| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yue Li, Hao Zhang, Feng Tu, Jing Cao, Hou Xiang, Yanan Chen, Junshu Ya. Effects of resveratrol and its derivative pterostilbene on hepatic injury and immunological stress of weaned piglets challenged with lipopolysaccharide. Journal of animal science. 2022-10-15. PMID:36242589. |
lipopolysaccharide stimulation caused massive apoptosis, activated inflammatory responses, and incited severe oxidative stress in the piglet livers while also promoting the nuclear translocation of nuclear factor kappa b (nf-κb) p65 (p < 0.001) and the protein expression of nod-like receptor pyrin domain containing 3 (nlrp3; p = 0.001) and cleaved caspase 1 (p < 0.001). |
2022-10-15 |
2023-08-14 |
Not clear |
| Lili Nie, Hui Zou, Chi Ma, Xiaoke Wan. miR-223-3p Regulates NLRP3 to Inhibit Proliferation and Promote Apoptosis of ONG Cells. Computational and mathematical methods in medicine. vol 2022. 2022-10-14. PMID:36238473. |
mir-223-3p regulates nlrp3 to inhibit proliferation and promote apoptosis of ong cells. |
2022-10-14 |
2023-08-14 |
Not clear |
| Yi-Hsin Wang, Jiuan-Miaw Liao, Ke-Min Chen, Hsing-Hui Su, Pei-Hsun Liu, Yi-Hung Chen, Yuang-Seng Tsuei, Chin-Feng Tsai, Shiang-Suo Huan. Lumbrokinase regulates endoplasmic reticulum stress to improve neurological deficits in ischemic stroke. Neuropharmacology. 2022-10-12. PMID:36223864. |
lumbrokinase dramatically decreased the expressions of the endoplasmic reticulum (er) transmembrane receptor protein inositol-requiring enzyme-1 (ire1) and its downstream transcription factor, xbp-1, caspase-12, and nf-κb activity, thereby significantly inhibiting apoptosis and autophagy and decreasing the nlrp3 inflammasome. |
2022-10-12 |
2023-08-14 |
mouse |
| Yicen Zhou, Qijing Wu, Zhenfang Du, Min Huang, Kun Gao, Xiaowei Ma, Hui Zhang, Sheng Qiang, Wei Su. Verbena Attenuates Adriamycin-Induced Renal Tubular Injury via Inhibition of ROS-ERK1/2-NLRP3 Signal Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-10-10. PMID:36212965. |
results showed that total aqueous exact of verbena (taev) ameliorated adr-induced cell disruption, loss of cellular viability, and apoptosis via inhibition of ros-erk1/2-mediated activation of nlrp3 signal pathway, suggesting that taev serves as a promising renoprotective agent in delaying the progression of ckd, while ros-erk1/2-mediated nlrp3 signal pathway might be a novel target in treating kidney diseases. |
2022-10-10 |
2023-08-14 |
Not clear |
| Fang Xu, Yi Wu, Qianyu Yang, Ying Cheng, Jialu Xu, Yue Zhang, Huaxing Dai, Beilei Wang, Qingle Ma, Yitong Chen, Fang Lin, Chao Wan. Engineered Extracellular Vesicles with SHP2 High Expression Promote Mitophagy for Alzheimer's Disease Treatment. Advanced materials (Deerfield Beach, Fla.). 2022-10-04. PMID:36193769. |
in addition, msc-evs-shp2 significantly induces mitophagy of neuronal cells, which alleviates mitochondrial damage-mediated apoptosis and nlrp3 inflammasome activation. |
2022-10-04 |
2023-08-14 |
mouse |
| Yongjun Cao, Yumeng Sun, Xiaowen Jin, Xiaoqian Li, Le Chen, Yan Qi. TIM4/NLRP3 axis participates in the effects of M1 macrophages on inflammatory factor release, apoptosis and cell adhesion in thyroid follicular cells. Experimental and therapeutic medicine. vol 24. issue 5. 2022-10-03. PMID:36185763. |
in summary, the present study demonstrated that tim4-silencing alleviated the inflammatory damage, apoptosis and cell adhesion of m1 macrophages co-cultured with nthy-ori 3-1 cells through downregulation of nlrp3. |
2022-10-03 |
2023-08-14 |
Not clear |
| Ling You, Yanjie Zheng, Jing Yang, Qian Hou, Lianxia Wang, Yan Zhang, Chunxia Zhao, Ruiqin Xi. LncRNA MDRL Mitigates Atherosclerosis through miR-361/SQSTM1/NLRP3 Signaling. Mediators of inflammation. vol 2022. 2022-10-03. PMID:36186576. |
