| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bin Wu, Xu Wang, Zuo-fei Chi, Rong Hu, Rong Zhang, Wei Yang, Zhuo-gang Li. Ursolic acid-induced apoptosis in K562 cells involving upregulation of PTEN gene expression and inactivation of the PI3K/Akt pathway. Archives of pharmacal research. vol 35. issue 3. 2012-07-31. PMID:22477202. |
ursolic acid-induced apoptosis in k562 cells involving upregulation of pten gene expression and inactivation of the pi3k/akt pathway. |
2012-07-31 |
2023-08-12 |
human |
| Bin Wu, Xu Wang, Zuo-fei Chi, Rong Hu, Rong Zhang, Wei Yang, Zhuo-gang Li. Ursolic acid-induced apoptosis in K562 cells involving upregulation of PTEN gene expression and inactivation of the PI3K/Akt pathway. Archives of pharmacal research. vol 35. issue 3. 2012-07-31. PMID:22477202. |
here, we demonstrated that ua was able to inhibit growth, induce apoptosis in a human chronic myelogenous leukemia cell line (k562 cells) via upregulation of pten gene expression, inhibit akt kinase activity, change mitochondrial transmembrane potential and reduce the release of cytochrome c and the activity of caspases. |
2012-07-31 |
2023-08-12 |
human |
| Yin-Hsun Feng, Chao-Liang Wu, Ai-Li Shiau, Jenq-Chang Lee, Jan-Gowth Chang, Pei-Jung Lu, Chao-Ling Tung, Li-Yia Feng, Wen-Tsung Huang, Chao-Jung Tsa. MicroRNA-21-mediated regulation of Sprouty2 protein expression enhances the cytotoxic effect of 5-fluorouracil and metformin in colon cancer cells. International journal of molecular medicine. vol 29. issue 5. 2012-07-16. PMID:22322462. |
spry2 promoted apoptosis of cancer cells in association with activation of the phosphatase and tensin homolog deleted on chromosome 10 (pten) pathway and the blockade of ras-raf-erk signaling. |
2012-07-16 |
2023-08-12 |
Not clear |
| Thomas Bogenrieder, Meenhard Herly. The molecular pathology of cutaneous melanoma. Cancer biomarkers : section A of Disease markers. vol 9. issue 1-6. 2012-07-12. PMID:22112480. |
herein, we review our rapidly growing understanding of the molecular biology of cutaneous melanoma, including the pathogenic roles of the mitogen-associated protein kinase (mapk) pathway, the phosphatidylinositol 3 kinase [pi3k]/phosphatase and tensin homologue deleted on chromosome 10 [pten]/akt/mammalian target of rapamycin [mtor])pten (phosphatase and tensin homolog) pathway, met (hepatocyte growth factor), notch signaling, and other key molecules regulating cell cycle progression and apoptosis. |
2012-07-12 |
2023-08-12 |
Not clear |
| Mahshid Nickkho-Amiry, Rhona McVey, Cathrine Hollan. Peroxisome proliferator-activated receptors modulate proliferation and angiogenesis in human endometrial carcinoma. Molecular cancer research : MCR. vol 10. issue 3. 2012-07-05. PMID:22205725. |
to determine the functions of ppars within the endometrium, we investigated proliferation, apoptosis, pten expression, and secretion of vascular endothelial growth factor (vegf) in endometrial cell lines after reducing the expression of pparα and pparγ with antisense rna. |
2012-07-05 |
2023-08-12 |
human |
| Jinqiao Qian, Shukuan Ling, Alexander C Castillo, Bo Long, Yochai Birnbaum, Yumei Y. Regulation of phosphatase and tensin homolog on chromosome 10 in response to hypoxia. American journal of physiology. Heart and circulatory physiology. vol 302. issue 9. 2012-07-03. PMID:22367504. |
inhibition of pten in cardiomyocytes attenuated hypoxia-induced cell death and apoptosis. |
2012-07-03 |
2023-08-12 |
Not clear |
