| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jingyi Wang, Ming Li, Wenda Wu, HuiJing Zhang, Yue Yang, Muhammad Usman, Ben Aernouts, Juan J Loor, Chuang X. Inflammatory Signaling via PEIZO1 Engages and Enhances the LPS-Mediated Apoptosis during Clinical Mastitis. Journal of agricultural and food chemistry. 2024-09-04. PMID:39229907. |
notably, the effects of piezo1 artificial activator yoda1 increased apoptosis and nlrp3 expression, effects mitigated by piezo1 silencing or nlrp3 inhibition. |
2024-09-04 |
2024-09-06 |
mouse |
| Michela Luciano, Helene Sieberer, Peter W Krenn, Hieu-Hoa Dang, Julia Vetter, Theresa Neuper, Diana Amend, Constantin Blöchl, Christian X Weichenberger, Anna Eglseer, Michael S Unger, Ancuela Andosch, Philip Steiner, Daniel Neureiter, Renate Bauer, Laura Hummer, Suzana Tesanovic, Stephanie Binder, Dominik P Elmer, Helen Strandt, Susanne Schaller, Dirk Strunk, Lisa Pleyer, Richard Greil, Stephan Winkler, Tanja N Hartmann, Dirk Schmidt-Arras, Christian G Huber, Fritz Aberger, Jutta Horejs-Hoec. Targeting NLRP3 inhibits AML progression by inducing PERK/eIF2-mediated apoptosis. Cell communication and signaling : CCS. vol 22. issue 1. 2024-09-03. PMID:39223663. |
targeting nlrp3 inhibits aml progression by inducing perk/eif2-mediated apoptosis. |
2024-09-03 |
2024-09-05 |
Not clear |
| Xiaoyan Tian, Chuanqiang Zhang, Daojuan Wang, Xiaowei Li, Qiang Wan. Ginseng polysaccharide promotes the apoptosis of colon cancer cells via activating the NLRP3 inflammasome. Immunopharmacology and immunotoxicology. 2024-09-02. PMID:39219032. |
ginseng polysaccharide promotes the apoptosis of colon cancer cells via activating the nlrp3 inflammasome. |
2024-09-02 |
2024-09-04 |
Not clear |
| Huaijuan Liu, Peijun Zhang, Jingwen Yu, Jiwei Wang, Jiezhong Yu, Minfang Gu. [Fasudil improves cognitive function in APP/PS1 transgenic mice by promoting mitophagy and inhibiting NLRP3 inflammasome activation]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 40. issue 8. 2024-08-31. PMID:39215667. |
terminal deoxynucleotidyl transferase-mediated dutp-biotin nick end labeling assay (tunel) staining was used to detect neuronal apoptosis; the expression of p62 and nlrp3 was detected by immunofluorescence histochemical staining; real time fluorescence quantitative pcr was used to detect the mrna expression levels of phosphatase and tensin homolog deleted on chromosome ten (pten) -induced putative kinase 1 (pink1), parkin and nlrp3; western blot analysis was used to detect the expression of pink1, parkin, p62, microtubule-associated protein 1 light chain 3 (lc3), nlrp3, adapter protein apoptosis-associated speck-like protein (asc) and interleukin-18 (il-18). |
2024-08-31 |
2024-09-04 |
mouse |
| Yifeng Dai, Xijin Xu, Xia Huo, Joost H N Schuitemaker, Marijke M Faa. Differential effect of lead and cadmium on mitochondrial function and NLRP3 inflammasome activation in human trophoblast. The Journal of physiology. 2024-08-28. PMID:39197088. |
then, we evaluated cell viability, apoptosis, mitochondrial dna copy number (mtdnacn), mitochondrial membrane potential (ΔΨ), nlrp3 inflammasome proteins and interleukin (il)-1β secretion. |
2024-08-28 |
2024-08-31 |
human |
| Aiguo Zhang, Xuefei Wang, Mingming Fan, Yibo Guan, Yuchen Jiang, Shuangxing Jin, Lingling Liu, Heping Huangfu, Chao Son. Lycopene alleviates zearalenone-induced oxidative stress, apoptosis, and NLRP3 inflammasome activation in mice kidneys. Toxicon : official journal of the International Society on Toxinology. vol 249. 2024-08-25. PMID:39181415. |
