| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Assaad A Eid, Bridget M Ford, Karen Block, Balakuntalam S Kasinath, Yves Gorin, Goutam Ghosh-Choudhury, Jeffrey L Barnes, Hanna E Abbou. AMP-activated protein kinase (AMPK) negatively regulates Nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes. The Journal of biological chemistry. vol 285. issue 48. 2010-12-30. PMID:20861022. |
activation of ampk blocked hg-induced expression of nox4, nadph oxidase activity, and apoptosis. |
2010-12-30 |
2023-08-12 |
mouse |
| Assaad A Eid, Bridget M Ford, Karen Block, Balakuntalam S Kasinath, Yves Gorin, Goutam Ghosh-Choudhury, Jeffrey L Barnes, Hanna E Abbou. AMP-activated protein kinase (AMPK) negatively regulates Nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes. The Journal of biological chemistry. vol 285. issue 48. 2010-12-30. PMID:20861022. |
our results uncover a novel function of ampk that integrates metabolic input to nox4 and provide new insight for activation of p53 to induce podocyte apoptosis. |
2010-12-30 |
2023-08-12 |
mouse |
| Junya Kuroda, Junichi Sadoshim. NADPH oxidase and cardiac failure. Journal of cardiovascular translational research. vol 3. issue 4. 2010-11-16. PMID:20559780. |
nox4 is localized primarily at mitochondria in cardiac myocytes, and upregulation of nox4 hypertrophic stimuli enhances o(2)(-) production, apoptosis, and mitochondrial dysfunction, thereby playing an important role in mediating cardiac dysfunction. |
2010-11-16 |
2023-08-12 |
Not clear |
| Junya Kuroda, Tetsuro Ago, Shouji Matsushima, Peiyong Zhai, Michael D Schneider, Junichi Sadoshim. NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 35. 2010-11-15. PMID:20713697. |
in response to pressure overload (po), however, increases in nox4 expression and o(2)(-) production in mitochondria were abolished in c-nox4(-/-) mice, and c-nox4(-/-) mice exhibited significantly attenuated cardiac hypertrophy, interstitial fibrosis and apoptosis, and better cardiac function compared with wt mice. |
2010-11-15 |
2023-08-12 |
mouse |
| Junya Kuroda, Tetsuro Ago, Shouji Matsushima, Peiyong Zhai, Michael D Schneider, Junichi Sadoshim. NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 35. 2010-11-15. PMID:20713697. |
on the other hand, overexpression of nox4 in mouse hearts exacerbated cardiac dysfunction, fibrosis, and apoptosis in response to po. |
2010-11-15 |
2023-08-12 |
mouse |
| Xiao-Mei Bao, Chun-Fang Wu, Guo-Ping L. Atorvastatin inhibits homocysteine-induced oxidative stress and apoptosis in endothelial progenitor cells involving Nox4 and p38MAPK. Atherosclerosis. vol 210. issue 1. 2010-08-16. PMID:20018284. |
atorvastatin inhibits homocysteine-induced oxidative stress and apoptosis in endothelial progenitor cells involving nox4 and p38mapk. |
2010-08-16 |
2023-08-12 |
Not clear |
| David W Infanger, Xian Cao, Scott D Butler, Melissa A Burmeister, Yi Zhou, John A Stupinski, Ram V Sharma, Robin L Davisso. Silencing nox4 in the paraventricular nucleus improves myocardial infarction-induced cardiac dysfunction by attenuating sympathoexcitation and periinfarct apoptosis. Circulation research. vol 106. issue 11. 2010-07-09. PMID:20413786. |
silencing nox4 in the paraventricular nucleus improves myocardial infarction-induced cardiac dysfunction by attenuating sympathoexcitation and periinfarct apoptosis. |
2010-07-09 |
2023-08-12 |
Not clear |
| K Choi, S-W Ryu, S Song, H Choi, S W Kang, C Cho. Caspase-dependent generation of reactive oxygen species in human astrocytoma cells contributes to resistance to TRAIL-mediated apoptosis. Cell death and differentiation. vol 17. issue 5. 2010-06-28. PMID:19876066. |
these results collectively indicate that trail-induced activation of pkcdelta and nox4 can modulate trail-mediated apoptosis by promoting oxidative modification of active caspase-3 in a negative-feedback manner. |
2010-06-28 |
2023-08-12 |
human |
| Tetsuro Ago, Junya Kuroda, Jayashree Pain, Cexiong Fu, Hong Li, Junichi Sadoshim. Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes. Circulation research. vol 106. issue 7. 2010-04-30. PMID:20185797. |
upregulation of nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes. |
2010-04-30 |
2023-08-12 |
Not clear |
| Laia Caja, Patricia Sancho, Esther Bertran, Daniel Iglesias-Serret, Joan Gil, Isabel Fabrega. Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-{beta}-induced cell death through impairing up-regulation of the NADPH oxidase NOX4. Cancer research. vol 69. issue 19. 2009-12-03. PMID:19773433. |
we have recently reported that the apoptosis induced by tgf-beta in hepatocytes requires up-regulation of the nadph oxidase nox4, which mediates reactive oxygen species (ros) production. |
2009-12-03 |
2023-08-12 |
human |
| Laia Caja, Patricia Sancho, Esther Bertran, Daniel Iglesias-Serret, Joan Gil, Isabel Fabrega. Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-{beta}-induced cell death through impairing up-regulation of the NADPH oxidase NOX4. Cancer research. vol 69. issue 19. 2009-12-03. PMID:19773433. |
the aim of the present work was to analyze whether resistance to tgf-beta-induced apoptosis in hcc cells is related to the impairment of nox4 up-regulation due to overactivation of survival signals. |
