| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ningxi Zhu, Lubing Gu, Fengzhi Li, Muxiang Zho. Inhibition of the Akt/survivin pathway synergizes the antileukemia effect of nutlin-3 in acute lymphoblastic leukemia cells. Molecular cancer therapeutics. vol 7. issue 5. 2008-08-22. PMID:18483299. |
we used a set of all cell lines with wild-type p53 and mdm2 overexpression, but different status of pten expression/pi3k/akt activation, to test the ability of nutlin-3 to induce p53 and apoptosis. |
2008-08-22 |
2023-08-12 |
Not clear |
| Ningxi Zhu, Lubing Gu, Fengzhi Li, Muxiang Zho. Inhibition of the Akt/survivin pathway synergizes the antileukemia effect of nutlin-3 in acute lymphoblastic leukemia cells. Molecular cancer therapeutics. vol 7. issue 5. 2008-08-22. PMID:18483299. |
nutlin-3 activated p53 in all the all cell lines; however, induction of apoptosis was dependent on pten status. |
2008-08-22 |
2023-08-12 |
Not clear |
| Ningxi Zhu, Lubing Gu, Fengzhi Li, Muxiang Zho. Inhibition of the Akt/survivin pathway synergizes the antileukemia effect of nutlin-3 in acute lymphoblastic leukemia cells. Molecular cancer therapeutics. vol 7. issue 5. 2008-08-22. PMID:18483299. |
nutlin-3 induced potent apoptosis in cells with pten expression but not in those without pten, suggesting that pten/pi3k/akt pathway may play a role in this process. |
2008-08-22 |
2023-08-12 |
Not clear |
| A N Cornforth, J S Davis, E Khanifar, K L Nastiuk, J J Krolewsk. FOXO3a mediates the androgen-dependent regulation of FLIP and contributes to TRAIL-induced apoptosis of LNCaP cells. Oncogene. vol 27. issue 32. 2008-08-21. PMID:18391984. |
finally, lncap cells are sensitized to trail-induced apoptosis by pten or ly294002, and rescued by androgens. |
2008-08-21 |
2023-08-12 |
rat |
| Dong-Yun Shi, Hong-Lei Liu, Jeremy S Stern, Pei-Zhong Yu, Shan-Lin Li. Alpha-lipoic acid induces apoptosis in hepatoma cells via the PTEN/Akt pathway. FEBS letters. vol 582. issue 12. 2008-07-24. PMID:18435927. |
apoptosis induced by alpha-la was found to be mediated through the tensin homologue deleted on chromosome 10 (pten)/akt pathway. |
2008-07-24 |
2023-08-12 |
human |
| Dong-Yun Shi, Hong-Lei Liu, Jeremy S Stern, Pei-Zhong Yu, Shan-Lin Li. Alpha-lipoic acid induces apoptosis in hepatoma cells via the PTEN/Akt pathway. FEBS letters. vol 582. issue 12. 2008-07-24. PMID:18435927. |
prior to cell apoptosis, pten was activated and its downstream target akt was inhibited. |
2008-07-24 |
2023-08-12 |
human |
| ShouWei Han, Jeffrey D Ritzenthaler, Ying Zheng, Jesse Roma. PPARbeta/delta agonist stimulates human lung carcinoma cell growth through inhibition of PTEN expression: the involvement of PI3K and NF-kappaB signals. American journal of physiology. Lung cellular and molecular physiology. vol 294. issue 6. 2008-07-21. PMID:18390835. |
we show that gw501516 decreased phosphate and tensin homolog deleted on chromosome 10 (pten), a tumor suppressor known to decrease cell growth and induce apoptosis. |
2008-07-21 |
2023-08-12 |
human |
| Ping Song, Zhonglin Xie, Yong Wu, Jian Xu, Yunzhou Dong, Ming-Hui Zo. Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells. The Journal of biological chemistry. vol 283. issue 18. 2008-06-19. PMID:18321849. |
these effects were accompanied by increased activity of the lipid phosphatase pten, decreased activity and phosphorylation (ser(473)) of akt, and induction of apoptosis. |
2008-06-19 |
2023-08-12 |
human |
| Jing Tao, Jiongxin Xiong, Tao Li, Zhiyong Yang, Xiaohui Li, Kai Li, Heshui Wu, Chunyou Wan. Correlation between protein expression of PTEN in human pancreatic cancer and the proliferation, infiltration, metastasis and prognosis. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 26. issue 4. 2008-06-06. PMID:17120744. |
in order to investigate the correlation between protein expression of pten and the proliferation, infiltration, metastasis and prognosis in pancreatic cancer, immunohistochemical sp method was used to examine the protein expression of pten, pcna, mvd, mmp-2, mmp-9 and tunel method to detect the levels of apoptosis of pancreatic cells in 41 pancreatic head cancers from regional pancreatectomy (rp) and 10 normal pancreatic tissues. |
2008-06-06 |
2023-08-12 |
human |
| Sabine Rottmann, Stefanie Speckgens, Juliane Lüscher-Firzlaff, Bernhard Lüsche. Inhibition of apoptosis by MAD1 is mediated by repression of the PTEN tumor suppressor gene. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 4. 2008-05-16. PMID:17998413. |
inhibition of apoptosis by mad1 is mediated by repression of the pten tumor suppressor gene. |
2008-05-16 |
2023-08-12 |
human |
| Sabine Rottmann, Stefanie Speckgens, Juliane Lüscher-Firzlaff, Bernhard Lüsche. Inhibition of apoptosis by MAD1 is mediated by repression of the PTEN tumor suppressor gene. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 4. 2008-05-16. PMID:17998413. |
