| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bing Li, Zhikun Yang, Xufeng Zhao, Youxin Chen, Donghui Li, Li Zhang, Hanyi Min, Weihong Yu, Min She. Early onset drusen and RPE dysfunction in a patient with NLRP3-AID. Ocular immunology and inflammation. 2022-11-17. PMID:36395369. |
previous animal studies have proven that the activation of nlrp3 inflammasome in rpe leads to apoptosis and pyroptosis, which may play a very important role in the development of age-related macular degeneration (amd). |
2022-11-17 |
2023-08-14 |
Not clear |
| Dongju Zhu, Jie Zhong, Xuefeng Gong, Xiang W. Augmenter of liver regeneration reduces mitochondria-derived ROS and NLRP3 inflammasome activation through PINK1/Parkin-mediated mitophagy in ischemia-reperfusion-induced renal tubular injury. Apoptosis : an international journal on programmed cell death. 2022-11-12. PMID:36370259. |
the overexpression of alr reduced the production of mitochondria-derived ros (mtros), the activation of the nlrp3 inflammasome, and the rate of apoptosis. |
2022-11-12 |
2023-08-14 |
Not clear |
| Dongju Zhu, Jie Zhong, Xuefeng Gong, Xiang W. Augmenter of liver regeneration reduces mitochondria-derived ROS and NLRP3 inflammasome activation through PINK1/Parkin-mediated mitophagy in ischemia-reperfusion-induced renal tubular injury. Apoptosis : an international journal on programmed cell death. 2022-11-12. PMID:36370259. |
these results suggest that alr can alleviate ir-induced apoptosis via the pink1/parkin mitophagy pathway to reduce the production of mtros and limit the activation of the nlrp3 inflammasome. |
2022-11-12 |
2023-08-14 |
Not clear |
| Yuanyuan Zhou, Hanyu Liao, Shanshan Yin, Pengqiao Wang, Xiaoqing Ye, Jianyun Zhan. Aryl-, halogenated- and alkyl- organophosphate esters induced oxidative stress, endoplasmic reticulum stress and NLRP3 inflammasome activation in HepG2 cells. Environmental pollution (Barking, Essex : 1987). 2022-11-03. PMID:36328282. |
the cytotoxicity, apoptosis, oxidative stress, endoplasmic reticulum (er) stress and nlrp3 inflammasome activation induced by opes were evaluated in human hepatocellular carcinomas hepg2 cells. |
2022-11-03 |
2023-08-14 |
human |
| Ruera Carolina, Miculan Emanuel, Ducca Gerónimo, Pérez Federico, Iribarren María Luz, Carasi Paula, Chirdo Fernando Gabrie. IL-1β blockade prevents cell death and mucosal damage of the small intestine in a model of sterile inflammation. Immunology letters. 2022-10-29. PMID:36309159. |
here we show that specific inhibition of caspase-1 or nlrp3 abolishes the damage induced by p31-43, and that antibody-mediated blocking of il-1β inhibits the both the histological changes and the induction of apoptosis and caspase-3 activation driven by p31-43. |
2022-10-29 |
2023-08-14 |
Not clear |
| Liang Zheng, Hongbiao Xu, Fufu Zheng, Yuanhui Lai, Jie Li, Weiming Lv, Zuojun Hu, Wenjian Wan. Intervention time decides the status of autophagy, NLRP3 activity and apoptosis in macrophages induced by ox-LDL. Lipids in health and disease. vol 21. issue 1. 2022-10-26. PMID:36284323. |
intervention time decides the status of autophagy, nlrp3 activity and apoptosis in macrophages induced by ox-ldl. |
2022-10-26 |
2023-08-14 |
Not clear |
| Yue Li, Hao Zhang, Feng Tu, Jing Cao, Hou Xiang, Yanan Chen, Junshu Ya. Effects of resveratrol and its derivative pterostilbene on hepatic injury and immunological stress of weaned piglets challenged with lipopolysaccharide. Journal of animal science. 2022-10-15. PMID:36242589. |
