| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Yang, Takayuki Ikezoe, Chie Nishioka, Yuka Takezaki, Kazuhiro Hanazaki, Takahiro Taguchi, Akihito Yokoyam. Long-term exposure of gastrointestinal stromal tumor cells to sunitinib induces epigenetic silencing of the PTEN gene. International journal of cancer. vol 130. issue 4. 2012-02-27. PMID:21445973. |
notably, forced-expression of pten in gist-t1r cells negatively regulated the akt/mtor pathways and sensitized these cells to sunitinib-mediated growth arrest and apoptosis. |
2012-02-27 |
2023-08-12 |
Not clear |
| Nisreen Sherif Alyasiri, Syed Jafar Mehdi, M Shabbir Alam, Asgar Ali, Ashish K Mandal, Sunita Gupta, Ishwar Singh, M Moshahid Alam Rizv. PTEN-mediated AKT activation contributes to the reduced apoptosis among Indian oral squamous cell carcinoma patients. Journal of cancer research and clinical oncology. vol 138. issue 1. 2012-02-24. PMID:22033727. |
several studies have reported the role of pten gene in akt downregulation and apoptosis induction in different cancers and cell lines. |
2012-02-24 |
2023-08-12 |
Not clear |
| Nisreen Sherif Alyasiri, Syed Jafar Mehdi, M Shabbir Alam, Asgar Ali, Ashish K Mandal, Sunita Gupta, Ishwar Singh, M Moshahid Alam Rizv. PTEN-mediated AKT activation contributes to the reduced apoptosis among Indian oral squamous cell carcinoma patients. Journal of cancer research and clinical oncology. vol 138. issue 1. 2012-02-24. PMID:22033727. |
however, the role of loss of pten expression in akt activation and spontaneous apoptosis in oral squamous cell carcinoma clinical specimens is not well established. |
2012-02-24 |
2023-08-12 |
Not clear |
| C Rory Goodwin, Bachchu Lal, Sandra Ho, Crystal L Woodard, Xin Zhou, Alexandra Taeger, Shuli Xia, John Laterr. PTEN reconstitution alters glioma responses to c-Met pathway inhibition. Anti-cancer drugs. vol 22. issue 9. 2012-02-03. PMID:21654317. |
in contrast, xenograft cell apoptosis was greatest in response to anti-hgf therapy alone and pten reconstitution abrogated the apoptotic response to anti-hgf therapy. |
2012-02-03 |
2023-08-12 |
Not clear |
| Yang Li, Ai-Jun Liao, Bin Wu, Meng-Yao Pan, Zhuo-Gang Li. [Effects of oleanolic acid on apoptosis and PTEN expression of Jurkat cells]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 2. 2012-01-12. PMID:21518490. |
[effects of oleanolic acid on apoptosis and pten expression of jurkat cells]. |
2012-01-12 |
2023-08-12 |
Not clear |
| Yang Li, Ai-Jun Liao, Bin Wu, Meng-Yao Pan, Zhuo-Gang Li. [Effects of oleanolic acid on apoptosis and PTEN expression of Jurkat cells]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 2. 2012-01-12. PMID:21518490. |
this study was aimed to explore the effects of oleanolic acid on pten expression and apoptosis of jurkat cells. |
2012-01-12 |
2023-08-12 |
Not clear |
| Yang Li, Ai-Jun Liao, Bin Wu, Meng-Yao Pan, Zhuo-Gang Li. [Effects of oleanolic acid on apoptosis and PTEN expression of Jurkat cells]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 2. 2012-01-12. PMID:21518490. |
it is concluded that up-regulation of pten mrna and pten protein may be involved in oleanolic acid-induced jurkat cell apoptosis. |
2012-01-12 |
2023-08-12 |
Not clear |
