| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xianjun Tan, Tao Li, Shaowei Zhu, Weiying Zhong, Feng Li, Yunyan Wan. Induction of SPARC on Oxidative Stress, Inflammatory Phenotype Transformation, and Apoptosis of Human Brain Smooth Muscle Cells Via TGF-β1-NOX4 Pathway. Journal of molecular neuroscience : MN. vol 70. issue 11. 2021-07-29. PMID:32495004. |
the results showed that sparc upregulated the expression of nox4 through the tgf-β1-dependent signaling pathway, leading to oxidative stress and pro-inflammatory matrix behavior and apoptosis in hbvsmcs. |
2021-07-29 |
2023-08-13 |
human |
| Chao Song, Dongmei Shi, Kaiwen Chang, Xianghui Li, Qing Dong, Xia Ma, Xuefei Wang, Zhenhuan Guo, Yonglu Liu, Jundong Wan. Sodium fluoride activates the extrinsic apoptosis via regulating NOX4/ROS-mediated p53/DR5 signaling pathway in lung cells both in vitro and in vivo. Free radical biology & medicine. vol 169. 2021-06-28. PMID:33857626. |
further in vivo investigation demonstrated that nox4 deficiency markedly attenuates naf-induced lung injury, apoptosis, and ros levels in the lung. |
2021-06-28 |
2023-08-13 |
mouse |
| Xiaoye Fan, Wenjing Gu, Yun Gao, Ning Ma, Changqing Fan, Xinxin C. Daphnetin ameliorated GM-induced renal injury through the suppression of oxidative stress and apoptosis in mice. International immunopharmacology. vol 96. 2021-06-22. PMID:33812255. |
gm upregulated the expression levels of nox4, cleaved caspase-3 and p53 and the bax/bcl2 ratio in vivo to stimulate oxidative stress and apoptosis. |
2021-06-22 |
2023-08-13 |
mouse |
| Hyun-Kyoung Kim, Hwa-Young Lee, Thoufiqul Alam Riaz, Kashi Raj Bhattarai, Manoj Chaudhary, Jin Hee Ahn, Jieun Jeong, Hyung-Ryung Kim, Han-Jung Cha. Chalcone suppresses tumor growth through NOX4-IRE1α sulfonation-RIDD-miR-23b axis. Redox biology. vol 40. 2021-06-21. PMID:33445069. |
here, chalcone was demonstrated to trigger endoplasmic reticulum (er) stress-induced apoptosis through sulfonation of ire1α by er-localized nadph oxidase 4 (nox4). |
2021-06-21 |
2023-08-13 |
mouse |
| M Herranz-Itúrbide, J López-Luque, E Gonzalez-Sanchez, D Caballero-Díaz, E Crosas-Molist, B Martín-Mur, M Gut, A Esteve-Codina, V Jaquet, J X Jiang, N J Török, I Fabrega. NADPH oxidase 4 (Nox4) deletion accelerates liver regeneration in mice. Redox biology. vol 40. 2021-06-21. PMID:33493901. |
the nadph oxidase nox4 mediates transforming growth factor-beta (tgf-β) actions, including apoptosis in hepatocytes and activation of stellate cells to myofibroblasts. |
2021-06-21 |
2023-08-13 |
mouse |
| Jianzhong Li, Jian Chen, Yucheng Yang, Rui Ding, Meili Wang, Zhenhua G. Ginkgolide A attenuates sepsis-associated kidney damage via upregulating microRNA-25 with NADPH oxidase 4 as the target. International immunopharmacology. vol 95. 2021-06-10. PMID:33677255. |
the aim of the present study was to explore the effects of ginkgolide a (ga) on renal function of mice with sepsis and whether ga could attenuate sepsis-associated inflammation and apoptosis in kidney via upregulating microrna (mir)-25 with nadph oxidase 4 (nox4) as the target. |
2021-06-10 |
2023-08-13 |
mouse |
| Jianzhong Li, Jian Chen, Yucheng Yang, Rui Ding, Meili Wang, Zhenhua G. Ginkgolide A attenuates sepsis-associated kidney damage via upregulating microRNA-25 with NADPH oxidase 4 as the target. International immunopharmacology. vol 95. 2021-06-10. PMID:33677255. |
treatment with mir-25 inhibited nox4 expression, while nox4 over-expression reversed the inhibiting effects of mir-25 agomir on lps-induced increases of inflammatory factors and apoptosis in nrk-52e cells. |
