| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min Chen, Zhihong Li, Longbiao Da, Jie Liu, Chun Huang, Zhengjiang Zh. LncRNA PVT1 Promotes Intracranial Aneurysm Development via USP10/KLF4/NLRP3 Axis-Mediated Pyroptosis in Human Cerebral Smooth Muscle Cells. Journal of biochemical and molecular toxicology. vol 39. issue 1. 2024-12-24. PMID:39717929. |
we assessed cell apoptosis and measured the levels of il-18, il-1β, nlrp3, asc, gsdmd-n, cleaved-caspase-3, and cleaved-caspase-1. |
2024-12-24 |
2024-12-26 |
human |
| Mingyan Chen, Yanfang Zhang, Yangbo Zhao, Kewei Cao, Ruiyan Niu, Dongguang Guo, Zilong Su. Complex immunotoxic effects of T-2 Toxin on the murine spleen and thymus: Oxidative damage, inflammasomes, apoptosis, and immunosuppression. Ecotoxicology and environmental safety. vol 289. 2024-12-07. PMID:39644562. |
the key mechanisms identified include oxidative stress, activation of the nlrp3 inflammasome, apoptosis, and mitochondrial dysfunction. |
2024-12-07 |
2024-12-10 |
mouse |
| Ruedeemars Yubolphan, Anongporn Kobroob, Apisek Kongkaew, Natthakarn Chiranthanut, Natthanicha Jinadang, Orawan Wongmekia. Berberine Mitigates Sepsis-Associated Acute Kidney Injury in Aged Rats by Preserving Mitochondrial Integrity and Inhibiting TLR4/NF-κB and NLRP3 Inflammasome Activations. Antioxidants (Basel, Switzerland). vol 13. issue 11. 2024-11-27. PMID:39594541. |
key indicators of kidney oxidative stress, mitochondrial dysfunction, apoptosis, and activations of the toll-like receptor 4/nuclear factor-kappa b (tlr4/nf-κb) signaling, including the nucleotide-binding domain, leucine-rich-containing family, and pyrin domain-containing-3 (nlrp3) inflammasome pathway, were also elevated following clp induction. |
2024-11-27 |
2024-11-29 |
rat |
| Xiaopei Huang, Wenliang Zhu, Huifeng Zhang, Shi Qiu, Huanzhang Sha. SARS-CoV-2 N protein induces alveolar epithelial apoptosis via NLRP3 pathway in ARDS. International immunopharmacology. vol 144. 2024-11-26. PMID:39591821. |
sars-cov-2 n protein induces alveolar epithelial apoptosis via nlrp3 pathway in ards. |
2024-11-26 |
2024-11-29 |
mouse |
| Xiaopei Huang, Wenliang Zhu, Huifeng Zhang, Shi Qiu, Huanzhang Sha. SARS-CoV-2 N protein induces alveolar epithelial apoptosis via NLRP3 pathway in ARDS. International immunopharmacology. vol 144. 2024-11-26. PMID:39591821. |
in vitro experiments demonstrated that n protein overexpression in mh-s macrophages activates the nlrp3 pathway, promoting m1 macrophage polarization and inducing apoptosis in co-cultured mle-12 epithelial cells. |
2024-11-26 |
2024-11-29 |
mouse |
| Xiaopei Huang, Wenliang Zhu, Huifeng Zhang, Shi Qiu, Huanzhang Sha. SARS-CoV-2 N protein induces alveolar epithelial apoptosis via NLRP3 pathway in ARDS. International immunopharmacology. vol 144. 2024-11-26. PMID:39591821. |
these results suggest that the sars-cov-2 n protein activates the nlrp3 signaling pathway, driving m1 macrophage polarization and the release of pro-inflammatory factors, thereby inducing alveolar epithelial cell apoptosis and worsening ards. |
2024-11-26 |
2024-11-29 |
mouse |
| Rong Yan, Xinghua Liang, Juan H. MALAT1 promotes colonic epithelial cell apoptosis and pyroptosis by sponging miR-22-3p to enhance NLRP3 expression. PeerJ. vol 12. 2024-11-22. PMID:39575175. |
malat1 promotes colonic epithelial cell apoptosis and pyroptosis by sponging mir-22-3p to enhance nlrp3 expression. |
2024-11-22 |
2024-11-24 |
Not clear |