here, we sought to determine that mitochondrial dynamic related lncrna (mdrl) modulates nlrp3 inflammasome activation and apoptosis of vascular smooth muscle cells (vsmcs) and protects arteries against atherosclerosis. |
2022-10-03 |
2023-08-14 |
Not clear |
| Umeharu Oht. Activation and regulation mechanisms of NOD-like receptors based on structural biology. Frontiers in immunology. vol 13. 2022-10-03. PMID:36189327. |
these include nod2, neuronal apoptosis inhibitory protein (naip)/nlrc4, nlr family pyrin domain containing 1 (nlrp1), nlrp3, nlrp6, and nlrp9. |
2022-10-03 |
2023-08-14 |
Not clear |
| Anna Perri, Sabrina Bossio, Vittoria Rago, Emanuela A Greco, Danilo Lofaro, Antonella LA Russa, Luigi DI Luigi, Sandro LA Vignera, Antonio Avers. NLRP3-inflammasome activation in male reproductive system diseases. Minerva endocrinology. 2022-09-30. PMID:36177957. |
recently, in vitro and animal models of both infectious and non-infectious male genital tract diseases affecting fertility, demonstrated the activation of the innate immune system, leading to increased levels of pro-inflammatory cytokines, as well as apoptosis and pyroptosis and that it was likely mediated by activation of the nlrp3 inflammasome. |
2022-09-30 |
2023-08-14 |
Not clear |
| Zhongyuan Zhou, Meng Wang, Chengyu Huang, Yan Li, Lin Gao, Yandong Zhu, Changjiang Ying, Xiaoyan Zho. Treadmill exercise training alleviates diabetes-induced depressive-like behavior and cognitive impairment by improving hippocampal CA1 neurons injury in db/db mice. Brain research bulletin. 2022-09-29. PMID:36174874. |
in summary, the results indicated that treadmill exercise training significantly ameliorates hippocampus injury by suppressing oxidative stress-induced apoptosis and nlrp3 inflammasome activation, consequently ameliorating diabetes-induced depressive-like behavior and cognitive impairment in db/db mice. |
2022-09-29 |
2023-08-14 |
mouse |
| Yao Xue, Yunqian Zhang, Li Chen, Yan Wang, Zhou Lv, Li-Qiao Yang, Siyuan L. Citrulline protects against LPS‑induced acute lung injury by inhibiting ROS/NLRP3‑dependent pyroptosis and apoptosis via the Nrf2 signaling pathway. Experimental and therapeutic medicine. vol 24. issue 4. 2022-09-26. PMID:36160882. |
citrulline pretreatment decreased the expression of nod-, lrr- and pyrin domain-containing protein 3 (nlrp3) inflammasome and decreased pyroptosis and apoptosis. |
2022-09-26 |
2023-08-14 |
mouse |
| Yao Xue, Yunqian Zhang, Li Chen, Yan Wang, Zhou Lv, Li-Qiao Yang, Siyuan L. Citrulline protects against LPS‑induced acute lung injury by inhibiting ROS/NLRP3‑dependent pyroptosis and apoptosis via the Nrf2 signaling pathway. Experimental and therapeutic medicine. vol 24. issue 4. 2022-09-26. PMID:36160882. |
intervention with the total reactive oxygen species (ros) scavenger n-acetyl-l-cysteine attenuated nlrp3 inflammasome-associated pyroptosis and apoptosis in lps-treated mlvecs. |
2022-09-26 |
2023-08-14 |
mouse |
| Yao Xue, Yunqian Zhang, Li Chen, Yan Wang, Zhou Lv, Li-Qiao Yang, Siyuan L. Citrulline protects against LPS‑induced acute lung injury by inhibiting ROS/NLRP3‑dependent pyroptosis and apoptosis via the Nrf2 signaling pathway. Experimental and therapeutic medicine. vol 24. issue 4. 2022-09-26. PMID:36160882. |
furthermore, the nrf2 inhibitor ml385 reversed ros generation, nlrp3 inflammasome-mediated pyroptosis and apoptosis suppressed by citrulline. |
2022-09-26 |
2023-08-14 |
mouse |
| Yanmin Gao, Di Xie, Yang Wang, Lei Niu, Hua Jian. Short-Chain Fatty Acids Reduce Oligodendrocyte Precursor Cells Loss by Inhibiting the Activation of Astrocytes via the SGK1/IL-6 Signalling Pathway. Neurochemical research. 2022-09-13. PMID:36098889. |
