| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sayo Koike, Shozo Yano, Sayuri Tanaka, Abdullah M Sheikh, Atsushi Nagai, Toshitsugu Sugimot. Advanced Glycation End-Products Induce Apoptosis of Vascular Smooth Muscle Cells: A Mechanism for Vascular Calcification. International journal of molecular sciences. vol 17. issue 9. 2017-04-03. PMID:27649164. |
furthermore, age3-induced apoptosis was significantly inhibited by sirna-mediated knockdown of nox4 or p22(phox). |
2017-04-03 |
2023-08-13 |
rat |
| Sayo Koike, Shozo Yano, Sayuri Tanaka, Abdullah M Sheikh, Atsushi Nagai, Toshitsugu Sugimot. Advanced Glycation End-Products Induce Apoptosis of Vascular Smooth Muscle Cells: A Mechanism for Vascular Calcification. International journal of molecular sciences. vol 17. issue 9. 2017-04-03. PMID:27649164. |
double knockdown of nox4 and p22(phox) showed a similar inhibitory effect on apoptosis as single gene silencing. |
2017-04-03 |
2023-08-13 |
rat |
| Kunihiro Ito, Akinobu Ota, Takayuki Ono, Toshiki Nakaoka, Md Wahiduzzaman, Sivasundaram Karnan, Hiroyuki Konishi, Akifumi Furuhashi, Tomio Hayashi, Yoichi Yamada, Yoshitaka Hosokawa, Yoshiaki Kazaok. Inhibition of Nox1 induces apoptosis by attenuating the AKT signaling pathway in oral squamous cell carcinoma cell lines. Oncology reports. vol 36. issue 5. 2017-03-10. PMID:27600098. |
in addition, knockdown of nox1, but not nox4, significantly suppressed cell viability and induced apoptosis in the hsc-2 and hsc-3 cells. |
2017-03-10 |
2023-08-13 |
Not clear |
| Zhuohang Li, Yiyu Sheng, Cheng Liu, Kuiqing Li, Xin Huang, Jian Huang, Kewei X. Nox4 has a crucial role in uric acid‑induced oxidative stress and apoptosis in renal tubular cells. Molecular medicine reports. vol 13. issue 5. 2017-02-21. PMID:27052425. |
nox4 has a crucial role in uric acid‑induced oxidative stress and apoptosis in renal tubular cells. |
2017-02-21 |
2023-08-13 |
human |
| Zhuohang Li, Yiyu Sheng, Cheng Liu, Kuiqing Li, Xin Huang, Jian Huang, Kewei X. Nox4 has a crucial role in uric acid‑induced oxidative stress and apoptosis in renal tubular cells. Molecular medicine reports. vol 13. issue 5. 2017-02-21. PMID:27052425. |
the purpose of the present study was to evaluate the effects of uric acid in promoting tubular cell apoptosis and verify the role of nicotinamide adenine dinucleotide phosphate oxidase 4 (nox4)‑induced oxidative stress in this process. |
2017-02-21 |
2023-08-13 |
human |
| Zhuohang Li, Yiyu Sheng, Cheng Liu, Kuiqing Li, Xin Huang, Jian Huang, Kewei X. Nox4 has a crucial role in uric acid‑induced oxidative stress and apoptosis in renal tubular cells. Molecular medicine reports. vol 13. issue 5. 2017-02-21. PMID:27052425. |
in conclusion, it was demonstrated that elevated uric acid promoted ros‑induced tubular cell apoptosis by upregulating nox4 expression. |
2017-02-21 |
2023-08-13 |
human |
| Dapeng Fu, Jianmin Lu, Sheng Yan. Oleic/Palmitate Induces Apoptosis in Human Articular Chondrocytes via Upregulation of NOX4 Expression and ROS Production. Annals of clinical and laboratory science. vol 46. issue 4. 2017-01-13. PMID:27466293. |
oleic/palmitate induces apoptosis in human articular chondrocytes via upregulation of nox4 expression and ros production. |
2017-01-13 |
2023-08-13 |
human |
