| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qian Wu, Rui Li, Yifei You, Wei Cheng, Yan Li, Yan Feng, Yuqin Fan, Yan Wan. Lung microbiota participated in fibrous microplastics (MPs) aggravating OVA-induced asthma disease in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-06-08. PMID:38851522. |
in addition, mp fibers exposure induced lung epithelial cells apoptosis, disruption of epithelial barrier integrity and activation of nlrp3 related signaling pathways. |
2024-06-08 |
2024-06-11 |
mouse |
| Esra Adiyeke, Nurten Bakan, Ayca Uvez, Devrim Oz Arslan, Sima Kilic, Berkcan Koc, Samed Ozer, Ozlem Saatci, Elif İlkay Armuta. THE EFFECT OF N- ACETYLCYSTEINE ON THE NEUROTOXICITY OF SEVOFLURANE IN DEVELOPING HIPPOCAMPUS CELLS. Neurotoxicology. 2024-06-06. PMID:38843996. |
protein levels of nrf-2, nlrp3, il-1β, caspase-1, beclin 1, p62, lc3a, and apoptosis markers were assessed. |
2024-06-06 |
2024-06-10 |
rat |
| Qi Zhang, Xi-Rui Yang, Yao Den. Iguratimod Alleviates Experimental Sjögren's Syndrome by Inhibiting NLRP3 Inflammasome Activation. Cell biochemistry and biophysics. 2024-06-05. PMID:38839699. |
apoptosis and nlrp3 inflammasome-related proteins were detected by western blotting. |
2024-06-05 |
2024-06-08 |
mouse |
| Qi Zhang, Xi-Rui Yang, Yao Den. Iguratimod Alleviates Experimental Sjögren's Syndrome by Inhibiting NLRP3 Inflammasome Activation. Cell biochemistry and biophysics. 2024-06-05. PMID:38839699. |
in vitro, results corroborated that t-614 could protect hsg cells from ifn-α-induced cell apoptosis and inflammation by inhibiting nlrp3 inflammasome activation. |
2024-06-05 |
2024-06-08 |
mouse |
| Huizhen Wei, Mengru Sun, Ruixuan Wang, Hairong Zeng, Bei Zhao, Shenyi Ji. Puerarin mitigated LPS-ATP or HG-primed endothelial cells damage and diabetes-associated cardiovascular disease via ROS-NLRP3 signalling. Journal of cellular and molecular medicine. vol 28. issue 10. 2024-05-22. PMID:38774996. |
in the study, pue ameliorated lipopolysaccharide-adenosine triphosphate (lps-atp) or hg-primed cytotoxicity and apoptosis, while inhibited reactive oxygen species (ros)-mediated nlr family pyrin domain containing 3 (nlrp3) inflammasome in huvecs, as evidenced by significantly decreased ros level, nox4, caspase-1 activity and expression of nlrp3, gsdmd, cleaved caspase-1, il-1β and il-18. |
2024-05-22 |
2024-05-27 |
Not clear |
| Jaili Li, Ting Luo, Yao Zhao, Dou Wang, Yuanxiang Jin, Zufang Wu, Guiling Yang, Xingjiang Q. Cardioprotective potentials of myricetin on doxorubicin-induced cardiotoxicity based on biochemical and transcriptomic analysis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 175. 2024-05-22. PMID:38776683. |
myr effectively suppressed nlrp3 and asc gene expression levels to inhibit pyroptosis while regulating caspase1 and bax levels to reduce cardiac cell apoptosis. |
2024-05-22 |
2024-05-27 |
mouse |
| Shuang Gao, Na Li, Zhongjing Lin, Yisheng Zhong, Yanuo Wang, Xi She. Inhibition of NLRP3 inflammasome by MCC950 under hypoxia alleviates photoreceptor apoptosis via inducing autophagy in Müller glia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 10. 2024-05-16. PMID:38752538. |
inhibition of nlrp3 inflammasome by mcc950 under hypoxia alleviates photoreceptor apoptosis via inducing autophagy in müller glia. |
2024-05-16 |
2024-05-27 |
mouse |
| Shuang Gao, Na Li, Zhongjing Lin, Yisheng Zhong, Yanuo Wang, Xi She. Inhibition of NLRP3 inflammasome by MCC950 under hypoxia alleviates photoreceptor apoptosis via inducing autophagy in Müller glia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 10. 2024-05-16. PMID:38752538. |
