| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bai-Cheng Kuang, Shuai-Heng Hou, G Ji Zhan, Meng-Qin Wang, Jia-Si Zhang, Kai-Lun Sun, Zhi-Heng Wang, Qing-Wen Li, Nian-Qiao Gon. [Effect of methyl eugenol on hypoxia/reoxygenation injury of human renal tubular epithelial cells and its mechanism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 24. 2022-01-07. PMID:34994143. |
as revealed by further experiments, me inhibited the release of reactive oxygen species and the decline in mitochondrial membrane potential of hk-2 cells after h/r injury, promoted nrf2/ho-1 expression and nrf2 translocation to the nucleus, and down-regulated the expression of nox4, thereby significantly reducing apoptosis. |
2022-01-07 |
2023-08-13 |
human |
| Tae Woo Kim, Seong-Gyu K. The Herbal Formula JI017 Induces ER Stress via Nox4 in Breast Cancer Cells. Antioxidants (Basel, Switzerland). vol 10. issue 12. 2021-12-24. PMID:34942984. |
the ros inhibitors diphenyleneiodonium and n-acetyl cysteine suppressed apoptosis and excessive er stress by inhibiting nox4 in ji017-treated breast cancer cells. |
2021-12-24 |
2023-08-13 |
Not clear |
| Hengjiang Guo, Yan Jiang, Zhiqing Gu, Lulu Ren, Change Zhu, Shenghua Yu, Rong We. ZFP36 protects against oxygen-glucose deprivation/reoxygenation-induced mitochondrial fragmentation and neuronal apoptosis through inhibiting NOX4-DRP1 pathway. Brain research bulletin. 2021-12-13. PMID:34896479. |
besides, we found that nadph oxidase 4 (nox4) was upregulated by ogd/r, and nox4 inhibition remarkably attenuated ogd/r-instigated drp1 activity, mitochondrial fragmentation and neuronal apoptosis. |
2021-12-13 |
2023-08-13 |
Not clear |
| Yu-Si Liu, Hui Gu, Tian-Chu Huang, Xiao-Wei Wei, Wei Ma, Dan Liu, Yi-Wen He, Wen-Ting Luo, Jie-Ting Huang, Duan Zhao, Shan-Shan Jia, Fang Wang, Ting Zhang, Yu-Zuo Bai, Wei-Lin Wang, Zheng-Wei Yua. miR-322 treatment rescues cell apoptosis and neural tube defect formation through silencing NADPH oxidase 4. CNS neuroscience & therapeutics. vol 26. issue 9. 2021-10-26. PMID:32329577. |
in this study, we investigated the effect of nox4 on the embryonic neuroepithelium in ntds and reveal a new regulatory mechanism for mir-322 that disrupts neurulation by ameliorating cell apoptosis. |
2021-10-26 |
2023-08-13 |
Not clear |
| Ning Gao, Yuzhen Zhang, Lei Lei, Li Li, Ping Cao, Xuan Zhao, Lin Lin, Rui X. Low doses of folic acid can reduce hyperhomocysteinemia-induced glomerular injury in spontaneously hypertensive rats. Hypertension research : official journal of the Japanese Society of Hypertension. vol 43. issue 11. 2021-10-11. PMID:32439914. |
increased extracellular matrix of the glomerulus and an increased glomerular sclerosis index, podocyte foot process effacement and fusion, as well as increased podocyte apoptosis, were observed in the hhcy group compared with the control group; these effects were associated with increased expression of nox2 and nox4 and decreased nephrin expression in renal tissue from shrs with hhcy. |
2021-10-11 |
2023-08-13 |
rat |
| Wanxu Guo, Hang Gao, Wei Pan, Panapn Yu, Guanghua Ch. High glucose induces Nox4 expression and podocyte apoptosis through the Smad3/ezrin/PKA pathway. Biology open. vol 10. issue 5. 2021-09-27. PMID:33046439. |
high glucose induces nox4 expression and podocyte apoptosis through the smad3/ezrin/pka pathway. |
2021-09-27 |
2023-08-13 |
human |
