| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yonghua Yang, Huayan Hou, Edward M Haller, Santo V Nicosia, Wenlong Ba. Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation. The EMBO journal. vol 24. issue 5. 2005-04-28. PMID:15692560. |
forkhead box class o (foxo) proteins are transcription factors that function downstream of the pten tumor suppressor and directly control the expression of genes involved in apoptosis, cell cycle progression, and stress responses. |
2005-04-28 |
2023-08-12 |
Not clear |
| Soichiro Honjo, Mitsuhiko Osaki, Tonang Dwi Ardyanto, Toshiki Hiramatsu, Noritaka Maeta, Hisao It. COX-2 inhibitor, NS398, enhances Fas-mediated apoptosis via modulation of the PTEN-Akt pathway in human gastric carcinoma cell lines. DNA and cell biology. vol 24. issue 3. 2005-04-07. PMID:15767780. |
these findings suggest that cox-2 might inhibit fas-mediated apoptosis in human gastric carcinoma cell lines, especially mkn-45, by modulating pten and akt. |
2005-04-07 |
2023-08-12 |
human |
| Bernadette Ferraro, Gerold Bepler, Swati Sharma, Alan Cantor, Eric B Haur. EGR1 predicts PTEN and survival in patients with non-small-cell lung cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. vol 23. issue 9. 2005-04-05. PMID:15774784. |
egr1 expression has been linked to tumor suppression as a result of cell cycle arrest and apoptosis through regulation of tumor suppressor pathways including pten. |
2005-04-05 |
2023-08-12 |
Not clear |
| Kartiki V Desai, Aleksandra M Michalowska, Paturu Kondaiah, Jerrold M Ward, Joanna H Shih, Jeffrey E Gree. Gene expression profiling identifies a unique androgen-mediated inflammatory/immune signature and a PTEN (phosphatase and tensin homolog deleted on chromosome 10)-mediated apoptotic response specific to the rat ventral prostate. Molecular endocrinology (Baltimore, Md.). vol 18. issue 12. 2005-03-25. PMID:15358834. |
microarray and rt-pcr analyses demonstrated the androgen repression of igf binding protein-3 and -5, ccaat-enhancer binding protein-delta, and phosphatase and tensin homolog deleted on chromosome 10 (pten) genes, previously implicated in apoptosis. |
2005-03-25 |
2023-08-12 |
rat |
| Kartiki V Desai, Aleksandra M Michalowska, Paturu Kondaiah, Jerrold M Ward, Joanna H Shih, Jeffrey E Gree. Gene expression profiling identifies a unique androgen-mediated inflammatory/immune signature and a PTEN (phosphatase and tensin homolog deleted on chromosome 10)-mediated apoptotic response specific to the rat ventral prostate. Molecular endocrinology (Baltimore, Md.). vol 18. issue 12. 2005-03-25. PMID:15358834. |
we show that pten protein was increased only in the luminal epithelial cells of the vp, suggesting that it may be a key mediator of vp apoptosis in the absence of androgens. |
2005-03-25 |
2023-08-12 |
rat |
| Rolf Schwarzer, Daniel Tondera, Wolfgang Arnold, Klaus Giese, Anke Klippel, Jörg Kaufman. REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase. Oncogene. vol 24. issue 7. 2005-03-14. PMID:15592522. |
chronic activation of the pi 3-kinase-akt pathway through loss of the tumor suppressor pten is one mechanism by which these cells can gain increased protection against apoptosis. |
2005-03-14 |
2023-08-12 |
human |
| Mark A Rochester, Johann Riedemann, Giles O Hellawell, Simon F Brewster, Valentine M Macaula. Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wild-type and mutant human prostate cancer. Cancer gene therapy. vol 12. issue 1. 2005-03-08. PMID:15499378. |
