| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ranjan Das, Shanhua Xu, Tuyet Thi Nguyen, Xianglan Quan, Seong-Kyung Choi, Soo-Jin Kim, Eun Young Lee, Seung-Kuy Cha, Kyu-Sang Par. Transforming Growth Factor β1-induced Apoptosis in Podocytes via the Extracellular Signal-regulated Kinase-Mammalian Target of Rapamycin Complex 1-NADPH Oxidase 4 Axis. The Journal of biological chemistry. vol 290. issue 52. 2016-05-10. PMID:26565025. |
transient adenoviral overexpression of mtor-wt and constitutively active mtorΔ augmented tgf-β1-treated nox4 expression, reactive oxygen species (ros) generation, and apoptosis, whereas mtor kinase-dead suppressed the above changes. |
2016-05-10 |
2023-08-13 |
Not clear |
| Ranjan Das, Shanhua Xu, Tuyet Thi Nguyen, Xianglan Quan, Seong-Kyung Choi, Soo-Jin Kim, Eun Young Lee, Seung-Kuy Cha, Kyu-Sang Par. Transforming Growth Factor β1-induced Apoptosis in Podocytes via the Extracellular Signal-regulated Kinase-Mammalian Target of Rapamycin Complex 1-NADPH Oxidase 4 Axis. The Journal of biological chemistry. vol 290. issue 52. 2016-05-10. PMID:26565025. |
inhibition of mtorc1 by low-dose rapamycin or knockdown of p70s6k protected podocytes through attenuation of nox4 expression and subsequent oxidative stress-induced apoptosis by tgf-β1. |
2016-05-10 |
2023-08-13 |
Not clear |
| Ranjan Das, Shanhua Xu, Tuyet Thi Nguyen, Xianglan Quan, Seong-Kyung Choi, Soo-Jin Kim, Eun Young Lee, Seung-Kuy Cha, Kyu-Sang Par. Transforming Growth Factor β1-induced Apoptosis in Podocytes via the Extracellular Signal-regulated Kinase-Mammalian Target of Rapamycin Complex 1-NADPH Oxidase 4 Axis. The Journal of biological chemistry. vol 290. issue 52. 2016-05-10. PMID:26565025. |
inhibition of either erk1/2 or mtorc1 did not reduce the tgf-β1-stimulated increase in nox4 mrna level but significantly inhibited total nox4 expression, ros generation, and apoptosis induced by tgf-β1. |
2016-05-10 |
2023-08-13 |
Not clear |
| Zhong-Bao Yang, Bin Tan, Ting-Bo Li, Zheng Lou, Jun-Lin Jiang, Ying-Jun Zhou, Jie Yang, Xiu-Ju Luo, Jun Pen. Protective effect of vitexin compound B-1 against hypoxia/reoxygenation-induced injury in differentiated PC12 cells via NADPH oxidase inhibition. Naunyn-Schmiedeberg's archives of pharmacology. vol 387. issue 9. 2016-03-21. PMID:24947869. |
our results showed that cell injury (indicated by apoptosis ratio, caspase 3/7-like activity, and ldh release), oxidative stress (indicated by ros production, 4-hne, and mda contents), nox activity, and nox expression (nox2 and nox4 isoforms) were dramatically increased in pc12 cells following h/r, which were attenuated in the presence of vb-1 at dosage of 10(-7) or 10(-6) m. |
2016-03-21 |
2023-08-13 |
Not clear |
| Shuang Liang, Tatiana Kisseleva, David A Brenne. The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. Frontiers in physiology. vol 7. 2016-02-12. PMID:26869935. |
nox isoforms, including nox1, nox2 and nox4, and nox-derived ros, have all been implicated to regulate hsc activation and hepatocyte apoptosis, both of which are essential steps for initiating liver fibrosis. |
2016-02-12 |
2023-08-13 |
Not clear |
| Yuhong Ma, Weizu Li, Yanyan Yin, Weiping L. AST IV inhibits H₂O₂-induced human umbilical vein endothelial cell apoptosis by suppressing Nox4 expression through the TGF-β1/Smad2 pathway. International journal of molecular medicine. vol 35. issue 6. 2016-01-25. PMID:25891879. |
ast iv inhibits h₂o₂-induced human umbilical vein endothelial cell apoptosis by suppressing nox4 expression through the tgf-β1/smad2 pathway. |
2016-01-25 |
2023-08-13 |
human |