2009-12-03 |
2023-08-12 |
human |
| Laia Caja, Patricia Sancho, Esther Bertran, Daniel Iglesias-Serret, Joan Gil, Isabel Fabrega. Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-{beta}-induced cell death through impairing up-regulation of the NADPH oxidase NOX4. Cancer research. vol 69. issue 19. 2009-12-03. PMID:19773433. |
in conclusion, overactivation of the mek/erk pathway in liver tumor cells confers resistance to tgf-beta-induced cell death through impairing nox4 up-regulation, which is required for an efficient mitochondrial-dependent apoptosis. |
2009-12-03 |
2023-08-12 |
human |
| Shyamali Basuroy, Sujoy Bhattacharya, Charles W Leffler, Helena Parfenov. Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells. American journal of physiology. Cell physiology. vol 296. issue 3. 2009-04-27. PMID:19118162. |
nox4 nadph oxidase mediates oxidative stress and apoptosis caused by tnf-alpha in cerebral vascular endothelial cells. |
2009-04-27 |
2023-08-12 |
Not clear |
| Shyamali Basuroy, Sujoy Bhattacharya, Charles W Leffler, Helena Parfenov. Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells. American journal of physiology. Cell physiology. vol 296. issue 3. 2009-04-27. PMID:19118162. |
nox4 small interfering rna, but not nox2, knockdown prevented oxidative stress and apoptosis caused by tnf-alpha in cmvec. |
2009-04-27 |
2023-08-12 |
Not clear |
| Shyamali Basuroy, Sujoy Bhattacharya, Charles W Leffler, Helena Parfenov. Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells. American journal of physiology. Cell physiology. vol 296. issue 3. 2009-04-27. PMID:19118162. |
we conclude that nox4 is the primary source of inflammation- and tnf-alpha-induced oxidative stress leading to apoptosis in brain endothelial cells. |
2009-04-27 |
2023-08-12 |
Not clear |
| Hao Pan, Partha Mukhopadhyay, Mohanraj Rajesh, Vivek Patel, Bani Mukhopadhyay, Bin Gao, György Haskó, Pál Pache. Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death. The Journal of pharmacology and experimental therapeutics. vol 328. issue 3. 2009-03-24. PMID:19074681. |
cisplatin induced increased expression of superoxide-generating enzymes renox (nox4) and nox1, enhanced reactive oxygen species generation, inducible nitric-oxide synthase expression, nitrotyrosine formation, apoptosis (caspase-3/7 activity, dna fragmentation, and terminal deoxynucleotidyl transferase dutp nick-end labeling staining), poly(adp-ribose) polymerase activity, and inflammation (tumor necrosis factor-alpha and interleukin-1beta) in the kidneys of mice, associated with marked histopathological damage and impaired renal function (elevated serum blood urea nitrogen and creatinine levels) 72 h after the administration of the drug. |
2009-03-24 |
2023-08-12 |
mouse |
| Shu Li, Sarvenaz Shafiei Tabar, Viktor Malec, Bastian G Eul, Walter Klepetko, Norbert Weissmann, Friedrich Grimminger, Werner Seeger, Frank Rose, Jörg Hänz. NOX4 regulates ROS levels under normoxic and hypoxic conditions, triggers proliferation, and inhibits apoptosis in pulmonary artery adventitial fibroblasts. Antioxidants & redox signaling. vol 10. issue 10. 2008-11-03. PMID:18593227. |
nox4 regulates ros levels under normoxic and hypoxic conditions, triggers proliferation, and inhibits apoptosis in pulmonary artery adventitial fibroblasts. |
2008-11-03 |
2023-08-12 |
Not clear |
| Shu Li, Sarvenaz Shafiei Tabar, Viktor Malec, Bastian G Eul, Walter Klepetko, Norbert Weissmann, Friedrich Grimminger, Werner Seeger, Frank Rose, Jörg Hänz. NOX4 regulates ROS levels under normoxic and hypoxic conditions, triggers proliferation, and inhibits apoptosis in pulmonary artery adventitial fibroblasts. Antioxidants & redox signaling. vol 10. issue 10. 2008-11-03. PMID:18593227. |
pafb proliferation was significantly decreased in cells transfected with nox4 sirna, whereas apoptosis was enhanced. |
2008-11-03 |
2023-08-12 |
Not clear |
| Shu Li, Sarvenaz Shafiei Tabar, Viktor Malec, Bastian G Eul, Walter Klepetko, Norbert Weissmann, Friedrich Grimminger, Werner Seeger, Frank Rose, Jörg Hänz. NOX4 regulates ROS levels under normoxic and hypoxic conditions, triggers proliferation, and inhibits apoptosis in pulmonary artery adventitial fibroblasts. Antioxidants & redox signaling. vol 10. issue 10. 2008-11-03. PMID:18593227. |
in conclusion, nox4 maintains ros levels under normoxic and hypoxic conditions and enhances proliferation and inhibits apoptosis of pafb. |
2008-11-03 |
2023-08-12 |
Not clear |
| Tadahisa Shono, Nobuhiko Yokoyama, Toshio Uesaka, Junya Kuroda, Ryu Takeya, Tomoko Yamasaki, Toshiyuki Amano, Masahiro Mizoguchi, Satoshi O Suzuki, Hiroaki Niiro, Kyoko Miyamoto, Koichi Akashi, Toru Iwaki, Hideki Sumimoto, Tomio Sasak. Enhanced expression of NADPH oxidase Nox4 in human gliomas and its roles in cell proliferation and survival. International journal of cancer. vol 123. issue 4. 2008-07-15. PMID:18508317. |
in addition, we show that specific knockdown of nox4 expression by rna interference results in cell-growth inhibition and enhances induction of apoptosis by chemotherapeutic agents, such as cisplatin, in cultured glioma cell lines. |
2008-07-15 |
2023-08-12 |
human |