here, we identified the effect of a potent, selective nlrp3 inhibitor, mcc950, on autophagy and apoptosis under hypoxia. |
2024-05-16 |
2024-05-27 |
mouse |
| Shuang Gao, Na Li, Zhongjing Lin, Yisheng Zhong, Yanuo Wang, Xi She. Inhibition of NLRP3 inflammasome by MCC950 under hypoxia alleviates photoreceptor apoptosis via inducing autophagy in Müller glia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 10. 2024-05-16. PMID:38752538. |
autophagic activity in müller glia after nlrp3 inflammasome inhibition, together with its influence on photoreceptor death, was studied using western blot, immunofluorescence staining, mrfp-gfp-lc3 adenovirus transfection, cell viability, proliferation, and apoptosis assays. |
2024-05-16 |
2024-05-27 |
mouse |
| Marina Blanc, Lama Habbouche, Peng Xiao, Cynthia Lebeaupin, Marion Janona, Nathalie Vaillant, Marie Irondelle, Jérôme Gilleron, Florent Murcy, Déborah Rousseau, Carmelo Luci, Thibault Barouillet, Sandrine Marchetti, Sandra Lacas-Gervais, Laurent Yvan-Charvet, Philippe Gual, Alessandra K Cardozo, Béatrice Bailly-Maitr. Bax Inhibitor-1 preserves pancreatic β-cell proteostasis by limiting proinsulin misfolding and programmed cell death. Cell death & disease. vol 15. issue 5. 2024-05-14. PMID:38744890. |
in fine, bi-1 in β-cells limited ire1α rnase activity from triggering programmed β-cell death through apoptosis and pyroptosis (caspase-1, il-1β) via nlrp3 inflammasome activation and metabolic dysfunction. |
2024-05-14 |
2024-05-27 |
mouse |
| Xing Ye, Zi-Jie Lin, Guang-Hui Hong, Zhi-Min Wang, Run-Ting Dou, Jun-Yi Lin, Jian-Hui Xie, Yi-Wen She. Pyroptosis inhibitors MCC950 and VX-765 mitigate myocardial injury by alleviating oxidative stress, inflammation, and apoptosis in acute myocardial hypoxia. Experimental cell research. 2024-05-01. PMID:38692345. |
concurrently, pharmacological inhibition of nlrp3 inflammasome-mediated pyroptosis with mcc950 and vx-765 effectively decreased hypoxia-induced cardiomyocytes injury, while mitigating myocardial oxidative stress, apoptosis and inflammation caused by hypoxia. |
2024-05-01 |
2024-05-04 |
mouse |
| Yixuan Huang, Chengcheng Jiang, Xiaojie Liu, Wei Tang, Hongya Gui, Tao Sun, Doudou Xu, Maozhang He, Maozhen Han, Huan Qiu, Mingwei Chen, Shenghai Huan. Melatonin suppresses TLR4-mediated RSV infection in the central nervous cells by inhibiting NLRP3 inflammasome formation and autophagy. Journal of cellular and molecular medicine. vol 28. issue 9. 2024-04-29. PMID:38683122. |
furthermore, tlr4 activation induced autophagy and apoptosis in neuronal cells, promoted the formation of the nod-like receptor family pyrin domain containing 3 (nlrp3) inflammasome, and increased the secretion of downstream inflammatory cytokines such as interleukin-1β (il-1β), interleukin-18 (il-18) and tumour necrosis factor-α (tnf-α). |
2024-04-29 |
2024-05-02 |
human |
| Osama A Mohammed, Sameh Saber, Mustafa Ahmed Abdel-Reheim, Mohannad Mohammad S Alamri, Jaber Alfaifi, Masoud I E Adam, Muffarah Hamid Alharthi, Ali M S Eleragi, Hanan B Eltahir, Mohamed Osama Abdalla, Emad Bahashwan, Elwathiq Khalid Ibrahim, Assad Ali Rezigalla, Sameh Abdel-Ghany, Amany A Alzokaky, Ahmed S Doghish, Hussein M El-Husseiny, Mushabab Alghamdi, Mahmoud E Yousse. Tracking the therapeutic efficacy of a ketone mono ester and β-hydroxybutyrate for ulcerative colitis in rats: New perspectives. Toxicology and applied pharmacology. 2024-04-27. PMID:38677600. |