| Yue Wang, Yuhang Wu, Jiayu Ren, Ying Wang, Imran Perwaiz, Hongtong Su, Jing Li, Peng Q. Pharmacological inhibition of the NLRP3 inflammasome attenuates kidney apoptosis, fibrosis, and injury in Dahl salt-sensitive rats. Clinical and experimental nephrology. 2024-11-22. PMID:39576390. |
pharmacological inhibition of the nlrp3 inflammasome attenuates kidney apoptosis, fibrosis, and injury in dahl salt-sensitive rats. |
2024-11-22 |
2024-11-24 |
rat |
| b' Benedikt S Saller, Svenja W\\xc3\\xb6hrle, Larissa Fischer, Clara Dufossez, Isabella L Ingerl, Susanne Kessler, Maria Mateo-Tortola, Oliver Gorka, Felix Lange, Yurong Cheng, Emilia Neuwirt, Adinarayana Marada, Christoph Koentges, Chiara Urban, Philipp Aktories, Peter Reuther, Sebastian Giese, Susanne Kirschnek, Carolin Mayer, Johannes Pilic, Hugo Falquez-Medina, Aline Oelgeklaus, Veerasikku Gopal Deepagan, Farzaneh Shojaee, Julia A Zimmermann, Damian Weber, Yi-Heng Tai, Anna Crois, Kevin Ciminski, Remi Peyronnet, Katharina S Brandenburg, Gang Wu, Ralf Baumeister, Thomas Heimbucher, Marta Rizzi, Dietmar Riedel, Martin Helmst\\xc3\\xa4dter, Joerg Buescher, Konstantin Neumann, Thomas Misgeld, Martin Kerschensteiner, Peter Walentek, Clemens Kreutz, Ulrich Maurer, Angelika S Rambold, James E Vince, Frank Edlich, Roland Malli, Georg H\\xc3\\xa4cker, Katrin Kierdorf, Chris Meisinger, Anna K\\xc3\\xb6ttgen, Stefan Jakobs, Alexander N R Weber, Martin Schwemmle, Christina J Gro\\xc3\\x9f, Olaf Gro\\xc3\\x9. Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation. Immunity. 2024-11-21. PMID:39571574.' |
acute suppression of mitochondrial atp production prevents apoptosis and provides an essential signal for nlrp3 inflammasome activation. |
2024-11-21 |
2024-11-24 |
Not clear |
| b' Benedikt S Saller, Svenja W\\xc3\\xb6hrle, Larissa Fischer, Clara Dufossez, Isabella L Ingerl, Susanne Kessler, Maria Mateo-Tortola, Oliver Gorka, Felix Lange, Yurong Cheng, Emilia Neuwirt, Adinarayana Marada, Christoph Koentges, Chiara Urban, Philipp Aktories, Peter Reuther, Sebastian Giese, Susanne Kirschnek, Carolin Mayer, Johannes Pilic, Hugo Falquez-Medina, Aline Oelgeklaus, Veerasikku Gopal Deepagan, Farzaneh Shojaee, Julia A Zimmermann, Damian Weber, Yi-Heng Tai, Anna Crois, Kevin Ciminski, Remi Peyronnet, Katharina S Brandenburg, Gang Wu, Ralf Baumeister, Thomas Heimbucher, Marta Rizzi, Dietmar Riedel, Martin Helmst\\xc3\\xa4dter, Joerg Buescher, Konstantin Neumann, Thomas Misgeld, Martin Kerschensteiner, Peter Walentek, Clemens Kreutz, Ulrich Maurer, Angelika S Rambold, James E Vince, Frank Edlich, Roland Malli, Georg H\\xc3\\xa4cker, Katrin Kierdorf, Chris Meisinger, Anna K\\xc3\\xb6ttgen, Stefan Jakobs, Alexander N R Weber, Martin Schwemmle, Christina J Gro\\xc3\\x9f, Olaf Gro\\xc3\\x9. Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation. Immunity. 2024-11-21. PMID:39571574.' |
how mitochondria reconcile roles in functionally divergent cell death pathways of apoptosis and nlrp3 inflammasome-mediated pyroptosis remains elusive, as is their precise role in nlrp3 activation and the evolutionarily conserved physiological function of nlrp3. |
2024-11-21 |
2024-11-24 |
Not clear |