lycopene alleviates zearalenone-induced oxidative stress, apoptosis, and nlrp3 inflammasome activation in mice kidneys. |
2024-08-25 |
2024-08-28 |
mouse |
| Aiguo Zhang, Xuefei Wang, Mingming Fan, Yibo Guan, Yuchen Jiang, Shuangxing Jin, Lingling Liu, Heping Huangfu, Chao Son. Lycopene alleviates zearalenone-induced oxidative stress, apoptosis, and NLRP3 inflammasome activation in mice kidneys. Toxicon : official journal of the International Society on Toxinology. vol 249. 2024-08-25. PMID:39181415. |
lycopene supplementation could alleviate zen-induced renal toxicity by inhibiting oxidative stress, apoptosis, and nlrp3 inflammasome activation. |
2024-08-25 |
2024-08-28 |
mouse |
| Zeqian Wang, Yanzhe Duan, Yige Wu, Cungen Ma, Yuqing Yan, Lijuan Son. [Research progress on the pyroptosis mediated by the NLRP3 inflammasome in the pathology of ischemic stroke]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 40. issue 7. 2024-08-23. PMID:39179409. |
pyroptosis, which is characterized by both apoptosis and necrosis, is mediated by activation of inflammasomes, such as nod-like receptor family, pyrin domain containing 3 (nlrp3). |
2024-08-23 |
2024-08-27 |
human |
| Xiao-Li Wang, Yun-Xia Gao, Qiong-Zhen Yuan, Ming Zhan. NLRP3 and autophagy in retinal ganglion cell inflammation in age-related macular degeneration: potential therapeutic implications. International journal of ophthalmology. vol 17. issue 8. 2024-08-19. PMID:39156786. |
the nlrp3 inflammasome was a protein complex that, upon activation, produces caspase-1, mediating the apoptosis of retinal cells and promoting the occurrence and development of retinal degenerative diseases. |
2024-08-19 |
2024-08-21 |
Not clear |
| Guang-Nan Jin, Yu Wang, Yi-Ming Liu, Yu-Nan Lu, Jing-Mei Lu, Jing-He Wang, Jing-Wen Ma, Yan-Zhu Quan, Hong-Yan Gao, Yue-Xian Cui, Xiang Xu, Lian-Xun Pia. Arctiin Mitigates Neuronal Injury by Modulating the P2X7R/NLPR3 Inflammasome Signaling Pathway. Inflammation. 2024-08-17. PMID:39154088. |
arc attenuated neuroinflammatory responses and neuronal apoptosis by inhibiting the overactivation of the p2x7 receptor (p2x7r)/nod-like receptor family pyrin domain-containing 3 (nlrp3) inflammasome signaling pathway, similar to the effect of a438079 (p2x7r antagonist). |
2024-08-17 |
2024-08-20 |
mouse |
| Jinjin Wang, Xingzhi Jing, Xiaoyang Liu, Feifei Chen, Zhongpeng Ge, Xiaodong Liu, Heng Yang, Yifei Guo, Xingang Cu. Naringin safeguards vertebral endplate chondrocytes from apoptosis and NLRP3 inflammasome activation through SIRT3-mediated mitophagy. International immunopharmacology. vol 140. 2024-08-09. PMID:39121608. |
naringin safeguards vertebral endplate chondrocytes from apoptosis and nlrp3 inflammasome activation through sirt3-mediated mitophagy. |
2024-08-09 |
2024-08-13 |
Not clear |
| Jianbing Hao, Xinyu Guo, Siyu Wang, Xiaojun Guo, Kun Yuan, Ruihong Chen, Lirong Ha. LincRNA-p21/AIF-1/CMPK2/NLRP3 pathway promoted inflammation, autophagy and apoptosis of human tubular epithelial cell induced by urate via exosomes. Scientific reports. vol 14. issue 1. 2024-08-05. PMID:39103417. |
furthermore, manipulating the activity of lincrna-p21, aif-1, cmpk2, and nlrp3 through overexpression or interference vectors regulated the level of inflammation, autophagy, and apoptosis in hk2 cells. |
2024-08-05 |
2024-08-08 |
human |
| Qingshuang Zhou, Xiaojiang Pu, Zhuang Qian, Haojie Chen, Nannan Wang, Sinian Wang, Zhenhua Feng, Zezhang Zhu, Bin Wang, Yong Qiu, Xu Su. Nuclear receptor Rev-erbα alleviates intervertebral disc degeneration by recruiting NCoR-HDAC3 co-repressor and inhibiting NLRP3 inflammasome. Cell proliferation. 2024-07-24. PMID:39045886. |
