| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yulin Zhang, Hongxian Wu, Chaozhi Xu, Shanqian Li, Yue Hu, Zongyi Zhang, Guixian Wu, Yuling Liu, Lin Yang, Yue Huang, Wenjun Lu, Lina H. (-)-Epigallocatechin gallate alleviates chronic unpredictable mild stress-induced depressive symptoms in mice by regulating the mTOR autophagy pathway and inhibiting NLRP3 inflammasome activation. Food science & nutrition. vol 12. issue 1. 2024-01-25. PMID:38268911. |
egcg alleviated cums-induced depression-like behavioral changes in mice, reduced activation of the nlrp3 inflammasome, inhibited the mtor signaling pathway, restored autophagy levels, reduced apoptosis marker expression and attenuated abnormal changes in blood lipid levels. |
2024-01-25 |
2024-01-27 |
mouse |
| Tengyu Jin, Haoyuan Wang, Yuelin Liu, Hebo Wan. Circular RNAs: Regulators of endothelial cell dysfunction in atherosclerosis. Journal of molecular medicine (Berlin, Germany). 2024-01-24. PMID:38265445. |
this review focuses on their roles in inflammation, proliferation, migration, angiogenesis, apoptosis, senescence, and autophagy in ecs from the perspective of signaling pathways, such as nuclear factor κb (nf-κb), nucleotide-binding domain, leucine-rich-repeat family, pyrin-domain-containing 3 (nlrp3)/caspase-1, janus kinase/signal transducer and activator of transcription (jak/stat), and phosphoinositide-3 kinase/protein kinase b (pi3k/akt). |
2024-01-24 |
2024-01-26 |
Not clear |
| Jianxiong Gui, Jie Liu, Lingman Wang, Xiaoyue Yang, Bing Tian, Hanyu Luo, Dishu Huang, Ziyao Han, Jiaxin Yang, Ran Ding, Zhixu Fang, Xue Li, Li Cheng, Li Jian. Autophagy alleviates hippocampal neuroinflammation by inhibiting the NLRP3 inflammasome in a juvenile rat model exposed particulate matter. Toxicology. 2024-01-18. PMID:38237716. |
notably, autophagy mitigated nlrp3 inflammasome activation, potentially by reducing neuronal ros and apoptosis. |
2024-01-18 |
2024-01-21 |
rat |
| Yao Chen, Hanzhou Li, Yan Yang, Lei Feng, Ling Yang, Jie Zhao, Xiaochi Xin, Shuquan Lv, Xixing Fang, Weibo Wen, Youxiang Cui, Huantian Cu. Polygalasaponin F ameliorates middle cerebral artery occlusion-induced focal ischemia / reperfusion injury in rats through inhibiting TXNIP/NLRP3 signaling pathway. Journal of neuroimmunology. vol 387. 2024-01-10. PMID:38198981. |
meanwhile, pgsf treatment inhibited apoptosis, and reduced the levels of ros, inflammatory cytokine and txnip/nlrp3 pathway-related proteins (txnip, nlrp3, asc, cleaved caspase-1, il-1β, and il-18) in ogd/r-induced neuronal injury cells. |
2024-01-10 |
2024-01-13 |
rat |
| Yuyi Yuan, Fang Wang, Xingxing Liu, Bo Shuai, Heng Fa. The Role of AMPK Signaling in Ulcerative Colitis. Drug design, development and therapy. vol 17. 2024-01-03. PMID:38170149. |
emerging evidence indicates that interventions involving traditional chinese medicine (tcm) components, as well as other pharmacological measures, exert beneficial effects on the intestinal mucosal inflammation and epithelial barrier dysfunction in uc by modulating ampk signaling, thereby influencing biological processes such as cellular autophagy, apoptosis, inflammatory responses, macrophage polarization, and nlrp3 inflammasome-mediated pyroptosis. |
2024-01-03 |
2024-01-06 |
Not clear |
| Li Xu, Jie Su, Caili Du, Hui Liu, Wei L. Ghrelin suppresses hypoxia/reoxygenation-induced H9C2 cell pyroptosis via NLRP3. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 13. 2023-12-30. PMID:38158667. |
ghrelin overexpression could suppress cell apoptosis and both nlrp3 and caspase-1 expressions. |
2023-12-30 |
2024-01-05 |
Not clear |