| b' Benedikt S Saller, Svenja W\\xc3\\xb6hrle, Larissa Fischer, Clara Dufossez, Isabella L Ingerl, Susanne Kessler, Maria Mateo-Tortola, Oliver Gorka, Felix Lange, Yurong Cheng, Emilia Neuwirt, Adinarayana Marada, Christoph Koentges, Chiara Urban, Philipp Aktories, Peter Reuther, Sebastian Giese, Susanne Kirschnek, Carolin Mayer, Johannes Pilic, Hugo Falquez-Medina, Aline Oelgeklaus, Veerasikku Gopal Deepagan, Farzaneh Shojaee, Julia A Zimmermann, Damian Weber, Yi-Heng Tai, Anna Crois, Kevin Ciminski, Remi Peyronnet, Katharina S Brandenburg, Gang Wu, Ralf Baumeister, Thomas Heimbucher, Marta Rizzi, Dietmar Riedel, Martin Helmst\\xc3\\xa4dter, Joerg Buescher, Konstantin Neumann, Thomas Misgeld, Martin Kerschensteiner, Peter Walentek, Clemens Kreutz, Ulrich Maurer, Angelika S Rambold, James E Vince, Frank Edlich, Roland Malli, Georg H\\xc3\\xa4cker, Katrin Kierdorf, Chris Meisinger, Anna K\\xc3\\xb6ttgen, Stefan Jakobs, Alexander N R Weber, Martin Schwemmle, Christina J Gro\\xc3\\x9f, Olaf Gro\\xc3\\x9. Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation. Immunity. 2024-11-21. PMID:39571574.' |
here, we have shown that when cells were challenged simultaneously, apoptosis was inhibited and nlrp3 activation prevailed. |
2024-11-21 |
2024-11-24 |
Not clear |
| b' Benedikt S Saller, Svenja W\\xc3\\xb6hrle, Larissa Fischer, Clara Dufossez, Isabella L Ingerl, Susanne Kessler, Maria Mateo-Tortola, Oliver Gorka, Felix Lange, Yurong Cheng, Emilia Neuwirt, Adinarayana Marada, Christoph Koentges, Chiara Urban, Philipp Aktories, Peter Reuther, Sebastian Giese, Susanne Kirschnek, Carolin Mayer, Johannes Pilic, Hugo Falquez-Medina, Aline Oelgeklaus, Veerasikku Gopal Deepagan, Farzaneh Shojaee, Julia A Zimmermann, Damian Weber, Yi-Heng Tai, Anna Crois, Kevin Ciminski, Remi Peyronnet, Katharina S Brandenburg, Gang Wu, Ralf Baumeister, Thomas Heimbucher, Marta Rizzi, Dietmar Riedel, Martin Helmst\\xc3\\xa4dter, Joerg Buescher, Konstantin Neumann, Thomas Misgeld, Martin Kerschensteiner, Peter Walentek, Clemens Kreutz, Ulrich Maurer, Angelika S Rambold, James E Vince, Frank Edlich, Roland Malli, Georg H\\xc3\\xa4cker, Katrin Kierdorf, Chris Meisinger, Anna K\\xc3\\xb6ttgen, Stefan Jakobs, Alexander N R Weber, Martin Schwemmle, Christina J Gro\\xc3\\x9f, Olaf Gro\\xc3\\x9. Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation. Immunity. 2024-11-21. PMID:39571574.' |
apoptosis inhibition by structurally diverse nlrp3 activators, including nigericin, imiquimod, extracellular atp, particles, and viruses, was not a consequence of inflammasome activation but rather of their effects on mitochondria. |
2024-11-21 |
2024-11-24 |
Not clear |
| b' Benedikt S Saller, Svenja W\\xc3\\xb6hrle, Larissa Fischer, Clara Dufossez, Isabella L Ingerl, Susanne Kessler, Maria Mateo-Tortola, Oliver Gorka, Felix Lange, Yurong Cheng, Emilia Neuwirt, Adinarayana Marada, Christoph Koentges, Chiara Urban, Philipp Aktories, Peter Reuther, Sebastian Giese, Susanne Kirschnek, Carolin Mayer, Johannes Pilic, Hugo Falquez-Medina, Aline Oelgeklaus, Veerasikku Gopal Deepagan, Farzaneh Shojaee, Julia A Zimmermann, Damian Weber, Yi-Heng Tai, Anna Crois, Kevin Ciminski, Remi Peyronnet, Katharina S Brandenburg, Gang Wu, Ralf Baumeister, Thomas Heimbucher, Marta Rizzi, Dietmar Riedel, Martin Helmst\\xc3\\xa4dter, Joerg Buescher, Konstantin Neumann, Thomas Misgeld, Martin Kerschensteiner, Peter Walentek, Clemens Kreutz, Ulrich Maurer, Angelika S Rambold, James E Vince, Frank Edlich, Roland Malli, Georg H\\xc3\\xa4cker, Katrin Kierdorf, Chris Meisinger, Anna K\\xc3\\xb6ttgen, Stefan Jakobs, Alexander N R Weber, Martin Schwemmle, Christina J Gro\\xc3\\x9f, Olaf Gro\\xc3\\x9. Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation. Immunity. 2024-11-21. PMID:39571574.' |
therefore, oxphos and apoptosis inhibition by nlrp3 activators provide stringency in cell death decisions. |
2024-11-21 |
2024-11-24 |
Not clear |
| Ning Tang, Nuojin Geng, Xinhua Zh. Evaluation of Xihuang Pill in inducing pyroptosis in glioma cells through modulation of miR-21-5p. 3 Biotech. vol 14. issue 12. 2024-11-14. PMID:39529806. |