the mechanism of action involves modulating the nf-κb signaling, inhibiting the nlrp3 inflammasome, regulating antioxidant capacity, controlling tight junction protein expression and a potential to inhibit apoptosis and pyroptosis. |
2024-04-27 |
2024-04-30 |
rat |
| Shimaa O Ali, Heba R Ghaiad, Ghada F Elmasry, Noha A Mehan. Sinapic Acid Mitigates Pentylenetetrazol-induced Acute Seizures By Modulating the NLRP3 Inflammasome and Regulating Calcium/calcineurin Signaling: In Vivo and In Silico Approaches. Inflammation. 2024-04-25. PMID:38662166. |
the results showed that sa alleviated oxidative stress, restored the gaba/glutamate balance and calcium/calcineurin signaling, downregulated nlrp3 and apoptosis, and improved recognition and ambulatory activity in ptz-treated mice. |
2024-04-25 |
2024-04-28 |
mouse |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Zhao Zhang, Fengming Liang, Jun Chang, Xiaoqian Shan, Zhixian Yin, Li Wang, Shujiao L. Autophagy in dry AMD: a promising therapeutic strategy for retinal pigment epithelial cell damage. Experimental eye research. 2024-04-09. PMID:38593971. |
oxidative stress and chronic inflammation are major contributors to rpe cell damage, and the nod-like receptor thermoprotein structural domain-associated protein 3 (nlrp3) inflammasome mediates the inflammatory response leading to apoptosis in rpe cells. |
2024-04-09 |
2024-04-12 |
Not clear |
| Yifeng Dai, Xijin Xu, Xia Huo, Joost H N Schuitemaker, Marijke M Faa. Cell type-dependent response to benzo(a)pyrene exposure of human placental cell lines under normoxic, hypoxic, and pro-inflammatory conditions. Ecotoxicology and environmental safety. vol 276. 2024-04-05. PMID:38579532. |
in this study, we aimed to investigate the effects of bap on mitochondrial function, pyrin domain-containing protein 3 (nlrp3) inflammasome, and apoptosis in three human trophoblast cell lines under normoxia, hypoxia, and inflammatory conditions. |
2024-04-05 |
2024-04-10 |
human |
| Yifeng Dai, Xijin Xu, Xia Huo, Joost H N Schuitemaker, Marijke M Faa. Cell type-dependent response to benzo(a)pyrene exposure of human placental cell lines under normoxic, hypoxic, and pro-inflammatory conditions. Ecotoxicology and environmental safety. vol 276. 2024-04-05. PMID:38579532. |
this increased ΔΨm may have rescued the trophoblast cells from activation of the nlrp3 inflammasome and apoptosis after bap treatment. |
2024-04-05 |
2024-04-10 |
human |
| Xiang Xiong, Caiyun Yin, Aidi Tong, Guowei Zhong, Zhou Wu, Chunyi Tong, Xiancheng Wang, Bin Li. Dermal extracellular matrix gelatin delivering Prussian blue nanoparticles to relieve skin flap ischemia. International journal of biological macromolecules. 2024-04-04. PMID:38574902. |
in vivo assays further confirmed that alp@pb-gel could effectively alleviate necrosis in the early and late stages after surgery, downregulate the levels of nlrp3 and cd68 to inhibit apoptosis and attenuate inflammation, while upregulate the levels of vegf and cd31 to promote vascular tissue regeneration. |
2024-04-04 |
2024-04-07 |
human |
| Keyvan Amirshahrokhi, Mahsa Iman. Therapeutic Effect of Levetiracetam Against Thioacetamide-Induced Hepatic Encephalopathy Through Inhibition of Oxidative Stress and Downregulation of NF-κB, NLRP3, iNOS/NO, Pro-Inflammatory Cytokines and Apoptosis. Inflammation. 2024-03-26. PMID:38530519. |
therapeutic effect of levetiracetam against thioacetamide-induced hepatic encephalopathy through inhibition of oxidative stress and downregulation of nf-κb, nlrp3, inos/no, pro-inflammatory cytokines and apoptosis. |
2024-03-26 |
2024-03-29 |
mouse |