| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Man Di, Qianfeng Zhang, Jingjing Wang, Xifeng Xiao, Jianlei Huang, Yuan Ma, Hongya Yang, Mao L. Epigallocatechin-3-gallate (EGCG) attenuates inflammatory responses and oxidative stress in lipopolysaccharide (LPS)-induced endometritis via silent information regulator transcript-1 (SIRT1)/nucleotide oligomerization domain (NOD)-like receptor pyrin domain-containing 3 (NLRP3) pathway. Journal of biochemical and molecular toxicology. 2022-09-03. PMID:36056792. |
additionally, egcg decreased oxidative stress and reduced cell apoptosis by upregulating sirt1 expression, downregulating the nlrp3 inflammasome activation. |
2022-09-03 |
2023-08-14 |
mouse |
| Yueshan Wu, Jing Chang, Juanjuan Ge, Kangyan Xu, Quan Zhou, Xiaowen Zhang, Ni Zhu, Meichun H. Isobavachalcone's Alleviation of Pyroptosis Contributes to Enhanced Apoptosis in Glioblastoma: Possible Involvement of NLRP3. Molecular neurobiology. 2022-09-02. PMID:36053436. |
isobavachalcone's alleviation of pyroptosis contributes to enhanced apoptosis in glioblastoma: possible involvement of nlrp3. |
2022-09-02 |
2023-08-14 |
Not clear |
| Yueshan Wu, Jing Chang, Juanjuan Ge, Kangyan Xu, Quan Zhou, Xiaowen Zhang, Ni Zhu, Meichun H. Isobavachalcone's Alleviation of Pyroptosis Contributes to Enhanced Apoptosis in Glioblastoma: Possible Involvement of NLRP3. Molecular neurobiology. 2022-09-02. PMID:36053436. |
experimentally, ibc alleviated nlrp3 inflammasome-related pyroptosis and inflammation, arrested cell cycle at g1 phase, and induced mitochondria-dependent apoptosis in gbm cells. |
2022-09-02 |
2023-08-14 |
Not clear |
| Marwa Gamal Al-Shawadfy, Gellan Alaa Mohamed Kamel, Adel R A Abd-Alla. Crosstalk among apoptosis, inflammation, and autophagy in relation to melatonin protective effect against contrast-induced nephropathy in rats. Canadian journal of physiology and pharmacology. 2022-08-26. PMID:36017872. |
moreover, cin-induced oxidative stress, nlrp3 inflammasome, and apoptosis were attenuated by m. furthermore, m modulates autophagy in cin rats. |
2022-08-26 |
2023-08-14 |
rat |
| Zhi-Qiang Cui, Xiao-Ying Hu, Tuo Yang, Jing-Wei Guan, Ying Gu, Hui-Yuan Li, Hui-Yu Zhang, Qing-Huan Xiao, Xiao-Hong Su. TMEM16F may be a new therapeutic target for Alzheimer's disease. Neural regeneration research. vol 18. issue 3. 2022-08-26. PMID:36018189. |
after tmem16f knockdown in mice, spatial memory ability was improved, microglia polarization to the m2 phenotype was promoted, nlrp3 inflammasome activation was inhibited, cell apoptosis and aβ plaque deposition in brain tissue were reduced, and brain injury was alleviated. |
2022-08-26 |
2023-08-14 |
mouse |
| Xiaoyu Li, Jun Long, Ligeng Zong, Chengcheng Zhang, Zhongxin Yang, Shengnan Gu. ZNF561-AS1 Regulates Cell Proliferation and Apoptosis in Myocardial Infarction Through miR-223-3p/NLRP3 Axis. Cell transplantation. vol 31. 2022-08-23. PMID:35997481. |
through cell function assays including cck-8, 5-ethynyl-2'-deoxyuridine (edu), flow cytometry, and tdt-mediated dutp nick-end labeling (tunel), supported by wb analysis, we verified that silencing of nlrp3 facilitated proliferation but impeded apoptosis of hypoxia-induced myocardial cell. |
2022-08-23 |
2023-08-14 |
mouse |
| Xiaoxiao Liu, Minghui Li, Zhiwei Chen, Yong Yu, Hui Shi, Ying Yu, Yucheng Wang, Ruizhen Chen, Junbo G. Mitochondrial calpain-1 activates NLRP3 inflammasome by cleaving ATP5A1 and inducing mitochondrial ROS in CVB3-induced myocarditis. Basic research in cardiology. vol 117. issue 1. 2022-08-23. PMID:35997820. |
