| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cheng-Fang Yang, Yu-Juan Zhong, Zuheng Ma, Li Li, Lin Shi, Li Chen, Chen Li, Dan Wu, Qi Chen, Yong-Wen L. NOX4/ROS mediate ethanol‑induced apoptosis via MAPK signal pathway in L‑02 cells. International journal of molecular medicine. vol 41. issue 4. 2018-08-23. PMID:29336467. |
in conclusion, ethanol induced apoptosis in the l‑02 hepatocyte cell line via generation of ros and elevated expression of nox4. |
2018-08-23 |
2023-08-13 |
Not clear |
| Stellor Nlandu-Khodo, Romain Dissard, Udo Hasler, Matthias Schäfer, Haymo Pircher, Pidder Jansen-Durr, Karl Heinz Krause, Pierre-Yves Martin, Sophie de Seigneu. NADPH oxidase 4 deficiency increases tubular cell death during acute ischemic reperfusion injury. Scientific reports. vol 6. 2018-06-06. PMID:27924932. |
nox4 ko mice displayed decreased renal function and more severe tubular apoptosis, decreased bcl-2 expression and higher histologic damage scores compared to wt. |
2018-06-06 |
2023-08-13 |
mouse |
| Stellor Nlandu-Khodo, Romain Dissard, Udo Hasler, Matthias Schäfer, Haymo Pircher, Pidder Jansen-Durr, Karl Heinz Krause, Pierre-Yves Martin, Sophie de Seigneu. NADPH oxidase 4 deficiency increases tubular cell death during acute ischemic reperfusion injury. Scientific reports. vol 6. 2018-06-06. PMID:27924932. |
in vitro silencing of nox4 in cells showed an enhanced propensity to apoptosis, with reduced expression of nrf2, glutathione content and bcl-2 expression, similar to cells derived from nox4 ko mice. |
2018-06-06 |
2023-08-13 |
mouse |
| Joaquim Moreno-Càceres, Daniel Caballero-Díaz, Zeribe Chike Nwosu, Christoph Meyer, Judit López-Luque, Andrea Malfettone, Raquel Lastra, Teresa Serrano, Emilio Ramos, Steven Dooley, Isabel Fabrega. The level of caveolin-1 expression determines response to TGF-β as a tumour suppressor in hepatocellular carcinoma cells. Cell death & disease. vol 8. issue 10. 2018-06-04. PMID:29022911. |
apoptosis induced by tgf-β is mediated by upregulation of the nadph oxidase nox4, but counteracted by transactivation of the epidermal growth factor receptor (egfr) pathway. |
2018-06-04 |
2023-08-13 |
Not clear |
| Scott A Barman, David Fulto. Adventitial Fibroblast Nox4 Expression and ROS Signaling in Pulmonary Arterial Hypertension. Advances in experimental medicine and biology. vol 967. 2018-04-10. PMID:29047077. |
elevated production of reactive oxygen species (ros) by nadph oxidase 4 (nox4), a constitutively active enzyme, has been associated with oxygen sensing, vasomotor control, cellular proliferation, differentiation, migration, apoptosis, senescence, fibrosis, and angiogenesis. |
2018-04-10 |
2023-08-13 |
Not clear |
| Zhimin Zhang, Congying Wei, Yanfen Zhou, Tao Yan, Zhengqiang Wang, Wei Li, Lianyou Zha. Homocysteine Induces Apoptosis of Human Umbilical Vein Endothelial Cells via Mitochondrial Dysfunction and Endoplasmic Reticulum Stress. Oxidative medicine and cellular longevity. vol 2017. 2018-03-20. PMID:28630659. |
the inhibition of nox4 decreased the production of ros and alleviated the hcy-induced huvec apoptosis and er stress. |
2018-03-20 |
2023-08-13 |
human |