in human du145, lncap and pc3 prostate cancer cells, transfection with igf1r small interfering rna induced significant enhancement of apoptosis and inhibition of survival, not only in pten wild-type du145 but also in pten mutant lncap and pc3. |
2005-03-08 |
2023-08-12 |
human |
| Hui-Kuan Lin, Yueh-Chiang Hu, Dong Kun Lee, Chawnshang Chan. Regulation of androgen receptor signaling by PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor through distinct mechanisms in prostate cancer cells. Molecular endocrinology (Baltimore, Md.). vol 18. issue 10. 2005-03-03. PMID:15205473. |
the interaction between pten and ar inhibits the ar nuclear translocation and promotes the ar protein degradation that result in the suppression of ar transactivation and induction of apoptosis. |
2005-03-03 |
2023-08-12 |
mouse |
| Hui-Kuan Lin, Yueh-Chiang Hu, Dong Kun Lee, Chawnshang Chan. Regulation of androgen receptor signaling by PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor through distinct mechanisms in prostate cancer cells. Molecular endocrinology (Baltimore, Md.). vol 18. issue 10. 2005-03-03. PMID:15205473. |
the minimum interaction peptide within ar (amino acids 483-651) disrupts the interaction of pten with ar and reduces the pten effect on ar transactivation and apoptosis. |
2005-03-03 |
2023-08-12 |
mouse |
| T Maehama, F Okahara, Y Kanah. The tumour suppressor PTEN: involvement of a tumour suppressor candidate protein in PTEN turnover. Biochemical Society transactions. vol 32. issue Pt 2. 2004-12-22. PMID:15046605. |
the tumour suppressor pten (phosphatase and tensin homologue deleted on chromosome 10) plays essential roles in regulating signalling pathways involved in cell growth and apoptosis, and is inactivated in a wide variety of tumours. |
2004-12-22 |
2023-08-12 |
Not clear |
| Salma Khan, Takashi Kumagai, Jaimini Vora, Namrata Bose, Indu Sehgal, Phillip H Koeffler, Shikha Bos. PTEN promoter is methylated in a proportion of invasive breast cancers. International journal of cancer. vol 112. issue 3. 2004-12-02. PMID:15382065. |
the pten protein is a negative regulator of the akt pathway, leading to suppression of apoptosis and increased cell survival. |
2004-12-02 |
2023-08-12 |
human |
| Fumiaki Okahara, Hideki Ikawa, Yasunori Kanaho, Tomohiko Maeham. Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein. The Journal of biological chemistry. vol 279. issue 44. 2004-11-30. PMID:15355975. |
the tumor suppressor pten plays an essential role in regulating signaling pathways involved in cell growth and apoptosis and is inactivated in a wide variety of tumors. |
2004-11-30 |
2023-08-12 |
Not clear |
| Sucharita Bandyopadhyay, Sudha K Pai, Shigeru Hirota, Sadahiro Hosobe, Taisei Tsukada, Kunio Miura, Yukio Takano, Ken Saito, Therese Commes, David Piquemal, Misako Watabe, Steven Gross, Ying Wang, Jodi Huggenvik, Kounosuke Watab. PTEN up-regulates the tumor metastasis suppressor gene Drg-1 in prostate and breast cancer. Cancer research. vol 64. issue 21. 2004-11-30. PMID:15520163. |
although pten is known to play a key role in controlling cell growth and apoptosis, how pten exerts the metastasis suppressor function remains largely unknown. |
2004-11-30 |
2023-08-12 |
Not clear |
| Hyun Woo Kim, In Kyu Park, Chong Su Cho, Kee Ho Lee, George R Beck, Nancy H Colburn, Myung Haing Ch. Aerosol delivery of glucosylated polyethylenimine/phosphatase and tensin homologue deleted on chromosome 10 complex suppresses Akt downstream pathways in the lung of K-ras null mice. Cancer research. vol 64. issue 21. 2004-11-30. PMID:15520204. |
