| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liang Li, Xiao-Fang Wei, Zhi-Yong Yang, Rui Zhu, Deng-Lai Li, Guo-Jun Shang, Hao-Tong Wang, Si-Tong Meng, Yin-Tao Wang, Si-Ying Liu, Li-Fang W. Alleviative effect of poly-β-hydroxybutyrate on lipopolysaccharide-induced oxidative stress, inflammation and cell apoptosis in Cyprinus carpio. International journal of biological macromolecules. 2023-09-10. PMID:37690640. |
summary, this study suggested that appropriate level of dietary phb alleviated lps-induced oxidative stress, inflammation, apoptosis and the activation of nlrp3 inflammasome in common carp. |
2023-09-10 |
2023-10-07 |
cat |
| Haoyue Guan, Wenxue Ma, Qiong Wu, Jingzeng Cai, Ziwei Zhan. Exploring the Toxic Effects of ZEA on IPEC-J2 Cells from the Inflammatory Response and Apoptosis. Animals : an open access journal from MDPI. vol 13. issue 17. 2023-09-09. PMID:37684994. |
zea also caused apoptosis in porcine small intestine cells, resulting in a significant reduction in protein and/or mrna expression of apoptosis-related pathway factors such as p53, caspase 3, caspase 9, bax, and cyt-c, which in turn caused a significant decrease in protein and/or mrna expression of inflammatory-related factors such as il-1β, il-2, cox-2, nf-κd, nlrp3, il-6, and il -18, which in turn caused a significant increase in protein and/or mrna expression levels. |
2023-09-09 |
2023-10-07 |
cat |
| Bingling Dai, Hanbing Cao, Yu Hu, Zhengyan Gong, Xiaoyue Huang, Yanbin Chen, Feng Liu, Xiujuan Peng, Yanmin Zhang, Xinjun Le. Role of NLRP3 inflammasome activation in HCC cell progression. Heliyon. vol 9. issue 9. 2023-09-08. PMID:37681160. |
our results revealed that nlrp3 inflammasome activation inhibited the proliferation of bel-7402 and smmc-7721 cells, arrested the cell cycle at the g1 phase, and suppressed cell migration, while apoptosis remained unaffected. |
2023-09-08 |
2023-10-07 |
Not clear |
| Cuicui Zhuang, Jinhui Zhao, Shiyao Zhang, Muhammad Shahi. Escherichia coli infection mediates pyroptosis via activating p53-p21 pathway-regulated apoptosis and cell cycle arrest in bovine mammary epithelial cells. Microbial pathogenesis. 2023-09-08. PMID:37683833. |
lactic dehydrogenase activities, interleukin (il)-10, il-1β, il-18 and tumor necrosis factor-α concentrations, total apoptosis indexes, and protein expressions of p-cdc25c, p-cdk1, cleaved caspase 9, cleaved caspase 3, cleaved parp, p-nf-κb, nlrp3, asc, caspase 1, gasdermin d n-terminal, il-1β and il-18 were significantly increased in e. coli infected bmecs. |
2023-09-08 |
2023-10-07 |
cattle |
| Di Jia, Jiahui Han, Jimin Cai, Zhirong Huan, Yan Wang, Xin G. Mesenchymal stem cells overexpressing PBX1 alleviates haemorrhagic shock-induced kidney damage by inhibiting NF-κB activation. Biochimica et biophysica acta. Molecular cell research. 2023-09-06. PMID:37673222. |
furthermore, administration with rbmscs overexpressing pbx1 inhibited hs-induced nod-like receptor family pyrin domain containing 3 (nlrp3) inflammasome activation and the release of proinflammatory cytokines, and further attenuated apoptosis. |
2023-09-06 |
2023-10-07 |
human |
| Di Jia, Jiahui Han, Jimin Cai, Zhirong Huan, Yan Wang, Xin G. Mesenchymal stem cells overexpressing PBX1 alleviates haemorrhagic shock-induced kidney damage by inhibiting NF-κB activation. Biochimica et biophysica acta. Molecular cell research. 2023-09-06. PMID:37673222. |
hbmscs overexpressing pbx1 also exhibited protective effects on hk-2 cells exposed to hypoxia, as shown by the increase in cell viability, the mitigation of apoptosis, the decrease in inflammation, and the inhibition of nf-κb and nlrp3 inflammasome activation. |
2023-09-06 |
2023-10-07 |
human |
| K Bibha, T M Akhigbe, M A Hamed, R E Akhigb. Metabolic Derangement by Arsenic: a Review of the Mechanisms. Biological trace element research. 2023-09-05. PMID:37670201. |
