Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Nini Chen, Peiyu Chen, Yanhe Zhou, Sidong Chen, Sitang Gong, Ming Fu, Lanlan Gen. HuNoV Non-Structural Protein P22 Induces Maturation of IL-1β and IL-18 and N-GSDMD-Dependent Pyroptosis through Activating NLRP3 Inflammasome. Vaccines. vol 11. issue 5. 2023-05-27. PMID:37243097. |
the nlrp3 inflammasome plays a key role in host innate immune responses by activating caspase1 to facilitate il-1β and il-18 secretion and n-gsdmd-driven apoptosis, while nlrp3 inflammasome overactivation plays an important role in the development of various inflammatory diseases. |
2023-05-27 |
2023-08-14 |
human |
Jiaxuan Wu, Shengya Fang, Pengfei Feng, Chunjiang Cai, Leying Zhang, Ling Yan. Changes in expression levels of Nod-like receptors in the spleen of ewes. Animal reproduction. vol 20. issue 1. 2023-05-25. PMID:37228386. |
expression of nlr family, including nod1, nod2, class ii transactivator (ciita), nlr family apoptosis inhibitory protein (naip), nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1 (nlrp1), nlrp3 and nlrp7, was analyzed using quantitative real-time pcr, western blot and immunohistochemistry analysis. |
2023-05-25 |
2023-08-14 |
Not clear |
Huijie Zhao, Yiming Zhang, Yanting Zhang, Chaoran Chen, Huiyang Liu, Yihan Yang, Honggang Wan. The role of NLRP3 inflammasome in hepatocellular carcinoma. Frontiers in pharmacology. vol 14. 2023-05-09. PMID:37153780. |
so far, the best studied and most characteristic inflammasome is the nlr-family pyrin domain-containing protein 3(nlrp3) inflammasome, which is composed of nlrp3, apoptosis associated speck like protein (asc) and pro-caspase-1. |
2023-05-09 |
2023-08-14 |
Not clear |
Baoshan Hu, Shan Lin, Shengrong Lin, Gang Ru. Ginkgetin Alleviates Intervertebral Disc Degeneration by Inhibiting Apoptosis, Inflammation, and Disturbance of Extracellular Matrix Synthesis and Catabolism via Inactivation of NLRP3 Inflammasome. Immunological investigations. 2023-05-08. PMID:37154418. |
ginkgetin alleviates intervertebral disc degeneration by inhibiting apoptosis, inflammation, and disturbance of extracellular matrix synthesis and catabolism via inactivation of nlrp3 inflammasome. |
2023-05-08 |
2023-08-14 |
Not clear |
Yu Zhang, Chong Li, Zhifang Wang, Tingting Wang, Yahui Zhou, Lili Zhen. Blocking CXC Motif Chemokine Ligand 2 Ameliorates Diabetic Peripheral Neuropathy via Inhibiting Apoptosis and NLRP3 Inflammasome Activation. Biological & pharmaceutical bulletin. vol 46. issue 5. 2023-04-30. PMID:37121693. |
blocking cxc motif chemokine ligand 2 ameliorates diabetic peripheral neuropathy via inhibiting apoptosis and nlrp3 inflammasome activation. |
2023-04-30 |
2023-08-14 |
rat |
Yu Zhang, Chong Li, Zhifang Wang, Tingting Wang, Yahui Zhou, Lili Zhen. Blocking CXC Motif Chemokine Ligand 2 Ameliorates Diabetic Peripheral Neuropathy via Inhibiting Apoptosis and NLRP3 Inflammasome Activation. Biological & pharmaceutical bulletin. vol 46. issue 5. 2023-04-30. PMID:37121693. |
in conclusion, these results indicated that cxcl2 knockdown exhibited amelioration of hyperglycemia-induced dpn by inhibiting cell apoptosis and nlrp3 inflammasome activation, suggesting that targeting cxcl2 might be a potential strategy for dpn treatment. |
2023-04-30 |
2023-08-14 |
rat |
Yuanshui Liu, Hang Yang, Fei Zhu, Yanhong Ouyang, Pinhua Pa. Inhibition of STAT3 phosphorylation by colchicine regulates NLRP3 activation to alleviate sepsis-induced acute lung injury. Inflammopharmacology. 2023-04-28. PMID:37115345. |
colchicine significantly attenuated ali in mice caused by sepsis by alleviating respiratory dysfunction and pulmonary edema in mice, inhibiting nlrp3 inflammasome formation, and reducing oxidative stress, pyroptosis, and apoptosis of murine alveolar macrophage (j774a.1) cells. |
