| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Giovanna Scioli, Valerio Cervelli, Gaetano Arcuri, Pietro Gentile, Elena Doldo, Alessandra Bielli, Elena Bonanno, Augusto Orland. High insulin-induced down-regulation of Erk-1/IGF-1R/FGFR-1 signaling is required for oxidative stress-mediated apoptosis of adipose-derived stem cells. Journal of cellular physiology. vol 229. issue 12. 2014-10-20. PMID:24818995. |
insulin-induced apoptosis associated to reactive oxygen species (ros) accumulation and inhibition of nadph oxidase 4 (nox4) activity prevented asc apoptosis. |
2014-10-20 |
2023-08-13 |
human |
| Dorota Przybylska, Grazyna Mosienia. [The role of NADPH oxidase NOX4 in regulation of proliferation, senescence and differentiation of the cells]. Postepy biochemii. vol 60. issue 1. 2014-10-20. PMID:25033544. |
it was shown that nox4 has an impact on vasoconstriction, atherosclerosis development, vascular cells hypertrophy, apoptosis and differentiation. |
2014-10-20 |
2023-08-13 |
human |
| Hyo-Seol Lee, Jongeun Lee, Seong-Oh Kim, Je-Seon Song, Jae-Ho Lee, Syng-Ill Lee, Han-Sung Jung, Byung-Jai Cho. Comparative gene-expression analysis of the dental follicle and periodontal ligament in humans. PloS one. vol 8. issue 12. 2014-10-13. PMID:24376796. |
the most strongly expressed genes in the dental follicle were those related to bone development and remodeling (egfl6, mmp8, frzb, and nell1), apoptosis and chemotaxis (nox4, cxcl13, and ccl2), and tooth and embryo development (wnt2, pax3, fgf7, ambn, amtn, and slc4a4), while in the pdl it was the tumor-suppressor gene wif1. |
2014-10-13 |
2023-08-12 |
human |
| Masatake Tanaka, Kosuke Tanaka, Yuko Masaki, Masayuki Miyazaki, Masaki Kato, Kazuhiro Kotoh, Munechika Enjoji, Makoto Nakamuta, Ryoichi Takayanag. Intrahepatic microcirculatory disorder, parenchymal hypoxia and NOX4 upregulation result in zonal differences in hepatocyte apoptosis following lipopolysaccharide- and D-galactosamine-induced acute liver failure in rats. International journal of molecular medicine. vol 33. issue 2. 2014-09-18. PMID:24317376. |
intrahepatic microcirculatory disorder, parenchymal hypoxia and nox4 upregulation result in zonal differences in hepatocyte apoptosis following lipopolysaccharide- and d-galactosamine-induced acute liver failure in rats. |
2014-09-18 |
2023-08-12 |
rat |
| F Yan, Y Wang, X Wu, H M Peshavariya, G J Dusting, M Zhang, F Jian. Nox4 and redox signaling mediate TGF-β-induced endothelial cell apoptosis and phenotypic switch. Cell death & disease. vol 5. 2014-09-02. PMID:24457954. |
nox4 and redox signaling mediate tgf-β-induced endothelial cell apoptosis and phenotypic switch. |
2014-09-02 |
2023-08-12 |
human |
| F Yan, Y Wang, X Wu, H M Peshavariya, G J Dusting, M Zhang, F Jian. Nox4 and redox signaling mediate TGF-β-induced endothelial cell apoptosis and phenotypic switch. Cell death & disease. vol 5. 2014-09-02. PMID:24457954. |
in summary, our results suggest that nox4 and ros have pivotal roles in mediating tgf-β-induced endothelial apoptosis and phenotype specification. |
2014-09-02 |
2023-08-12 |
human |
| Jessica A Sipkens, Nynke Hahn, Carlien S van den Brand, Christof Meischl, Saskia A G M Cillessen, Desirée E C Smith, Lynda J M Juffermans, René J P Musters, Dirk Roos, Cornelis Jakobs, Henk J Blom, Yvo M Smulders, Paul A J Krijnen, Coen D A Stehouwer, Jan A Rauwerda, Victor W M van Hinsbergh, Hans W M Niesse. Homocysteine-induced apoptosis in endothelial cells coincides with nuclear NOX2 and peri-nuclear NOX4 activity. Cell biochemistry and biophysics. vol 67. issue 2. 2014-06-07. PMID:22038300. |
homocysteine-induced apoptosis in endothelial cells coincides with nuclear nox2 and peri-nuclear nox4 activity. |