| Xiao-Lu Lin, Li Yang, Seng-Wang Fu, Wen-Feng Lin, Yun-Jie Gao, Hao-Yan Chen, Zhi-Zheng G. Overexpression of NOX4 predicts poor prognosis and promotes tumor progression in human colorectal cancer. Oncotarget. vol 8. issue 20. 2018-03-05. PMID:28422720. |
furthermore, we demonstrated that when nox4 expression was knocked down by sirnas, cell proliferation, cell-cycle and apoptosis, migration and invasion were significantly altered in crc cell lines hct116 and lovo. |
2018-03-05 |
2023-08-13 |
human |
| Xiao-Lu Lin, Li Yang, Seng-Wang Fu, Wen-Feng Lin, Yun-Jie Gao, Hao-Yan Chen, Zhi-Zheng G. Overexpression of NOX4 predicts poor prognosis and promotes tumor progression in human colorectal cancer. Oncotarget. vol 8. issue 20. 2018-03-05. PMID:28422720. |
meanwhile, nox4 promoted cancer cell proliferation and apoptosis, migration and invasion by regulating the expression of relevant genes. |
2018-03-05 |
2023-08-13 |
human |
| Min Yao, Feng Gao, Xiaomeng Wang, Yonghong Shi, Shuxia Liu, Huijun Dua. Nox4 is involved in high glucose-induced apoptosis in renal tubular epithelial cells via Notch pathway. Molecular medicine reports. vol 15. issue 6. 2018-02-23. PMID:28487945. |
nox4 is involved in high glucose-induced apoptosis in renal tubular epithelial cells via notch pathway. |
2018-02-23 |
2023-08-13 |
Not clear |
| Min Yao, Feng Gao, Xiaomeng Wang, Yonghong Shi, Shuxia Liu, Huijun Dua. Nox4 is involved in high glucose-induced apoptosis in renal tubular epithelial cells via Notch pathway. Molecular medicine reports. vol 15. issue 6. 2018-02-23. PMID:28487945. |
the present study aimed to examine the effect of nox4 on the alteration of the notch pathway and cell apoptosis in the renal tubular epithelial cell line, hkc, under conditions of high glucose (hg; 30 mmol/l glucose). |
2018-02-23 |
2023-08-13 |
Not clear |
| Min Yao, Feng Gao, Xiaomeng Wang, Yonghong Shi, Shuxia Liu, Huijun Dua. Nox4 is involved in high glucose-induced apoptosis in renal tubular epithelial cells via Notch pathway. Molecular medicine reports. vol 15. issue 6. 2018-02-23. PMID:28487945. |
the protein levels of nox4, notch1, notch intracellular domain 1 (nicd1), phosphorylated (p) ras‑related c3 botulinum toxin substrate 1 (rac1), rac1, b‑cell lymphoma 2 apoptosis regulator (bcl‑2), bcl‑2 associated protein x apoptosis regulator (bax) and cleaved caspase‑3 were determined by western blotting. |
2018-02-23 |
2023-08-13 |
Not clear |
| Min Yao, Feng Gao, Xiaomeng Wang, Yonghong Shi, Shuxia Liu, Huijun Dua. Nox4 is involved in high glucose-induced apoptosis in renal tubular epithelial cells via Notch pathway. Molecular medicine reports. vol 15. issue 6. 2018-02-23. PMID:28487945. |
inhibition of nox4 by nac and dpi inhibited the notch signaling pathway and ros generation, which prevented hkc cell apoptosis. |
2018-02-23 |
2023-08-13 |
Not clear |
| Min Yao, Feng Gao, Xiaomeng Wang, Yonghong Shi, Shuxia Liu, Huijun Dua. Nox4 is involved in high glucose-induced apoptosis in renal tubular epithelial cells via Notch pathway. Molecular medicine reports. vol 15. issue 6. 2018-02-23. PMID:28487945. |
these findings indicated that nox4 potentially mediates hg‑induced hkc cell apoptosis via the notch pathway, and may be involved in renal tubular epithelial cell injury in dn. |
2018-02-23 |
2023-08-13 |
Not clear |
