| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan Sun, Hua Tian, Lin Wan. Effects of PTEN on the proliferation and apoptosis of colorectal cancer cells via the phosphoinositol-3-kinase/Akt pathway. Oncology reports. vol 33. issue 4. 2016-02-04. PMID:25683168. |
lovo and sw480 cells with upregulated pten were sensitive to apoptosis induced by 5-fu. |
2016-02-04 |
2023-08-13 |
Not clear |
| Maryam Esfahani, Negar Ataei, Mojtaba Panjehpou. Biomarkers for evaluation of prostate cancer prognosis. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 7. 2016-01-26. PMID:25854335. |
we here selected a group of candidate biomarkers including psa, psa velocity, percentage free psa, tgfβ1, amacr, chromogranin a, il-6, igfbps, psca, biomarkers related to cell cycle regulation, apoptosis, pten, androgen receptor, cellular adhesion and angiogenesis, and also prognostic biomarkers with genomic tests for discussion. |
2016-01-26 |
2023-08-13 |
Not clear |
| Qian Hou, Minxiang Lei, Ke Hu, Min Wan. The effects of high glucose levels on reactive oxygen species-induced apoptosis and involved signaling in human vascular endothelial cells. Cardiovascular toxicology. vol 15. issue 2. 2016-01-15. PMID:25158671. |
silencing nox4 and pten gene expression and inhibiting caspase-3 activation significantly protected huvecs from glucose-induced cell apoptosis. |
2016-01-15 |
2023-08-13 |
human |
| Angela Bononi, Paolo Pinto. Study of PTEN subcellular localization. Methods (San Diego, Calif.). vol 77-78. 2016-01-15. PMID:25312582. |
the repertoire of roles fulfilled by pten has recently been expanded to include crucial functions in the nucleus, where it favors genomic stability and restrains cell cycle progression, as well as protein phosphatase dependent activity at the endoplasmic reticulum (er) and mitochondria-associated membranes (mams), where pten interacts with the inositol 1,4,5-trisphosphate receptors (ip3rs) and regulates ca(2+) release from the er and sensitivity to apoptosis. |
2016-01-15 |
2023-08-13 |
Not clear |
| Alessandro Morotti, Cristina Panuzzo, Sabrina Crivellaro, Giovanna Carrà, Davide Torti, Angelo Guerrasio, Giuseppe Sagli. The Role of PTEN in Myeloid Malignancies. Hematology reports. vol 7. issue 4. 2016-01-06. PMID:26734127. |
targeting those mechanisms that affect pten function could indeed promote pten reactivation with consequent cancer selective apoptosis induction. |
2016-01-06 |
2023-08-13 |
mouse |
| Xian Yu, Zhengmin Xu, Jun Lei, Tingting Li, Yan Wan. VP22 mediates intercellular trafficking and enhances the in vitro antitumor activity of PTEN. Molecular medicine reports. vol 12. issue 1. 2016-01-04. PMID:25816150. |
in cell proliferation and apoptosis assays, pten-vp22 gene transfer induces a stronger anti-proliferative effect and apoptotic activity compared with pten gene transfer alone. |
2016-01-04 |
2023-08-13 |
Not clear |
| Yan Guo, Hui Chang, Jing Li, Xin-yuan Xu, Lan Shen, Zhi-bin Yu, Wen-chao Li. Thymosin alpha 1 suppresses proliferation and induces apoptosis in breast cancer cells through PTEN-mediated inhibition of PI3K/Akt/mTOR signaling pathway. Apoptosis : an international journal on programmed cell death. vol 20. issue 8. 2016-01-04. PMID:26002438. |
together these findings suggest that pten mediates tα1-induced apoptosis through the mitochondrial death cascade and inhibition of the pi3k/akt/mtor signaling pathway in breast cancer cells. |
2016-01-04 |
2023-08-13 |
human |
| Alessandro Morotti, Cristina Panuzzo, Sabrina Crivellaro, Giovanna Carrà, Carmen Fava, Angelo Guerrasio, Pier Paolo Pandolfi, Giuseppe Sagli. BCR-ABL inactivates cytosolic PTEN through Casein Kinase II mediated tail phosphorylation. Cell cycle (Georgetown, Tex.). vol 14. issue 7. 2015-12-28. PMID:25608112. |
targeting mechanisms that inactivate pten promotes apoptosis induction of cancer cells, without affecting normal cells, with appealing therapeutic implications. |
2015-12-28 |
2023-08-13 |
Not clear |
| Alessandro Morotti, Cristina Panuzzo, Sabrina Crivellaro, Giovanna Carrà, Carmen Fava, Angelo Guerrasio, Pier Paolo Pandolfi, Giuseppe Sagli. BCR-ABL inactivates cytosolic PTEN through Casein Kinase II mediated tail phosphorylation. Cell cycle (Georgetown, Tex.). vol 14. issue 7. 2015-12-28. PMID:25608112. |
targeting casein kinase ii promotes pten reactivation with apoptosis induction. |
2015-12-28 |
2023-08-13 |
Not clear |
| Zhishan Xu, Lingyun Zhu, Min Yao, Genshen Zhong, Qiaoyan Dong, Aiping Y. PTEN plays an important role in thrombin-mediated lung cancer cell functions. BioMed research international. vol 2015. 2015-12-28. PMID:25861627. |
the results indicated that thrombin downregulates the pten expression level and that pten plays an important role in thrombin-mediated glc-82 functions, including cell cycle progression, cell apoptosis, and cell migration. |
2015-12-28 |