| Wanxu Guo, Hang Gao, Wei Pan, Panapn Yu, Guanghua Ch. High glucose induces Nox4 expression and podocyte apoptosis through the Smad3/ezrin/PKA pathway. Biology open. vol 10. issue 5. 2021-09-27. PMID:33046439. |
this study investigated the regulatory role of smad3, ezrin, and protein kinase a (pka) in nadph oxidase (nox4) expression, reactive oxidative species (ros) production, and apoptosis in hg-treated podocytes. |
2021-09-27 |
2023-08-13 |
human |
| Wanxu Guo, Hang Gao, Wei Pan, Panapn Yu, Guanghua Ch. High glucose induces Nox4 expression and podocyte apoptosis through the Smad3/ezrin/PKA pathway. Biology open. vol 10. issue 5. 2021-09-27. PMID:33046439. |
forskolin, a pka activator, significantly inhibited hg-mediated upregulation of nox4 expression, ros generation, and apoptosis. |
2021-09-27 |
2023-08-13 |
human |
| Wanxu Guo, Hang Gao, Wei Pan, Panapn Yu, Guanghua Ch. High glucose induces Nox4 expression and podocyte apoptosis through the Smad3/ezrin/PKA pathway. Biology open. vol 10. issue 5. 2021-09-27. PMID:33046439. |
taken together, our findings provided evidence that smad3-mediated ezrin activation upregulates nox4 expression and ros production, by suppressing pka activity, which may at least in part contribute to hg-induced podocyte apoptosis. |
2021-09-27 |
2023-08-13 |
human |
| Zuowei Pei, Chenguang Yang, Ying Guo, Min Dong, Fang Wan. Effect of different exercise training intensities on age-related cardiac damage in male mice. Aging. vol 13. issue 17. 2021-09-24. PMID:34520392. |
metabolic characteristics, cardiac function and morphology, myocardial remodeling, myocardial fibrosis (collagen iii, α-sma, and tgf-β), oxidative stress (nrf2, ho-1, sod, and nox4), and apoptosis (bax, bak, bcl-2, and bcl-xl) were analyzed 24 weeks after the different treatments. |
2021-09-24 |
2023-08-13 |
mouse |
| Zahide Cavdar, Mehmet Asi Oktan, Cemre Ural, Ayse Kocak, Meryem Calisir, Cihan Heybeli, Serkan Yildiz, Seda Ozbal, Sevki Arslan, Bekir Ugur Ergur, Osman Yilmaz, Caner Cavda. Alpha lipoic acid attenuates iron induced oxidative acute kidney injury in rats. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 96. issue 6. 2021-09-17. PMID:32921159. |
we investigated the reno-protective effects of alpha lipoic acid (ala) by investigating its effects on the kidney isoform of nadph oxidase (nox4) and the specific signaling pathways, p38 mapk and pi3k/akt, which participate in apoptosis and survival, respectively. |
2021-09-17 |
2023-08-13 |
rat |
| Yiran Liang, Hong Liu, Yi Fang, Pan Lin, Zhihui Lu, Pan Zhang, Xiaoyan Jiao, Jie Teng, Xiaoqiang Ding, Yan Da. Salvianolate ameliorates oxidative stress and podocyte injury through modulation of NOX4 activity in db/db mice. Journal of cellular and molecular medicine. vol 25. issue 2. 2021-09-14. PMID:33332718. |
in human podocytes, nox4 was predominantly localized to mitochondria and sal b treatment blocked hg-induced mitochondrial nox4 derived superoxide generation and thereby ameliorating podocyte apoptosis, which can be abrogated by ampk knockdown. |
2021-09-14 |
2023-08-13 |
mouse |
| Xiang Li, Yuanyuan Wang, Zhuyun Cai, Qi Zhou, Lexiang Li, Peiliang F. Exosomes from human umbilical cord mesenchymal stem cells inhibit ROS production and cell apoptosis in human articular chondrocytes via the miR-100-5p/NOX4 axis. Cell biology international. vol 45. issue 10. 2021-09-14. PMID:34197004. |
cyclic strain promotes ros production and apoptosis in primary articular chondrocytes, which was abolished by hucmscs-derived exosomal mir-100-5p through its target nox4. |
2021-09-14 |
2023-08-13 |