| Xiao-Juan Zhang, Xiao-Qing Cao, Chun-Sheng Zhang, Zhuo Zha. 17β-estradiol protects against doxorubicin-induced cardiotoxicity in male Sprague-Dawley rats by regulating NADPH oxidase and apoptosis genes. Molecular medicine reports. vol 15. issue 5. 2018-02-16. PMID:28447737. |
these results demonstrate that e2 treatment may protect the heart against dox-induced cardiotoxicity in male rats potentially through the regulation of nox2, nox4 and apoptosis genes. |
2018-02-16 |
2023-08-13 |
rat |
| Cheng Zeng, Qipeng Wu, Jing Wang, Bei Yao, Lei Ma, Zhicheng Yang, Juan Li, Bing Li. NOX4 supports glycolysis and promotes glutamine metabolism in non-small cell lung cancer cells. Free radical biology & medicine. vol 101. 2017-12-29. PMID:27989748. |
specifically, the data showed that ectopic nox4 expression did not induce apoptosis of nsclc cells; however, inhibition of gsh production resulted in obvious apoptotic death of nox4-overexpressed nsclc cells. |
2017-12-29 |
2023-08-13 |
Not clear |
| Wenwen Zhao, Haitao Feng, Wen Sun, Kang Liu, Jin-Jian Lu, Xiuping Che. Tert-butyl hydroperoxide (t-BHP) induced apoptosis and necroptosis in endothelial cells: Roles of NOX4 and mitochondrion. Redox biology. vol 11. 2017-11-20. PMID:28088644. |
tert-butyl hydroperoxide (t-bhp) induced apoptosis and necroptosis in endothelial cells: roles of nox4 and mitochondrion. |
2017-11-20 |
2023-08-13 |
Not clear |
| Junwei Zhang, Suxia Yang, Huicong Li, Fang Chen, Jun Sh. Naringin ameliorates diabetic nephropathy by inhibiting NADPH oxidase 4. European journal of pharmacology. vol 804. 2017-11-10. PMID:28395989. |
loss of function indicated that nadph oxidases 4 (nox4) down-regulation suppressed apoptosis and reactive oxygen species level in hg-treated podocytes. |
2017-11-10 |
2023-08-13 |
rat |
| Shouji Matsushima, Junya Kuroda, Peiyong Zhai, Tong Liu, Shohei Ikeda, Narayani Nagarajan, Shin-Ichi Oka, Takashi Yokota, Shintaro Kinugawa, Chiao-Po Hsu, Hong Li, Hiroyuki Tsutsui, Junichi Sadoshim. Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling. The Journal of clinical investigation. vol 126. issue 9. 2017-09-26. PMID:27525436. |
fyn and nox4 colocalized in perinuclear mitochondria, er, and nuclear fractions in cms, and fyn expression negatively regulated nox4-induced o2- production and apoptosis in cms. |
2017-09-26 |
2023-08-13 |
mouse |
| Li Zhang, Zhen Li, Dongxia Feng, Haitao Shen, Xiaodi Tian, Haiying Li, Zhong Wang, Gang Che. Involvement of Nox2 and Nox4 NADPH oxidases in early brain injury after subarachnoid hemorrhage. Free radical research. vol 51. issue 3. 2017-07-31. PMID:28330417. |
consistently, in in vitro sah model, sirna-mediated silencing of nox2 and nox4 suppressed the oxyhb-induced neuronal apoptosis, whereas nox2 and nox4 co-knockdown also did not show a remarkable overlay effect. |
2017-07-31 |
2023-08-13 |
human |
| Qipeng Wu, Bei Yao, Ning Li, Lei Ma, Yanchao Deng, Yang Yang, Cheng Zeng, Zhicheng Yang, Bing Li. Nrf2 mediates redox adaptation in NOX4-overexpressed non-small cell lung cancer cells. Experimental cell research. vol 352. issue 2. 2017-05-26. PMID:28196727. |
our previous studies have confirmed that nadph oxidase 4 (nox4) is abundantly expressed in non-small cell lung cancer (nsclc) and confers apoptosis resistance on nsclc cells. |
2017-05-26 |
2023-08-13 |
Not clear |