| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert J McKallip, Wentao Jia, Jerome Schlomer, James W Warren, Prakash S Nagarkatti, Mitzi Nagarkatt. Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression. Molecular pharmacology. vol 70. issue 3. 2006-09-28. PMID:16754784. |
cannabidiol-induced apoptosis in human leukemia cells: a novel role of cannabidiol in the regulation of p22phox and nox4 expression. |
2006-09-28 |
2023-08-12 |
human |
| T Mochizuki, S Furuta, J Mitsushita, W H Shang, M Ito, Y Yokoo, M Yamaura, S Ishizone, J Nakayama, A Konagai, K Hirose, K Kiyosawa, T Kamat. Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells. Oncogene. vol 25. issue 26. 2006-08-08. PMID:16532036. |
here, we show that both a flavoprotein inhibitor, diphenylene iodonium (dpi), and small interfering rnas designed to target nox4 mrna (sinox4rnas) inhibited superoxide production in panc-1 pancreatic cancer cells, and depletion of ros by dpi or sinox4rnas induced apoptosis. |
2006-08-08 |
2023-08-12 |
human |
| T Mochizuki, S Furuta, J Mitsushita, W H Shang, M Ito, Y Yokoo, M Yamaura, S Ishizone, J Nakayama, A Konagai, K Hirose, K Kiyosawa, T Kamat. Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells. Oncogene. vol 25. issue 26. 2006-08-08. PMID:16532036. |
taken together, these findings suggest that ros generated by nox4, at least in part, transmit cell survival signals through the akt-ask1 pathway in pancreatic cancer cells and their depletion leads to apoptosis. |
2006-08-08 |
2023-08-12 |
human |
| Mouad Edderkaoui, Peggy Hong, Eva C Vaquero, Jong K Lee, Lars Fischer, Helmut Friess, Markus W Buchler, Markus M Lerch, Stephen J Pandol, Anna S Gukovskay. Extracellular matrix stimulates reactive oxygen species production and increases pancreatic cancer cell survival through 5-lipoxygenase and NADPH oxidase. American journal of physiology. Gastrointestinal and liver physiology. vol 289. issue 6. 2005-12-19. PMID:16037546. |
inhibition of 5-lo or nadph oxidase with pharmacological inhibitors of these enzymes and with nox4 or 5-lo antisense oligonucleotides markedly stimulated apoptosis in cancer cells cultured on fibronectin. |
2005-12-19 |
2023-08-12 |
human |
| Eva C Vaquero, Mouad Edderkaoui, Stephen J Pandol, Ilya Gukovsky, Anna S Gukovskay. Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells. The Journal of biological chemistry. vol 279. issue 33. 2004-09-24. PMID:15155719. |
inhibiting ros with the antioxidants, nox4 antisense, or mnsod overexpression all stimulated apoptosis in pancreatic cancer cells as measured by internucleosomal dna fragmentation, phosphatidylserine externalization, cytochrome c release, and effector caspase activation. |
2004-09-24 |
2023-08-12 |
human |
| Eva C Vaquero, Mouad Edderkaoui, Stephen J Pandol, Ilya Gukovsky, Anna S Gukovskay. Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells. The Journal of biological chemistry. vol 279. issue 33. 2004-09-24. PMID:15155719. |
the results show that growth factor-induced ros produced by nad(p)h oxidase (probably nox4) protect pancreatic cancer cells from apoptosis. |
2004-09-24 |
2023-08-12 |
human |