| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Liu, YingFeng Wei, NingSheng Xie, Hong Cai, Ye Li. Mitochondria-targeted reactive oxygen species blockor SS-31 blocks hepatic stellate cell activation and alleviates hepatic fibrosis by regulating NLRP3 inflammasomes. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 2. 2024-03-02. PMID:38430023. |
after tgf-β1 induction, hsc proliferation increased, apoptosis decreased, and col1a1, α-sma, and nlrp3 inflammasome protein expression increased. |
2024-03-02 |
2024-03-04 |
mouse |
| Li Liu, YingFeng Wei, NingSheng Xie, Hong Cai, Ye Li. Mitochondria-targeted reactive oxygen species blockor SS-31 blocks hepatic stellate cell activation and alleviates hepatic fibrosis by regulating NLRP3 inflammasomes. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 2. 2024-03-02. PMID:38430023. |
after ss-31 treatment, mitochondrial ros expression decreased, mmp recovered, atp level increased, hsc proliferation decreased, apoptosis increased, and the expressions of col1a1, α-sma, and nlrp3 inflammasome decreased. |
2024-03-02 |
2024-03-04 |
mouse |
| Xin Fang, Yaoxuan Ji, Shuang Li, Lei Wang, Bo He, Bo Li, Boshen Liang, Hongke Yin, Haotian Chen, Duojie Dingda, Bing Wu, Fabao Ga. Paeoniflorin attenuates cuproptosis and ameliorates left ventricular remodeling after AMI in hypobaric hypoxia environments. Journal of natural medicines. 2024-03-01. PMID:38427210. |
it also attenuated apoptosis, inflammation, and fibrosis by modulating bcl-2, bax, nlrp3, and oxidative stress markers. |
2024-03-01 |
2024-03-03 |
rat |
| Linxian Zhao, Haina Zhang, Peng Jiang, Guangmeng X. Isoliquiritin counteracts cadmium-induced intestinal damage in mice through enhancing intestinal barrier function and inhibiting apoptosis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-02-24. PMID:38401882. |
furthermore, iso could significantly suppress cd-induced intestinal apoptosis and activation of nlrp3 inflammasome. |
2024-02-24 |
2024-02-27 |
mouse |
| Linxian Zhao, Haina Zhang, Peng Jiang, Guangmeng X. Isoliquiritin counteracts cadmium-induced intestinal damage in mice through enhancing intestinal barrier function and inhibiting apoptosis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-02-24. PMID:38401882. |
interestingly, inhibiting the activation of nlrp3 by nigericin completely blocking the effect of iso on apoptosis. |
2024-02-24 |
2024-02-27 |
mouse |
| Linxian Zhao, Haina Zhang, Peng Jiang, Guangmeng X. Isoliquiritin counteracts cadmium-induced intestinal damage in mice through enhancing intestinal barrier function and inhibiting apoptosis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-02-24. PMID:38401882. |
taken together, these findings suggest that iso reduces cd-induced intestinal damage by increasing the goblet cells, improving intestinal barrier, suppressing nlrp3 inflammasome activation and inhibiting apoptosis, which may offer a novel strategy against the toxic effects of heavy metals. |
2024-02-24 |
2024-02-27 |
mouse |
| Kristy T Rodríguez-Ramírez, María Norte-Muñoz, Fernando Lucas-Ruiz, Alejandro Gallego-Ortega, Francesco Calzaferri, David García-Bernal, Carlos M Martínez, Caridad Galindo-Romero, Cristóbal de Los Ríos, Manuel Vidal-Sanz, Marta Agudo-Barrius. Retinal response to systemic inflammation differs between sexes and neurons. Frontiers in immunology. vol 15. 2024-02-22. PMID:38384465. |
here, we investigate the effect of systemic inflammation induced by intraperitoneal administration of lipopolysaccharide (lps) on the retina of male and female mice and determine whether antagonism of the nlrp3 inflammasome and the extrinsic pathway of apoptosis have protective effects on the retina. |
2024-02-22 |
2024-02-24 |
mouse |