| Yuan-da Wang, Li Zhang, Guang-Yan Cai, Xue-guang Zhang, Yang Lv, Quan Hong, Suo-zhu Shi, Zhong Yin, Xiang-fei Liu, Xiang-mei Che. Fasudil ameliorates rhabdomyolysis-induced acute kidney injury via inhibition of apoptosis. Renal failure. vol 33. issue 8. 2012-01-10. PMID:21797820. |
cell apoptosis and the expression of rho-associated protein kinase member (rock1), phosphatase and tensin homolog (pten), p-akt, and caspase-8, -9, and -3 were measured. |
2012-01-10 |
2023-08-12 |
rat |
| R Deevi, A Fatehullah, I Jagan, M Nagaraju, V Bingham, F C Campbel. PTEN regulates colorectal epithelial apoptosis through Cdc42 signalling. British journal of cancer. vol 105. issue 9. 2011-12-14. PMID:21952626. |
pten regulates colorectal epithelial apoptosis through cdc42 signalling. |
2011-12-14 |
2023-08-12 |
Not clear |
| R Deevi, A Fatehullah, I Jagan, M Nagaraju, V Bingham, F C Campbel. PTEN regulates colorectal epithelial apoptosis through Cdc42 signalling. British journal of cancer. vol 105. issue 9. 2011-12-14. PMID:21952626. |
phosphatase and tensin homologue deleted on chromosome 10 (pten) regulation of the rho-like gtpase cdc42 has a central role in epithelial polarised growth, but effects of this molecular network on apoptosis remain unclear. |
2011-12-14 |
2023-08-12 |
Not clear |
| Hongbo Chen, Lin Mei, Lanzhen Zhou, Xiaomeng Shen, Caiping Guo, Yi Zheng, Huijun Zhu, Yongqiang Zhu, Laiqiang Huan. PTEN restoration and PIK3CB knockdown synergistically suppress glioblastoma growth in vitro and in xenografts. Journal of neuro-oncology. vol 104. issue 1. 2011-12-07. PMID:21188471. |
restoration of pten or knockdown of pik3cb, but not pik3ca, in glioblastoma cells markedly down-regulates the phosphorylation level of akt, inhibits cell proliferation and colony formation, arrests the cell cycle at the g0/g1 stage, and promotes caspase-dependent apoptosis. |
2011-12-07 |
2023-08-12 |
mouse |
| Hongbo Chen, Lin Mei, Lanzhen Zhou, Xiaomeng Shen, Caiping Guo, Yi Zheng, Huijun Zhu, Yongqiang Zhu, Laiqiang Huan. PTEN restoration and PIK3CB knockdown synergistically suppress glioblastoma growth in vitro and in xenografts. Journal of neuro-oncology. vol 104. issue 1. 2011-12-07. PMID:21188471. |
in addition, we found that the mrna levels of inhibitors of apoptosis proteins (iaps) are reduced in u251 cells by pten restoration, suggesting that combined antitumor effects may also be partly attributed to the inhibition of the iap pathway by pten restoration. |
2011-12-07 |
2023-08-12 |
mouse |
| Jason A Lehman, David L Waning, Christopher N Batuello, Rocky Cipriano, Madhavi P Kadakia, Lindsey D May. Induction of apoptotic genes by a p73-phosphatase and tensin homolog (p73-PTEN) protein complex in response to genotoxic stress. The Journal of biological chemistry. vol 286. issue 42. 2011-12-07. PMID:21873427. |
pten can directly or indirectly activate p53 to promote apoptosis. |
2011-12-07 |
2023-08-12 |
Not clear |
| Naotoshi Sugimoto, Shinji Miwa, Takako Ohno-Shosaku, Hiroyuki Tsuchiya, Yoshiaki Hitomi, Hiroyuki Nakamura, Katsuro Tomita, Akihiro Yachie, Shoichi Koizum. Activation of tumor suppressor protein PTEN and induction of apoptosis are involved in cAMP-mediated inhibition of cell number in B92 glial cells. Neuroscience letters. vol 497. issue 1. 2011-10-31. PMID:21529704. |