2023-08-13 |
Not clear |
| Y Qi, J Liu, S Saadat, X Tian, Y Han, G-H Fong, P P Pandolfi, L Y Lee, S L. PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation. Cell death and differentiation. vol 22. issue 5. 2015-12-24. PMID:25394489. |
pten induces apoptosis and cavitation via hif-2-dependent bnip3 upregulation during epithelial lumen formation. |
2015-12-24 |
2023-08-13 |
mouse |
| Y Qi, J Liu, S Saadat, X Tian, Y Han, G-H Fong, P P Pandolfi, L Y Lee, S L. PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation. Cell death and differentiation. vol 22. issue 5. 2015-12-24. PMID:25394489. |
pten is upregulated during eb morphogenesis in parallel with apoptosis of core cells, which mediates eb cavitation. |
2015-12-24 |
2023-08-13 |
mouse |
| Y Qi, J Liu, S Saadat, X Tian, Y Han, G-H Fong, P P Pandolfi, L Y Lee, S L. PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation. Cell death and differentiation. vol 22. issue 5. 2015-12-24. PMID:25394489. |
genetic ablation of pten causes akt overactivation, apoptosis resistance and cavitation blockade. |
2015-12-24 |
2023-08-13 |
mouse |
| Y Qi, J Liu, S Saadat, X Tian, Y Han, G-H Fong, P P Pandolfi, L Y Lee, S L. PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation. Cell death and differentiation. vol 22. issue 5. 2015-12-24. PMID:25394489. |
mechanistically, suppression of bnip3 following pten loss is likely due to reduction of hypoxia-inducible factor-2α (hif-2α) because forced expression of an oxygen-stable hif-2α mutant rescues bnip3 expression and apoptosis. |
2015-12-24 |
2023-08-13 |
mouse |
| Raju K Mandal, Naseem Akhter, Mohammad Irshad, Aditya K Panda, Arif Ali, Shafiul Haqu. Association of the PTEN IVS4 (rs3830675) gene polymorphism with reduced risk of cancer: evidence from a meta-analysis. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 3. 2015-12-08. PMID:25735379. |
pten (phosphatase and tensin homologue), as a tumor suppressor gene, plays a significant role in regulating cell growth, proliferation, and apoptosis. |
2015-12-08 |
2023-08-13 |
Not clear |
| Lin Zhang, Siyuan Zhang, Jun Yao, Frank J Lowery, Qingling Zhang, Wen-Chien Huang, Ping Li, Min Li, Xiao Wang, Chenyu Zhang, Hai Wang, Kenneth Ellis, Mujeeburahiman Cheerathodi, Joseph H McCarty, Diane Palmieri, Jodi Saunus, Sunil Lakhani, Suyun Huang, Aysegul A Sahin, Kenneth D Aldape, Patricia S Steeg, Dihua Y. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature. vol 527. issue 7576. 2015-12-07. PMID:26479035. |
furthermore, this adaptive pten loss in brain metastatic tumour cells leads to an increased secretion of the chemokine ccl2, which recruits iba1-expressing myeloid cells that reciprocally enhance the outgrowth of brain metastatic tumour cells via enhanced proliferation and reduced apoptosis. |
2015-12-07 |
2023-08-13 |
mouse |
| Lihua Huang, Liwu F. Mechanisms of resistance to EGFR tyrosine kinase inhibitors. Acta pharmaceutica Sinica. B. vol 5. issue 5. 2015-11-20. PMID:26579470. |
resistance to egfr-tkis is inevitable due to various mechanisms, such as the secondary mutation (t790m), activation of alternative pathways (c-met, hgf, axl), aberrance of the downstream pathways (k-ras mutations, loss of pten), impairment of the egfr-tkis-mediated apoptosis pathway (bcl2-like 11/bim deletion polymorphism), histologic transformation, atp binding cassette (abc) transporter effusion, etc. |
2015-11-20 |
2023-08-13 |
Not clear |
| Zhuoran Wang, Xiaoming Hou, Bo Qu, Jie Wang, Xuejun Gao, Qingzhang L. Pten regulates development and lactation in the mammary glands of dairy cows. PloS one. vol 9. issue 7. 2015-11-10. PMID:25009983. |
pten is a tumor suppressor gene regulating many cellular processes, including growth, adhesion, and apoptosis. |
2015-11-10 |
2023-08-13 |
Not clear |
| Kai Zhang, Jing Chen, Dongqin Chen, Jiayuan Huang, Bing Feng, Siqi Han, Yitian Chen, Haizhu Song, Wei De, Ziman Zhu, Rui Wang, Longbang Che. Aurora-A promotes chemoresistance in hepatocelluar carcinoma by targeting NF-kappaB/microRNA-21/PTEN signaling pathway. Oncotarget. vol 5. issue 24. 2015-11-09. PMID:25428915. |
furthermore, overexpression of aurora-a reduces chemotherapy-induced apoptosis by promoting microrna-21 expression, which negatively regulates pten and then inhibits caspase-3-mediated apoptosis induction. |
2015-11-09 |
2023-08-13 |
Not clear |
| Nehad M R Abd El-Maqsoud, Saad El-Gelan. Differential Expression Patterns of PTEN in Cyclic, Hyperplastic and Malignant Endometrium: Its Relation with ER, PR and Clinicopathological Parameters. Journal of the Egyptian National Cancer Institute. vol 21. issue 4. 2015-11-05. PMID:21415869. |
pten is a tumor suppressor gene, which is frequently mutated and involved in the control of cell proliferation, differentiation, and apoptosis in a variety of human tumors including endometrium. |
2015-11-05 |
2023-08-12 |
human |