| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ghedeir M Alshammari, Mohammed S Al-Ayed, Mohamed Anwar Abdelhalim, Laila Naif Al-Harbi, Mohammed Abdo Yahy. Effects of Antioxidant Combinations on the Renal Toxicity Induced Rats by Gold Nanoparticles. Molecules (Basel, Switzerland). vol 28. issue 4. 2023-02-25. PMID:36838869. |
in conclusion, in rats, aunps impair kidney function by provoking oxidative stress, inflammation, and apoptosis by suppressing antioxidants, promoting mitochondrial uncoupling, activating nf-κb, and upregulating nox4. |
2023-02-25 |
2023-08-14 |
rat |
| Bo-Yun Ding, Chang-Nan Xie, Jia-Yu Xie, Zhuo-Wei Gao, Xiao-Wei Fei, En-Hui Hong, Wen-Jin Chen, Yi-Zhao Che. Knockdown of NADPH oxidase 4 reduces mitochondrial oxidative stress and neuronal pyroptosis following intracerebral hemorrhage. Neural regeneration research. vol 18. issue 8. 2023-02-08. PMID:36751799. |
our previous study found that increased expression of nicotinamide adenine dinucleotide phosphate oxidase 4 (nadph oxidase 4, nox4) led to neuronal apoptosis and damage to the blood-brain barrier after intracerebral hemorrhage. |
2023-02-08 |
2023-08-14 |
rat |
| Bo-Yun Ding, Chang-Nan Xie, Jia-Yu Xie, Zhuo-Wei Gao, Xiao-Wei Fei, En-Hui Hong, Wen-Jin Chen, Yi-Zhao Che. Knockdown of NADPH oxidase 4 reduces mitochondrial oxidative stress and neuronal pyroptosis following intracerebral hemorrhage. Neural regeneration research. vol 18. issue 8. 2023-02-08. PMID:36751799. |
the purpose of this study was to investigate the role of nox4 in the circle involving the neuronal tolerance to oxidative stress, mitochondrial reactive oxygen species and modes of neuronal death other than apoptosis after intracerebral hemorrhage. |
2023-02-08 |
2023-08-14 |
rat |
| Yi-Kai Wang, Shi-Jie Li, Lu-Lu Zhou, Duan Li, Li-Wei Gu. GALNT3 protects against vascular calcification by reducing oxidative stress and apoptosis of smooth muscle cells. European journal of pharmacology. vol 939. 2022-12-16. PMID:36473594. |
moreover, overexpression of galnt3 significantly down-regulated the expression of the oxidative stress markers nox2 and nox4, up-regulated total antioxidant capacity, decreased the expression of pro-inflammatory factors il-1β, tnf-α and il-8, matrix metalloproteinases mmp2 and mmp9, as well as reduced the apoptosis of cells in phosphate induced hasmcs. |
2022-12-16 |
2023-08-14 |
mouse |
| Ayman Alzu'bi, Mazhar Salim Al Zoubi, Bahaa Al-Trad, Manal Isam AbuAlArjah, Malek Shehab, Hiba Alzoubi, Dima Albals, Gamal T Abdelhady, Waseem El-Huneid. Acute Hepatic Injury Associated with Acute Administration of Synthetic Cannabinoid XLR-11 in Mouse Animal Model. Toxics. vol 10. issue 11. 2022-11-10. PMID:36355959. |
using real-time quantitative rt-pcr, mda assay, and tunel assay, we found consistent up-regulation of a variety of genes involved in oxidative stress (nox2, nox4, and inos), inflammation (tnf-α, il-1β, il-6), and apoptosis (bax) in the liver of xlr-11 treated mice compared to control mice. |
2022-11-10 |
2023-08-14 |
mouse |
| Xixiang Tang, Jinli Wang, Hanna E Abboud, Yanming Chen, Joshua J Wang, Sarah X Zhan. Sustained Upregulation of Endothelial Nox4 Mediates Retinal Vascular Pathology in Type 1 Diabetes. Diabetes. 2022-11-02. PMID:36321974. |
in contrast, ec-specific deletion of nox4 decreased mitochondrial ros generation, alleviated mitochondrial damage, reduced ec apoptosis, and protected the retina from acellular capillary formation and vascular hyperpermeability in a streptozotocin-induced diabetes mouse model. |
2022-11-02 |