| Dandan Chu, Mengyang Zhao, Shisong Rong, Wonho Jhe, Xiaolu Cai, Yi Xiao, Wei Zhang, Xingchen Geng, Zhanrong Li, Xingcai Zhang, Jingguo L. Dual-Atom Nanozyme Eye Drops Attenuate Inflammation and Break the Vicious Cycle in Dry Eye Disease. Nano-micro letters. vol 16. issue 1. 2024-02-19. PMID:38372846. |
the in vitro and in vivo results demonstrate the dan is endowed with superior biological activity in scavenging excessive ros, inhibiting nlrp3 inflammasome activation, decreasing proinflammatory cytokines expression, and suppressing cell apoptosis. |
2024-02-19 |
2024-02-21 |
Not clear |
| Qiaoyun Bai, Ruobai Liu, Changlin Quan, Xue Han, Dandan Wang, Chongyang Wang, Zhiguang Wang, Li Li, Liangchang Li, Hongmei Piao, Yilan Song, Guanghai Ya. DEK deficiency suppresses mitophagy to protect against house dust mite-induced asthma. Frontiers in immunology. vol 14. 2024-01-26. PMID:38274803. |
this study aims to investigate the role and mechanism of dek in asthmatic airway inflammation and in regulating pink1-parkin-mediated mitophagy, nlrp3 inflammasome activation, and apoptosis. |
2024-01-26 |
2024-01-28 |
mouse |
| Qiaoyun Bai, Ruobai Liu, Changlin Quan, Xue Han, Dandan Wang, Chongyang Wang, Zhiguang Wang, Li Li, Liangchang Li, Hongmei Piao, Yilan Song, Guanghai Ya. DEK deficiency suppresses mitophagy to protect against house dust mite-induced asthma. Frontiers in immunology. vol 14. 2024-01-26. PMID:38274803. |
pink1-parkin mitophagy, nlrp3 inflammasome, and apoptosis were examined after gene silencing or treatment with specific inhibitors (mitotempo, mcc950, and ac-devd-cho) in house dust mite (hdm) or recombinant dek (rmdek)-induced wt and dek-/- asthmatic mice and beas-2b cells. |
2024-01-26 |
2024-01-28 |
mouse |
| Qiaoyun Bai, Ruobai Liu, Changlin Quan, Xue Han, Dandan Wang, Chongyang Wang, Zhiguang Wang, Li Li, Liangchang Li, Hongmei Piao, Yilan Song, Guanghai Ya. DEK deficiency suppresses mitophagy to protect against house dust mite-induced asthma. Frontiers in immunology. vol 14. 2024-01-26. PMID:38274803. |
moreover, rmdek also increased drp1 expression, pink1-parkin-mediated mitophagy, nlrp3 inflammasome activation, and apoptosis. |
2024-01-26 |
2024-01-28 |
mouse |
| Yulin Zhang, Hongxian Wu, Chaozhi Xu, Shanqian Li, Yue Hu, Zongyi Zhang, Guixian Wu, Yuling Liu, Lin Yang, Yue Huang, Wenjun Lu, Lina H. (-)-Epigallocatechin gallate alleviates chronic unpredictable mild stress-induced depressive symptoms in mice by regulating the mTOR autophagy pathway and inhibiting NLRP3 inflammasome activation. Food science & nutrition. vol 12. issue 1. 2024-01-25. PMID:38268911. |
then, elisa, western blot and qt-pcr tests were used to assess the expression of the key components of the nlrp3 inflammasome and its downstream inflammatory effectors (e.g., il-1β, il-18), autophagy markers (beclin-1, lc3, p62) and apoptosis markers (bax, bcl-2) in mouse brain tissues. |
2024-01-25 |
2024-01-27 |
mouse |
| Yulin Zhang, Hongxian Wu, Chaozhi Xu, Shanqian Li, Yue Hu, Zongyi Zhang, Guixian Wu, Yuling Liu, Lin Yang, Yue Huang, Wenjun Lu, Lina H. (-)-Epigallocatechin gallate alleviates chronic unpredictable mild stress-induced depressive symptoms in mice by regulating the mTOR autophagy pathway and inhibiting NLRP3 inflammasome activation. Food science & nutrition. vol 12. issue 1. 2024-01-25. PMID:38268911. |
egcg alleviated cums-induced depression-like behavioral changes in mice, reduced activation of the nlrp3 inflammasome, inhibited the mtor signaling pathway, restored autophagy levels, reduced apoptosis marker expression and attenuated abnormal changes in blood lipid levels. |
2024-01-25 |
2024-01-27 |
mouse |
| Tengyu Jin, Haoyuan Wang, Yuelin Liu, Hebo Wan. Circular RNAs: Regulators of endothelial cell dysfunction in atherosclerosis. Journal of molecular medicine (Berlin, Germany). 2024-01-24. PMID:38265445. |