lipopolysaccharide stimulation caused massive apoptosis, activated inflammatory responses, and incited severe oxidative stress in the piglet livers while also promoting the nuclear translocation of nuclear factor kappa b (nf-κb) p65 (p < 0.001) and the protein expression of nod-like receptor pyrin domain containing 3 (nlrp3; p = 0.001) and cleaved caspase 1 (p < 0.001). |
2022-10-15 |
2023-08-14 |
Not clear |
| Lili Nie, Hui Zou, Chi Ma, Xiaoke Wan. miR-223-3p Regulates NLRP3 to Inhibit Proliferation and Promote Apoptosis of ONG Cells. Computational and mathematical methods in medicine. vol 2022. 2022-10-14. PMID:36238473. |
mir-223-3p regulates nlrp3 to inhibit proliferation and promote apoptosis of ong cells. |
2022-10-14 |
2023-08-14 |
Not clear |
| Yi-Hsin Wang, Jiuan-Miaw Liao, Ke-Min Chen, Hsing-Hui Su, Pei-Hsun Liu, Yi-Hung Chen, Yuang-Seng Tsuei, Chin-Feng Tsai, Shiang-Suo Huan. Lumbrokinase regulates endoplasmic reticulum stress to improve neurological deficits in ischemic stroke. Neuropharmacology. 2022-10-12. PMID:36223864. |
lumbrokinase dramatically decreased the expressions of the endoplasmic reticulum (er) transmembrane receptor protein inositol-requiring enzyme-1 (ire1) and its downstream transcription factor, xbp-1, caspase-12, and nf-κb activity, thereby significantly inhibiting apoptosis and autophagy and decreasing the nlrp3 inflammasome. |
2022-10-12 |
2023-08-14 |
mouse |
| Yicen Zhou, Qijing Wu, Zhenfang Du, Min Huang, Kun Gao, Xiaowei Ma, Hui Zhang, Sheng Qiang, Wei Su. Verbena Attenuates Adriamycin-Induced Renal Tubular Injury via Inhibition of ROS-ERK1/2-NLRP3 Signal Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-10-10. PMID:36212965. |
results showed that total aqueous exact of verbena (taev) ameliorated adr-induced cell disruption, loss of cellular viability, and apoptosis via inhibition of ros-erk1/2-mediated activation of nlrp3 signal pathway, suggesting that taev serves as a promising renoprotective agent in delaying the progression of ckd, while ros-erk1/2-mediated nlrp3 signal pathway might be a novel target in treating kidney diseases. |
2022-10-10 |
2023-08-14 |
Not clear |
| Fang Xu, Yi Wu, Qianyu Yang, Ying Cheng, Jialu Xu, Yue Zhang, Huaxing Dai, Beilei Wang, Qingle Ma, Yitong Chen, Fang Lin, Chao Wan. Engineered Extracellular Vesicles with SHP2 High Expression Promote Mitophagy for Alzheimer's Disease Treatment. Advanced materials (Deerfield Beach, Fla.). 2022-10-04. PMID:36193769. |
in addition, msc-evs-shp2 significantly induces mitophagy of neuronal cells, which alleviates mitochondrial damage-mediated apoptosis and nlrp3 inflammasome activation. |
2022-10-04 |
2023-08-14 |
mouse |
| Yongjun Cao, Yumeng Sun, Xiaowen Jin, Xiaoqian Li, Le Chen, Yan Qi. TIM4/NLRP3 axis participates in the effects of M1 macrophages on inflammatory factor release, apoptosis and cell adhesion in thyroid follicular cells. Experimental and therapeutic medicine. vol 24. issue 5. 2022-10-03. PMID:36185763. |
in summary, the present study demonstrated that tim4-silencing alleviated the inflammatory damage, apoptosis and cell adhesion of m1 macrophages co-cultured with nthy-ori 3-1 cells through downregulation of nlrp3. |
2022-10-03 |
2023-08-14 |
Not clear |
| Ling You, Yanjie Zheng, Jing Yang, Qian Hou, Lianxia Wang, Yan Zhang, Chunxia Zhao, Ruiqin Xi. LncRNA MDRL Mitigates Atherosclerosis through miR-361/SQSTM1/NLRP3 Signaling. Mediators of inflammation. vol 2022. 2022-10-03. PMID:36186576. |
here, we sought to determine that mitochondrial dynamic related lncrna (mdrl) modulates nlrp3 inflammasome activation and apoptosis of vascular smooth muscle cells (vsmcs) and protects arteries against atherosclerosis. |
2022-10-03 |
2023-08-14 |
Not clear |
| Umeharu Oht. Activation and regulation mechanisms of NOD-like receptors based on structural biology. Frontiers in immunology. vol 13. 2022-10-03. PMID:36189327. |