human |
| Zhenglong Zhong, Yuqing Tian, Xiaoming Luo, Jianjie Zou, Lin Wu, Julong Tia. Extracellular Vesicles Derived From Human Umbilical Cord Mesenchymal Stem Cells Protect Against DOX-Induced Heart Failure Through the miR-100-5p/NOX4 Pathway. Frontiers in bioengineering and biotechnology. vol 9. 2021-09-14. PMID:34513812. |
overexpression of nox4 abolished the effects in which hucmsc-evs inhibited dox-induced ros, oxidative stress, and apoptosis increases. |
2021-09-14 |
2023-08-13 |
human |
| Jing-Ting Chiou, Yi-Jun Shi, Yuan-Chin Lee, Liang-Jun Wang, Ying-Jung Chen, Long-Sen Chan. Carboxyl group-modified α-lactalbumin induces TNF-α-mediated apoptosis in leukemia and breast cancer cells through the NOX4/p38 MAPK/PP2A axis. International journal of biological macromolecules. vol 187. 2021-09-07. PMID:34310992. |
sem-la induced apoptosis in u937 cells, which showed increased nox4 expression, procaspase-8 degradation, and t-bid production. |
2021-09-07 |
2023-08-13 |
human |
| Shifeng Zhao, Xueqiao Wang, Xiaoqing Zheng, Xiu Liang, Zhigang Wang, Juanlian Zhang, Xudong Zhao, Shougang Zhuang, Qiuhui Pan, Fenyong Sun, Wenjun Shang, Jonathan Barasch, Andong Qi. Iron deficiency exacerbates cisplatin- or rhabdomyolysis-induced acute kidney injury through promoting iron-catalyzed oxidative damage. Free radical biology & medicine. vol 173. 2021-09-02. PMID:34298093. |
iron deficiency exacerbated cisplatin-induced iaki by markedly increasing non-heme catalytic iron and nox4 protein which together catalyze production of hydroxyl radicals followed by protein and dna oxidation, apoptosis and ferroptosis. |
2021-09-02 |
2023-08-13 |
Not clear |
| Yan Shi, Shu-Ai Ho. Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4. Molecular medicine reports. vol 24. issue 4. 2021-08-31. PMID:34396450. |
in conclusion, the present study indicated that metformin activated ampk to inhibit the expression of nox4, leading to a decrease in myocardial oxidative damage and apoptosis, thus alleviating reperfusion injury. |
2021-08-31 |
2023-08-13 |
rat |
| Jennifer L Larson-Casey, Linlin Gu, Jungsoon Kang, Ashish Dhyani, A Brent Carte. NOX4 regulates macrophage apoptosis resistance to induce fibrotic progression. The Journal of biological chemistry. vol 297. issue 1. 2021-08-24. PMID:34023385. |
nox4 regulates macrophage apoptosis resistance to induce fibrotic progression. |
2021-08-24 |
2023-08-13 |
mouse |
| Jennifer L Larson-Casey, Linlin Gu, Jungsoon Kang, Ashish Dhyani, A Brent Carte. NOX4 regulates macrophage apoptosis resistance to induce fibrotic progression. The Journal of biological chemistry. vol 297. issue 1. 2021-08-24. PMID:34023385. |
here, we confirm that macrophages isolated from asbestosis subjects are resistant to apoptosis and show they are associated with enhanced mitochondrial content of nadph oxidase 4 (nox4), which generates mitochondrial ros generation. |
2021-08-24 |
2023-08-13 |
mouse |
| Xianjun Tan, Tao Li, Shaowei Zhu, Weiying Zhong, Feng Li, Yunyan Wan. Induction of SPARC on Oxidative Stress, Inflammatory Phenotype Transformation, and Apoptosis of Human Brain Smooth Muscle Cells Via TGF-β1-NOX4 Pathway. Journal of molecular neuroscience : MN. vol 70. issue 11. 2021-07-29. PMID:32495004. |
the aim of this study is to investigate the pathological mechanism of sparc in oxidative stress, inflammation, and apoptosis during the formation of ias, as well as the involvement of tgf-β1 and nox4 molecules. |
2021-07-29 |
2023-08-13 |
human |