in addition, knockdown of pten using small interfering rna (sirna) or the lack of pten rendered cells insensitive to inhibition of apoptosis by mad1. |
2008-05-16 |
2023-08-12 |
human |
| Sabine Rottmann, Stefanie Speckgens, Juliane Lüscher-Firzlaff, Bernhard Lüsche. Inhibition of apoptosis by MAD1 is mediated by repression of the PTEN tumor suppressor gene. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 4. 2008-05-16. PMID:17998413. |
these findings identify the pten gene as a target of the myc-antagonist mad1 and provide a molecular framework critical for the ability of mad1 to inhibit apoptosis. |
2008-05-16 |
2023-08-12 |
human |
| Cristina Montiel-Duarte, Lucia Cordeu, Xabier Agirre, José Román-Gómez, Antonio Jiménez-Velasco, Edurne San José-Eneriz, Leire Gárate, Enrique J Andreu, Maria José Calasanz, Anabel Heiniger, Antonio Torres, Felipe Próspe. Resistance to Imatinib Mesylate-induced apoptosis in acute lymphoblastic leukemia is associated with PTEN down-regulation due to promoter hypermethylation. Leukemia research. vol 32. issue 5. 2008-05-13. PMID:17942153. |
resistance to imatinib mesylate-induced apoptosis in acute lymphoblastic leukemia is associated with pten down-regulation due to promoter hypermethylation. |
2008-05-13 |
2023-08-12 |
Not clear |
| Cristina Montiel-Duarte, Lucia Cordeu, Xabier Agirre, José Román-Gómez, Antonio Jiménez-Velasco, Edurne San José-Eneriz, Leire Gárate, Enrique J Andreu, Maria José Calasanz, Anabel Heiniger, Antonio Torres, Felipe Próspe. Resistance to Imatinib Mesylate-induced apoptosis in acute lymphoblastic leukemia is associated with PTEN down-regulation due to promoter hypermethylation. Leukemia research. vol 32. issue 5. 2008-05-13. PMID:17942153. |
treatment of ph+ all cells with 5-aza-2'-deoxycytidine was associated with an increased expression of pten and an increase in cell apoptosis. |
2008-05-13 |
2023-08-12 |
Not clear |
| T Cirpan, M C Terek, M Ulukus, E C Ulukus, L Akman, L Kani. Immunohistochemical evaluation of cell proliferation and apoptosis markers in ovaries and uterus of tamoxifen-treated rats. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 18. issue 1. 2008-03-25. PMID:17466037. |
the sections were immunohistochemically stained with cell proliferation marker ki-67 and the apoptosis markers pten and cd95. |
2008-03-25 |
2023-08-12 |
rat |
| T Cirpan, M C Terek, M Ulukus, E C Ulukus, L Akman, L Kani. Immunohistochemical evaluation of cell proliferation and apoptosis markers in ovaries and uterus of tamoxifen-treated rats. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 18. issue 1. 2008-03-25. PMID:17466037. |
apoptosis markers of pten and cd95 did not demonstrate significant difference after the tamoxifen treatment. |
2008-03-25 |
2023-08-12 |
rat |
| W Wu, J Celestino, M R Milam, K M Schmeler, R R Broaddus, L H Ellenson, K H L. Primary chemoprevention of endometrial hyperplasia with the peroxisome proliferator-activated receptor gamma agonist rosiglitazone in the PTEN heterozygote murine model. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 18. issue 2. 2008-03-25. PMID:18334011. |
ppar-gamma agonist rosiglitazone inhibits proliferation and induces apoptosis in both pten intact and pten null cancer cell lines and in hyperplastic endometrial lesions in the pten(+/)(-)murine model. |
2008-03-25 |
2023-08-12 |
mouse |
| Maria Escrivà, Sandra Peiró, Nicolás Herranz, Patricia Villagrasa, Natàlia Dave, Bàrbara Montserrat-Sentís, Stephen A Murray, Clara Francí, Thomas Gridley, Ismo Virtanen, Antonio García de Herrero. Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis. Molecular and cellular biology. vol 28. issue 5. 2008-03-17. PMID:18172008. |
repression of pten phosphatase by snail1 transcriptional factor during gamma radiation-induced apoptosis. |
2008-03-17 |
2023-08-12 |
Not clear |
| Maria Escrivà, Sandra Peiró, Nicolás Herranz, Patricia Villagrasa, Natàlia Dave, Bàrbara Montserrat-Sentís, Stephen A Murray, Clara Francí, Thomas Gridley, Ismo Virtanen, Antonio García de Herrero. Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis. Molecular and cellular biology. vol 28. issue 5. 2008-03-17. PMID:18172008. |
in this study, we demonstrate that this resistance to gamma radiation-induced apoptosis caused by snail1 is associated with the inhibition of pten phosphatase. |
2008-03-17 |
2023-08-12 |
Not clear |
| Maria Escrivà, Sandra Peiró, Nicolás Herranz, Patricia Villagrasa, Natàlia Dave, Bàrbara Montserrat-Sentís, Stephen A Murray, Clara Francí, Thomas Gridley, Ismo Virtanen, Antonio García de Herrero. Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis. Molecular and cellular biology. vol 28. issue 5. 2008-03-17. PMID:18172008. |
these results stress the critical role of snail1 in the control of apoptosis and demonstrate the regulation of pten phosphatase by this transcriptional repressor. |
2008-03-17 |
2023-08-12 |
Not clear |