finally, apoptosis was detected in pten-delivered mouse lung by terminal deoxynucleotidyltransferase-mediated nick end labeling assay, suggesting that our aerosol pten delivery is capable of functionally altering cell phenotype in vivo. |
2004-11-30 |
2023-08-12 |
mouse |
| Jill M Stahl, Arati Sharma, Mitchell Cheung, Melissa Zimmerman, Jin Q Cheng, Marcus W Bosenberg, Mark Kester, Lakshman Sandirasegarane, Gavin P Robertso. Deregulated Akt3 activity promotes development of malignant melanoma. Cancer research. vol 64. issue 19. 2004-11-16. PMID:15466193. |
targeted reduction of akt3 activity with sirna or by expressing active pten protein stimulated apoptotic signaling, which reduced cell survival by increasing apoptosis rates thereby inhibiting melanoma tumor development. |
2004-11-16 |
2023-08-12 |
Not clear |
| B Wappenschmidt, E Wardelmann, A Gehrig, T Schöndorf, N Maass, G Bonatz, A-M Gassel, T Pietsch, P Mallmann, B H F Weber, R K Schmutzle. PTEN mutations do not cause nuclear beta-catenin accumulation in endometrial carcinomas. Human pathology. vol 35. issue 10. 2004-11-10. PMID:15492994. |
pten encodes a dual-specificity phosphatase with lipid phosphatase and protein tyrosine phosphatase activities that regulate both apoptosis and interactions with the extracellular matrix. |
2004-11-10 |
2023-08-12 |
Not clear |
| Yiping Wu, Michael Karas, Joelle Dupont, Hong Zhao, Yuka Toyoshima, Derek Le Roit. Multiple signaling pathways are involved in the regulation of IGF-I receptor inhibition of PTEN-enhanced apoptosis. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 14. issue 1. 2004-09-30. PMID:14700555. |
by stably transfecting pc12 cells with an antisense pten construct, endogenous pten protein levels were reduced by approximately 50% and etoposide-induced apoptosis was markedly decreased. |
2004-09-30 |
2023-08-12 |
Not clear |
| N S Cheung, M S Choy, B Halliwell, T S Teo, B H Bay, A Y-W Lee, R Z Qi, V H Koh, M Whiteman, E S-C Koay, L L Chiu, H-J Zhu, K P Wong, P M Beart, H-C Chen. Lactacystin-induced apoptosis of cultured mouse cortical neurons is associated with accumulation of PTEN in the detergent-resistant membrane fraction. Cellular and molecular life sciences : CMLS. vol 61. issue 15. 2004-09-21. PMID:15289934. |
lactacystin-induced apoptosis of cultured mouse cortical neurons is associated with accumulation of pten in the detergent-resistant membrane fraction. |
2004-09-21 |
2023-08-12 |
mouse |
| Huamin Wang, Hua Wang, Wei Zhang, Helen J Huang, Warren S L Liao, Gregory N Fulle. Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas. Laboratory investigation; a journal of technical methods and pathology. vol 84. issue 8. 2004-09-02. PMID:15184909. |
as downstream targets of the pten and egfr signaling pathways, akt, nfkappab, and signal transducer and activator of transcription-3 (stat3) have been shown to play important roles in the control of cell proliferation, apoptosis, and oncogenesis. |
2004-09-02 |
2023-08-12 |
human |
| Lin Yang, Han C Dan, Mei Sun, Qiyuan Liu, Xia-meng Sun, Richard I Feldman, Andrew D Hamilton, Mark Polokoff, Santo V Nicosia, Meenhard Herlyn, Said M Sebti, Jin Q Chen. Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt. Cancer research. vol 64. issue 13. 2004-08-26. PMID:15231645. |
the inhibition of akt kinase resulted in suppression of cell growth and induction of apoptosis in human cancer cells that harbor constitutively activated akt due to overexpression of akt or other genetic alterations such as pten mutation. |
2004-08-26 |
2023-08-12 |
mouse |