| Changkun Hu, Zebin Liao, Liangliang Zhang, Zengchun Ma, Chengrong Xiao, Shuai Shao, Yue Ga. Alleviation of Splenic Injury by CB001 after Low-Dose Irradiation Mediated by NLRP3/Caspase-1-BAX/Caspase-3 Axis. Radiation research. 2023-12-28. PMID:38154483. |
furthermore, the crosstalk between apoptosis signaling and nlrp3 inflammasome signaling in mediating the radio-protective activity of cb001 was clarified, in which the pro-apoptotic protein bax but not the anti-apoptotic protein bcl2 was found to be downstream of nlrp3. |
2023-12-28 |
2023-12-31 |
Not clear |
| Wenfeng Liu, Feng Zhang, Bing Quan, Fan Yao, Rongxin Chen, Zhenggang Ren, Xin Yi. NLRP3/IL-1β induced myeloid-derived suppressor cells recruitment and PD-L1 upregulation promotes oxaliplatin resistance of hepatocellular carcinoma. MedComm. vol 4. issue 6. 2023-12-20. PMID:38116060. |
to further understand its impact on drug resistance, we knocked down nlrp3 and observed that it sensitized hcc cells to the growth-inhibitory effects of oxaliplatin and induced cell apoptosis. |
2023-12-20 |
2023-12-23 |
mouse |
| Yunying Qian, Guiying Qian, Haiyan Ni, Danying Zhu, Weiqun Gu, Ximei Ca. Exploratory study on the mechanism of necrotic effect of nourishing cells in the context of genital tract infection in premature rupture of membranes. Medicine. vol 102. issue 50. 2023-12-20. PMID:38115314. |
prom is associated with a significant upregulation of placental nourishing cell apoptosis and necrotic factors, including caspase-1, caspase-3, nlrp3, and il-1β proteins. |
2023-12-20 |
2023-12-23 |
Not clear |
| Zeynep Dal, Başak Ar. The role of curcumin on apoptosis and NLRP3 inflammasome-dependent pyroptosis on colorectal cancer in vitro. Turkish journal of medical sciences. vol 53. issue 4. 2023-12-01. PMID:38031951. |
the role of curcumin on apoptosis and nlrp3 inflammasome-dependent pyroptosis on colorectal cancer in vitro. |
2023-12-01 |
2023-12-10 |
Not clear |
| Sen Zhou, Yang Liu, Binbin Xue, Peigen Yua. Low-dose Esketamine suppresses NLRP3-mediated apoptotic and pyroptotic cell death in microglial cells to ameliorate LPS-induced depression via ablating GSK-3β. Behavioural brain research. vol 459. 2023-11-30. PMID:38029844. |
next, by conducting mechanical experiments, we verified that low-dose esketamine downregulated gsk-3β to inactivate nlrp3 inflammasome, and the effects of low-dose esketamine on cell pyroptosis, neuroinflammation and apoptosis in the lps-treated microglial cells were all abrogated by overexpressing gsk-3β and nlrp3. |
2023-11-30 |
2023-12-10 |
mouse |
| Qingmei Gong, Yanbo Wang, Xiaowei Wang, Haiyan Pan, Ci Ya. Baicalein promotes the microglia M2 polarization and suppresses apoptosis by targeting HMOX1/PDE4D to alleviate Alzheimer's disease. Immunobiology. vol 228. issue 6. 2023-11-25. PMID:38006681. |
in app/ps1 mice, it was found that baicalein decreased the aβ plaque deposition in brain, attenuated nlrp3 inflammasome activation and neuronal apoptosis in app/ps1 mice. |
2023-11-25 |
2023-11-28 |
mouse |
| Meng Yuan, Asli F Ceylan, Rifeng Gao, Hong Zhu, Yingmei Zhang, Jun Re. Selective inhibition of the NLRP3 inflammasome protects against acute ethanol-induced cardiotoxicity in an FBXL2-dependent manner. Acta biochimica et biophysica Sinica. 2023-11-23. PMID:37994158. |
levels of nlrp3 inflammasome, mitophagy and apoptosis are evaluated by western blot analysis and immunofluorescence techniques. |
2023-11-23 |
2023-11-29 |
mouse |
| Meng Yuan, Asli F Ceylan, Rifeng Gao, Hong Zhu, Yingmei Zhang, Jun Re. Selective inhibition of the NLRP3 inflammasome protects against acute ethanol-induced cardiotoxicity in an FBXL2-dependent manner. Acta biochimica et biophysica Sinica. 2023-11-23. PMID:37994158. |
levels of nlrp3 inflammasome and apoptosis are elevated, and mitophagy flux is blocked (elevated pink1-parkin and lc3b along with diminished p62 and rab7) in mice receiving acute ethanol challenge. |
