| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patricia Sancho, Jèssica Mainez, Eva Crosas-Molist, César Roncero, Conrado M Fernández-Rodriguez, Fernando Pinedo, Heidemarie Huber, Robert Eferl, Wolfgang Mikulits, Isabel Fabrega. NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development. PloS one. vol 7. issue 9. 2013-04-22. PMID:23049784. |
nox4 was not necessary for tgf-β-induced epithelial-mesenchymal transition (emt), but was required for tgf-β-induced apoptosis in hepatocytes. |
2013-04-22 |
2023-08-12 |
mouse |
| Su-Mi Kim, Yang-Gyun Kim, Kyung-Hwan Jeong, Sang-Ho Lee, Tae-Won Lee, Chun-Gyoo Ihm, Ju-Young Moo. Angiotensin II-induced mitochondrial Nox4 is a major endogenous source of oxidative stress in kidney tubular cells. PloS one. vol 7. issue 7. 2013-03-26. PMID:22808054. |
ang-(1-7) attenuated ang ii-induced mitochondrial nox4 expression and apoptosis, and its effect was comparable to that of the nad(p)h oxidase inhibitor. |
2013-03-26 |
2023-08-12 |
Not clear |
| Stellor Nlandu Khodo, Eva Dizin, Gaetan Sossauer, Ildiko Szanto, Pierre-Yves Martin, Eric Feraille, Karl Heinz Krause, Sophie de Seigneu. NADPH-oxidase 4 protects against kidney fibrosis during chronic renal injury. Journal of the American Society of Nephrology : JASN. vol 23. issue 12. 2013-02-04. PMID:23100220. |
nox4 silencing in a mouse collecting duct (mccd(cl1)) cell line increased tgf-β1-induced apoptosis and decreased nrf2 protein along with expression of its target genes. |
2013-02-04 |
2023-08-12 |
mouse |
| Stellor Nlandu Khodo, Eva Dizin, Gaetan Sossauer, Ildiko Szanto, Pierre-Yves Martin, Eric Feraille, Karl Heinz Krause, Sophie de Seigneu. NADPH-oxidase 4 protects against kidney fibrosis during chronic renal injury. Journal of the American Society of Nephrology : JASN. vol 23. issue 12. 2013-02-04. PMID:23100220. |
in summary, these results demonstrate that the absence of nox4 promotes kidney fibrosis, independent of nox2, through enhanced tubular cell apoptosis, decreased microvascularization, and enhanced oxidative stress. |
2013-02-04 |
2023-08-12 |
mouse |
| Somasundaram Arumugam, Rajarajan A Thandavarayan, Punniyakoti T Veeraveedu, Takashi Nakamura, Wawaimuli Arozal, Flori R Sari, Vijayasree V Giridharan, Vivian Soetikno, Suresh S Palaniyandi, Meilei Harima, Kenji Suzuki, Masaki Nagata, Makoto Kodama, Kenichi Watanab. Beneficial effects of edaravone, a novel antioxidant, in rats with dilated cardiomyopathy. Journal of cellular and molecular medicine. vol 16. issue 9. 2013-01-07. PMID:22268705. |
left ventricular (lv) expression of nadph oxidase subunits (p47(phox), p67(phox), gp91(phox) and nox4), fibrosis markers (tgf-β(1) and opn), endoplasmic reticulum (er) stress markers (grp78 and gadd 153) and apoptosis markers (cytochrome c and caspase-3) were measured by western blotting. |
2013-01-07 |
2023-08-12 |
rat |
| Joy X Jiang, Xiangling Chen, Nobuko Serizawa, Cédric Szyndralewiez, Patrick Page, Katrin Schröder, Ralf P Brandes, Sridevi Devaraj, Natalie J Törö. Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo. Free radical biology & medicine. vol 53. issue 2. 2012-12-11. PMID:22618020. |
fasl or tnfα/actinomycin d-induced apoptosis was studied in wild-type and nox4(-/-) hepatocytes. |
2012-12-11 |
2023-08-12 |
mouse |
| Joy X Jiang, Xiangling Chen, Nobuko Serizawa, Cédric Szyndralewiez, Patrick Page, Katrin Schröder, Ralf P Brandes, Sridevi Devaraj, Natalie J Törö. Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo. Free radical biology & medicine. vol 53. issue 2. 2012-12-11. PMID:22618020. |
nox4(-/-) hepatocytes were more resistant to fasl or tnfα/actinomycin d-induced apoptosis. |
