| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ginevra Licandro, Hwei Ling Khor, Ottavio Beretta, Junyun Lai, Heidi Derks, Federica Laudisi, Cristina Conforti-Andreoni, Hong Liang Qian, Gim Gee Teng, Paola Ricciardi-Castagnoli, Alessandra Mortellar. The NLRP3 inflammasome affects DNA damage responses after oxidative and genotoxic stress in dendritic cells. European journal of immunology. vol 43. issue 8. 2013-10-31. PMID:23619996. |
using a transcriptomic approach, we found that dcs from nlrp3(-/-) mice responded to msu with differential expression of genes involved in the dna damage response and apoptosis. |
2013-10-31 |
2023-08-12 |
mouse |
| Stefanie Haasken, Fayyaz S Sutterwal. Damage control: management of cellular stress by the NLRP3 inflammasome. European journal of immunology. vol 43. issue 8. 2013-10-31. PMID:23928964. |
in addition, activation of the nlrp3 inflammasome modulates a number of pathways involved in dna damage repair, cell cycle, and apoptosis, suggesting a novel role for the nlrp3 inflammasome in dna damage responses following cellular stress. |
2013-10-31 |
2023-08-12 |
Not clear |
| Ryan W Grant, Vishwa D Dixi. Mechanisms of disease: inflammasome activation and the development of type 2 diabetes. Frontiers in immunology. vol 4. 2013-03-14. PMID:23483669. |
the secretion of bioactive il-1β is predominantly controlled by activation of caspase-1 through assembly of a multiprotein scaffold, "inflammasome" that is composed of nlrp3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) asc (apoptosis associated speck-like protein containing a card) and procaspase-1. |
2013-03-14 |
2023-08-12 |
Not clear |
| Takhellambam S Devi, Icksoo Lee, Maik Hüttemann, Ashok Kumar, Kwaku D Nantwi, Lalit P Sing. TXNIP links innate host defense mechanisms to oxidative stress and inflammation in retinal Muller glia under chronic hyperglycemia: implications for diabetic retinopathy. Experimental diabetes research. vol 2012. 2012-07-26. PMID:22474421. |
various cellular defense mechanisms are activated by hg: (i) nlrp3 inflammasome, (ii) er stress response (sxbp1), (iii) hypoxic-like hif-1α induction, (iv) autophagy/mitophagy, and (v) apoptosis. |
2012-07-26 |
2023-08-12 |
rat |
| Kenichi Shimada, Timothy R Crother, Justin Karlin, Jargalsaikhan Dagvadorj, Norika Chiba, Shuang Chen, V Krishnan Ramanujan, Andrea J Wolf, Laurent Vergnes, David M Ojcius, Altan Rentsendorj, Mario Vargas, Candace Guerrero, Yinsheng Wang, Katherine A Fitzgerald, David M Underhill, Terrence Town, Moshe Ardit. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity. vol 36. issue 3. 2012-05-18. PMID:22342844. |
oxidized mitochondrial dna activates the nlrp3 inflammasome during apoptosis. |
2012-05-18 |
2023-08-12 |
Not clear |
| Kenichi Shimada, Timothy R Crother, Justin Karlin, Jargalsaikhan Dagvadorj, Norika Chiba, Shuang Chen, V Krishnan Ramanujan, Andrea J Wolf, Laurent Vergnes, David M Ojcius, Altan Rentsendorj, Mario Vargas, Candace Guerrero, Yinsheng Wang, Katherine A Fitzgerald, David M Underhill, Terrence Town, Moshe Ardit. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity. vol 36. issue 3. 2012-05-18. PMID:22342844. |
nlrp3 secondary signal activators such as atp induced mitochondrial dysfunction and apoptosis, resulting in release of oxidized mitochondrial dna (mtdna) into the cytosol, where it bound to and activated the nlrp3 inflammasome. |
2012-05-18 |
2023-08-12 |
Not clear |
| Kenichi Shimada, Timothy R Crother, Justin Karlin, Jargalsaikhan Dagvadorj, Norika Chiba, Shuang Chen, V Krishnan Ramanujan, Andrea J Wolf, Laurent Vergnes, David M Ojcius, Altan Rentsendorj, Mario Vargas, Candace Guerrero, Yinsheng Wang, Katherine A Fitzgerald, David M Underhill, Terrence Town, Moshe Ardit. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity. vol 36. issue 3. 2012-05-18. PMID:22342844. |
mitochondrial dna directly induced nlrp3 inflammasome activation, because macrophages lacking mtdna had severely attenuated il-1β production, yet still underwent apoptosis. |
2012-05-18 |
2023-08-12 |
Not clear |
| Kenichi Shimada, Timothy R Crother, Justin Karlin, Jargalsaikhan Dagvadorj, Norika Chiba, Shuang Chen, V Krishnan Ramanujan, Andrea J Wolf, Laurent Vergnes, David M Ojcius, Altan Rentsendorj, Mario Vargas, Candace Guerrero, Yinsheng Wang, Katherine A Fitzgerald, David M Underhill, Terrence Town, Moshe Ardit. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity. vol 36. issue 3. 2012-05-18. PMID:22342844. |
these results provide a missing link between apoptosis and inflammasome activation, via binding of cytosolic oxidized mtdna to the nlrp3 inflammasome. |
2012-05-18 |
2023-08-12 |
Not clear |
| Nao Jounai, Kouji Kobiyama, Masaaki Shiina, Kazuhiro Ogata, Ken J Ishii, Fumihiko Takeshit. NLRP4 negatively regulates autophagic processes through an association with beclin1. Journal of immunology (Baltimore, Md. : 1950). vol 186. issue 3. 2011-03-07. PMID:21209283. |
in this article, we show that nlr members, such as nlrc4, nlrp3, nlrp4, and nlrp10 interact with beclin1, an important regulator of autophagy, through their neuronal apoptosis inhibitory protein, mhc class ii transcription activator, incompatibility locus protein from podospora anserina, and telomerase-associated protein domain. |
2011-03-07 |
2023-08-12 |
Not clear |
| Kou Motani, Kouji Kawase, Ryu Imamura, Takeshi Kinoshita, Hiroko Kushiyama, Takashi Sud. Activation of ASC induces apoptosis or necrosis, depending on the cell type, and causes tumor eradication. Cancer science. vol 101. issue 8. 2010-08-18. PMID:20500518. |
here, we found that asc activation using nlrc4 mimicry or an autoinflammatory disease-associated nlrp3 mutant induced necrosis in colo205 colon adenocarcinoma cells, but induced caspase-8-dependent apoptosis in nugc-4 stomach cancer cells. |
2010-08-18 |
2023-08-12 |
mouse |