| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Jiang, Yanli Li, Yuzhu Wang, Xiaoyu L. Furanodienone induces apoptosis via regulating the PRDX1/MAPKs/p53/caspases signaling axis through NOX4-derived mitochondrial ROS in colorectal cancer cells. Biochemical pharmacology. 2024-07-30. PMID:39079582. |
nevertheless, the specific nox4 inhibitor glx351322 attenuated cell apoptosis and mitochondrial ros production. |
2024-07-30 |
2024-08-02 |
human |
| Ying Jiang, Yanli Li, Yuzhu Wang, Xiaoyu L. Furanodienone induces apoptosis via regulating the PRDX1/MAPKs/p53/caspases signaling axis through NOX4-derived mitochondrial ROS in colorectal cancer cells. Biochemical pharmacology. 2024-07-30. PMID:39079582. |
in summary, the study demonstrated that furanodienone-induced apoptosis in crc cells is initiated by mitochondrial ros derived from nox4, which targeted the prdx1 and activated the downstream mapks/p53-mediated caspase-dependent signaling pathway. |
2024-07-30 |
2024-08-02 |
human |
| Jesús Ancer-Rodríguez, Yareth Gopar-Cuevas, Karol García-Aguilar, María-de-Lourdes Chávez-Briones, Ivett Miranda-Maldonado, Adriana Ancer-Arellano, Marta Ortega-Martínez, Gilberto Jaramillo-Range. Cell Proliferation and Apoptosis-Key Players in the Lung Aging Process. International journal of molecular sciences. vol 25. issue 14. 2024-07-27. PMID:39063108. |
the list of molecules that regulate cell proliferation, apoptosis, or both processes in lung aging includes tnc, foxm1, dna-pkcs, micrornas, bcl-w, bcl-xl, tcf21, p16, nox4, nrf2, mdm4, rpia, dhea, and mmp28. |
2024-07-27 |
2024-07-29 |
Not clear |
| Toshiaki Nakajima, Akiko Haruyama, Taira Fukuda, Kentaro Minami, Suguru Hirose, Hiroko Yazawa, Takafumi Nakajima, Takaaki Hasegawa, Yoshiyuki Kitagawa, Syotaro Obi, Shu Inami, Gaku Oguri, Ikuko Shibasaki, Hirohisa Amano, Takuo Arikawa, Masashi Sakuma, Shichiro Abe, Hirotsugu Fukuda, Shigeru Toyod. Left atrial reservoir strain is a marker of atrial fibrotic remodeling in patients undergoing cardiovascular surgery: Analysis of gene expression. PloS one. vol 19. issue 7. 2024-07-08. PMID:38976680. |
it also correlated ecm degradation-related genes (mmp2, timp1, and timp2), pro-fibrogenic cytokines (tgfb1 encoding tgfβ1, end1, pdgfd, ctgf), oxidant stress-related genes (nox2, nox4), ace, inflammation-related genes (nlrp, il1b, mcp-1), and apoptosis (bax). |
2024-07-08 |
2024-07-12 |
Not clear |
| Khaja Shameem Mohammed Abdul, Kimin Han, Alyssa B Guerrero, Cekia N Wilson, Amogh Kulkarni, Nicole H Purcel. Increased PHLPP1 expression through ERK-4E-BP1 signaling axis drives nicotine induced oxidative stress related damage of cardiomyocytes. Journal of molecular and cellular cardiology. 2024-06-08. PMID:38851627. |
in cardiomyocytes, nicotine significantly increased nadph oxidase 4 (nox4), which coincided with increased reactive oxygen species (ros) and increased cardiomyocyte apoptosis which were dependent on phlpp1 expression. |
2024-06-08 |
2024-06-11 |
Not clear |
| Huizhen Wei, Mengru Sun, Ruixuan Wang, Hairong Zeng, Bei Zhao, Shenyi Ji. Puerarin mitigated LPS-ATP or HG-primed endothelial cells damage and diabetes-associated cardiovascular disease via ROS-NLRP3 signalling. Journal of cellular and molecular medicine. vol 28. issue 10. 2024-05-22. PMID:38774996. |
in the study, pue ameliorated lipopolysaccharide-adenosine triphosphate (lps-atp) or hg-primed cytotoxicity and apoptosis, while inhibited reactive oxygen species (ros)-mediated nlr family pyrin domain containing 3 (nlrp3) inflammasome in huvecs, as evidenced by significantly decreased ros level, nox4, caspase-1 activity and expression of nlrp3, gsdmd, cleaved caspase-1, il-1β and il-18. |
2024-05-22 |
2024-05-27 |
Not clear |
| Hong Zeng, Pengtao Zou, Yanmei Chen, Ping Zhang, Liang Sha. NOX4 aggravates doxorubicin-induced cardiomyocyte pyroptosis by increasing reactive oxygen species content and activating the NLRP3 inflammasome. Cardiovascular diagnosis and therapy. vol 14. issue 1. 2024-03-04. PMID:38434559. |