2012-12-11 |
2023-08-12 |
mouse |
| Joy X Jiang, Xiangling Chen, Nobuko Serizawa, Cédric Szyndralewiez, Patrick Page, Katrin Schröder, Ralf P Brandes, Sridevi Devaraj, Natalie J Törö. Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo. Free radical biology & medicine. vol 53. issue 2. 2012-12-11. PMID:22618020. |
similarly, after pharmacological nox4 inhibition, ros production, the expression of fibrogenic markers, and hepatocyte apoptosis were reduced. |
2012-12-11 |
2023-08-12 |
mouse |
| Feng Chen, Stephen Haigh, Scott Barman, David J R Fulto. From form to function: the role of Nox4 in the cardiovascular system. Frontiers in physiology. vol 3. 2012-11-06. PMID:23125837. |
previous investigations have revealed that nox4 is involved in oxygen sensing, vasomotor control, cellular proliferation, differentiation, migration, apoptosis, senescence, fibrosis, and angiogenesis. |
2012-11-06 |
2023-08-12 |
Not clear |
| Bingqing Deng, Shuanglun Xie, Jingfeng Wang, Zhengyuan Xia, Ruqiong Ni. Inhibition of protein kinase C β(2) prevents tumor necrosis factor-α-induced apoptosis and oxidative stress in endothelial cells: the role of NADPH oxidase subunits. Journal of vascular research. vol 49. issue 2. 2012-06-04. PMID:22261918. |
tnf-α significantly induced huvec apoptosis and ros production, accompanying with dramatic upregulation of nadph oxidase subunits: nox2/gp91(phox), nox4, p47(phox) and p67(phox), whereas these enhancements were abolished by the treatment with pkc inhibitors. |
2012-06-04 |
2023-08-12 |
human |
| Mitsuko Moriguchi, Marie Yamada, Yasuo Miake, Takaaki Yanagisaw. Transforming growth factor β inducible apoptotic cascade in epithelial cells during rat molar tooth eruptions. Anatomical science international. vol 85. issue 2. 2011-07-14. PMID:19779767. |
we examined tgf-beta-receptor 1, tgf-beta inducible transcription factor 1 (tieg1), nadphoxidase 4 (nox4), cytochrome c, caspase-3 (active form and pro-enzyme), apoptosis-inducing protein daxx, apoptosis signal-regulating kinase 1 (ask1), glycogen synthase kinase-3 beta phosphorylated on serine 9 (p-gsk-3beta), and beta-catenin. |
2011-07-14 |
2023-08-12 |
rat |
| Kelly A Graham, Mariola Kulawiec, Kjerstin M Owens, Xiurong Li, Mohamed Mokhtar Desouki, Dhyan Chandra, Keshav K Sing. NADPH oxidase 4 is an oncoprotein localized to mitochondria. Cancer biology & therapy. vol 10. issue 3. 2011-04-07. PMID:20523116. |
overexpression of nox4 in normal breast epithelial cells resulted in cellular senescence, resistance to apoptosis, and tumorigenic transformation. |
2011-04-07 |
2023-08-12 |
Not clear |
| Shyamali Basuroy, Dilyara Tcheranova, Sujoy Bhattacharya, Charles W Leffler, Helena Parfenov. Nox4 NADPH oxidase-derived reactive oxygen species, via endogenous carbon monoxide, promote survival of brain endothelial cells during TNF-α-induced apoptosis. American journal of physiology. Cell physiology. vol 300. issue 2. 2011-03-21. PMID:21123734. |
nox4 nadph oxidase-derived reactive oxygen species, via endogenous carbon monoxide, promote survival of brain endothelial cells during tnf-α-induced apoptosis. |
2011-03-21 |
2023-08-12 |
Not clear |
| Shyamali Basuroy, Dilyara Tcheranova, Sujoy Bhattacharya, Charles W Leffler, Helena Parfenov. Nox4 NADPH oxidase-derived reactive oxygen species, via endogenous carbon monoxide, promote survival of brain endothelial cells during TNF-α-induced apoptosis. American journal of physiology. Cell physiology. vol 300. issue 2. 2011-03-21. PMID:21123734. |
nox4 is the major isoform of nadph oxidase responsible for tnf-α-induced oxidative stress and apoptosis in cmvec. |