activation of tumor suppressor protein pten and induction of apoptosis are involved in camp-mediated inhibition of cell number in b92 glial cells. |
2011-10-31 |
2023-08-12 |
rat |
| Naotoshi Sugimoto, Shinji Miwa, Takako Ohno-Shosaku, Hiroyuki Tsuchiya, Yoshiaki Hitomi, Hiroyuki Nakamura, Katsuro Tomita, Akihiro Yachie, Shoichi Koizum. Activation of tumor suppressor protein PTEN and induction of apoptosis are involved in cAMP-mediated inhibition of cell number in B92 glial cells. Neuroscience letters. vol 497. issue 1. 2011-10-31. PMID:21529704. |
these results suggested that camp-induced apoptosis may be mediated by pten activation and akt inhibition through protein phosphatase in b92 cells. |
2011-10-31 |
2023-08-12 |
rat |
| Naotoshi Sugimoto, Shinji Miwa, Takako Ohno-Shosaku, Hiroyuki Tsuchiya, Yoshiaki Hitomi, Hiroyuki Nakamura, Katsuro Tomita, Akihiro Yachie, Shoichi Koizum. Activation of tumor suppressor protein PTEN and induction of apoptosis are involved in cAMP-mediated inhibition of cell number in B92 glial cells. Neuroscience letters. vol 497. issue 1. 2011-10-31. PMID:21529704. |
our results provide new insight into the role of pten in camp-induced apoptosis in glial cells. |
2011-10-31 |
2023-08-12 |
rat |
| Omar M Rahal, Rosalia C M Simme. Paracrine-acting adiponectin promotes mammary epithelial differentiation and synergizes with genistein to enhance transcriptional response to estrogen receptor β signaling. Endocrinology. vol 152. issue 9. 2011-10-31. PMID:21712365. |
the enhancement of erβ signaling with apn + genistein cotreatments was associated with induction of apoptosis, increased expression of proapoptotic/prodifferentiation genes (bad, p53, and pten), and decreased antiapoptotic (bcl2 and survivin) transcript levels. |
2011-10-31 |
2023-08-12 |
Not clear |
| Hee-Don Chae, Hal E Broxmeye. SIRT1 deficiency downregulates PTEN/JNK/FOXO1 pathway to block reactive oxygen species-induced apoptosis in mouse embryonic stem cells. Stem cells and development. vol 20. issue 7. 2011-10-20. PMID:21083429. |
since pten is a negative regulator of akt and its activity can be modulated by acetylation, we investigated if sirt1 deacetylated pten to downregulate akt to trigger apoptosis in anti-oxidant-free culture conditions. |
2011-10-20 |
2023-08-12 |
mouse |
| Yumei Ye, Jose R Perez-Polo, Jinqiao Qian, Yochai Birnbau. The role of microRNA in modulating myocardial ischemia-reperfusion injury. Physiological genomics. vol 43. issue 10. 2011-10-18. PMID:20959496. |
by altering the expression of various key elements in cell survival and apoptosis [such as phosphoinositide 3-kinase (pi3k), phosphatase and tensin homolog deleted on chromosome 10 (pten), bcl-2, mcl-1, heat shock protein (hsp)60, hsp70, hsp20, programmed cell death 4 (pdcd4), lrrfip1, fas ligand (fasl), sirt-1, etc. |
2011-10-18 |
2023-08-12 |
Not clear |
| Su-Yun Wang, Zhi-Yong Cheng, Kai Deng, Hao Chen, Lin Pa. [Antioncogene PTEN-a new target for myeloma therapy]. Zhongguo shi yan xue ye xue za zhi. vol 18. issue 3. 2011-10-13. PMID:20561457. |
pten gene is the first antioncogene with dual phosphatase activity discovered so far, pten gene regulates the cell cycle progress, apoptosis, metastasis and invasion of the tumor cells through negatively regulating the multiple signaling transduction pathways. |
2011-10-13 |
2023-08-12 |
Not clear |