this review focuses on their roles in inflammation, proliferation, migration, angiogenesis, apoptosis, senescence, and autophagy in ecs from the perspective of signaling pathways, such as nuclear factor κb (nf-κb), nucleotide-binding domain, leucine-rich-repeat family, pyrin-domain-containing 3 (nlrp3)/caspase-1, janus kinase/signal transducer and activator of transcription (jak/stat), and phosphoinositide-3 kinase/protein kinase b (pi3k/akt). |
2024-01-24 |
2024-01-26 |
Not clear |
| Jianxiong Gui, Jie Liu, Lingman Wang, Xiaoyue Yang, Bing Tian, Hanyu Luo, Dishu Huang, Ziyao Han, Jiaxin Yang, Ran Ding, Zhixu Fang, Xue Li, Li Cheng, Li Jian. Autophagy alleviates hippocampal neuroinflammation by inhibiting the NLRP3 inflammasome in a juvenile rat model exposed particulate matter. Toxicology. 2024-01-18. PMID:38237716. |
notably, autophagy mitigated nlrp3 inflammasome activation, potentially by reducing neuronal ros and apoptosis. |
2024-01-18 |
2024-01-21 |
rat |
| Yao Chen, Hanzhou Li, Yan Yang, Lei Feng, Ling Yang, Jie Zhao, Xiaochi Xin, Shuquan Lv, Xixing Fang, Weibo Wen, Youxiang Cui, Huantian Cu. Polygalasaponin F ameliorates middle cerebral artery occlusion-induced focal ischemia / reperfusion injury in rats through inhibiting TXNIP/NLRP3 signaling pathway. Journal of neuroimmunology. vol 387. 2024-01-10. PMID:38198981. |
meanwhile, pgsf treatment inhibited apoptosis, and reduced the levels of ros, inflammatory cytokine and txnip/nlrp3 pathway-related proteins (txnip, nlrp3, asc, cleaved caspase-1, il-1β, and il-18) in ogd/r-induced neuronal injury cells. |
2024-01-10 |
2024-01-13 |
rat |
| Yuyi Yuan, Fang Wang, Xingxing Liu, Bo Shuai, Heng Fa. The Role of AMPK Signaling in Ulcerative Colitis. Drug design, development and therapy. vol 17. 2024-01-03. PMID:38170149. |
emerging evidence indicates that interventions involving traditional chinese medicine (tcm) components, as well as other pharmacological measures, exert beneficial effects on the intestinal mucosal inflammation and epithelial barrier dysfunction in uc by modulating ampk signaling, thereby influencing biological processes such as cellular autophagy, apoptosis, inflammatory responses, macrophage polarization, and nlrp3 inflammasome-mediated pyroptosis. |
2024-01-03 |
2024-01-06 |
Not clear |
| Li Xu, Jie Su, Caili Du, Hui Liu, Wei L. Ghrelin suppresses hypoxia/reoxygenation-induced H9C2 cell pyroptosis via NLRP3. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 13. 2023-12-30. PMID:38158667. |
ghrelin overexpression could suppress cell apoptosis and both nlrp3 and caspase-1 expressions. |
2023-12-30 |
2024-01-05 |
Not clear |
| Changkun Hu, Zebin Liao, Liangliang Zhang, Zengchun Ma, Chengrong Xiao, Shuai Shao, Yue Ga. Alleviation of Splenic Injury by CB001 after Low-Dose Irradiation Mediated by NLRP3/Caspase-1-BAX/Caspase-3 Axis. Radiation research. 2023-12-28. PMID:38154483. |
furthermore, the crosstalk between apoptosis signaling and nlrp3 inflammasome signaling in mediating the radio-protective activity of cb001 was clarified, in which the pro-apoptotic protein bax but not the anti-apoptotic protein bcl2 was found to be downstream of nlrp3. |
2023-12-28 |
2023-12-31 |
Not clear |
| Wenfeng Liu, Feng Zhang, Bing Quan, Fan Yao, Rongxin Chen, Zhenggang Ren, Xin Yi. NLRP3/IL-1β induced myeloid-derived suppressor cells recruitment and PD-L1 upregulation promotes oxaliplatin resistance of hepatocellular carcinoma. MedComm. vol 4. issue 6. 2023-12-20. PMID:38116060. |
to further understand its impact on drug resistance, we knocked down nlrp3 and observed that it sensitized hcc cells to the growth-inhibitory effects of oxaliplatin and induced cell apoptosis. |
2023-12-20 |
2023-12-23 |
mouse |