2023-04-28 |
2023-08-14 |
mouse |
Lin Yang, Qiuling Zhao, Ting Chen, Wenbin Liu, Xiuliang Qiu, Jincan Chen, Shengqiang Huang, Ruyi Huang, Liangliang Don. An HPK1 inhibitor enhanced the tumour response to anti-PD-1 immunotherapy in non-Hodgkin's lymphoma. Clinical and experimental medicine. 2023-04-27. PMID:37106265. |
hpk1 inhibitor treatment increased pd-1, pd-l1, bax, p53 and nk-kb expression but decreased nlrp3 expression, indicating that the hpk1 inhibitor promoted apoptosis and blocked the nlrp3 inflammasome pathway to affect anti-pd-1-mediated t-cell cytotoxicity. |
2023-04-27 |
2023-08-14 |
zebrafish |
Lin Yang, Qiuling Zhao, Ting Chen, Wenbin Liu, Xiuliang Qiu, Jincan Chen, Shengqiang Huang, Ruyi Huang, Liangliang Don. An HPK1 inhibitor enhanced the tumour response to anti-PD-1 immunotherapy in non-Hodgkin's lymphoma. Clinical and experimental medicine. 2023-04-27. PMID:37106265. |
in summary, this study provides evidence that an hpk1 inhibitor enhanced the tumour response to anti-pd-1 immunotherapy in nhl by promoting apoptosis and blocking the nlrp3 pathway. |
2023-04-27 |
2023-08-14 |
zebrafish |
Wen-Yu Zeng, Wen-Yan Gu, Li Xyu, Ying Zhang, Cong Ha. [miR-99b-5p inhibits the activation of NLRP3 inflammasome to alleviate the neurotoxicity induced by paclitaxel chemotherapy]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 38. issue 5. 2023-04-23. PMID:37088748. |
to study the effects of mir-99b-5p (non-coding rna) in alleviating pathological neuropathic pain after paclitaxel chemotherapy by inhibiting nlrp3 inflammatory vesicle activation and the effects on neuronal cells pyrosis and apoptosis. |
2023-04-23 |
2023-08-14 |
Not clear |
Lijuan He, Wei Zhou, Lamei Wang, Na Tang, Yongjia Wang, Hua Zhong, Yan Tang, Dongmei Xi, Fang H. Murine Cytomegalovirus Infection Induced miR-1929-3p Down-Regulation Promotes the Proliferation and Apoptosis of Vascular Smooth Muscle Cells in Mice by Targeting Endothelin A Receptor and Downstream NLRP3 Activation Pathway. Molecular biotechnology. 2023-04-06. PMID:37022597. |
murine cytomegalovirus infection induced mir-1929-3p down-regulation promotes the proliferation and apoptosis of vascular smooth muscle cells in mice by targeting endothelin a receptor and downstream nlrp3 activation pathway. |
2023-04-06 |
2023-08-14 |
mouse |
Lijuan He, Wei Zhou, Lamei Wang, Na Tang, Yongjia Wang, Hua Zhong, Yan Tang, Dongmei Xi, Fang H. Murine Cytomegalovirus Infection Induced miR-1929-3p Down-Regulation Promotes the Proliferation and Apoptosis of Vascular Smooth Muscle Cells in Mice by Targeting Endothelin A Receptor and Downstream NLRP3 Activation Pathway. Molecular biotechnology. 2023-04-06. PMID:37022597. |
western blot detected proteins of cell proliferation, apoptosis, and the nlrp3 inflammasome. |
2023-04-06 |
2023-08-14 |
mouse |
Shengyang Xiao, Xiaoning Song, Man Zheng, Xinran Cao, Guo Ai, Baona Li, Gang Zhao, Haitao Yua. Interleukin-37 ameliorates atherosclerosis by regulating autophagy-mediated endothelial cell apoptosis and inflammation. International immunopharmacology. vol 118. 2023-04-06. PMID:37023695. |
we observed that il-37 alleviated ox-ldl-induced endothelial cell inflammation and dysfunction, as evidenced by decreased nod-like receptor pyrin domain-containing 3 (nlrp3) inflammasome activation, ros production, apoptosis rate and secretion of inflammatory cytokines il-1β and tnf-α. |
2023-04-06 |
2023-08-14 |
mouse |
Julia Ma, Xiaojing Wang, Raymond Gu, Dandan Guo, Changying Shi, Michaela Kollisch-Singule, Liye Suo, Juntao Luo, Qinghe Meng, Robert N Coone. PROPHYLACTIC nCMT-3 ATTENUATES SEPSIS-INDUCED ACUTE KIDNEY INJURY IN ASSOCIATION WITH NLRP3 INFLAMMASOME ACTIVATION AND APOPTOSIS. Shock (Augusta, Ga.). 2023-03-20. PMID:36939682. |
