| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongbo Chen, Xiaomeng Shen, Caiping Guo, Huijun Zhu, Lanzhen Zhou, Yongqiang Zhu, Huixia Wang, Yi Zheng, Laiqiang Huan. Phosphatase and tensin homolog reconstruction and vascular endothelial growth factor knockdown synergistically inhibit the growth of glioblastoma. Cancer biotherapy & radiopharmaceuticals. vol 25. issue 6. 2011-05-27. PMID:21204766. |
in u251 gbm cells, pten restoration reduced proliferation, arrested the cell cycle at g0/g1 stage, and promoted apoptosis via inhibition of pik/akt signaling pathway. |
2011-05-27 |
2023-08-12 |
mouse |
| Li-Min Li, Dong-Xia Hou, Ya-Lan Guo, Jun-Wei Yang, Yuan Liu, Chen-Yu Zhang, Ke Ze. Role of microRNA-214-targeting phosphatase and tensin homolog in advanced glycation end product-induced apoptosis delay in monocytes. Journal of immunology (Baltimore, Md. : 1950). vol 186. issue 4. 2011-04-28. PMID:21228352. |
compared with normal monocytes, age-treated monocytes and monocytes from chronic renal failure patients exhibited lower pten levels and delayed apoptosis. |
2011-04-28 |
2023-08-12 |
human |
| Li-Min Li, Dong-Xia Hou, Ya-Lan Guo, Jun-Wei Yang, Yuan Liu, Chen-Yu Zhang, Ke Ze. Role of microRNA-214-targeting phosphatase and tensin homolog in advanced glycation end product-induced apoptosis delay in monocytes. Journal of immunology (Baltimore, Md. : 1950). vol 186. issue 4. 2011-04-28. PMID:21228352. |
overexpression of pre-mir-214 led to impaired pten expression and delayed apoptosis of thp-1 cells, whereas knockdown of mir-214 level largely abolished age-induced cell survival. |
2011-04-28 |
2023-08-12 |
human |
| Rocky Cipriano, John T Patton, Lindsey D Mayo, Mark W Jackso. Inactivation of p53 signaling by p73 or PTEN ablation results in a transformed phenotype that remains susceptible to Nutlin-3 mediated apoptosis. Cell cycle (Georgetown, Tex.). vol 9. issue 7. 2011-03-31. PMID:20305378. |
inactivation of p53 signaling by p73 or pten ablation results in a transformed phenotype that remains susceptible to nutlin-3 mediated apoptosis. |
2011-03-31 |
2023-08-12 |
Not clear |
| Rocky Cipriano, John T Patton, Lindsey D Mayo, Mark W Jackso. Inactivation of p53 signaling by p73 or PTEN ablation results in a transformed phenotype that remains susceptible to Nutlin-3 mediated apoptosis. Cell cycle (Georgetown, Tex.). vol 9. issue 7. 2011-03-31. PMID:20305378. |
however, despite the transformed phenotype conferred by p53 inactivation following p73 or pten loss, p53 could be fully activated by nutlin-3, resulting in efficient caspase-mediated apoptosis. |
2011-03-31 |
2023-08-12 |
Not clear |
| Preeti Tandon, Catherine A Gallo, Shikha Khatri, Jennifer F Barger, Hasmik Yepiskoposyan, David R Pla. Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 6. 2011-03-30. PMID:21262837. |
requirement for ribosomal protein s6 kinase 1 to mediate glycolysis and apoptosis resistance induced by pten deficiency. |
2011-03-30 |
2023-08-12 |
mouse |
| Ye-Hua Gan, Shan Zhan. PTEN/AKT pathway involved in histone deacetylases inhibitor induced cell growth inhibition and apoptosis of oral squamous cell carcinoma cells. Oral oncology. vol 45. issue 10. 2011-03-16. PMID:19574087. |
knock-down of pten expression with pten sirna could sufficiently block 0.25mug/ml tsa induced inhibition of cell growth, but failed to block 0.5mug/ml tsa induced inhibition of cell growth and apoptosis. |
2011-03-16 |
2023-08-12 |
human |