| Kunio Okamoto, Isamu Okamoto, Erina Hatashita, Kiyoko Kuwata, Haruka Yamaguchi, Aya Kita, Kentaro Yamanaka, Mayumi Ono, Kazuhiko Nakagaw. Overcoming erlotinib resistance in EGFR mutation-positive non-small cell lung cancer cells by targeting survivin. Molecular cancer therapeutics. vol 11. issue 1. 2012-06-29. PMID:22075159. |
the egfr-tki erlotinib did not affect survivin expression or induce apoptosis in egfr mutation-positive nsclc cells with pten loss. |
2012-06-29 |
2023-08-12 |
mouse |
| Kunio Okamoto, Isamu Okamoto, Erina Hatashita, Kiyoko Kuwata, Haruka Yamaguchi, Aya Kita, Kentaro Yamanaka, Mayumi Ono, Kazuhiko Nakagaw. Overcoming erlotinib resistance in EGFR mutation-positive non-small cell lung cancer cells by targeting survivin. Molecular cancer therapeutics. vol 11. issue 1. 2012-06-29. PMID:22075159. |
these results thus indicate that persistent activation of signaling by the akt-survivin pathway induced by pten loss underlies a mechanism of resistance to erlotinib-induced apoptosis in egfr mutation-positive nsclc. |
2012-06-29 |
2023-08-12 |
mouse |
| Mei Ming, Yu-Ying H. PTEN in DNA damage repair. Cancer letters. vol 319. issue 2. 2012-06-07. PMID:22266095. |
phosphatase and tensin homolog (pten) is a well-established tumor suppressor gene that induces apoptosis and controls cell growth by inhibiting the pi3k/akt pathway. |
2012-06-07 |
2023-08-12 |
human |
| Paul D Ray, Bo-Wen Huang, Yoshiaki Tsuj. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cellular signalling. vol 24. issue 5. 2012-06-06. PMID:22286106. |
this review focuses on the molecular mechanisms through which ros directly interact with critical signaling molecules to initiate signaling in a broad variety of cellular processes, such as proliferation and survival (map kinases, pi3 kinase, pten, and protein tyrosine phosphatases), ros homeostasis and antioxidant gene regulation (thioredoxin, peroxiredoxin, ref-1, and nrf-2), mitochondrial oxidative stress, apoptosis, and aging (p66shc), iron homeostasis through iron-sulfur cluster proteins (ire-irp), and atm-regulated dna damage response. |
2012-06-06 |
2023-08-12 |
Not clear |
| Xiao-Jia Chen, Fei-Die Duan, Hui-Hua Zhang, Yi Xiong, Jin Wan. Sodium selenite-induced apoptosis mediated by ROS attack in human osteosarcoma U2OS cells. Biological trace element research. vol 145. issue 1. 2012-05-21. PMID:21826611. |
sse-induced apoptosis correlated with the activation of casp 3, downregulation of bcl-2, and upregulation of p53 and pten in u2os cells. |
2012-05-21 |
2023-08-12 |
human |
| Jeffrey J Wallin, Kyle A Edgar, Jane Guan, Megan Berry, Wei Wei Prior, Leslie Lee, John D Lesnick, Cristina Lewis, Jim Nonomiya, Jodie Pang, Laurent Salphati, Alan G Olivero, Daniel P Sutherlin, Carol O'Brien, Jill M Spoerke, Sonal Patel, Letitia Lensun, Robert Kassees, Leanne Ross, Mark R Lackner, Deepak Sampath, Marcia Belvin, Lori S Friedma. GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway. Molecular cancer therapeutics. vol 10. issue 12. 2012-05-11. PMID:21998291. |
treatment of cancer cell lines with gdc-0980 resulted in g1 cell-cycle arrest, and in contrast to mtor inhibitors, gdc-0980 induced apoptosis in certain cancer cell lines, including those with direct pathway activation via pi3k and pten. |
2012-05-11 |
2023-08-12 |
Not clear |
| Youqing Tian, Abdelkader Daoud, Jing Shan. Effects of bpV(pic) and bpV(phen) on H9c2 cardiomyoblasts during both hypoxia/reoxygenation and H2O2-induced injuries. Molecular medicine reports. vol 5. issue 3. 2012-05-03. PMID:22200881. |
ros are known to inactivate lipid phosphatase and tension homolog on chromosome 10 (pten), an enzyme that increases apoptosis in neonatal cardiomyocytes. |