2021-06-10 |
2023-08-13 |
mouse |
| Jianzhong Li, Jian Chen, Yucheng Yang, Rui Ding, Meili Wang, Zhenhua G. Ginkgolide A attenuates sepsis-associated kidney damage via upregulating microRNA-25 with NADPH oxidase 4 as the target. International immunopharmacology. vol 95. 2021-06-10. PMID:33677255. |
these results indicated that ga could improve sepsis-induced renal damage by attenuating renal inflammation and apoptosis via upregulating mir-25 with nox4 as the target. |
2021-06-10 |
2023-08-13 |
mouse |
| Jianxiong Liu, Giri K Chandaka, Rong Zhang, Helena Parfenov. Acute antioxidant and cytoprotective effects of sulforaphane in brain endothelial cells and astrocytes during inflammation and excitotoxicity. Pharmacology research & perspectives. vol 8. issue 4. 2021-06-03. PMID:32715644. |
nox4 nadph oxidase is the main nox isoform in cmvec and cortical astrocytes that is acutely activated by tnf-α and glutamate leading to ros-mediated cell death by apoptosis. |
2021-06-03 |
2023-08-13 |
Not clear |
| Jianxiong Liu, Giri K Chandaka, Rong Zhang, Helena Parfenov. Acute antioxidant and cytoprotective effects of sulforaphane in brain endothelial cells and astrocytes during inflammation and excitotoxicity. Pharmacology research & perspectives. vol 8. issue 4. 2021-06-03. PMID:32715644. |
the nox4 inhibitor gkt137831 blocked nadph oxidase activity and overall ros elevation, and prevented apoptosis of cmvec and astrocytes exposed to tnf-α and glutamate, supporting the leading role of nox4 in the neurovascular injury. |
2021-06-03 |
2023-08-13 |
Not clear |
| XinYong Cai, Chunli Yang, Liang Shao, HongMin Zhu, YunXia Wang, Xiao Huang, Shu Wang, Lang Hon. Targeting NOX 4 by petunidin improves anoxia/reoxygenation-induced myocardium injury. European journal of pharmacology. vol 888. 2021-05-17. PMID:32828742. |
the results showed that petunidin could significantly improve isolated heart function, reduce oxidative stress, inhibit cardiomyocyte apoptosis, up-regulate bcl-2 protein expression, down-regulate nox4 and bax expression, and reduce the level of cytoplasmic cytochrome c after a/r. |
2021-05-17 |
2023-08-13 |
rat |
| Dong Cheng, Libo Chen, Wencheng Tu, Haoren Wang, Qinfu Wang, Lili Meng, Zhu Li, Qin Y. Protective effects of valsartan administration on doxorubicin‑induced myocardial injury in rats and the role of oxidative stress and NOX2/NOX4 signaling. Molecular medicine reports. vol 22. issue 5. 2021-04-30. PMID:33000246. |
h9c2 cells were used to perform in vitro experiments, reactive oxygen species (ros) production and apoptosis were observed under the conditions of down‑ or upregulation of nox2 and nox4 in dox‑ and dox+val‑treated h9c2 cells. |
2021-04-30 |
2023-08-13 |
rat |
| Dong Cheng, Libo Chen, Wencheng Tu, Haoren Wang, Qinfu Wang, Lili Meng, Zhu Li, Qin Y. Protective effects of valsartan administration on doxorubicin‑induced myocardial injury in rats and the role of oxidative stress and NOX2/NOX4 signaling. Molecular medicine reports. vol 22. issue 5. 2021-04-30. PMID:33000246. |
in vitro, ros production and apoptosis in dox‑treated h9c2 cells was significantly reduced by nox2‑small interfering (si)rna and nox4‑sirna, and significantly increased by overexpressing nox2 and nox4. |
2021-04-30 |
2023-08-13 |
rat |
| Zhao-Na Li, Ming-Xu Ge, Zhong-Fang Yua. MicroRNA-182-5p protects human lens epithelial cells against oxidative stress-induced apoptosis by inhibiting NOX4 and p38 MAPK signalling. BMC ophthalmology. vol 20. issue 1. 2021-04-14. PMID:32552665. |