2011-03-21 |
2023-08-12 |
Not clear |
| Shyamali Basuroy, Dilyara Tcheranova, Sujoy Bhattacharya, Charles W Leffler, Helena Parfenov. Nox4 NADPH oxidase-derived reactive oxygen species, via endogenous carbon monoxide, promote survival of brain endothelial cells during TNF-α-induced apoptosis. American journal of physiology. Cell physiology. vol 300. issue 2. 2011-03-21. PMID:21123734. |
in akt sirna-transfected cmvec and in cells with pharmacologically inhibited akt, erk1/2, and p38 mitogen-activated protein kinase (mapk) activities, corm-a1 was no longer capable of blocking nox4 activation and apoptosis caused by tnf-α. |
2011-03-21 |
2023-08-12 |
Not clear |
| Christoph Kleinschnitz, Henrike Grund, Kirstin Wingler, Melanie E Armitage, Emma Jones, Manish Mittal, David Barit, Tobias Schwarz, Christian Geis, Peter Kraft, Konstanze Barthel, Michael K Schuhmann, Alexander M Herrmann, Sven G Meuth, Guido Stoll, Sabine Meurer, Anja Schrewe, Lore Becker, Valérie Gailus-Durner, Helmut Fuchs, Thomas Klopstock, Martin Hrabé de Angelis, Karin Jandeleit-Dahm, Ajay M Shah, Norbert Weissmann, Harald H H W Schmid. Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration. PLoS biology. vol 8. issue 9. 2011-01-20. PMID:20877715. |
mice deficient in nox4 (nox4(-/-)) of either sex, but not those deficient for nox1 or nox2, were largely protected from oxidative stress, blood-brain-barrier leakage, and neuronal apoptosis, after both transient and permanent cerebral ischemia. |
2011-01-20 |
2023-08-12 |
mouse |
| S Ben Mkaddem, E Pedruzzi, C Werts, N Coant, M Bens, F Cluzeaud, J M Goujon, E Ogier-Denis, A Vandewall. Heat shock protein gp96 and NAD(P)H oxidase 4 play key roles in Toll-like receptor 4-activated apoptosis during renal ischemia/reperfusion injury. Cell death and differentiation. vol 17. issue 9. 2011-01-13. PMID:20224597. |
silencing nox4 mrna expression impaired hypoxia-induced activation of ask1 and both jnk and p38, leading to the inhibition of ros production and apoptosis in posthypoxic tlr4-expressing rtecs. |
2011-01-13 |
2023-08-12 |
mouse |
| S Ben Mkaddem, E Pedruzzi, C Werts, N Coant, M Bens, F Cluzeaud, J M Goujon, E Ogier-Denis, A Vandewall. Heat shock protein gp96 and NAD(P)H oxidase 4 play key roles in Toll-like receptor 4-activated apoptosis during renal ischemia/reperfusion injury. Cell death and differentiation. vol 17. issue 9. 2011-01-13. PMID:20224597. |
these findings show that, concomitantly to the activation of p38, the gp96/tlr4 interaction is required for activation of ask1/jnk signaling in posthypoxic mouse rtecs, and that the 28-kda nox4 has a key role in tlr4-mediated apoptosis during renal iri. |
2011-01-13 |
2023-08-12 |
mouse |
| Ki Soon Kim, Hae Woong Choi, Hee Eun Yoon, Ick Young Ki. Reactive oxygen species generated by NADPH oxidase 2 and 4 are required for chondrogenic differentiation. The Journal of biological chemistry. vol 285. issue 51. 2011-01-11. PMID:20952384. |
we also found that atdc5 cells depleted of nox2 or nox4 underwent apoptosis. |
2011-01-11 |
2023-08-12 |
mouse |
| Assaad A Eid, Bridget M Ford, Karen Block, Balakuntalam S Kasinath, Yves Gorin, Goutam Ghosh-Choudhury, Jeffrey L Barnes, Hanna E Abbou. AMP-activated protein kinase (AMPK) negatively regulates Nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes. The Journal of biological chemistry. vol 285. issue 48. 2010-12-30. PMID:20861022. |
here, we show that hg inactivates amp-activated protein kinase (ampk), up-regulates nox4, enhances nadph oxidase activity, and induces podocyte apoptosis. |
2010-12-30 |
2023-08-12 |
mouse |