prophylactic ncmt-3 attenuates sepsis-induced acute kidney injury in association with nlrp3 inflammasome activation and apoptosis. |
2023-03-20 |
2023-08-14 |
Not clear |
Xiaotao Feng, Wei Ren, Yuxiang Tang, Ruyan Wen, Huiming Duan, Li Ya. Palmitic acid impairs INS-1 cells and alters the global gene expression profile. Cellular and molecular biology (Noisy-le-Grand, France). vol 68. issue 9. 2023-03-11. PMID:36905272. |
moreover, pa promoted protein expression of chop, cleaved caspase-3, microtubule-associated proteins light chain 3 (lc3)-ii, nod-like receptor pyrin domain containing 3 (nlrp3), cleaved il-1β and lcn2, increased reactive oxygen species, apoptosis and the ratio of lc3-ii/i, and reduced p62 protein expression, intracellular glutathione peroxidase and catalase levels, suggesting activation of er stress, oxidative stress, autophagy and nlrp3 inflammasome. |
2023-03-11 |
2023-08-14 |
Not clear |
Siqi Liu, Chongyang Wang, Yulian Zhang, Yalin Zhang, Yilan Song, Jingzhi Jiang, Ruobai Liu, Hainan Jin, Guanghai Yan, Yongde Ji. Polydatin inhibits mitochondrial damage and mitochondrial ROS by promoting PINK1-Parkin-mediated mitophagy in allergic rhinitis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 4. 2023-03-11. PMID:36906289. |
the expressions of pink1, parkin, p62, lc3b, nlrp3 inflammasome proteins, and apoptosis proteins in nasal tissues and hnepcs were measured by western blot. |
2023-03-11 |
2023-08-14 |
mouse |
Siqi Liu, Chongyang Wang, Yulian Zhang, Yalin Zhang, Yilan Song, Jingzhi Jiang, Ruobai Liu, Hainan Jin, Guanghai Yan, Yongde Ji. Polydatin inhibits mitochondrial damage and mitochondrial ROS by promoting PINK1-Parkin-mediated mitophagy in allergic rhinitis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 4. 2023-03-11. PMID:36906289. |
meanwhile, pd enhanced pink1-parkin-mediated mitophagy but decreased mitochondrial reactive oxygen species (mtros) production, nlrp3 inflammasome activation, and apoptosis. |
2023-03-11 |
2023-08-14 |
mouse |
Siqi Liu, Chongyang Wang, Yulian Zhang, Yalin Zhang, Yilan Song, Jingzhi Jiang, Ruobai Liu, Hainan Jin, Guanghai Yan, Yongde Ji. Polydatin inhibits mitochondrial damage and mitochondrial ROS by promoting PINK1-Parkin-mediated mitophagy in allergic rhinitis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 4. 2023-03-11. PMID:36906289. |
moreover, mitochondrial damage, mtros production, nlrp3 inflammasome activation, and hnepcs apoptosis under il-13 exposure were more severe after pink1 knockdown or mdivi-1 treatment. |
2023-03-11 |
2023-08-14 |
mouse |
Siqi Liu, Chongyang Wang, Yulian Zhang, Yalin Zhang, Yilan Song, Jingzhi Jiang, Ruobai Liu, Hainan Jin, Guanghai Yan, Yongde Ji. Polydatin inhibits mitochondrial damage and mitochondrial ROS by promoting PINK1-Parkin-mediated mitophagy in allergic rhinitis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 4. 2023-03-11. PMID:36906289. |
conclusively, pd may exert protective effects on ar by promoting pink1-parkin-mediated mitophagy, which further suppresses apoptosis and tissue damage in ar through decreasing mtros production and nlrp3 inflammasome activation. |
2023-03-11 |
2023-08-14 |
mouse |
Can Li, Yuying Zhu, Weiwei Liu, Toshihiko Hayashi, Wendie Xiang, Sijun He, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejim. Increased mitochondrial fission induces NLRP3/cGAS-STING mediated pro-inflammatory pathways and apoptosis in UVB-irradiated immortalized human keratinocyte HaCaT cells. Archives of biochemistry and biophysics. 2023-03-06. PMID:36878340. |
mitochondrial dynamics was discovered to be crucial for nlrp3 inflammasome and cgas-sting pathway activation, as well as the induction of apoptosis. |
2023-03-06 |
2023-08-14 |
human |