nicotinamide adenine dinucleotide phosphate oxidase 4 (nox4)-mediated reactive oxygen species (ros) has been reported to induce cardiomyocyte apoptosis, but its effect on pyroptosis of cardiomyocytes has been rarely reported. |
2024-03-04 |
2024-03-06 |
Not clear |
| Weixi Xie, Lang Deng, Miao Lin, Xiaoting Huang, Rui Qian, Dayan Xiong, Wei Liu, Siyuan Tan. Sirtuin1 Mediates the Protective Effects of Echinacoside against Sepsis-Induced Acute Lung Injury via Regulating the NOX4-Nrf2 Axis. Antioxidants (Basel, Switzerland). vol 12. issue 11. 2023-11-25. PMID:38001778. |
as a pivotal aspect of acute lung injury, the pathologic activation and apoptosis of endothelial cells related to oxidative stress play a crucial role in disease progression, with nox4 and nrf2 being important targets in regulating ros production and clearance. |
2023-11-25 |
2023-11-28 |
Not clear |
| Zheng Jun, Wang Lei, Fang Ce, Ren Wen Tao, Meng Xiang Hui, Qing Ci Na. NADPH oxidase 4 facilitates progression of chondrosarcoma via generation of reactive oxygen species. Acta biochimica Polonica. 2023-09-18. PMID:37722070. |
in the present study, we studied nox4 expression in chondrosarcoma by immunochemical examination, and analyzed the role of nox4 in viability and apoptosis of human chondrosarcoma cell line sw1353 using nox4 sirna or nox4 inhibitor gkt137831. |
2023-09-18 |
2023-10-07 |
mouse |
| Zheng Jun, Wang Lei, Fang Ce, Ren Wen Tao, Meng Xiang Hui, Qing Ci Na. NADPH oxidase 4 facilitates progression of chondrosarcoma via generation of reactive oxygen species. Acta biochimica Polonica. 2023-09-18. PMID:37722070. |
knockdown of nox4 or inhibition of nox4 by gkt137831 both decreased generation of ros, and induced growth inhibition and apoptosis in sw1353, accompanied with the activation of caspases (caspase-3, caspase-8 and caspses-9), upregulation of bax, cytochrome c(cyt-c), cleaved-parp and down-regulation of bcl-2. |
2023-09-18 |
2023-10-07 |
mouse |
| Rut Espinosa-Sotelo, Noel P Fusté, Irene Peñuelas-Haro, Ania Alay, Gabriel Pons, Xènia Almodóvar, Júlia Albaladejo, Ismael Sánchez-Vera, Ricard Bonilla-Amadeo, Francesco Dituri, Grazia Serino, Emilio Ramos, Teresa Serrano, Mariona Calvo, María Luz Martínez-Chantar, Gianluigi Giannelli, Esther Bertran, Isabel Fabrega. Dissecting the role of the NADPH oxidase NOX4 in TGF-beta signaling in hepatocellular carcinoma. Redox biology. vol 65. 2023-07-18. PMID:37463530. |
the nadph oxidase nox4 has been proposed as necessary for the apoptosis induced by the transforming growth factor-beta (tgf-β) in hepatocytes and hepatocellular carcinoma (hcc) cells. |
2023-07-18 |
2023-08-14 |
human |
| Rut Espinosa-Sotelo, Noel P Fusté, Irene Peñuelas-Haro, Ania Alay, Gabriel Pons, Xènia Almodóvar, Júlia Albaladejo, Ismael Sánchez-Vera, Ricard Bonilla-Amadeo, Francesco Dituri, Grazia Serino, Emilio Ramos, Teresa Serrano, Mariona Calvo, María Luz Martínez-Chantar, Gianluigi Giannelli, Esther Bertran, Isabel Fabrega. Dissecting the role of the NADPH oxidase NOX4 in TGF-beta signaling in hepatocellular carcinoma. Redox biology. vol 65. 2023-07-18. PMID:37463530. |
tgf-β-mediated inhibition of cell proliferation and viability is attenuated in nox4 silenced cells, correlating with decreased response in terms of apoptosis, and maintenance of high expression of myc and cyclin d1. |
2023-07-18 |
2023-08-14 |
human |
| Yujie Zhong, Lei Wang, Ruyi Jin, Jiayu Liu, Ruilin Luo, Yinghan Zhang, Lin Zhu, Xiaoli Pen. Diosgenin Inhibits ROS Generation by Modulating NOX4 and Mitochondrial Respiratory Chain and Suppresses Apoptosis in Diabetic Nephropathy. Nutrients. vol 15. issue 9. 2023-07-11. PMID:37432297. |
diosgenin inhibits ros generation by modulating nox4 and mitochondrial respiratory chain and suppresses apoptosis in diabetic nephropathy. |
2023-07-11 |
2023-08-14 |
rat |
| Jing Liao, Biyan Peng, Guangyi Huang, Chunli Diao, Yuanjun Qin, Yiyi Hong, Jiali Lin, Yunru Lin, Li Jiang, Ningning Tang, Fen Tang, Jiamin Liang, Jun Zhang, Yumei Yan, Qi Chen, Zhou Zhou, Chaolan Shen, Wei Huang, Kongqian Huang, Qianqian Lan, Ling Cui, Haibin Zhong, Fan Xu, Min Li, Yantao Wei, Peng Lu, Mingyuan Zhan. Inhibition of NOX4 with GLX351322 alleviates acute ocular hypertension-induced retinal inflammation and injury by suppressing ROS mediated redox-sensitive factors activation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-03. PMID:37399715. |