2014-06-07 |
2023-08-12 |
human |
| Jessica A Sipkens, Nynke Hahn, Carlien S van den Brand, Christof Meischl, Saskia A G M Cillessen, Desirée E C Smith, Lynda J M Juffermans, René J P Musters, Dirk Roos, Cornelis Jakobs, Henk J Blom, Yvo M Smulders, Paul A J Krijnen, Coen D A Stehouwer, Jan A Rauwerda, Victor W M van Hinsbergh, Hans W M Niesse. Homocysteine-induced apoptosis in endothelial cells coincides with nuclear NOX2 and peri-nuclear NOX4 activity. Cell biochemistry and biophysics. vol 67. issue 2. 2014-06-07. PMID:22038300. |
the data presented in this article reveal accumulation of nuclear nox2 and peri-nuclear nox4 accumulation as potential source of ros production in hcy-induced apoptosis in endothelial cells. |
2014-06-07 |
2023-08-12 |
human |
| S-A Quast, A Berger, J Eberl. ROS-dependent phosphorylation of Bax by wortmannin sensitizes melanoma cells for TRAIL-induced apoptosis. Cell death & disease. vol 4. 2014-03-12. PMID:24113173. |
providing the link between ros and bax, we show that abrogated ros production by α-tocopherol or by nadph oxidase 4 (nox4) sirna suppressed apoptosis and bax activation. |
2014-03-12 |
2023-08-12 |
Not clear |
| Ranjan Das, Shanhua Xu, Xianglan Quan, Tuyet Thi Nguyen, In Deok Kong, Choon Hee Chung, Eun Young Lee, Seung-Kuy Cha, Kyu-Sang Par. Upregulation of mitochondrial Nox4 mediates TGF-β-induced apoptosis in cultured mouse podocytes. American journal of physiology. Renal physiology. vol 306. issue 2. 2014-03-06. PMID:24259511. |
upregulation of mitochondrial nox4 mediates tgf-β-induced apoptosis in cultured mouse podocytes. |
2014-03-06 |
2023-08-12 |
mouse |
| Ranjan Das, Shanhua Xu, Xianglan Quan, Tuyet Thi Nguyen, In Deok Kong, Choon Hee Chung, Eun Young Lee, Seung-Kuy Cha, Kyu-Sang Par. Upregulation of mitochondrial Nox4 mediates TGF-β-induced apoptosis in cultured mouse podocytes. American journal of physiology. Renal physiology. vol 306. issue 2. 2014-03-06. PMID:24259511. |
exogenous tgf-β1-induced podocyte apoptosis through caspase-3 activation, which was related to elevated ros levels generated by selective upregulation of nadph oxidase 4 (nox4). |
2014-03-06 |
2023-08-12 |
mouse |
| Ranjan Das, Shanhua Xu, Xianglan Quan, Tuyet Thi Nguyen, In Deok Kong, Choon Hee Chung, Eun Young Lee, Seung-Kuy Cha, Kyu-Sang Par. Upregulation of mitochondrial Nox4 mediates TGF-β-induced apoptosis in cultured mouse podocytes. American journal of physiology. Renal physiology. vol 306. issue 2. 2014-03-06. PMID:24259511. |
these results suggest that tgf-β1-induced mitochondrial nox4 upregulation via the tgf-β receptor-smad2/3 pathway is responsible for ros production, mitochondrial dysfunction, and apoptosis, which may at least in part contribute to the development and progression of proteinuric glomerular diseases such as diabetic nephropathy. |
2014-03-06 |
2023-08-12 |
mouse |
| Assaad A Eid, Bridget M Ford, Basant Bhandary, Rita de Cassia Cavaglieri, Karen Block, Jeffrey L Barnes, Yves Gorin, Goutam Ghosh Choudhury, Hanna E Abbou. Mammalian target of rapamycin regulates Nox4-mediated podocyte depletion in diabetic renal injury. Diabetes. vol 62. issue 8. 2013-10-01. PMID:23557706. |
inhibition of mtor by low-dose rapamycin decreases hg-induced nox4 and nox1, nadph oxidase activity, and podocyte apoptosis. |
2013-10-01 |
2023-08-12 |
mouse |
| Jian-Zhe Li, Shu-Yi Yu, Jian-Hua Wu, Qing-Rui Shao, Xiao-Min Don. Paeoniflorin protects myocardial cell from doxorubicin-induced apoptosis through inhibition of NADPH oxidase. Canadian journal of physiology and pharmacology. vol 90. issue 12. 2013-08-19. PMID:23210435. |