in addition, arsenic activates mapks, modulates p53/ bcl-2 signaling, suppresses mdm-2 and parp, activates nlrp3 inflammasome and caspase-mediated apoptosis, and induces er stress, and ox-mtdna-dependent mitophagy and autophagy. |
2023-09-05 |
2023-10-07 |
Not clear |
| Daru Guo, Kang Cheng, Chao Song, Fei Liu, Weiye Cai, Jingwen Chen, Yongliang Mei, Daqian Zhou, Silong Gao, Guoyou Wang, Zongchao Li. Mechanisms of inhibition of nucleus pulposus cells pyroptosis through SDF1/CXCR4-NFkB-NLRP3 axis in the treatment of intervertebral disc degeneration by Duhuo Jisheng Decoction. International immunopharmacology. vol 124. issue Pt A. 2023-08-30. PMID:37647678. |
through bioinformatics, we found that nlrp3, gsdmd, il-1βand other hub proteins of pyroptosis were highly expressed in ivdd sd rats, and network pharmacology discovered that dhjsd may control cellular senescence, apoptosis, and pyroptosis in order to treat ivdd. |
2023-08-30 |
2023-09-07 |
rat |
| Antoine Fayand, Margaux Cescato, Laurent Le Corre, Alexandre Terré, Margaux Wacheux, Yixiang Y J Zhu, Armelle Melet, Thomas R J Moreau, Bahram Bodaghi, Fabrice Bonnet, Didier Bronnimann, Laurence Cuisset, Raquel Faria, Gilles Grateau, Pascal Pillet, Catharina M Mulders-Manders, Benedicte Neven, Pierre Quartier, Olivier Richer, Léa Savey, Marie-Elise Truchetet, Bénédicte F Py, Guilaine Boursier, Jean-Philippe Herbeuval, Sophie Georgin-Lavialle, Mathieu P Roder. Pathogenic variants in the NLRP3 LRR domain at position 861 are responsible for a boost-dependent atypical CAPS phenotype. The Journal of allergy and clinical immunology. 2023-08-26. PMID:37506976. |
cryopyrin-associated periodic syndrome (caps) is associated with nlrp3 pathogenic variants, mostly located in the nacht (neuronal apoptosis inhibitor protein, mhc class 2 transcription activator, incompatibility locus protein from podospora anserina, telomerase-associated protein) domain. |
2023-08-26 |
2023-09-07 |
Not clear |
| Renxu Chang, Hongdou Jia, Zhihao Dong, Qiushi Xu, Lei Liu, Zolzaya Majigsuren, Tugsjargal Batbaatar, Chuang Xu, Qing Yang, Xudong Su. Free Fatty Acids Induce Apoptosis of Mammary Epithelial Cells of Ketotic Dairy Cows via the Mito-ROS/NLRP3 Signaling Pathway. Journal of agricultural and food chemistry. 2023-08-16. PMID:37585786. |
the pyrin domain 3 (nlrp3) pathway involving the mitochondrial reactive oxygen species (mito-ros)-induced nucleotide-binding oligomerization domain-like receptor has been recognized as a key mechanism in this inflammatory response and cell apoptosis. |
2023-08-16 |
2023-09-07 |
Not clear |
| Renxu Chang, Hongdou Jia, Zhihao Dong, Qiushi Xu, Lei Liu, Zolzaya Majigsuren, Tugsjargal Batbaatar, Chuang Xu, Qing Yang, Xudong Su. Free Fatty Acids Induce Apoptosis of Mammary Epithelial Cells of Ketotic Dairy Cows via the Mito-ROS/NLRP3 Signaling Pathway. Journal of agricultural and food chemistry. 2023-08-16. PMID:37585786. |
however, nlrp3 inhibitor mcc950 pretreatment or mito-ros scavenging by mitotempo attenuated apoptosis in ffa-induced mac-t cells by inhibiting the nlrp3 inflammasome pathway. |
2023-08-16 |
2023-09-07 |
Not clear |
| Yan Chen, Xiankun Cao, Bin Pan, Han Du, Baixing Li, Xiao Yang, Xuzhuo Chen, Xin Wang, Tangjun Zhou, An Qin, Changqing Zhao, Jie Zha. Verapamil attenuates intervertebral disc degeneration by suppressing ROS overproduction and pyroptosis via targeting the Nrf2/TXNIP/NLRP3 axis in four-week puncture-induced rat models both in vivo and in vitro. International immunopharmacology. vol 123. 2023-08-14. PMID:37579541. |
administration of verapamil, a classic clinical drug, mitigated the tbhp-induced overproduction of reactive oxygen species and activation of the nlrp3 inflammasome, thus protecting cells from pyroptosis, apoptosis, and extracellular matrix degradation. |
2023-08-14 |
2023-09-07 |
rat |
| Mahammad Ghouse Shaik, Swanand Vinayak Joshi, Ravikumar Akunuri, Preeti Rana, Ziaur Rahman, Anusha Polomoni, Venkata Madhavi Yaddanapudi, Manoj P Dandekar, Nanduri Sriniva. Small molecule inhibitors of NLRP3 inflammasome and GSK-3β in the management of traumatic brain injury: A review. European journal of medicinal chemistry. vol 259. 2023-08-13. PMID:37573828. |