| Dapeng Fu, Jianmin Lu, Sheng Yan. Oleic/Palmitate Induces Apoptosis in Human Articular Chondrocytes via Upregulation of NOX4 Expression and ROS Production. Annals of clinical and laboratory science. vol 46. issue 4. 2017-01-13. PMID:27466293. |
more importantly, inhibition of nox4 could partially eliminate o/p-induced chondrocytes apoptosis by reducing ros production. |
2017-01-13 |
2023-08-13 |
human |
| Dapeng Fu, Jianmin Lu, Sheng Yan. Oleic/Palmitate Induces Apoptosis in Human Articular Chondrocytes via Upregulation of NOX4 Expression and ROS Production. Annals of clinical and laboratory science. vol 46. issue 4. 2017-01-13. PMID:27466293. |
to conclude, o/p treatment enhances ros production and cell apoptosis mainly by upregulating the protein levels of nox4 and caspase3 activation in chondrocytes, indicating a potential therapeutic target of oa in obesity patients. |
2017-01-13 |
2023-08-13 |
human |
| Jia Li, Chongru He, Wenwen Tong, Yuming Zou, Dahe Li, Chen Zhang, Weidong X. Tanshinone IIA blocks dexamethasone-induced apoptosis in osteoblasts through inhibiting Nox4-derived ROS production. International journal of clinical and experimental pathology. vol 8. issue 10. 2016-12-13. PMID:26722597. |
overexpression of nox4 almost abolished the inhibitory effect of tan on dex-induced cell injury and apoptosis. |
2016-12-13 |
2023-08-13 |
Not clear |
| Jia Li, Chongru He, Wenwen Tong, Yuming Zou, Dahe Li, Chen Zhang, Weidong X. Tanshinone IIA blocks dexamethasone-induced apoptosis in osteoblasts through inhibiting Nox4-derived ROS production. International journal of clinical and experimental pathology. vol 8. issue 10. 2016-12-13. PMID:26722597. |
the results also demonstrated significant involvement of nox4 in the dex-induced apoptosis. |
2016-12-13 |
2023-08-13 |
Not clear |
| Jia Li, Chongru He, Wenwen Tong, Yuming Zou, Dahe Li, Chen Zhang, Weidong X. Tanshinone IIA blocks dexamethasone-induced apoptosis in osteoblasts through inhibiting Nox4-derived ROS production. International journal of clinical and experimental pathology. vol 8. issue 10. 2016-12-13. PMID:26722597. |
additionally, we evidenced that tan reversed dex-induced apoptosis via inactivation of nox4. |
2016-12-13 |
2023-08-13 |
Not clear |
| Jia Li, Chongru He, Wenwen Tong, Yuming Zou, Dahe Li, Chen Zhang, Weidong X. Tanshinone IIA blocks dexamethasone-induced apoptosis in osteoblasts through inhibiting Nox4-derived ROS production. International journal of clinical and experimental pathology. vol 8. issue 10. 2016-12-13. PMID:26722597. |
the present findings suggest that inhibition of nox4 may be a novel therapeutic approach of tan to prevent against glucocorticoids-induced osteoblasts apoptosis and osteoporosis. |
2016-12-13 |
2023-08-13 |
Not clear |
| Tiju Theccanat, Jennifer L Philip, Abdur M Razzaque, Nicholas Ludmer, Jinju Li, Xianyao Xu, Shahab A Akhte. Regulation of cellular oxidative stress and apoptosis by G protein-coupled receptor kinase-2; The role of NADPH oxidase 4. Cellular signalling. vol 28. issue 3. 2016-10-20. PMID:26631573. |
chronic β-agonist stimulation in mice increased nox4 expression and apoptosis compared to pbs or angii treatment. |
2016-10-20 |
2023-08-13 |
mouse |