mechanistically, rev-erbα knockdown in np cells aggravated rhil1β-induced nod-like receptor family pyrin domain containing 3 (nlrp3) inflammasome activation, exacerbating the imbalanced ecm and np cell apoptosis. |
2024-07-24 |
2024-07-26 |
Not clear |
| Xiannan Meng, Wei Li, Yongjing Qian, Xiaojing Cai, Jianfeng Wei, Ling Zhan. Mechanisms of colon toxicity induced by long-term perfluorooctanoic acid exposure in mice. Ecotoxicology and environmental safety. vol 282. 2024-07-24. PMID:39047366. |
additionally, pfoa induced inflammatory responses in colon tissue, facilitating nlr family, pyrin domain containing 3 (nlrp3) inflammasome activation and cell apoptosis. |
2024-07-24 |
2024-07-28 |
mouse |
| Lili Shi, Yingying Xu, Chao Zhao, Guangjin Qu, Ming Ha. Liraglutide ameliorates high glucose-induced vascular endothelial injury through TRIB3/NF-κB signaling pathway. In vitro cellular & developmental biology. Animal. 2024-07-22. PMID:39039329. |
furthermore, silencing of tribbles homolog 3 (trib3) could markedly reduce hg-induced huvec apoptosis, ros level, the expressions of txnip, cleaved caspase3, nlrp3, and caspase1, indicating trib3 inhibition protected huvecs against hg-induced vascular endothelial injury. |
2024-07-22 |
2024-07-25 |
human |
| Mallika Shekhar, Omer Iqbal, Adarsh Dharan, Hanin El-Khateeb, Kavya Jatavallabhula, Ping Bu, Charles Bouchar. The Role of NLRP3 Inflammasome in the Pathogenesis of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis. Medical research archives. vol 12. issue 1. 2024-07-19. PMID:39026932. |
the role of nlrp3 inflammasome in causing ocular surface disease and keratinocyte apoptosis is not fully explored. |
2024-07-19 |
2024-07-21 |
human |
| Bo Deng, Ruyu Xian, Yuan Shu, Haohan Xia, Chengcheng Fen. Paeonol attenuated high glucose-induced apoptosis via up-regulating miR-223-3p in mouse cardiac microvascular endothelial cells. Scientific reports. vol 14. issue 1. 2024-07-19. PMID:39030268. |
in contrast, transfection of exogenous mir-223-3p inhibitors into the mcmecs resulted in not only significantly increased apoptosis of the cells, but also significant suppression of nlrp3 and pro-apoptotic proteins in the cells. |
2024-07-19 |
2024-07-22 |
mouse |
| Bo Deng, Ruyu Xian, Yuan Shu, Haohan Xia, Chengcheng Fen. Paeonol attenuated high glucose-induced apoptosis via up-regulating miR-223-3p in mouse cardiac microvascular endothelial cells. Scientific reports. vol 14. issue 1. 2024-07-19. PMID:39030268. |
mir-223-3p may mediate the modulatory effects of pae on mcmec survival or apoptosis through targeting nlrp3 and regulating apoptosis-associated proteins. |
2024-07-19 |
2024-07-22 |
mouse |
| Hui Zhong, Tianshu Liu, You Shang, Chaolin Huang, Shangwen Pa. Breaking the vicious cycle: Targeting the NLRP3 inflammasome for treating sepsis-associated encephalopathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-07-14. PMID:39004064. |
activation of the nlrp3 inflammasome, situated within microglia, can be triggered by diverse danger signals, leading to cell pyroptosis, apoptosis, and tauopathy. |
2024-07-14 |
2024-07-18 |
Not clear |
| Cristina Agliardi, Franca Rosa Guerini, Milena Zanzottera, Elisabetta Bolognesi, Domenico Caputo, Marco Rovaris, Mario Cleric. Increased concentrations of P2X7R in oligodendrocyte derived extracellular vesicles of Multiple sclerosis patients. Neurobiology of disease. 2024-07-12. PMID:38996986. |
p2x7r activation can also result in apoptosis as a consequence of the activation of the caspase cascade via p2x7r-dependent stimulation of the nlrp3 inflammasome. |
2024-07-12 |
2024-07-15 |
human |