these include nod2, neuronal apoptosis inhibitory protein (naip)/nlrc4, nlr family pyrin domain containing 1 (nlrp1), nlrp3, nlrp6, and nlrp9. |
2022-10-03 |
2023-08-14 |
Not clear |
| Anna Perri, Sabrina Bossio, Vittoria Rago, Emanuela A Greco, Danilo Lofaro, Antonella LA Russa, Luigi DI Luigi, Sandro LA Vignera, Antonio Avers. NLRP3-inflammasome activation in male reproductive system diseases. Minerva endocrinology. 2022-09-30. PMID:36177957. |
recently, in vitro and animal models of both infectious and non-infectious male genital tract diseases affecting fertility, demonstrated the activation of the innate immune system, leading to increased levels of pro-inflammatory cytokines, as well as apoptosis and pyroptosis and that it was likely mediated by activation of the nlrp3 inflammasome. |
2022-09-30 |
2023-08-14 |
Not clear |
| Zhongyuan Zhou, Meng Wang, Chengyu Huang, Yan Li, Lin Gao, Yandong Zhu, Changjiang Ying, Xiaoyan Zho. Treadmill exercise training alleviates diabetes-induced depressive-like behavior and cognitive impairment by improving hippocampal CA1 neurons injury in db/db mice. Brain research bulletin. 2022-09-29. PMID:36174874. |
in summary, the results indicated that treadmill exercise training significantly ameliorates hippocampus injury by suppressing oxidative stress-induced apoptosis and nlrp3 inflammasome activation, consequently ameliorating diabetes-induced depressive-like behavior and cognitive impairment in db/db mice. |
2022-09-29 |
2023-08-14 |
mouse |
| Yao Xue, Yunqian Zhang, Li Chen, Yan Wang, Zhou Lv, Li-Qiao Yang, Siyuan L. Citrulline protects against LPS‑induced acute lung injury by inhibiting ROS/NLRP3‑dependent pyroptosis and apoptosis via the Nrf2 signaling pathway. Experimental and therapeutic medicine. vol 24. issue 4. 2022-09-26. PMID:36160882. |
citrulline pretreatment decreased the expression of nod-, lrr- and pyrin domain-containing protein 3 (nlrp3) inflammasome and decreased pyroptosis and apoptosis. |
2022-09-26 |
2023-08-14 |
mouse |
| Yao Xue, Yunqian Zhang, Li Chen, Yan Wang, Zhou Lv, Li-Qiao Yang, Siyuan L. Citrulline protects against LPS‑induced acute lung injury by inhibiting ROS/NLRP3‑dependent pyroptosis and apoptosis via the Nrf2 signaling pathway. Experimental and therapeutic medicine. vol 24. issue 4. 2022-09-26. PMID:36160882. |
intervention with the total reactive oxygen species (ros) scavenger n-acetyl-l-cysteine attenuated nlrp3 inflammasome-associated pyroptosis and apoptosis in lps-treated mlvecs. |
2022-09-26 |
2023-08-14 |
mouse |
| Yao Xue, Yunqian Zhang, Li Chen, Yan Wang, Zhou Lv, Li-Qiao Yang, Siyuan L. Citrulline protects against LPS‑induced acute lung injury by inhibiting ROS/NLRP3‑dependent pyroptosis and apoptosis via the Nrf2 signaling pathway. Experimental and therapeutic medicine. vol 24. issue 4. 2022-09-26. PMID:36160882. |
furthermore, the nrf2 inhibitor ml385 reversed ros generation, nlrp3 inflammasome-mediated pyroptosis and apoptosis suppressed by citrulline. |
2022-09-26 |
2023-08-14 |
mouse |
| Yanmin Gao, Di Xie, Yang Wang, Lei Niu, Hua Jian. Short-Chain Fatty Acids Reduce Oligodendrocyte Precursor Cells Loss by Inhibiting the Activation of Astrocytes via the SGK1/IL-6 Signalling Pathway. Neurochemical research. 2022-09-13. PMID:36098889. |
in this study, a rat model of hibi was established, and this study measured the changes in il-6 and nod-like receptor thermal protein domain associated protein 3 (nlrp3), in addition to proliferation and apoptosis indicators of oligodendrocyte precursor cells (opcs). |
2022-09-13 |
2023-08-14 |
rat |