in this study, a rat model of hibi was established, and this study measured the changes in il-6 and nod-like receptor thermal protein domain associated protein 3 (nlrp3), in addition to proliferation and apoptosis indicators of oligodendrocyte precursor cells (opcs). |
2022-09-13 |
2023-08-14 |
rat |
| Nan Chen, Jie Deng, Zhihui Zhang, Xia Feng, Hongkang Wang, Jian Chen, Ling Li, Yemin Cao, Chenglin Jia, Yongbing Ca. Oxidative stress-triggered pyroptosis mediates Candida albicans susceptibility in diabetic foot. Microbial pathogenesis. 2022-09-10. PMID:36087690. |
notably, in this study, through the investigation of murine diabetic footpad c. albicans infection model and molecular biotechnology, including histopathological staining, immunofluorescence (if) staining, quantitative real-time pcr (qpcr), western blot (wb), flow cytometry (fcm), sandwich enzyme-linked immunosorbent assay (elisa) assays, we found that intense os responses in the footpad tissue not only mediated the activation of nf-κb protein complex, but also triggered downstream pyroptosis and apoptosis through nlrp3 inflammasome, which is one of the potential reasons for the severe condition of infectious skin injuries in diabetic mice. |
2022-09-10 |
2023-08-14 |
mouse |
| Mengran Yao, Zhuoran Wang, Leyu Jiang, Lingyan Wang, Yuqiao Yang, Quan Wang, Xi Qian, Weijun Zeng, Wei Yang, Rongbi Liang, Jinqiao Qia. Oxytocin ameliorates high glucose- and ischemia/reperfusion-induced myocardial injury by suppressing pyroptosis via AMPK signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-09-09. PMID:36076588. |
in addition, ot increased cell viability, decreased cell apoptosis and the expressions of il-18, il-1β, cleaved-caspase-1, nlrp3, and gsdmd following h/r. |
2022-09-09 |
2023-08-14 |
rat |
| Jing Luo, Ning Jiang, Jialei Chen, Gao Yu, Jing Zhao, Changhong Yang, Yong Zha. Inhibition of miR-423-5p exerts neuroprotective effects in an experimental rat model of cerebral ischemia/reperfusion injury. Neuroscience. 2022-09-06. PMID:36067951. |
subsequently, western blot, elisa, mpo, tunel and commercial assay kits were applied to assess the influence of mir-423-5p on nlrp3 inflammasome, apoptosis, and oxidative stress levels in ischemic penumbra tissue. |
2022-09-06 |
2023-08-14 |
rat |
| Jing Luo, Ning Jiang, Jialei Chen, Gao Yu, Jing Zhao, Changhong Yang, Yong Zha. Inhibition of miR-423-5p exerts neuroprotective effects in an experimental rat model of cerebral ischemia/reperfusion injury. Neuroscience. 2022-09-06. PMID:36067951. |
the results showed that mir-423-5p knockdown could effectively improve neurological indicators, such as cerebral infarct volume, brain water content, neurological scores, and nerve tissue damage, and inhibit the nlrp3 inflammasome, apoptosis, and oxidative stress. |
2022-09-06 |
2023-08-14 |
rat |
| Hui Fan, Jiajia Cui, Feixue Liu, Wei Zhang, Haitao Yang, Nana He, Zibo Dong, Jingquan Don. Malvidin protects against lipopolysaccharide-induced acute liver injury in mice via regulating Nrf2 and NLRP3 pathways and suppressing apoptosis and autophagy. European journal of pharmacology. 2022-09-05. PMID:36063870. |
malvidin protects against lipopolysaccharide-induced acute liver injury in mice via regulating nrf2 and nlrp3 pathways and suppressing apoptosis and autophagy. |
2022-09-05 |
2023-08-14 |
mouse |
| Hui Fan, Jiajia Cui, Feixue Liu, Wei Zhang, Haitao Yang, Nana He, Zibo Dong, Jingquan Don. Malvidin protects against lipopolysaccharide-induced acute liver injury in mice via regulating Nrf2 and NLRP3 pathways and suppressing apoptosis and autophagy. European journal of pharmacology. 2022-09-05. PMID:36063870. |
in conclusion, our study firstly suggests that malvidin is a potentially protective agent against lps-induced ali through up-regulating nrf2 signaling pathway, suppressing nlrp3 inflammasome and inhibiting apoptosis and autophagy. |
2022-09-05 |
2023-08-14 |
mouse |