| James S Waldron, Isaac Yang, Seunggu Han, Tarik Tihan, Michael E Sughrue, Steven A Mills, Russell O Pieper, Andrew T Pars. Implications for immunotherapy of tumor-mediated T-cell apoptosis associated with loss of the tumor suppressor PTEN in glioblastoma. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 17. issue 12. 2011-03-10. PMID:20822910. |
implications for immunotherapy of tumor-mediated t-cell apoptosis associated with loss of the tumor suppressor pten in glioblastoma. |
2011-03-10 |
2023-08-12 |
human |
| James S Waldron, Isaac Yang, Seunggu Han, Tarik Tihan, Michael E Sughrue, Steven A Mills, Russell O Pieper, Andrew T Pars. Implications for immunotherapy of tumor-mediated T-cell apoptosis associated with loss of the tumor suppressor PTEN in glioblastoma. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 17. issue 12. 2011-03-10. PMID:20822910. |
here we demonstrate that loss of the pten tumor suppressor gene, with associated activation of the pi3k/akt/mtor pathway, leads to a human glioma phenotype that induces autologous t-cell apoptosis upon contact. |
2011-03-10 |
2023-08-12 |
human |
| James S Waldron, Isaac Yang, Seunggu Han, Tarik Tihan, Michael E Sughrue, Steven A Mills, Russell O Pieper, Andrew T Pars. Implications for immunotherapy of tumor-mediated T-cell apoptosis associated with loss of the tumor suppressor PTEN in glioblastoma. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 17. issue 12. 2011-03-10. PMID:20822910. |
when co-cultured with autologous t-cells, pten wild-type tumor cells induced apoptosis in a minimal number of activated t-cells (6-12% of t-cells), whereas tumors with pten loss induced much more profound levels of t-cell apoptosis (42-56% of t-cells). |
2011-03-10 |
2023-08-12 |
human |
| James S Waldron, Isaac Yang, Seunggu Han, Tarik Tihan, Michael E Sughrue, Steven A Mills, Russell O Pieper, Andrew T Pars. Implications for immunotherapy of tumor-mediated T-cell apoptosis associated with loss of the tumor suppressor PTEN in glioblastoma. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 17. issue 12. 2011-03-10. PMID:20822910. |
prior treatment of pten-deficient tumor cells with specific inhibitors of the pi3k/akt/mtor pathway diminished t-cell apoptosis to levels seen after co-culture with wild-type pten tumor cells, suggesting that pten loss confers this immunoresistant phenotype through the pi3k/akt/mtor pathway. |
2011-03-10 |
2023-08-12 |
human |
| El-Shaimaa A Arafa, Qianzheng Zhu, Zubair I Shah, Gulzar Wani, Bassant M Barakat, Ira Racoma, Mohamed A El-Mahdy, Altaf A Wan. Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells. Mutation research. vol 706. issue 1-2. 2011-03-03. PMID:21040738. |
thymoquinone up-regulates pten expression and induces apoptosis in doxorubicin-resistant human breast cancer cells. |
2011-03-03 |
2023-08-12 |
human |
| El-Shaimaa A Arafa, Qianzheng Zhu, Zubair I Shah, Gulzar Wani, Bassant M Barakat, Ira Racoma, Mohamed A El-Mahdy, Altaf A Wan. Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells. Mutation research. vol 706. issue 1-2. 2011-03-03. PMID:21040738. |
more importantly, pten silencing by target specific sirna enabled the suppression of tq-induced apoptosis resulting in increased cell survival. |
2011-03-03 |
2023-08-12 |
human |
| El-Shaimaa A Arafa, Qianzheng Zhu, Zubair I Shah, Gulzar Wani, Bassant M Barakat, Ira Racoma, Mohamed A El-Mahdy, Altaf A Wan. Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells. Mutation research. vol 706. issue 1-2. 2011-03-03. PMID:21040738. |
our results reveal that up-regulation of the key upstream signaling factor, pten, in mcf-7/dox cells inhibited akt phosphorylation, which ultimately causes increase in their regulatory p53 levels affecting the induction of g2/m cell cycle arrest and apoptosis. |