importantly, the nox4 inhibitor glx351322 reduced ros overproduction, inhibited inflammatory factor release, suppressed glial cell activation and hyperplasia, inhibited leukocyte infiltration, reduced retinal cell senescence and apoptosis in damaged areas, reduced retinal degeneration and improved retinal function. |
2023-07-03 |
2023-08-14 |
mouse |
| Jing Liao, Biyan Peng, Guangyi Huang, Chunli Diao, Yuanjun Qin, Yiyi Hong, Jiali Lin, Yunru Lin, Li Jiang, Ningning Tang, Fen Tang, Jiamin Liang, Jun Zhang, Yumei Yan, Qi Chen, Zhou Zhou, Chaolan Shen, Wei Huang, Kongqian Huang, Qianqian Lan, Ling Cui, Haibin Zhong, Fan Xu, Min Li, Yantao Wei, Peng Lu, Mingyuan Zhan. Inhibition of NOX4 with GLX351322 alleviates acute ocular hypertension-induced retinal inflammation and injury by suppressing ROS mediated redox-sensitive factors activation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-03. PMID:37399715. |
these results suggest that inhibition of nox4 with glx351322 attenuated aoh-induced retinal inflammation, cellular senescence, and apoptosis by inhibiting the activation of the redox-sensitive factor pathway mediated by ros overproduction, thereby protecting retinal structure and function. |
2023-07-03 |
2023-08-14 |
mouse |
| Wen-Jing Liu, Lin Wang, Feng-Mei Zhou, Shu-Wen Liu, Wei Wang, Er-Jiang Zhao, Quan-Jun Yao, Wei Li, Yan-Qiu Zhao, Zhi Shi, Jian-Ge Qiu, Bing-Hua Jian. Elevated NOX4 promotes tumorigenesis and acquired EGFR-TKIs resistance via enhancing IL-8/PD-L1 signaling in NSCLC. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. vol 70. 2023-07-01. PMID:37392558. |
furthermore, the combination of nox4 inhibitor gkt137831 and gefitinib had synergistic effect to inhibit cell proliferation and tumor growth and to increase cellular apoptosis. |
2023-07-01 |
2023-08-14 |
human |
| Jyotsana Pandey, Jennifer L Larson-Casey, Mallikarjun H Patil, Rutwij Joshi, Chun-Sun Jiang, Yong Zhou, Chao He, A Brent Carte. NOX4-TIM23 interaction regulates NOX4 mitochondrial import and metabolic reprogramming. The Journal of biological chemistry. 2023-04-12. PMID:37044213. |
asbestos-induced expression of nadph oxidase 4 (nox4) in lung macrophages mediates fibrotic progression by the generation of mitochondrial ros, modulating mitochondrial biogenesis, and promoting apoptosis resistance; however, the mechanism(s) by which nox4 localizes to mitochondria during fibrosis is not known. |
2023-04-12 |
2023-08-14 |
mouse |
| Yongzhen Du, Tong Xu, Dongliu Luo, Yixuan Wang, Hang Yin, Chengguo Liu, Shu L. Perfluorooctane sulfonate-induced apoptosis in kidney cells by triggering the NOX4/ROS/JNK axis and antagonism of cannabidiol. Environmental toxicology. 2023-03-29. PMID:36988283. |
we demonstrated that pfos led to renal insufficiency and structural damage in mice, induced overexpression of nox4 and the onset of oxidative stress, and activated apoptosis of the mitochondrial pathway via the jnk signaling pathway. |
2023-03-29 |
2023-08-14 |
mouse |
| Yongzhen Du, Tong Xu, Dongliu Luo, Yixuan Wang, Hang Yin, Chengguo Liu, Shu L. Perfluorooctane sulfonate-induced apoptosis in kidney cells by triggering the NOX4/ROS/JNK axis and antagonism of cannabidiol. Environmental toxicology. 2023-03-29. PMID:36988283. |
for further investigation of the potential mechanism of pfos-induced renal cell apoptosis, the expression of nox4 was inhibited in vitro experiments using apocynin, an effective nox4 inhibitor. |
2023-03-29 |
2023-08-14 |
mouse |
| Yongzhen Du, Tong Xu, Dongliu Luo, Yixuan Wang, Hang Yin, Chengguo Liu, Shu L. Perfluorooctane sulfonate-induced apoptosis in kidney cells by triggering the NOX4/ROS/JNK axis and antagonism of cannabidiol. Environmental toxicology. 2023-03-29. PMID:36988283. |
the outcomes showed that pfos-induced ros production and jnk signaling pathway activation and apoptosis in human embryonic kidney (hek293) cells were significantly reduced after inhibition of nox4. |
2023-03-29 |
2023-08-14 |
mouse |