| Yuhong Ma, Weizu Li, Yanyan Yin, Weiping L. AST IV inhibits H₂O₂-induced human umbilical vein endothelial cell apoptosis by suppressing Nox4 expression through the TGF-β1/Smad2 pathway. International journal of molecular medicine. vol 35. issue 6. 2016-01-25. PMID:25891879. |
nadph oxidase 4 (nox4)-dependent reactive oxygen species (ros) aggregation is the main cause of vascular endothelial cell apoptosis. |
2016-01-25 |
2023-08-13 |
human |
| Yuhong Ma, Weizu Li, Yanyan Yin, Weiping L. AST IV inhibits H₂O₂-induced human umbilical vein endothelial cell apoptosis by suppressing Nox4 expression through the TGF-β1/Smad2 pathway. International journal of molecular medicine. vol 35. issue 6. 2016-01-25. PMID:25891879. |
however, the association between vascular endothelial cell apoptosis and nox4, and the involvement of the tgf-β1/smad2 signaling pathway in vascular endothelial cell apoptosis remain unclear. |
2016-01-25 |
2023-08-13 |
human |
| Yuhong Ma, Weizu Li, Yanyan Yin, Weiping L. AST IV inhibits H₂O₂-induced human umbilical vein endothelial cell apoptosis by suppressing Nox4 expression through the TGF-β1/Smad2 pathway. International journal of molecular medicine. vol 35. issue 6. 2016-01-25. PMID:25891879. |
treatment with diphenyliodonium (dpi), a specific inhibitor of nox4 or astragaloside iv (ast iv), a monomer located in an extract of astragaloside, decreased nox4 expression and the levels of ros, decreased tgf-β1 and smad2 expression, altered the expression of apoptosis-related genes and decreased the apoptosis of huvecs. |
2016-01-25 |
2023-08-13 |
human |
| Yuhong Ma, Weizu Li, Yanyan Yin, Weiping L. AST IV inhibits H₂O₂-induced human umbilical vein endothelial cell apoptosis by suppressing Nox4 expression through the TGF-β1/Smad2 pathway. International journal of molecular medicine. vol 35. issue 6. 2016-01-25. PMID:25891879. |
our data indicate that the protective effects of ast iv against vascular endothelial cell apoptosis in dm are mainly associated with the decrease in nox4 expression through the tgf-β1/smad2 signaling pathway. |
2016-01-25 |
2023-08-13 |
human |
| Qian Hou, Minxiang Lei, Ke Hu, Min Wan. The effects of high glucose levels on reactive oxygen species-induced apoptosis and involved signaling in human vascular endothelial cells. Cardiovascular toxicology. vol 15. issue 2. 2016-01-15. PMID:25158671. |
silencing nox4 and pten gene expression and inhibiting caspase-3 activation significantly protected huvecs from glucose-induced cell apoptosis. |
2016-01-15 |
2023-08-13 |
human |
| Vishnu Vignesh Kanagaraj, Lakshmikanthan Panneerselvam, Vimal Govindarajan, Jaishabanu Ameeramja, Ekambaram Peruma. Caffeic acid, a phyto polyphenol mitigates fluoride induced hepatotoxicity in rats: A possible mechanism. BioFactors (Oxford, England). vol 41. issue 2. 2016-01-12. PMID:25845575. |
further, fluoride induced upregulation of nox4, p38α mapk, hsp60, and downregulation of hsp27 are the indicators for the detection of oxidative damage, apoptosis, and mitochondrial stress was also modulated by ca. |
2016-01-12 |
2023-08-13 |
rat |
| Lixia Yu, Yanbo Liu, Yanfeng Wu, Qifeng Liu, Jianhua Feng, Xiaoxia Gu, Yan Xiong, Qingfeng Fan, Jianming Y. Smad3/Nox4-mediated mitochondrial dysfunction plays a crucial role in puromycin aminonucleoside-induced podocyte damage. Cellular signalling. vol 26. issue 12. 2015-07-21. PMID:25229402. |
notably, both smad3 and nox4 silencing significantly prevented the reduction of the mtdna level, restored mitochondrial function, and decreased cellular apoptosis in pa-stimulated podocytes. |
2015-07-21 |
2023-08-13 |
mouse |