transgenic mice overexpressing the endogenous calpain inhibitor calpastatin (tg-cast mice) exhibited not only decreased apoptosis, inflammation, fibrosis, and enhanced cardiac function but also inhibition of nlrp3 inflammasome and pyroptosis. |
2022-08-23 |
2023-08-14 |
mouse |
| Hangfei Liang, Xiao Yang, Huilin Li, Xinhui Wang, Haiguo Su, Xuan Li, Jianing Tian, Chenghui Cai, Min Huang, Huichang B. Schisandrol B protects against cholestatic liver injury by inhibiting pyroptosis through pregnane X receptor. Biochemical pharmacology. 2022-08-21. PMID:35988735. |
further analysis revealed that both nod-like receptor protein 3 (nlrp3) inflammasome-induced canonical pyroptosis and apoptosis protease activating factor-1 (apaf-1) pyroptosome-induced noncanonical pyroptosis were significantly inhibited after solb pretreatment, as illustrated by the decreased expression levels of nlrp3, asc, caspase-1, and gsdmd and the levels of apaf-1, caspase-11 p20, caspase-3 p20, and gsdme. |
2022-08-21 |
2023-08-14 |
Not clear |
| Shilu Luo, Ming Yang, Yachun Han, Hao Zhao, Na Jiang, Li Li, Wei Chen, Chenrui Li, Jinfei Yang, Yan Liu, Chongbin Liu, Chanyue Zhao, Lin Su. β-Hydroxybutyrate against Cisplatin-Induced acute kidney injury via inhibiting NLRP3 inflammasome and oxidative stress. International immunopharmacology. vol 111. 2022-08-08. PMID:35940076. |
β-hydroxybutyric acid (bhb) is a metabolite in the body and acts as an inhibitor of oxidative stress and nlrp3 inflammasome, reducing inflammatory responses and apoptosis. |
2022-08-08 |
2023-08-14 |
mouse |
| Shilu Luo, Ming Yang, Yachun Han, Hao Zhao, Na Jiang, Li Li, Wei Chen, Chenrui Li, Jinfei Yang, Yan Liu, Chongbin Liu, Chanyue Zhao, Lin Su. β-Hydroxybutyrate against Cisplatin-Induced acute kidney injury via inhibiting NLRP3 inflammasome and oxidative stress. International immunopharmacology. vol 111. 2022-08-08. PMID:35940076. |
compared to the control, cisplatin-treated mice exhibited high level of serum creatinine, blood urea nitrogen and severe tubular injury, which accompanied with significantly increased expression level of nlrp3, il-1β, il-18, bax, cleaved-caspase 3, as well as aggravated oxidative stress and renal tubular cell apoptosis. |
2022-08-08 |
2023-08-14 |
mouse |
| Yongsheng Mei, Bingzi Dong, Zhuang Geng, Lili X. Excess Uric Acid Induces Gouty Nephropathy Through Crystal Formation: A Review of Recent Insights. Frontiers in endocrinology. vol 13. 2022-08-01. PMID:35909538. |
such a response stimulates macrophage activation, leads to the activation of nod-like receptor protein 3 (nlrp3) inflammasome vesicles, and ultimately the production and liberation of interleukin-1b (il-1b) and interleukin-18 (il-18), which can mediate inflammation, apoptosis and necroinflammation and cause an inflammatory cascade response. |
2022-08-01 |
2023-08-14 |
human |
| Xiujing Dou, Di Yan, Siqi Liu, Lujia Gao, Anshan Sha. Thymol Alleviates LPS-Induced Liver Inflammation and Apoptosis by Inhibiting NLRP3 Inflammasome Activation and the AMPK-mTOR-Autophagy Pathway. Nutrients. vol 14. issue 14. 2022-07-27. PMID:35889766. |
thymol alleviates lps-induced liver inflammation and apoptosis by inhibiting nlrp3 inflammasome activation and the ampk-mtor-autophagy pathway. |
2022-07-27 |
2023-08-14 |
mouse |
| Xuefeng Pang, Qigang Guan, Xue Lin, Ning Chan. Knockdown of HDAC6 alleviates ventricular remodeling in experimental dilated cardiomyopathy via inhibition of NLRP3 inflammasome activation and promotion of cardiomyocyte autophagy. Cell biology and toxicology. 2022-06-28. PMID:35764897. |