the results showed that dox significantly increased myocardial cell apoptosis, increased caspase-3 expression and activity concomitantly with enhanced ros production, and increased nox2, nox4 mrna and protein expression, and nox activity. |
2013-08-19 |
2023-08-12 |
Not clear |
| Jian-Zhe Li, Shu-Yi Yu, Jian-Hua Wu, Qing-Rui Shao, Xiao-Min Don. Paeoniflorin protects myocardial cell from doxorubicin-induced apoptosis through inhibition of NADPH oxidase. Canadian journal of physiology and pharmacology. vol 90. issue 12. 2013-08-19. PMID:23210435. |
our results suggested that pef has a protective effect against dox-induced myocardial cell apoptosis through a mechanism involving a decrease in ros production by inhibition of nox2, nox4 expression, and nox activity. |
2013-08-19 |
2023-08-12 |
Not clear |
| María U Moreno, Idoia Gallego, Begoña López, Arantxa González, Ana Fortuño, Gorka San José, Félix Valencia, Juan José Gómez-Doblas, Eduardo de Teresa, Ajay M Shah, Javier Díez, Guillermo Zalb. Decreased Nox4 levels in the myocardium of patients with aortic valve stenosis. Clinical science (London, England : 1979). vol 125. issue 6. 2013-07-23. PMID:23550626. |
nox4 levels directly correlated with cardiomyocyte cross-sectional area (r=0.299, p<0.05) and diameter (r=0.406, p<0.05) and capillary density (r=0.389, p<0.05), and inversely with cardiomyocyte apoptosis (r=-0.316, p<0.05) in as patients. |
2013-07-23 |
2023-08-12 |
human |
| Yong Wang, Chun Li, Yuli Ouyang, Tianjiao Shi, Xiaomin Yang, Junda Yu, Qi Qiu, Jing Han, Yan Wu, Binghua Tang, Wei Wan. QSYQ Attenuates Oxidative Stress and Apoptosis Induced Heart Remodeling Rats through Different Subtypes of NADPH-Oxidase. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-07-17. PMID:23861715. |
moreover, nox4 was another key targets to inhibit the p53 and caspase3, thus to reduce the hypertrophy and apoptosis, and eventually provide a synergetic cardiac protective effect. |
2013-07-17 |
2023-08-12 |
rat |
| Panfeng Fu, Vijay Mohan, Syed Mansoor, Chinnaswamy Tiruppathi, Ruxana T Sadikot, Viswanathan Nataraja. Role of nicotinamide adenine dinucleotide phosphate-reduced oxidase proteins in Pseudomonas aeruginosa-induced lung inflammation and permeability. American journal of respiratory cell and molecular biology. vol 48. issue 4. 2013-05-23. PMID:23306835. |
furthermore, the knockdown of nox4, but not nox2, with sirna reduced pa103-mediated apoptosis in hlmvecs. |
2013-05-23 |
2023-08-12 |
mouse |
| Panfeng Fu, Vijay Mohan, Syed Mansoor, Chinnaswamy Tiruppathi, Ruxana T Sadikot, Viswanathan Nataraja. Role of nicotinamide adenine dinucleotide phosphate-reduced oxidase proteins in Pseudomonas aeruginosa-induced lung inflammation and permeability. American journal of respiratory cell and molecular biology. vol 48. issue 4. 2013-05-23. PMID:23306835. |
these data show that p. aeruginosa lung infection up-regulates nox2 and nox4 expression and ros generation, which play distinct roles in regulating lung inflammation, apoptosis, and permeability. |
2013-05-23 |
2023-08-12 |
mouse |
| Yukiya Suzuki, Kozo Hattori, Junya Hamanaka, Tetsuji Murase, Yusuke Egashira, Keisuke Mishiro, Mitsunori Ishiguro, Kazuhiro Tsuruma, Yoshinobu Hirose, Hiroyuki Tanaka, Shinichi Yoshimura, Masamitsu Shimazawa, Naoki Inagaki, Hideko Nagasawa, Toru Iwama, Hideaki Har. Pharmacological inhibition of TLR4-NOX4 signal protects against neuronal death in transient focal ischemia. Scientific reports. vol 2. 2013-04-29. PMID:23193438. |
genetic and pharmacological inhibitions of tlr4 each reduced nox4 expression, leading to suppression of oxidative/nitrative stress and of neuronal apoptosis. |
2013-04-29 |
2023-08-12 |
mouse |