microrna-182-5p protects human lens epithelial cells against oxidative stress-induced apoptosis by inhibiting nox4 and p38 mapk signalling. |
2021-04-14 |
2023-08-13 |
human |
| Jing Huang, Dian Bao, Chun-Tao Lei, Hui Tang, Chun-Yun Zhang, Hua Su, Chun Zhan. Selenoprotein T protects against cisplatin-induced acute kidney injury through suppression of oxidative stress and apoptosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 9. 2021-03-10. PMID:32686857. |
furthermore, suppression of nox4 expression by gkt137831 partially alleviated selt knockdown-induced ros generation and cell apoptosis in cisplatin-treated kidney cells. |
2021-03-10 |
2023-08-13 |
cat |
| Dalia Saleh, Marawan Abdelbaset, Azza Hassan, Ola Sharaf, Sawsan Mahmoud, Rehab Hegaz. Omega-3 fatty acids ameliorate doxorubicin-induced cardiorenal toxicity: In-vivo regulation of oxidative stress, apoptosis and renal Nox4, and in-vitro preservation of the cytotoxic efficacy. PloS one. vol 15. issue 11. 2021-01-01. PMID:33180794. |
omega-3 fatty acids ameliorate doxorubicin-induced cardiorenal toxicity: in-vivo regulation of oxidative stress, apoptosis and renal nox4, and in-vitro preservation of the cytotoxic efficacy. |
2021-01-01 |
2023-08-13 |
rat |
| Dalia Saleh, Marawan Abdelbaset, Azza Hassan, Ola Sharaf, Sawsan Mahmoud, Rehab Hegaz. Omega-3 fatty acids ameliorate doxorubicin-induced cardiorenal toxicity: In-vivo regulation of oxidative stress, apoptosis and renal Nox4, and in-vitro preservation of the cytotoxic efficacy. PloS one. vol 15. issue 11. 2021-01-01. PMID:33180794. |
it proposes regulation of oxidative stress, nox4 activity and apoptosis as contributing protective mechanisms. |
2021-01-01 |
2023-08-13 |
rat |
| Yoonki Hong, Seongji Woo, Youngmi Kim, Jae Jun Lee, Ji Young Hon. Plasma concentrations of NOX4 are predictive of successful liberation from mechanical ventilation and 28-day mortality in intubated patients. Annals of translational medicine. vol 8. issue 21. 2020-12-16. PMID:33313121. |
nicotinamide adenine dinucleotide phosphate (nadph) oxidase (nox) enzymes play important roles in generating reactive oxygen species (ros); in particular, nox4 plays a distinct role in regulating lung inflammation and apoptosis. |
2020-12-16 |
2023-08-13 |
Not clear |
| Jiayu Xie, Enhui Hong, Baiyun Ding, Weiping Jiang, Shizhong Zheng, Zhichong Xie, Dan Tian, Yizhao Che. Inhibition of NOX4/ROS Suppresses Neuronal and Blood-Brain Barrier Injury by Attenuating Oxidative Stress After Intracerebral Hemorrhage. Frontiers in cellular neuroscience. vol 14. 2020-12-08. PMID:33281556. |
following nox4 knockdown, the level of oxidative stress in the brain decreased considerably, the neurobehavioral scores improved, the levels of neuronal apoptosis reduced markedly, and the impairment of blood-brain barrier function was significantly ameliorated in rats with ich. |
2020-12-08 |
2023-08-13 |
rat |
| Jiayu Xie, Enhui Hong, Baiyun Ding, Weiping Jiang, Shizhong Zheng, Zhichong Xie, Dan Tian, Yizhao Che. Inhibition of NOX4/ROS Suppresses Neuronal and Blood-Brain Barrier Injury by Attenuating Oxidative Stress After Intracerebral Hemorrhage. Frontiers in cellular neuroscience. vol 14. 2020-12-08. PMID:33281556. |
in conclusion, this study suggests that nox4 expression is upregulated after ich, which may cause an imbalance in the oxidative stress of relevant cells in the brain, leading to subsequent apoptosis of neurons and damage to the blood-brain barrier due to secondary brain injury following ich. |
2020-12-08 |
2023-08-13 |
rat |