besides, in dox-injured cardiomyocytes, hdac6 silencing also diminished nlrp3 inflammasome activation and cell apoptosis but enhanced cell autophagy, whereas ectopic nlrp3 expression negated the effects of hdac6 silencing. |
2022-06-28 |
2023-08-14 |
rat |
| Fang Hua, Jing Ya Li, Meng Zhang, Peng Zhou, Liang Wang, Tie Jun Ling, Guan Hu Ba. Kaempferol-3-O-rutinoside exerts cardioprotective effects through NF-κB/NLRP3/Caspase-1 pathway in ventricular remodeling after acute myocardial infarction. Journal of food biochemistry. 2022-06-27. PMID:35758877. |
our results showed that kr had a good binding activity with nlrp3, caspase-1, and gsdmd, significantly improved cardiac function, alleviated cardiac pathological changes, reduced the excessive deposition of myocardial interstitial collagen, and inhibited cardiomyocyte apoptosis in ami rats. |
2022-06-27 |
2023-08-14 |
rat |
| Kai Wang, Gang Wang, Botao Zho. TSPO knockdown attenuates OGD/R-induced neuroinflammation and neural apoptosis by decreasing NLRP3 inflammasome activity through PPARγ pathway. Brain research bulletin. 2022-06-23. PMID:35738501. |
tspo knockdown attenuates ogd/r-induced neuroinflammation and neural apoptosis by decreasing nlrp3 inflammasome activity through pparγ pathway. |
2022-06-23 |
2023-08-14 |
Not clear |
| Kai Wang, Gang Wang, Botao Zho. TSPO knockdown attenuates OGD/R-induced neuroinflammation and neural apoptosis by decreasing NLRP3 inflammasome activity through PPARγ pathway. Brain research bulletin. 2022-06-23. PMID:35738501. |
tspo silencing attenuated ogd/r-induced inflammation and apoptosis by decreasing nlrp3 inflammasome activity. |
2022-06-23 |
2023-08-14 |
Not clear |
| Kai Wang, Gang Wang, Botao Zho. TSPO knockdown attenuates OGD/R-induced neuroinflammation and neural apoptosis by decreasing NLRP3 inflammasome activity through PPARγ pathway. Brain research bulletin. 2022-06-23. PMID:35738501. |
pparγ knockdown abolished the effect of tspo silence on nlrp3 inflammasome activity, inflammation, and cell apoptosis in ogd/r-treated cells, while pparγ overexpression alleviated ogd/r-induced injury in sh-sy5y cells. |
2022-06-23 |
2023-08-14 |
Not clear |
| Kai Wang, Gang Wang, Botao Zho. TSPO knockdown attenuates OGD/R-induced neuroinflammation and neural apoptosis by decreasing NLRP3 inflammasome activity through PPARγ pathway. Brain research bulletin. 2022-06-23. PMID:35738501. |
in conclusion, tspo knockdown attenuates neuroinflammation and neural apoptosis by decreasing nlrp3 inflammasome activity through pparγ pathway. |
2022-06-23 |
2023-08-14 |
Not clear |
| Lei Huang, Xinyu He, Wen Peng, Xueqing He, Bei Xu, Hu Xu, Yaoxing Wang, Wenjun Xu, Wentong Chen, Sheng Wang, Lanlan Zhou, Ning Liu, Youzhi Xu, Wenjie L. Hyperuricemia induces liver injury by upregulating HIF-1α and inhibiting arginine biosynthesis pathway in mouse liver and human L02 hepatocytes. Biochemical and biophysical research communications. vol 617. issue Pt 2. 2022-06-13. PMID:35696777. |
ua directly activated the hepatic nlrp3 inflammasome and bax apoptosis pathway invivo and invitro. |
2022-06-13 |
2023-08-14 |
mouse |
| Isha Sharma, Karan Singh Yadav, Madhav Nilakanth Mugal. Redoxisome and Diabetic Retinopathy: Pathophysiology and Therapeutic Interventions. Pharmacological research. 2022-06-12. PMID:35691540. |
recent studies indicate the association of trx/txnip with redox signal transduction pathways including activation of nod-like receptor pyrin domain containing protein-3 (nlrp3) inflammasome, apoptosis, autophagy/mitophagy, epigenetic modifications in a redox-dependent manner. |
2022-06-12 |
2023-08-14 |
Not clear |