| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hao-Yue Feng, Rui Ding, Qi Zhou, Ting-Chao Wu, Hui Li, Xi-Tao Ma, Ren-Song Yu. [Role of NLRP3 inflammasome in diabetic neuropathy and prevention and treatment with traditional Chinese medicine]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 2. 2023-02-01. PMID:36725219. |
nod-like receptor pyrin domain-containing 3(nlrp3) inflammasome is a group of subcellular multiprotein complexes, including nlrp3, apoptosis associated speck-like protein(asc), and pro-cysteinyl aspartate specific proteinase 1(pro-caspase-1). |
2023-02-01 |
2023-08-14 |
Not clear |
| Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James M Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, Marc Pellegrini, Marco Herold, Ivan K H Poon, Seth L Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lanlan Geng, James E Vinc. Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency. The EMBO journal. 2023-01-17. PMID:36647737. |
neither caspase-3 and caspase-7-mediated activation of the pannexin-1 channel, or gsdmd loss, prevented nlrp3 inflammasome assembly and consequent caspase-1 and il-1β maturation downstream of xiap inhibition and caspase-8 activation, even though the pannexin-1 channel was required for nlrp3 triggering upon mitochondrial apoptosis. |
2023-01-17 |
2023-08-14 |
Not clear |
| Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James M Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, Marc Pellegrini, Marco Herold, Ivan K H Poon, Seth L Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lanlan Geng, James E Vinc. Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency. The EMBO journal. 2023-01-17. PMID:36647737. |
these findings uncouple the mechanisms of cell death and nlrp3 activation resulting from extrinsic and intrinsic apoptosis signalling, reveal how xiap loss can co-opt dual cell death programs, and uncover strategies for targeting the cell death and inflammatory pathways that result from xiap deficiency. |
2023-01-17 |
2023-08-14 |
Not clear |
| Chenyun Song, Xinyu Chen, Jixin Ma, Hada Buhe, Yang Liu, Hexige Saiyin, Lixiang M. Construction of a pancreatic cancer nerve invasion system using brain and pancreatic cancer organoids. Journal of tissue engineering. vol 14. 2023-01-13. PMID:36636100. |
the approximating of mpcos to hbros accelerated the proliferation of neuronal progenitor cells, intensified the apoptosis of neurons in the hbros, and increased the expression of inflammatory molecules in hbros, including nlrp3, il-8, and il-1β. |
2023-01-13 |
2023-08-14 |
mouse |
| Zongqi You, Xinying Huang, Yaoxian Xiang, Junxi Dai, Lei Xu, Junjian Jiang, Jianguang X. Ablation of NLRP3 inflammasome attenuates muscle atrophy via inhibiting pyroptosis, proteolysis and apoptosis following denervation. Theranostics. vol 13. issue 1. 2023-01-03. PMID:36593964. |
ablation of nlrp3 inflammasome attenuates muscle atrophy via inhibiting pyroptosis, proteolysis and apoptosis following denervation. |
2023-01-03 |
2023-08-14 |
Not clear |
| Anil Kumar Kalvala, Ramesh Nimma, Arvind Bagde, Sunil Kumar Surapaneni, Nilkumar Patel, Peggy Arthur, Li Sun, Rakesh Singh, Nagavendra Kommineni, Aakash Nathani, Yan Li, Mandip Sing. The role of Cannabidiol and tetrahydrocannabivarin to overcome doxorubicin resistance in MDA-MB-231 xenografts in athymic nude mice. Biochimie. 2022-12-19. PMID:36535544. |
transcriptomics and proteomics studies revealed that cbd and thcv, by downregulating pd-l1, tgf-β, sp1, nlrp3, p38-mapk, and upregulating ampk induced apoptosis leading to improved dox's chemosensitivity against dox resistant mda-mb-231 tumors in balb/c nude mice. |
2022-12-19 |
2023-08-14 |
mouse |
| Dexiang Xia, Yanmei Chen, Guifang Luo, Dangheng We. Atherosclerosis: from the disruption of mitochondrial membrane potential to the potential interventional strategies. Current medicinal chemistry. 2022-12-05. PMID:36464879. |