2012-05-03 |
2023-08-12 |
Not clear |
| Liang Guo, Liang Chen, Sheng Bi, Linlin Chai, Zengxiang Wang, Chuan Cao, Ling Tao, Shirong L. PTEN inhibits proliferation and functions of hypertrophic scar fibroblasts. Molecular and cellular biochemistry. vol 361. issue 1-2. 2012-04-27. PMID:21989717. |
furthermore, we found that adenovirus-mediated pten overexpression led to decreased akt activation, and significantly reduced cell proliferation and collagen synthesis of hsfbs, while increased the apoptosis. |
2012-04-27 |
2023-08-12 |
Not clear |
| Ying Ni, Xin He, Jinlian Chen, Jessica Moline, Jessica Mester, Mohammed S Orloff, Matthew D Ringel, Charis En. Germline SDHx variants modify breast and thyroid cancer risks in Cowden and Cowden-like syndrome via FAD/NAD-dependant destabilization of p53. Human molecular genetics. vol 21. issue 2. 2012-04-26. PMID:21979946. |
patient-derived sdh(var+) lymphoblastoid cells had elevated cellular reactive oxygen species, highest in pten(mut+)/sdh(var+) cells, correlating with apoptosis resistance. |
2012-04-26 |
2023-08-12 |
Not clear |
| Gang Li, Jingfeng Zhao, Xianjing Peng, Jian Liang, Xin Deng, Yuxiang Che. The mechanism involved in the loss of PTEN expression in NSCLC tumor cells. Biochemical and biophysical research communications. vol 418. issue 3. 2012-04-11. PMID:22290228. |
we found that radiation induced cell apoptosis and hypomethylation in pten promoter, pten and mir-29b expression, and downregulation of dnmt1, 3a and 3b expression in h358 tumor cells. |
2012-04-11 |
2023-08-12 |
mouse |
| b' Zhihua Jiang, Nan Yu, Pingping Kuang, Melody Chen, Fengzhi Shao, Gregory Martin, David H K Chui, Wellington V Cardoso, Xingbin Ai, Jining L\\xc3\\xb. Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm. The Journal of biological chemistry. vol 287. issue 8. 2012-04-09. PMID:22187428.' |
specifically, growth arrest and apoptosis phenotype are associated with significant derepression of cdkn1a (p21), cdkn1c (p27), lats1, lats2, rb1, rbl, bim, and pten, known targets of mirnas from mir-17/20/93/106 clusters highly expressed in yolk sac endoderm. |
2012-04-09 |
2023-08-12 |
mouse |
| M Krausch, A Raffel, M Anlauf, M Schott, H Willenberg, N Lehwald, D Hafner, K Cupisti, C F Eisenberger, W T Knoefe. Loss of PTEN expression in neuroendocrine pancreatic tumors. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 43. issue 12. 2012-03-15. PMID:22105477. |
pten plays an important role in controlling cell growth, apoptosis, cell adhesion, and cell migration. |
2012-03-15 |
2023-08-12 |
Not clear |
| Chong Zhang, Yong-Ku Ryu, Taylor Z Chen, Connor P Hall, Daniel R Webster, Min H Kan. Synergistic activity of rapamycin and dexamethasone in vitro and in vivo in acute lymphoblastic leukemia via cell-cycle arrest and apoptosis. Leukemia research. vol 36. issue 3. 2012-03-06. PMID:22137317. |
compared with either drug alone, dexamethasone+rapamycin showed significantly greater apoptosis and cell cycle arrest in some cell lines, and was more frequently seen in t-lineage cell lines with pten mutation. |
2012-03-06 |
2023-08-12 |
mouse |
| Leila R Martins, Paulo Lúcio, Milene C Silva, Paula Gameiro, Maria G Silva, João T Barat. On CK2 regulation of chronic lymphocytic leukemia cell viability. Molecular and cellular biochemistry. vol 356. issue 1-2. 2012-02-28. PMID:21750986. |
further, we observed that ck2 blockade decreases pten phosphorylation, leading to pten activation, and that apoptosis of cll cells upon ck2 inhibition is mediated by pkc inactivation. |
2012-02-28 |
2023-08-12 |
Not clear |