2023-08-14 |
mouse |
| Anja Hofmann, Frieda Frank, Steffen Wolk, Albert Busch, Anna Klimova, Pamela Sabarstinski, Michael Gerlach, Dmitry Egorov, Irakli Kopaliani, Sönke Weinert, Bianca Hamann, David M Poitz, Coy Brunssen, Henning Morawietz, Katrin Schröder, Christian Reep. NOX4 mRNA correlates with plaque stability in patients with carotid artery stenosis. Redox biology. vol 57. 2022-10-01. PMID:36182808. |
in fact, nox4 appears to be linked to plaque stability, apoptosis and plaque hemorrhage. |
2022-10-01 |
2023-08-14 |
human |
| Tao Zhang, Haiping Han, Yan Zhou, Zhimei Liu, Tingjie Ma, Xuqing Ca. MicroRNA-454 modulates the oxidative stress and neuronal apoptosis after cerebral ischemia/reperfusion injury via targeting NADPH oxidase 4 (NOX4). Journal of biochemical and molecular toxicology. 2022-08-31. PMID:36043333. |
microrna-454 modulates the oxidative stress and neuronal apoptosis after cerebral ischemia/reperfusion injury via targeting nadph oxidase 4 (nox4). |
2022-08-31 |
2023-08-14 |
rat |
| Meng Ning, Yingwu Liu, Donglian Wang, Jin Wei, Guoyong Hu, Pengcheng Xin. Knockdown of TRIM27 alleviated sepsis-induced inflammation, apoptosis, and oxidative stress via suppressing ubiquitination of PPARγ and reducing NOX4 expression. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2022-08-13. PMID:35962797. |
knockdown of trim27 alleviated sepsis-induced inflammation, apoptosis, and oxidative stress via suppressing ubiquitination of pparγ and reducing nox4 expression. |
2022-08-13 |
2023-08-14 |
Not clear |
| Yan Li, Jia Xu, Lingxia Li, Lu Bai, Yunping Wang, Jianfang Zhang, Haixu Wan. Inhibition of Nicotinamide adenine dinucleotide phosphate oxidase 4 attenuates cell apoptosis and oxidative stress in a rat model of polycystic ovary syndrome through the activation of Nrf-2/HO-1 signaling pathway. Molecular and cellular endocrinology. 2022-04-12. PMID:35413388. |
nox4 deficiency increased bcl-2 levels and decreased bax, cleaved caspase-3 and cleaved caspase-9 levels and dhea-induced cell apoptosis in rat ovaries. |
2022-04-12 |
2023-08-13 |
rat |
| Yan Li, Jia Xu, Lingxia Li, Lu Bai, Yunping Wang, Jianfang Zhang, Haixu Wan. Inhibition of Nicotinamide adenine dinucleotide phosphate oxidase 4 attenuates cell apoptosis and oxidative stress in a rat model of polycystic ovary syndrome through the activation of Nrf-2/HO-1 signaling pathway. Molecular and cellular endocrinology. 2022-04-12. PMID:35413388. |
similar to the in vivo results, nox4 silencing inhibited oxidative stress and cell apoptosis in dhea-treated rat granulosa cells. |
2022-04-12 |
2023-08-13 |
rat |
| Yan Li, Jia Xu, Lingxia Li, Lu Bai, Yunping Wang, Jianfang Zhang, Haixu Wan. Inhibition of Nicotinamide adenine dinucleotide phosphate oxidase 4 attenuates cell apoptosis and oxidative stress in a rat model of polycystic ovary syndrome through the activation of Nrf-2/HO-1 signaling pathway. Molecular and cellular endocrinology. 2022-04-12. PMID:35413388. |
thus, nox4 deficiency may ameliorate pcos in rats by reducing oxidative stress and cell apoptosis via activating the nrf-2/ho-1 signal pathway. |
2022-04-12 |
2023-08-13 |
rat |
| Yongpan Huang, Jiayu Tang, Xiaojuan Li, Xian Long, Yansong Huang, Xi Zhan. miR-92b-3p Exerts Neuroprotective Effects on Ischemia/Reperfusion-Induced Cerebral Injury via Targeting NOX4 in a Rat Model. Oxidative medicine and cellular longevity. vol 2022. 2022-04-11. PMID:35401931. |
in addition, we noted a significant decrease in the expression of mir-92b-3p, as well as increases in apoptosis and oxidative stress and an increase in nox4. |