the activation of nlrp3 post-tbi increases the production of pro-inflammatory cytokines and caspase-1, which are major drivers of neuroinflammation and apoptosis. |
2023-08-13 |
2023-08-16 |
Not clear |
| Yu Chen, Junren Chen, Ziwei Xing, Cheng Peng, Dan L. Autophagy in Neuroinflammation: A Focus on Epigenetic Regulation. Aging and disease. 2023-08-07. PMID:37548945. |
inhibition of mtor and activation of ampk and foxo1 enhance autophagy and thereby suppress nlrp3 inflammasome activity and apoptosis, leading to the relief of neuroinflammatory response. |
2023-08-07 |
2023-08-14 |
Not clear |
| Lingyan Wang, Jin Liu, Zhuoran Wang, Xi Qian, Yu Zhao, Quan Wang, Na Dai, Yuhan Xie, Weijun Zeng, Wei Yang, Xiangfeng Bai, Yuqiao Yang, Jinqiao Qia. Dexmedetomidine abates myocardial ischemia reperfusion injury through inhibition of pyroptosis via regulation of miR-665/MEF2D/Nrf2 axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-08-07. PMID:37549462. |
dex markedly augmented cell viability, while suppressing cell apoptosis and expressions of nlrp3, cleaved-caspase-1, asc, gsdmd, il-1β, and il-18 in h9c2 cells subjected to h/r injury. |
2023-08-07 |
2023-08-14 |
rat |
| Lixia Zhang, Weibing Yang, Jin Yang, Fu Su. GPRC5A regulates proliferation and oxidative stress by inhibiting the STAT3/Socs3/c-MYC pathway in hepatocellular carcinoma. Journal of clinical biochemistry and nutrition. vol 73. issue 1. 2023-08-03. PMID:37534091. |
these results suggest that gprc5a suppresses proliferation and emt, induces oxidative stress and leads to apoptosis of hcc cells, potentially by regulating stat3/socs3/c-myc signalling and the nlrp3 inflammasome. |
2023-08-03 |
2023-08-14 |
Not clear |
| Su-Bin Choi, Sehee Kwon, Ji-Hye Kim, Na-Hyun Ahn, Joo-Hee Lee, Seung-Hoon Yan. The Molecular Mechanisms of Neuroinflammation in Alzheimer's Disease, the Consequence of Neural Cell Death. International journal of molecular sciences. vol 24. issue 14. 2023-07-29. PMID:37511515. |
neural cell death, occurring via apoptosis and autophagy, is widely observed in the ad brain in addition to neuroinflammation mediated by necroptosis and the nlrp3 inflammasome. |
2023-07-29 |
2023-08-14 |
Not clear |
| Sameh Saber, Mohannad Mohammad S Alamri, Jaber Alfaifi, Lobna A Saleh, Sameh Abdel-Ghany, Adel Mohamed Aboregela, Alshaimaa A Farrag, Abdulrahman H Almaeen, Masoud I E Adam, AbdulElah Al Jarallah AlQahtani, Ali M S Eleragi, Mustafa Ahmed Abdel-Reheim, Heba A Ramadan, Osama A Mohamme. (R,R)-BD-AcAc2 Mitigates Chronic Colitis in Rats: A Promising Multi-Pronged Approach Modulating Inflammasome Activity, Autophagy, and Pyroptosis. Pharmaceuticals (Basel, Switzerland). vol 16. issue 7. 2023-07-29. PMID:37513865. |
these effects were attributed to inhibiting nfκb and nlrp3 inflammasome activation and restraining pyroptosis and apoptosis while enhancing autophagy as revealed by reduced p62 and increased becn1. |
2023-07-29 |
2023-08-14 |
human |
| W Zhang, F J Hu, C X Yao, B P Li, M Zhang, X M Yan. [Visualization analysis of research hotspots in pathogenesis of diabetic nephropathy in China]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. vol 57. issue 7. 2023-07-24. PMID:37482743. |
the frontier hotspots in this field include biomarkers, nrf2, gut microbiota, nlrp3 inflammasome, apoptosis, microrna, etc. |
2023-07-24 |
2023-08-14 |
Not clear |
| Weiwei Wang, Dan Min. Oridonin attenuates apoptosis and NLRP3 inflammasome activation in IL-4-stimulated human bronchial epithelial cells in an in vitro pediatric asthma model. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2023-07-24. PMID:37486694. |
oridonin attenuates apoptosis and nlrp3 inflammasome activation in il-4-stimulated human bronchial epithelial cells in an in vitro pediatric asthma model. |
2023-07-24 |
2023-08-14 |
human |