recent studies have shown that disruption of the mitochondrial membrane potential (deltapsi (m)) directly affects the electron transport chain (etc), which in turn leads to oxidative stress, and furthermore, its alteration leads to apoptosis and activation of the nlrp3 inflammasome, thereby promoting the development of as. |
2022-12-05 |
2023-08-14 |
Not clear |
| Dexiang Xia, Yanmei Chen, Guifang Luo, Dangheng We. Atherosclerosis: from the disruption of mitochondrial membrane potential to the potential interventional strategies. Current medicinal chemistry. 2022-12-05. PMID:36464879. |
here, this review describes how deltapsi (m) contributes to the development of as by mediating oxidative stress, apoptosis, and nlrp3 inflammasome activation, and potential as intervention strategies by targeting oxidative stress, apoptosis, and nlrp3 inflammasome activation induced by deltapsi (m). |
2022-12-05 |
2023-08-14 |
Not clear |
| Jingwen Cao, Ran Xu, Fuhan Wang, Yuan Geng, Tianchao Xu, Mengran Zhu, Hongli Lv, Shiwen Xu, Meng-Yao Gu. Polyethylene microplastics trigger cell apoptosis and inflammation via inducing oxidative stress and activation of the NLRP3 inflammasome in carp gills. Fish & shellfish immunology. 2022-12-05. PMID:36470402. |
polyethylene microplastics trigger cell apoptosis and inflammation via inducing oxidative stress and activation of the nlrp3 inflammasome in carp gills. |
2022-12-05 |
2023-08-14 |
Not clear |
| Jingwen Cao, Ran Xu, Fuhan Wang, Yuan Geng, Tianchao Xu, Mengran Zhu, Hongli Lv, Shiwen Xu, Meng-Yao Gu. Polyethylene microplastics trigger cell apoptosis and inflammation via inducing oxidative stress and activation of the NLRP3 inflammasome in carp gills. Fish & shellfish immunology. 2022-12-05. PMID:36470402. |
these results suggested that oxidative stress acted as an activation signal of apoptosis triggered by the nf-κb pathway and activating the nlrp3 inflammasome to promote inflammatory immune responses. |
2022-12-05 |
2023-08-14 |
Not clear |
| Tengfei Wang, Yufei Xiao, Ronglong Luo, Yingjie Wang, Mengyun Zou, Yingfei Sun, Lulu Wang, Qiao Guo, Xiuli Pen. Host resistance to Mycoplasma gallisepticum infection is enhanced by inhibiting PI3K/Akt pathway in Andrographolide-treating chickens. International immunopharmacology. vol 113. issue Pt A. 2022-12-03. PMID:36461587. |
furthermore, ag treatment down-regulated inflammasome nlrp3 and apoptosis genes caspase3 and caspase9, and up-regulated autophagy protein light chain 3 (lc3) by regulating the pi3k/akt signaling pathway in vitro. |
2022-12-03 |
2023-08-14 |
chicken |
| Zhiguang Liu, Xiaochun Zhu, Chenglin Xu, Feng Min, Guofeng Yu, Chuhong Che. Ulinastatin ameliorates the malignant progression of prostate cancer cells by blocking the RhoA/ROCK/NLRP3 pathway. Drug development research. 2022-12-03. PMID:36461611. |
in addition, pc-3 cells were pretreated with rhoa agonist cn03 (1 μg/ml) or nlrp3 agonist nigericin (10 μm) before uti treatment, and the cellular behaviors above were detected again. it was demonstrated that uti significantly suppressed cell proliferation, migration, and invasion but promoted apoptosis in pc-3 cells in a concentration-dependent manner. |
2022-12-03 |
2023-08-14 |
Not clear |
| Zhiguang Liu, Xiaochun Zhu, Chenglin Xu, Feng Min, Guofeng Yu, Chuhong Che. Ulinastatin ameliorates the malignant progression of prostate cancer cells by blocking the RhoA/ROCK/NLRP3 pathway. Drug development research. 2022-12-03. PMID:36461611. |
meanwhile, uti could block rhoa/rock/nlrp3 inflammasome pathway in pc-3 cells, and the activation of rhoa or nlrp3 inflammasome partly weakened the impacts of uti on cell proliferation, migration, and apoptosis in pc-3 cells, respectively. in summary, our study demonstrated the antitumor activity of uti against prostate cancer by regulating rhoa/nlrp3 inflammasome pathway, providing a promising candidate drug for the therapeutic treatment of prostate cancer. |