| Grant R Drummond, Christopher G Sobe. Endothelial NADPH oxidases: which NOX to target in vascular disease? Trends in endocrinology and metabolism: TEM. vol 25. issue 9. 2015-05-07. PMID:25066192. |
studies on arteries from patients with coronary artery disease, and in animals with experimentally induced hypertension, diabetes, or atherosclerosis, suggest that nox1, nox2, and nox5 promote endothelial dysfunction, inflammation, and apoptosis in the vessel wall, whereas nox4 is by contrast vasoprotective in increasing nitric oxide bioavailability and suppressing cell death pathways. |
2015-05-07 |
2023-08-13 |
Not clear |
| Haiying Li, Yang Wang, Dongxia Feng, Yin Liu, Min Xu, Anju Gao, Fengxuan Tian, Li Zhang, Yonghua Cui, Zhong Wang, Gang Che. Alterations in the time course of expression of the Nox family in the brain in a rat experimental cerebral ischemia and reperfusion model: effects of melatonin. Journal of pineal research. vol 57. issue 1. 2015-03-30. PMID:24867613. |
compared with i/r + vehicle group, melatonin pretreatment diminished the increased expression of nox2 and nox4, reduced ros levels, and inhibited cell apoptosis. |
2015-03-30 |
2023-08-13 |
rat |
| Guei-Sheung Liu, Jian-Ching Wu, Han-En Tsai, Gregory J Dusting, Elsa C Chan, Chieh-Shan Wu, Ming-Hong Ta. Proopiomelanocortin gene delivery induces apoptosis in melanoma through NADPH oxidase 4-mediated ROS generation. Free radical biology & medicine. vol 70. 2014-12-09. PMID:24412703. |
silencing nox4 gene expression with nox4 sirna suppressed the stimulatory effect of α-msh-induced ros generation and cell apoptosis during hypoxia. |
2014-12-09 |
2023-08-12 |
mouse |
| Guei-Sheung Liu, Jian-Ching Wu, Han-En Tsai, Gregory J Dusting, Elsa C Chan, Chieh-Shan Wu, Ming-Hong Ta. Proopiomelanocortin gene delivery induces apoptosis in melanoma through NADPH oxidase 4-mediated ROS generation. Free radical biology & medicine. vol 70. 2014-12-09. PMID:24412703. |
in summary, we demonstrate that pomc gene delivery suppressed melanoma growth by inducing apoptosis, which was at least partly dependent on nox4 upregulation. |
2014-12-09 |
2023-08-12 |
mouse |
| Louise Hecker, Naomi J Logsdon, Deepali Kurundkar, Ashish Kurundkar, Karen Bernard, Thomas Hock, Eric Meldrum, Yan Y Sanders, Victor J Thannicka. Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance. Science translational medicine. vol 6. issue 231. 2014-11-26. PMID:24718857. |
nox4 mediated senescence and apoptosis resistance in ipf fibroblasts. |
2014-11-26 |
2023-08-13 |
mouse |
| Jinyi Wang, Zhibo Hong, Chao Zeng, Qiujun Yu, Haichang Wan. NADPH oxidase 4 promotes cardiac microvascular angiogenesis after hypoxia/reoxygenation in vitro. Free radical biology & medicine. vol 69. 2014-11-08. PMID:24480752. |
downregulation of nox4 by small interfering rna transfection did not affect cell viability or ros production under normoxia, but exacerbated h/r injury as evidenced by increased apoptosis and inhibited cell survival, migration, and angiogenesis after h/r. |
2014-11-08 |
2023-08-12 |
rat |
| Jinyi Wang, Zhibo Hong, Chao Zeng, Qiujun Yu, Haichang Wan. NADPH oxidase 4 promotes cardiac microvascular angiogenesis after hypoxia/reoxygenation in vitro. Free radical biology & medicine. vol 69. 2014-11-08. PMID:24480752. |
in conclusion, this study demonstrated a previously unrecognized protective role of nox4, a ros-generating enzyme and the major nox isoform in cmecs, against h/r injury by inhibiting apoptosis and promoting migration and angiogenesis via a phd2-dependent upregulation of hif-1/vegf proangiogenic signaling. |
2014-11-08 |
2023-08-12 |
rat |