin inhibitors sensitize multiple myeloma cells to dexamethasone-induced apoptosis. Cancer research. vol 66. issue 4. 2006-04-13. PMID:16489035. |
sensitization was achieved in multiple myeloma cells irrespective of their pten or p53 status, enhanced by activation of akt, and associated with stimulation of both intrinsic and extrinsic pathways of apoptosis. |
2006-04-13 |
2023-08-12 |
Not clear |
| Jong-Soo Lee, Jun-Han Lee, Haryoung Poo, Mi-Suk Kim, Seung-Hoon Lee, Moon-Hee Sung, Chul-Joong Ki. Growth inhibitory effect of triple anti-tumor gene transfer using Semliki Forest virus vector in glioblastoma cells. International journal of oncology. vol 28. issue 3. 2006-03-28. PMID:16465369. |
as such, the current study presents a new delivery system that can simultaneously express three anti-tumor genes using a semliki forest virus (sfv) vector in the expectation of combined or synergistic effects of angiogenesis inhibition by angiostatin and apoptosis induction by p53, pten and the rsfv particle itself. |
2006-03-28 |
2023-08-12 |
mouse |
| C Festuccia, P Muzi, D Millimaggi, L Biordi, G L Gravina, S Speca, A Angelucci, V Dolo, C Vicentini, M Bologn. Molecular aspects of gefitinib antiproliferative and pro-apoptotic effects in PTEN-positive and PTEN-negative prostate cancer cell lines. Endocrine-related cancer. vol 12. issue 4. 2006-03-10. PMID:16322337. |
we reported that the egfr-selective tyrosine kinase inhibitor gefitinib (zd1839; iressa) is able to induce growth inhibition, g(1) arrest and apoptosis in pca cells and that its effectiveness is associated primarily with phosphatase and tensin homologue deleted from chromosome 10 (pten) expression (and thus akt activity). |
2006-03-10 |
2023-08-12 |
Not clear |
| C Festuccia, P Muzi, D Millimaggi, L Biordi, G L Gravina, S Speca, A Angelucci, V Dolo, C Vicentini, M Bologn. Molecular aspects of gefitinib antiproliferative and pro-apoptotic effects in PTEN-positive and PTEN-negative prostate cancer cell lines. Endocrine-related cancer. vol 12. issue 4. 2006-03-10. PMID:16322337. |
therefore, our data suggest that the inhibition of egfr signalling can result in a significant growth reduction and in increased apoptosis in egfr-overexpressing pca cells with different modalities, which are regulated by pten status, and this may have relevance in the clinical setting of pca. |
2006-03-10 |
2023-08-12 |
Not clear |
| Joommo Kim, Young Han Lee, Taeg Kyu Kwon, Jong-Soo Chang, Kwang Chul Chung, Do Sik Mi. Phospholipase D prevents etoposide-induced apoptosis by inhibiting the expression of early growth response-1 and phosphatase and tensin homologue deleted on chromosome 10. Cancer research. vol 66. issue 2. 2006-02-14. PMID:16424010. |
we show for the first time that elevated expression of pld isozymes attenuates expression of the tumor suppressors early growth response-1 (egr-1) and the phosphatase and tensin homologue deleted on chromosome 10 (pten) tumor suppressor and apoptosis during etoposide treatment. |
2006-02-14 |
2023-08-12 |
Not clear |
| Joommo Kim, Young Han Lee, Taeg Kyu Kwon, Jong-Soo Chang, Kwang Chul Chung, Do Sik Mi. Phospholipase D prevents etoposide-induced apoptosis by inhibiting the expression of early growth response-1 and phosphatase and tensin homologue deleted on chromosome 10. Cancer research. vol 66. issue 2. 2006-02-14. PMID:16424010. |
deletion of a specific egr-1-binding site present in the pten promoter blocked etoposide-induced pten activity and elevated expression of pld decreased the sensitivity to apoptosis induced by ectopic expression of egr-1. |
2006-02-14 |
2023-08-12 |
Not clear |