| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xue Gao, Yi Liu, Lin Wang, Na Sai, Yixiu Liu, Jian N. Morroniside Inhibits H Frontiers in pharmacology. vol 11. 2020-10-22. PMID:33071778. |
the overexpression of nox4, a key enzyme involved in oxidative stress, has been proved to participate in the occurrence of podocyte apoptosis. |
2020-10-22 |
2023-08-13 |
Not clear |
| Tatsunori Oguchi, Ran Ono, Mayumi Tsuji, Hidenobu Shozawa, Masayuki Somei, Manami Inagaki, Yukiko Mori, Taro Yasumoto, Kenjiro Ono, Yuji Kiuch. Cilostazol Suppresses Aβ-induced Neurotoxicity in SH-SY5Y Cells through Inhibition of Oxidative Stress and MAPK Signaling Pathway. Frontiers in aging neuroscience. vol 9. 2020-09-30. PMID:29089887. |
to evaluate the effect of csz on oxidative stress, we examined levels of reactive oxygen species (ros), nicotinamide adenine dinucleotide phosphate oxidase (nox) activity, mrna expression of nox4, and cu/zn-superoxide dismutase (sod), as well as apoptosis biomarkers [mtt, (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), caspase-3 and -9 activities and staining of annexin v]. |
2020-09-30 |
2023-08-13 |
human |
| Sara Damiano, Chiara Lauritano, Consiglia Longobardi, Emanuela Andretta, Ali Murat Elagoz, Paolo Rapisarda, Mattia Di Iorio, Salvatore Florio, Roberto Ciarci. Effects of a Red Orange and Lemon Extract in Obese Diabetic Zucker Rats: Role of Nicotinamide Adenine Dinucleotide Phosphate Oxidase. Journal of clinical medicine. vol 9. issue 5. 2020-09-28. PMID:32466228. |
this study showed that rle could prevent the renal damage induced by dn through its capacity to inhibit nox4 and apoptosis mechanisms. |
2020-09-28 |
2023-08-13 |
rat |
| Sherry L Werner, Ramaswamy Sharma, Kathleen Woodruff, Diane Horn, Stephen E Harris, Yves Gorin, Doug-Yoon Lee, Rui Hua, Sumin Gu, Roberto J Fajardo, Samy L Habib, Jean X Jian. CSF-1 in Osteocytes Inhibits Nox4-mediated Oxidative Stress and Promotes Normal Bone Homeostasis. JBMR plus. vol 4. issue 7. 2020-09-28. PMID:32666016. |
here, we show that osteocyte apoptosis previously reported in our global csf-1ko mice is associated with increased nox4, as well as 4-hne expression in osteocytes. |
2020-09-28 |
2023-08-13 |
mouse |
| Sherry L Werner, Ramaswamy Sharma, Kathleen Woodruff, Diane Horn, Stephen E Harris, Yves Gorin, Doug-Yoon Lee, Rui Hua, Sumin Gu, Roberto J Fajardo, Samy L Habib, Jean X Jian. CSF-1 in Osteocytes Inhibits Nox4-mediated Oxidative Stress and Promotes Normal Bone Homeostasis. JBMR plus. vol 4. issue 7. 2020-09-28. PMID:32666016. |
notably, csf-1 inhibited nox4 expression and apoptosis cascade signals. |
2020-09-28 |
2023-08-13 |
mouse |
| Sherry L Werner, Ramaswamy Sharma, Kathleen Woodruff, Diane Horn, Stephen E Harris, Yves Gorin, Doug-Yoon Lee, Rui Hua, Sumin Gu, Roberto J Fajardo, Samy L Habib, Jean X Jian. CSF-1 in Osteocytes Inhibits Nox4-mediated Oxidative Stress and Promotes Normal Bone Homeostasis. JBMR plus. vol 4. issue 7. 2020-09-28. PMID:32666016. |
in additional studies, shnox4 decreased these signals in csf-1ko osteocytes, whereas overexpression of nox4 in wt osteocytes activated the apoptosis pathway. |
2020-09-28 |
2023-08-13 |
mouse |
| Sherry L Werner, Ramaswamy Sharma, Kathleen Woodruff, Diane Horn, Stephen E Harris, Yves Gorin, Doug-Yoon Lee, Rui Hua, Sumin Gu, Roberto J Fajardo, Samy L Habib, Jean X Jian. CSF-1 in Osteocytes Inhibits Nox4-mediated Oxidative Stress and Promotes Normal Bone Homeostasis. JBMR plus. vol 4. issue 7. 2020-09-28. PMID:32666016. |
osteocyte defects in csf-1cko mice overlapped with those in csf-1ko mice, including increased apoptosis, nox4, and 4-hne-expressing osteocytes. |
