| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Can Li, Yuying Zhu, Weiwei Liu, Toshihiko Hayashi, Wendie Xiang, Sijun He, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejim. Increased mitochondrial fission induces NLRP3/cGAS-STING mediated pro-inflammatory pathways and apoptosis in UVB-irradiated immortalized human keratinocyte HaCaT cells. Archives of biochemistry and biophysics. 2023-03-06. PMID:36878340. |
application of an antioxidant, n-acetyl-l-cysteine (nac), which scavenges excessive ros, attenuated inflammatory responses through suppressing nlrp3 inflammasome and cgas-sting pathway activation, and rescued cells from apoptosis caused by uvb-irradiation. |
2023-03-06 |
2023-08-14 |
human |
| Jing Ma, Yun Xu, Min Zhang, Yi L. Geraniol ameliorates acute liver failure induced by lipopolysaccharide/D-galactosamine via regulating macrophage polarization and NLRP3 inflammasome activation by PPAR-γ methylation Geraniol alleviates acute liver failure. Biochemical pharmacology. 2023-02-27. PMID:36849063. |
in vitro, ger reduced the activation of nlrp3 inflammasome and apoptosis through regulating ppar-γ methylation by inhibiting m1 macrophage polarization. |
2023-02-27 |
2023-08-14 |
mouse |
| Wanglong Zheng, Anjing Liu, Nengwen Xia, Nanhua Chen, François Meurens, Jianzhong Zh. How the Innate Immune DNA Sensing cGAS-STING Pathway Is Involved in Apoptosis. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36769349. |
the cgas-sting pathway can induce apoptosis through er stress, nlrp3, nf-κb, irf3, and ifn signals. |
2023-02-11 |
2023-08-14 |
Not clear |
| Dongcai Liu, Qingquan Tian, Kuijie Liu, Feng Ren, Ganglei Liu, Jingyu Zhou, Lianwen Yuan, Zhixue Fang, Bing Zou, Shalong Wan. Ginsenoside Rg3 Ameliorates DSS-Induced Colitis by Inhibiting NLRP3 Inflammasome Activation and Regulating Microbial Homeostasis. Journal of agricultural and food chemistry. 2023-02-08. PMID:36752740. |
the results showed that gin rg3 inhibited nlrp3 inflammasome activation, pyroptosis, and apoptosis in vitro and in vivo. |
2023-02-08 |
2023-08-14 |
mouse |
| Tahmineh Mokhtari, Lu-Peng Yue, Li H. Exogenous melatonin alleviates neuropathic pain-induced affective disorders by suppressing NF-κB/ NLRP3 pathway and apoptosis. Scientific reports. vol 13. issue 1. 2023-02-07. PMID:36747075. |
exogenous melatonin alleviates neuropathic pain-induced affective disorders by suppressing nf-κb/ nlrp3 pathway and apoptosis. |
2023-02-07 |
2023-08-14 |
rat |
| Mélanie Bodnar-Wachtel, Anne-Laure Huber, Julie Gorry, Sabine Hacot, Delphine Burlet, Laetitia Gérossier, Baptiste Guey, Nadège Goutagny, Birke Bartosch, Elise Ballot, Julie Lecuelle, Caroline Truntzer, François Ghiringhelli, Bénédicte F Py, Yohann Couté, Annabelle Ballesta, Sylvie Lantuejoul, Janet Hall, Agnès Tissier, Virginie Petrill. Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stress. Life science alliance. vol 6. issue 4. 2023-02-06. PMID:36746533. |
nlrp3 down-regulation in both broncho- and mammary human epithelial cells significantly impairs atm pathway activation, leading to lower p53 activation, and provides cells with the ability to resist apoptosis induced by acute genotoxic stress. |
2023-02-06 |
2023-08-14 |
human |
| Hao-Yue Feng, Rui Ding, Qi Zhou, Ting-Chao Wu, Hui Li, Xi-Tao Ma, Ren-Song Yu. [Role of NLRP3 inflammasome in diabetic neuropathy and prevention and treatment with traditional Chinese medicine]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 2. 2023-02-01. PMID:36725219. |
nod-like receptor pyrin domain-containing 3(nlrp3) inflammasome is a group of subcellular multiprotein complexes, including nlrp3, apoptosis associated speck-like protein(asc), and pro-cysteinyl aspartate specific proteinase 1(pro-caspase-1). |
2023-02-01 |
2023-08-14 |
Not clear |
| Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James M Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, Marc Pellegrini, Marco Herold, Ivan K H Poon, Seth L Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lanlan Geng, James E Vinc. Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency. The EMBO journal. 2023-01-17. PMID:36647737. |
neither caspase-3 and caspase-7-mediated activation of the pannexin-1 channel, or gsdmd loss, prevented nlrp3 inflammasome assembly and consequent caspase-1 and il-1β maturation downstream of xiap inhibition and caspase-8 activation, even though the pannexin-1 channel was required for nlrp3 triggering upon mitochondrial apoptosis. |
2023-01-17 |
2023-08-14 |
Not clear |
| Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James M Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, Marc Pellegrini, Marco Herold, Ivan K H Poon, Seth L Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lanlan Geng, James E Vinc. Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency. The EMBO journal. 2023-01-17. PMID:36647737. |
these findings uncouple the mechanisms of cell death and nlrp3 activation resulting from extrinsic and intrinsic apoptosis signalling, reveal how xiap loss can co-opt dual cell death programs, and uncover strategies for targeting the cell death and inflammatory pathways that result from xiap deficiency. |
2023-01-17 |
2023-08-14 |
Not clear |
| Chenyun Song, Xinyu Chen, Jixin Ma, Hada Buhe, Yang Liu, Hexige Saiyin, Lixiang M. Construction of a pancreatic cancer nerve invasion system using brain and pancreatic cancer organoids. Journal of tissue engineering. vol 14. 2023-01-13. PMID:36636100. |
the approximating of mpcos to hbros accelerated the proliferation of neuronal progenitor cells, intensified the apoptosis of neurons in the hbros, and increased the expression of inflammatory molecules in hbros, including nlrp3, il-8, and il-1β. |
2023-01-13 |
2023-08-14 |
mouse |
| Zongqi You, Xinying Huang, Yaoxian Xiang, Junxi Dai, Lei Xu, Junjian Jiang, Jianguang X. Ablation of NLRP3 inflammasome attenuates muscle atrophy via inhibiting pyroptosis, proteolysis and apoptosis following denervation. Theranostics. vol 13. issue 1. 2023-01-03. PMID:36593964. |
ablation of nlrp3 inflammasome attenuates muscle atrophy via inhibiting pyroptosis, proteolysis and apoptosis following denervation. |
2023-01-03 |
2023-08-14 |
Not clear |
| Anil Kumar Kalvala, Ramesh Nimma, Arvind Bagde, Sunil Kumar Surapaneni, Nilkumar Patel, Peggy Arthur, Li Sun, Rakesh Singh, Nagavendra Kommineni, Aakash Nathani, Yan Li, Mandip Sing. The role of Cannabidiol and tetrahydrocannabivarin to overcome doxorubicin resistance in MDA-MB-231 xenografts in athymic nude mice. Biochimie. 2022-12-19. PMID:36535544. |
transcriptomics and proteomics studies revealed that cbd and thcv, by downregulating pd-l1, tgf-β, sp1, nlrp3, p38-mapk, and upregulating ampk induced apoptosis leading to improved dox's chemosensitivity against dox resistant mda-mb-231 tumors in balb/c nude mice. |
2022-12-19 |
2023-08-14 |
mouse |
| Dexiang Xia, Yanmei Chen, Guifang Luo, Dangheng We. Atherosclerosis: from the disruption of mitochondrial membrane potential to the potential interventional strategies. Current medicinal chemistry. 2022-12-05. PMID:36464879. |
recent studies have shown that disruption of the mitochondrial membrane potential (deltapsi (m)) directly affects the electron transport chain (etc), which in turn leads to oxidative stress, and furthermore, its alteration leads to apoptosis and activation of the nlrp3 inflammasome, thereby promoting the development of as. |
2022-12-05 |
2023-08-14 |
Not clear |
| Dexiang Xia, Yanmei Chen, Guifang Luo, Dangheng We. Atherosclerosis: from the disruption of mitochondrial membrane potential to the potential interventional strategies. Current medicinal chemistry. 2022-12-05. PMID:36464879. |