2011-03-03 |
2023-08-12 |
human |
| Chen Quyun, Zhiyun Ye, Sheng-Cai Lin, Biaoyang Li. Recent patents and advances in genomic biomarker discovery for colorectal cancers. Recent patents on DNA & gene sequences. vol 4. issue 2. 2011-03-01. PMID:20426761. |
the interesting patents include: 1) a patent for a method to differentiate normal exfoliated cells from cancer cells based on whether they were subjected to apoptosis and dna degradation; 2) a model (pm-33 multiple molecular marker model) based on expression changes of up-regulation of the mdm2, dusp6, and nfl genes down-regulation of the rnf4, mmd and eif2s3 genes, which achieved an 88% sensitivity, and an 82% specificity for crc diagnosis; 3) gene mutations in pten, kras, pik3ca for predicting the response to anti-egfr therapies, a common drug used for crc treatment; 4) patents on epigenetic changes of itga4, sept9, alx4, tfap2e foxl2, sarm1, id4 etc. |
2011-03-01 |
2023-08-12 |
Not clear |
| Javier Redondo-Muñoz, Elizabeth Escobar-Díaz, Mercedes Hernández Del Cerro, Atanasio Pandiella, María José Terol, José A García-Marco, Angeles García-Pard. Induction of B-chronic lymphocytic leukemia cell apoptosis by arsenic trioxide involves suppression of the phosphoinositide 3-kinase/Akt survival pathway via c-jun-NH2 terminal kinase activation and PTEN upregulation. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 16. issue 17. 2011-02-28. PMID:20534739. |
induction of b-chronic lymphocytic leukemia cell apoptosis by arsenic trioxide involves suppression of the phosphoinositide 3-kinase/akt survival pathway via c-jun-nh2 terminal kinase activation and pten upregulation. |
2011-02-28 |
2023-08-12 |
Not clear |
| Toshikatsu Okumur. Mechanisms by which thiazolidinediones induce anti-cancer effects in cancers in digestive organs. Journal of gastroenterology. vol 45. issue 11. 2011-02-28. PMID:20824291. |
tzds induce apoptosis through increased levels of apoptotic molecules, such as p53 and pten and/or decreased level of anti-apoptotic molecules, such as bcl-2 and survivin. |
2011-02-28 |
2023-08-12 |
Not clear |
| Tongsen Zheng, Xianzhi Meng, Jiabei Wang, Xi Chen, Dalong Yin, Yingjian Liang, Xuan Song, Shangha Pan, Hongchi Jiang, Lianxin Li. PTEN- and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice. Journal of cellular biochemistry. vol 111. issue 1. 2011-02-14. PMID:20506484. |
suppression of pten expression with sirna significantly reduced the p53 and p21 levels and activated akt, resulting in decreased apoptosis and increased cell survival. |
2011-02-14 |
2023-08-12 |
mouse |
| Tongsen Zheng, Xianzhi Meng, Jiabei Wang, Xi Chen, Dalong Yin, Yingjian Liang, Xuan Song, Shangha Pan, Hongchi Jiang, Lianxin Li. PTEN- and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice. Journal of cellular biochemistry. vol 111. issue 1. 2011-02-14. PMID:20506484. |
in conclusion, our results suggest that fty720 induces a significant increase of pten, which inhibits p-akt and mdm2, and then increases the level of p53, thereby inducing g1 phase arrest and apoptosis. |
2011-02-14 |
2023-08-12 |
mouse |
| Nayoung Kim, Sami Kukkonen, Sumeet Gupta, Anna Aldovin. Association of Tat with promoters of PTEN and PP2A subunits is key to transcriptional activation of apoptotic pathways in HIV-infected CD4+ T cells. PLoS pathogens. vol 6. issue 9. 2011-02-14. PMID:20862322. |
rnai experiments support the role of pten and pp2a in the initiation of the tat-mediated cascade, which is critical to apoptosis. |
2011-02-14 |
2023-08-12 |
Not clear |