2020-09-28 |
2023-08-13 |
mouse |
| Kelly Stam, Zongye Cai, Nikki van der Velde, Richard van Duin, Esther Lam, Jolanda van der Velden, Alexander Hirsch, Dirk J Duncker, Daphne Merku. Cardiac remodelling in a swine model of chronic thromboembolic pulmonary hypertension: comparison of right vs. left ventricle. The Journal of physiology. vol 597. issue 17. 2020-08-20. PMID:31194256. |
rv remodelling in our cteph swine model is associated with increased expression of the genes involved in inflammation (tgfβ), oxidative stress (rock2, nox1 and nox4), and apoptosis (bcl2 and caspase-3). |
2020-08-20 |
2023-08-13 |
Not clear |
| Qi-Quan Wu, Bin Zheng, Guo-Bin Weng, Hou-Meng Yang, Yu Ren, Xi-Jun Weng, Shu-Wei Zhang, Wei-Zhi Zh. Downregulated NOX4 underlies a novel inhibitory role of microRNA-137 in prostate cancer. Journal of cellular biochemistry. vol 120. issue 6. 2020-07-20. PMID:30637800. |
furthermore, mir-137 overexpression and nox4 silencing contributed to decreased lactate production, glucose uptake, atp production, and cell proliferation, but increased apoptosis rate. |
2020-07-20 |
2023-08-13 |
Not clear |
| Qining Yang, Changyuan Wang, Yue Jin, Xiaodong Ma, Tianqi Xie, Jiaying Wang, Kexin Liu, Huijun Su. Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/- mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis. Pharmacological research. vol 148. 2020-06-29. PMID:31449974. |
in vitro, the results of colorimetric assay showed that dioscin decreased the level of mda and ldh, increased the level of sod and gsh in ox-ldl-induced haec cells; dioscin also suppressed the release of ros in ox-ldl-induced haecs by fluorescence staining; dioscin decreased the levels of nox4, p22phox, p-p65, n-p65, icam-1, vcam-1, caspase-3, caspase-9, but increased the levels of pgc-1α, erα, erβ, iκb, bcl-2 and the ratio of lc3-ii/lc3-i in ox-ldl-induced haecs; dioscin significantly elevated the autophagy level of ox-ldl-induced haecs by transmission electron microscopy analysis; in addition, by si-rna transfection, we found that the inhibitory effects of dioscin on oxidative stress, inflammatory response and apoptosis might partly through pgc-1α/erα pathway in ox-ldl induced haecs. |
2020-06-29 |
2023-08-13 |
mouse |
| E-Li Wang, Miao-Miao Jia, Fang-Mei Luo, Tao Li, Jing-Jie Peng, Xiu-Ju Luo, Feng-Lin Song, Jin-Fu Yang, Jun Peng, Bin Li. Coordination between NADPH oxidase and vascular peroxidase 1 promotes dysfunctions of endothelial progenitor cells in hypoxia-induced pulmonary hypertensive rats. European journal of pharmacology. vol 857. 2020-01-14. PMID:31216444. |
the rats were exposed to 10% hypoxia for 3 weeks to establish a ph model, which showed increases in right ventricle systolic pressure, right ventricular and pulmonary vascular remodeling, acceleration in apoptosis and impairment in functions of the peripheral blood derived - epcs (the reduced abilities in adhesion, migration and tube formation), accompanied by up-regulation of nox (nox2 and nox4) and vpo1. |
2020-01-14 |
2023-08-13 |
rat |
| S Chen, J Ma, H Zhu, S Deng, M Gu, S Q. Hydroxysafflor yellow A attenuates high glucose-induced human umbilical vein endothelial cell dysfunction. Human & experimental toxicology. vol 38. issue 6. 2020-01-02. PMID:30873871. |
our data indicated that hg increases huvec apoptosis, vascular permeability, monocyte adhesion, the level of cams, the formation of ros, and nox4 expression. |
2020-01-02 |
2023-08-13 |
human |
| Jinjin Wang, Yin Liu, Haitao Shen, Haiying Li, Zhong Wang, Gang Che. Nox2 and Nox4 Participate in ROS-Induced Neuronal Apoptosis and Brain Injury During Ischemia-Reperfusion in Rats. Acta neurochirurgica. Supplement. vol 127. 2019-10-28. PMID:31407062. |