2023-11-23 |
2023-11-29 |
mouse |
| Meng Yuan, Asli F Ceylan, Rifeng Gao, Hong Zhu, Yingmei Zhang, Jun Re. Selective inhibition of the NLRP3 inflammasome protects against acute ethanol-induced cardiotoxicity in an FBXL2-dependent manner. Acta biochimica et biophysica Sinica. 2023-11-23. PMID:37994158. |
although mcc950 does not elicit a notable effect on myocardial function, apoptosis or inflammasome activation in the absence of ethanol exposure, it effectively rescues acute ethanol cardiotoxicity, as manifested by restored myocardial and cardiomyocyte functional homeostasis, suppressed nlrp3 inflammasome activation and apoptosis, and improved mitophagy flux. |
2023-11-23 |
2023-11-29 |
mouse |
| Soumya Ranjan Mishra, Bishnu Prasad Behera, Vineet Kumar Singh, Kewal Kumar Mahapatra, Deepak Mundkinajeddu, Deeksha Bhat, Aruna Mukti Minz, Gautam Sethi, Thomas Efferth, Surajit Das, Sujit Kumar Bhuti. Anticancer activity of Bacopa monnieri through apoptosis induction and mitophagy-dependent NLRP3 inflammasome inhibition in oral squamous cell carcinoma. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 123. 2023-11-11. PMID:37951147. |
anticancer activity of bacopa monnieri through apoptosis induction and mitophagy-dependent nlrp3 inflammasome inhibition in oral squamous cell carcinoma. |
2023-11-11 |
2023-11-20 |
human |
| Yi Xu, Yanling Yang, Xi Chen, Danling Jiang, Fei Zhang, Yao Guo, Bin Hu, Guohai Xu, Shengliang Peng, Lidong Wu, Jialing H. NLRP3 inflammasome in cognitive impairment and pharmacological properties of its inhibitors. Translational neurodegeneration. vol 12. issue 1. 2023-11-02. PMID:37915104. |
we also explore the intrinsic relationship between the nlrp3 inflammasome and cognitive impairment, which involves immune cell activation, cell apoptosis, oxidative stress, mitochondrial autophagy, and neuroinflammation. |
2023-11-02 |
2023-11-08 |
Not clear |
| Fei Li, Hongxiang Zhu, Zijuan Chang, Ying L. Gentiopicroside alleviates acute myocardial infarction injury in rats by disrupting Nrf2/NLRP3 signaling. Experimental biology and medicine (Maywood, N.J.). 2023-10-18. PMID:37850391. |
reactive oxygen species (ros) and cell apoptosis were assessed, while nrf2 and the expression of the nlrp3 inflammatory body signal pathway were evaluated using western blot and immunofluorescence techniques. |
2023-10-18 |
2023-11-08 |
rat |
| Mary Speir, Hazel Tye, Timothy A Gottschalk, Daniel S Simpson, Tirta M Djajawi, Pankaj Deo, Rebecca L Ambrose, Stephanie A Conos, Jack Emery, Gilu Abraham, Ashlyn Pascoe, Sebastian A Hughes, Ashley Weir, Edwin D Hawkins, Isabella Kong, Marco J Herold, Jaclyn S Pearson, Najoua Lalaoui, Thomas Naderer, James E Vince, Kate E Lawlo. A1 is induced by pathogen ligands to limit myeloid cell death and NLRP3 inflammasome activation. EMBO reports. 2023-10-17. PMID:37846472. |
we show that, due to its tight transcriptional and post-translational regulation, a1 acts as a molecular rheostat to regulate bax/bak-dependent apoptosis and the subsequent nlrp3 inflammasome-dependent and inflammasome-independent maturation of the inflammatory cytokine il-1β. |
2023-10-17 |
2023-11-08 |
mouse |
| Hui Xu, Jiangtao Dong, Yang Li, Lei Zhang, Jiangwen Yin, Chao Zhu, Xu Wang, Kunhao Ren, Hao Zhang, Dong Zha. Neuritin has a neuroprotective role in the rat model of acute ischemia stroke by inhibiting neuronal apoptosis and NLRP3 inflammasome. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. vol 32. issue 12. 2023-10-13. PMID:37832268. |
neuritin has a neuroprotective role in the rat model of acute ischemia stroke by inhibiting neuronal apoptosis and nlrp3 inflammasome. |
2023-10-13 |
2023-10-15 |
rat |