2022-12-03 |
2023-08-14 |
Not clear |
| Jianbo Zhou, Qinzhi Wan. Daphnoretin relieves IL-1β-mediated chondrocytes apoptosis via repressing endoplasmic reticulum stress and NLRP3 inflammasome. Journal of orthopaedic surgery and research. vol 17. issue 1. 2022-11-17. PMID:36384642. |
daphnoretin relieves il-1β-mediated chondrocytes apoptosis via repressing endoplasmic reticulum stress and nlrp3 inflammasome. |
2022-11-17 |
2023-08-14 |
Not clear |
| Bing Li, Zhikun Yang, Xufeng Zhao, Youxin Chen, Donghui Li, Li Zhang, Hanyi Min, Weihong Yu, Min She. Early onset drusen and RPE dysfunction in a patient with NLRP3-AID. Ocular immunology and inflammation. 2022-11-17. PMID:36395369. |
previous animal studies have proven that the activation of nlrp3 inflammasome in rpe leads to apoptosis and pyroptosis, which may play a very important role in the development of age-related macular degeneration (amd). |
2022-11-17 |
2023-08-14 |
Not clear |
| Dongju Zhu, Jie Zhong, Xuefeng Gong, Xiang W. Augmenter of liver regeneration reduces mitochondria-derived ROS and NLRP3 inflammasome activation through PINK1/Parkin-mediated mitophagy in ischemia-reperfusion-induced renal tubular injury. Apoptosis : an international journal on programmed cell death. 2022-11-12. PMID:36370259. |
the overexpression of alr reduced the production of mitochondria-derived ros (mtros), the activation of the nlrp3 inflammasome, and the rate of apoptosis. |
2022-11-12 |
2023-08-14 |
Not clear |
| Dongju Zhu, Jie Zhong, Xuefeng Gong, Xiang W. Augmenter of liver regeneration reduces mitochondria-derived ROS and NLRP3 inflammasome activation through PINK1/Parkin-mediated mitophagy in ischemia-reperfusion-induced renal tubular injury. Apoptosis : an international journal on programmed cell death. 2022-11-12. PMID:36370259. |
these results suggest that alr can alleviate ir-induced apoptosis via the pink1/parkin mitophagy pathway to reduce the production of mtros and limit the activation of the nlrp3 inflammasome. |
2022-11-12 |
2023-08-14 |
Not clear |
| Yuanyuan Zhou, Hanyu Liao, Shanshan Yin, Pengqiao Wang, Xiaoqing Ye, Jianyun Zhan. Aryl-, halogenated- and alkyl- organophosphate esters induced oxidative stress, endoplasmic reticulum stress and NLRP3 inflammasome activation in HepG2 cells. Environmental pollution (Barking, Essex : 1987). 2022-11-03. PMID:36328282. |
the cytotoxicity, apoptosis, oxidative stress, endoplasmic reticulum (er) stress and nlrp3 inflammasome activation induced by opes were evaluated in human hepatocellular carcinomas hepg2 cells. |
2022-11-03 |
2023-08-14 |
human |
| Ruera Carolina, Miculan Emanuel, Ducca Gerónimo, Pérez Federico, Iribarren María Luz, Carasi Paula, Chirdo Fernando Gabrie. IL-1β blockade prevents cell death and mucosal damage of the small intestine in a model of sterile inflammation. Immunology letters. 2022-10-29. PMID:36309159. |
here we show that specific inhibition of caspase-1 or nlrp3 abolishes the damage induced by p31-43, and that antibody-mediated blocking of il-1β inhibits the both the histological changes and the induction of apoptosis and caspase-3 activation driven by p31-43. |
2022-10-29 |
2023-08-14 |
Not clear |
| Liang Zheng, Hongbiao Xu, Fufu Zheng, Yuanhui Lai, Jie Li, Weiming Lv, Zuojun Hu, Wenjian Wan. Intervention time decides the status of autophagy, NLRP3 activity and apoptosis in macrophages induced by ox-LDL. Lipids in health and disease. vol 21. issue 1. 2022-10-26. PMID:36284323. |
intervention time decides the status of autophagy, nlrp3 activity and apoptosis in macrophages induced by ox-ldl. |
2022-10-26 |
2023-08-14 |
Not clear |