nox2 and nox4 participate in ros-induced neuronal apoptosis and brain injury during ischemia-reperfusion in rats. |
2019-10-28 |
2023-08-13 |
rat |
| Ting Yu, Qing Xin, Fei Xu, Lei L. [Research on the mechanism of high glucose affecting the apoptosis of schwann cells by Nox4 NADPH oxidase]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 35. issue 2. 2019-09-05. PMID:31250603. |
[research on the mechanism of high glucose affecting the apoptosis of schwann cells by nox4 nadph oxidase]. |
2019-09-05 |
2023-08-13 |
Not clear |
| Ting Yu, Qing Xin, Fei Xu, Lei L. [Research on the mechanism of high glucose affecting the apoptosis of schwann cells by Nox4 NADPH oxidase]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 35. issue 2. 2019-09-05. PMID:31250603. |
to investigate the mechanism of high glucose affecting the apoptosis of schwann cells through nox4 nadph oxidase. |
2019-09-05 |
2023-08-13 |
Not clear |
| Chao-Tao Tang, Xiao-Lu Lin, Shan Wu, Qian Liang, Li Yang, Yun-Jie Gao, Zhi-Zheng G. NOX4-driven ROS formation regulates proliferation and apoptosis of gastric cancer cells through the GLI1 pathway. Cellular signalling. vol 46. 2019-08-20. PMID:29496628. |
nadph oxidase 4 (nox4), a member of the nox family, has emerged as a significant source of reactive oxygen species, playing an important role in tumor cell proliferation, apoptosis, and other physiological processes. |
2019-08-20 |
2023-08-13 |
Not clear |
| Chao-Tao Tang, Xiao-Lu Lin, Shan Wu, Qian Liang, Li Yang, Yun-Jie Gao, Zhi-Zheng G. NOX4-driven ROS formation regulates proliferation and apoptosis of gastric cancer cells through the GLI1 pathway. Cellular signalling. vol 46. 2019-08-20. PMID:29496628. |
in summary, the findings indicate that nox4 plays an important role in gastric cancer cell growth and apoptosis through the generation of ros and subsequent activation of gli1 signaling. |
2019-08-20 |
2023-08-13 |
Not clear |
| Katrin Brockhaus, Michael R R Böhm, Harutyun Melkonyan, Solon Thano. Age-related Beta-synuclein Alters the p53/Mdm2 Pathway and Induces the Apoptosis of Brain Microvascular Endothelial Cells In Vitro. Cell transplantation. vol 27. issue 5. 2019-05-17. PMID:29808713. |
viability, apoptosis, expression levels of snca, and the members of phospholipase d2 (pld2)/ p53/ mouse double minute 2 homolog (mdm2)/p19(arf) pathway, response in rac-alpha serine/threonine-protein kinase (akt), and stress-mediating factors such as heme oxygenase (decycling) 1 (hmox) and nicotinamide adenine dinucleotide phosphate oxygenase 4 (nox4) were examined. |
2019-05-17 |
2023-08-13 |
mouse |
| Quan Li, Yajun Lin, Shu Wang, Lina Zhang, Lixin Gu. GLP-1 Inhibits High-Glucose-Induced Oxidative Injury of Vascular Endothelial Cells. Scientific reports. vol 7. issue 1. 2019-02-28. PMID:28808291. |
we measured reactive oxygen species (ros) production, cell apoptosis, the expression of nox4 and its subunits, and p47phox translocation in human umbilical vein endothelial cells (huvecs). |
2019-02-28 |
2023-08-13 |
human |
| Rongli Sun, Xing Meng, Yunqiu Pu, Fengxia Sun, Zhaodi Man, Juan Zhang, Lihong Yin, Yuepu P. Overexpression of HIF-1a could partially protect K562 cells from 1,4-benzoquinone induced toxicity by inhibiting ROS, apoptosis and enhancing glycolysis. Toxicology in vitro : an international journal published in association with BIBRA. vol 55. 2019-01-14. PMID:30448556. |
overall, our results indicated that hif-1a overexpression could alleviate ros and apoptosis caused by 1,4-bq through targeting nox4, bcl-2 and key enzymes in glycolysis. |
2019-01-14 |
2023-08-13 |
Not clear |