here, this review describes how deltapsi (m) contributes to the development of as by mediating oxidative stress, apoptosis, and nlrp3 inflammasome activation, and potential as intervention strategies by targeting oxidative stress, apoptosis, and nlrp3 inflammasome activation induced by deltapsi (m). |
2022-12-05 |
2023-08-14 |
Not clear |
| Jingwen Cao, Ran Xu, Fuhan Wang, Yuan Geng, Tianchao Xu, Mengran Zhu, Hongli Lv, Shiwen Xu, Meng-Yao Gu. Polyethylene microplastics trigger cell apoptosis and inflammation via inducing oxidative stress and activation of the NLRP3 inflammasome in carp gills. Fish & shellfish immunology. 2022-12-05. PMID:36470402. |
polyethylene microplastics trigger cell apoptosis and inflammation via inducing oxidative stress and activation of the nlrp3 inflammasome in carp gills. |
2022-12-05 |
2023-08-14 |
Not clear |
| Jingwen Cao, Ran Xu, Fuhan Wang, Yuan Geng, Tianchao Xu, Mengran Zhu, Hongli Lv, Shiwen Xu, Meng-Yao Gu. Polyethylene microplastics trigger cell apoptosis and inflammation via inducing oxidative stress and activation of the NLRP3 inflammasome in carp gills. Fish & shellfish immunology. 2022-12-05. PMID:36470402. |
these results suggested that oxidative stress acted as an activation signal of apoptosis triggered by the nf-κb pathway and activating the nlrp3 inflammasome to promote inflammatory immune responses. |
2022-12-05 |
2023-08-14 |
Not clear |
| Tengfei Wang, Yufei Xiao, Ronglong Luo, Yingjie Wang, Mengyun Zou, Yingfei Sun, Lulu Wang, Qiao Guo, Xiuli Pen. Host resistance to Mycoplasma gallisepticum infection is enhanced by inhibiting PI3K/Akt pathway in Andrographolide-treating chickens. International immunopharmacology. vol 113. issue Pt A. 2022-12-03. PMID:36461587. |
furthermore, ag treatment down-regulated inflammasome nlrp3 and apoptosis genes caspase3 and caspase9, and up-regulated autophagy protein light chain 3 (lc3) by regulating the pi3k/akt signaling pathway in vitro. |
2022-12-03 |
2023-08-14 |
chicken |
| Zhiguang Liu, Xiaochun Zhu, Chenglin Xu, Feng Min, Guofeng Yu, Chuhong Che. Ulinastatin ameliorates the malignant progression of prostate cancer cells by blocking the RhoA/ROCK/NLRP3 pathway. Drug development research. 2022-12-03. PMID:36461611. |
in addition, pc-3 cells were pretreated with rhoa agonist cn03 (1 μg/ml) or nlrp3 agonist nigericin (10 μm) before uti treatment, and the cellular behaviors above were detected again. it was demonstrated that uti significantly suppressed cell proliferation, migration, and invasion but promoted apoptosis in pc-3 cells in a concentration-dependent manner. |
2022-12-03 |
2023-08-14 |
Not clear |
| Zhiguang Liu, Xiaochun Zhu, Chenglin Xu, Feng Min, Guofeng Yu, Chuhong Che. Ulinastatin ameliorates the malignant progression of prostate cancer cells by blocking the RhoA/ROCK/NLRP3 pathway. Drug development research. 2022-12-03. PMID:36461611. |
meanwhile, uti could block rhoa/rock/nlrp3 inflammasome pathway in pc-3 cells, and the activation of rhoa or nlrp3 inflammasome partly weakened the impacts of uti on cell proliferation, migration, and apoptosis in pc-3 cells, respectively. in summary, our study demonstrated the antitumor activity of uti against prostate cancer by regulating rhoa/nlrp3 inflammasome pathway, providing a promising candidate drug for the therapeutic treatment of prostate cancer. |
2022-12-03 |
2023-08-14 |
Not clear |
| Jianbo Zhou, Qinzhi Wan. Daphnoretin relieves IL-1β-mediated chondrocytes apoptosis via repressing endoplasmic reticulum stress and NLRP3 inflammasome. Journal of orthopaedic surgery and research. vol 17. issue 1. 2022-11-17. PMID:36384642. |
daphnoretin relieves il-1β-mediated chondrocytes apoptosis via repressing endoplasmic reticulum stress and nlrp3 inflammasome. |
2022-11-17 |
2023-08-14 |
Not clear |