| Weijun Ma, Jianping Li, Juan Hu, Ying Cheng, Junli Wang, Xiaotong Zhang, Min X. miR214-regulated p53-NOX4/p66shc pathway plays a crucial role in the protective effect of Ginkgolide B against cisplatin-induced cytotoxicity in HEI-OC1 cells. Chemico-biological interactions. vol 245. 2016-05-26. PMID:26768586. |
over-expression of nox4 or p66(shc) suppressed the inhibitory effects of gb on superoxide generation and the protective effects of gb on loss of cell viability and apoptosis associated with cisplatin. |
2016-05-26 |
2023-08-13 |
Not clear |
| Weijun Ma, Jianping Li, Juan Hu, Ying Cheng, Junli Wang, Xiaotong Zhang, Min X. miR214-regulated p53-NOX4/p66shc pathway plays a crucial role in the protective effect of Ginkgolide B against cisplatin-induced cytotoxicity in HEI-OC1 cells. Chemico-biological interactions. vol 245. 2016-05-26. PMID:26768586. |
over-expression of p53 suppressed the inhibitory effects of gb on nox4 and p66(shc) expression and superoxide generation and the protective effects of gb on loss of cell viability and apoptosis associated with cisplatin. |
2016-05-26 |
2023-08-13 |
Not clear |
| Hong-Feng Zhang, Ting-Bo Li, Bin Liu, Zheng Lou, Jie-Jie Zhang, Jing-Jie Peng, Xiao-Jie Zhang, Qi-Lin Ma, Jun Peng, Xiu-Ju Lu. Inhibition of myosin light chain kinase reduces NADPH oxidase-mediated oxidative injury in rat brain following cerebral ischemia/reperfusion. Naunyn-Schmiedeberg's archives of pharmacology. vol 388. issue 9. 2016-05-23. PMID:25920934. |
the results showed that i/r treatment led to increase in neurological deficit score, infarct volume and cellular apoptosis, accompanied by the elevated activities of mlck and nox, expressions of nox2 and nox4, levels of phosphorylation mlc20 and h2o2, these effects were attenuated by mlck specific inhibitor (ml-7). |
2016-05-23 |
2023-08-13 |
rat |
| Shuhui Guo, Xiuping Che. The human Nox4: gene, structure, physiological function and pathological significance. Journal of drug targeting. vol 23. issue 10. 2016-05-16. PMID:25950600. |
increased expression of nox4 in cancer has been observed, which participates in metastasis, angiogenesis and apoptosis. |
2016-05-16 |
2023-08-13 |
human |
| Ranjan Das, Shanhua Xu, Tuyet Thi Nguyen, Xianglan Quan, Seong-Kyung Choi, Soo-Jin Kim, Eun Young Lee, Seung-Kuy Cha, Kyu-Sang Par. Transforming Growth Factor β1-induced Apoptosis in Podocytes via the Extracellular Signal-regulated Kinase-Mammalian Target of Rapamycin Complex 1-NADPH Oxidase 4 Axis. The Journal of biological chemistry. vol 290. issue 52. 2016-05-10. PMID:26565025. |
we have reported previously that tgf-β1 induces the selective up-regulation of mitochondrial nox4, playing critical roles in podocyte apoptosis. |
2016-05-10 |
2023-08-13 |
Not clear |
| Ranjan Das, Shanhua Xu, Tuyet Thi Nguyen, Xianglan Quan, Seong-Kyung Choi, Soo-Jin Kim, Eun Young Lee, Seung-Kuy Cha, Kyu-Sang Par. Transforming Growth Factor β1-induced Apoptosis in Podocytes via the Extracellular Signal-regulated Kinase-Mammalian Target of Rapamycin Complex 1-NADPH Oxidase 4 Axis. The Journal of biological chemistry. vol 290. issue 52. 2016-05-10. PMID:26565025. |
here we investigated the regulatory mechanism of nox4 up-regulation by mtorc1 activation on tgf-β1-induced apoptosis in immortalized podocytes. |
2016-05-10 |
2023-08-13 |
Not clear |