2022-04-11 |
2023-08-13 |
rat |
| Ping Tang, Jianfeng Sheng, Xiujuan Peng, Renfei Zhang, Tao Xu, Jun Hu, Yuexi Kang, Baiyi Wu, Hao Dan. Targeting NOX4 disrupts the resistance of papillary thyroid carcinoma to chemotherapeutic drugs and lenvatinib. Cell death discovery. vol 8. issue 1. 2022-04-09. PMID:35396551. |
nox4 knockdown impairs cell viability, increases cell apoptosis, extends g1 phase during cell cycle and modulates the level of energy-associated metabolites in starved cells. |
2022-04-09 |
2023-08-13 |
cattle |
| Ping Tang, Jianfeng Sheng, Xiujuan Peng, Renfei Zhang, Tao Xu, Jun Hu, Yuexi Kang, Baiyi Wu, Hao Dan. Targeting NOX4 disrupts the resistance of papillary thyroid carcinoma to chemotherapeutic drugs and lenvatinib. Cell death discovery. vol 8. issue 1. 2022-04-09. PMID:35396551. |
when the starved cells or lrbcs are treated with chemotherapeutic drugs or lenvatinib, nox4 knockdown inhibits cell viability and aggravates cell apoptosis depending on nox4-derived ros production. |
2022-04-09 |
2023-08-13 |
cattle |
| Ping Tang, Jianfeng Sheng, Xiujuan Peng, Renfei Zhang, Tao Xu, Jun Hu, Yuexi Kang, Baiyi Wu, Hao Dan. Targeting NOX4 disrupts the resistance of papillary thyroid carcinoma to chemotherapeutic drugs and lenvatinib. Cell death discovery. vol 8. issue 1. 2022-04-09. PMID:35396551. |
the upregulated nox4 then triggers erks and pi3k/akt pathway to influence cell apoptosis. |
2022-04-09 |
2023-08-13 |
cattle |
| Mariko Miyashita-Ishiwata, Malak El Sabeh, Lauren D Reschke, Sadia Afrin, Mostafa A Boraha. Hypoxia Induces Proliferation via NOX4-Mediated Oxidative Stress and TGF-β3 Signaling in Uterine Leiomyoma Cells. Free radical research. 2022-04-04. PMID:35377824. |
the specific nox4 inhibitor glx351322 abrogated this hypoxia-induced ros generation, cellular proliferation, and apoptosis inhibition. |
2022-04-04 |
2023-08-13 |
human |
| Chongshan Dai, Meng Li, Tun Sun, Yuan Zhang, Yang Wang, Zhangqi Shen, Tony Velkov, Shusheng Tang, Jianzhong She. Colistin-induced pulmonary toxicity involves the activation of NOX4/TGF-β/mtROS pathway and the inhibition of Akt/mTOR pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-04-04. PMID:35378205. |
our results showed that intraperitoneal colistin treatment significantly increased the expression of tgf-β and nox4 protein and mrna, then triggers oxidative stress, mitochondrial dysfunction, and apoptosis in the lung tissue of mice and a549 cells. |
2022-04-04 |
2023-08-13 |
mouse |
| Chongshan Dai, Meng Li, Tun Sun, Yuan Zhang, Yang Wang, Zhangqi Shen, Tony Velkov, Shusheng Tang, Jianzhong She. Colistin-induced pulmonary toxicity involves the activation of NOX4/TGF-β/mtROS pathway and the inhibition of Akt/mTOR pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-04-04. PMID:35378205. |
inhibition of nox4 protected a549 cells against colistin-induced mtros and apoptosis. |
2022-04-04 |
2023-08-13 |
mouse |
| Ying Liu, Zhao-Jie Dong, Jia-Wei Song, Li-Rong Liang, Lan-Lan Sun, Xiao-Yan Liu, Ran Miao, Ying-Le Xu, Xue-Ting Li, Mi-Wen Zhang, Zhen-Zhou Zhang, Jiu-Chang Zhon. MicroRNA-122-5p promotes renal fibrosis and injury in spontaneously hypertensive rats by targeting FOXO3. Experimental cell research. 2022-01-09. PMID:34998813. |
transfection with raav-mir-122-5p triggered renal fibrosis, apoptosis and inflammatory injury in shr, associated with downregulated levels of foxo3, sirt6, atg5 and bnip3 as well as upregulated expression of kim-1, nox4, ctgf, and tgf-β1. |
2022-01-09 |
2023-08-13 |
mouse |