results showed that xihuang pill significantly reduced cell viability, increased apoptosis, and upregulated the expression of pyroptosis-related proteins such as nlrp3, il-1β, cleaved caspase-1, and gsdmd-n, while reducing p-stat3/stat3 and mir-21-5p levels (p < 0.05). |
2024-11-14 |
2024-11-17 |
human |
| Ngo Tin Ern, Thamil Vaani Komarasamy, Nur Amelia Azreen Adnan, Vinod R M T Balasubramania. Dengue Virus Infection: Immune Response and Therapeutic Targets. The American journal of tropical medicine and hygiene. 2024-11-12. PMID:39531732. |
it also discusses the role of nlrp3 in activating cellular apoptosis and pyroptosis leading to systemic failure, especially in peripheral tissues. |
2024-11-12 |
2024-11-17 |
Not clear |
| Dongxu Hua, Wanlin Huang, Qiyang Xie, Wenna Xu, Lu Tang, Mingwei Liu, Xiaoguang Wu, Qiaodong Zhang, Xu Cao, Peng Li, Yanhui Shen. Targeting GPR39 in structure-based drug discovery reduces Ang II-induced hypertension. Communications biology. vol 7. issue 1. 2024-11-05. PMID:39500998. |
gpr39 ko and the small molecule ligand z1780628919 potentially downregulates nlrp3, thereby mitigating vascular fibrosis, endothelial inflammation, oxidative stress, and apoptosis. |
2024-11-05 |
2024-11-08 |
mouse |
| Shu-Rui Xie, Yan-Jun Liu, Fen-Qiao Chen, Zhao Pa. Berberine safeguards sepsis-triggered acute gastric damage and inhibits pyroptosis in gastric epithelial cells via suppressing the ubiquitination and degradation of Nrf2. The Kaohsiung journal of medical sciences. 2024-11-01. PMID:39484787. |
in vitro, bbr fostered ges-1 cell proliferation, hindered apoptosis, and suppressed the levels of tnf-α, il-18, il-1β, nlrp3, asc, and gsdmd-n. further analysis revealed that knocking down nrf2 reversed bbr's inhibitory effect on pyroptosis in lps-treated ges-1 cells. |
2024-11-01 |
2024-11-03 |
mouse |
| Tshiamo T Maluleke, Ashmeetha Manilall, Nandi Shezi, Sooraj Baijnath, Aletta M E Mille. Acute exposure to LPS induces cardiac dysfunction via the activation of the NLRP3 inflammasome. Scientific reports. vol 14. issue 1. 2024-10-18. PMID:39420211. |
in addition, in vitro findings suggest that while the nlrp3 inflammasome mediates pyroptotic pathways, regulation of apoptosis that is independent of the inflammasome. |
2024-10-18 |
2024-10-20 |
rat |
| Ying Han, Jin Gong, Min Pan, Zhoufei Fang, Xiaowen Ou, Wenqin Cai, Xiane Pen. EMP1 knockdown mitigated high glucose-induced pyroptosis and oxidative stress in rat H9c2 cardiomyocytes by inhibiting the RAS/RAF/MAPK signaling pathway. Journal of biochemical and molecular toxicology. vol 38. issue 11. 2024-10-17. PMID:39415664. |
our results also suggested that emp1 sirna transfection significantly decreased the apoptosis and pyroptosis of hg-induced cells, as indicated by the reduction of nlrp3 il-1β, asc, gsdmd, cleaved-caspase1 and cleaved-caspase3 levels in hg-induced h9c2 cells. |
2024-10-17 |
2024-10-19 |
rat |
| Wioleta Justyna Omeljaniuk, Marzena Garley, Anna Pryczynicz, Joanna Motyka, Angelika Edyta Charkiewicz, Elżbieta Milewska, Piotr Laudański, Wojciech Milty. NLRP3 Inflammasome in the Pathogenesis of Miscarriages. International journal of molecular sciences. vol 25. issue 19. 2024-10-16. PMID:39408839. |
in the placental tissue, the expression of nlrp3, il-1β, il-18, and caspase-1 as well as that of the classical apoptosis biomarkers fas, fasl, bcl-2, and ca was evaluated by means of immunohistochemistry techniques. |
2024-10-16 |
2024-10-18 |
Not clear |