| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Somayeh Vafaei, Hamed Taheri, Yasamin Hajimomeni, Amirhossein Fakhre Yaseri, Firoozeh Abolhasani Zade. The role of NLRP3 inflammasome in colorectal cancer: potential therapeutic target. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 2022-06-10. PMID:35689136. |
nlrp3 can modulate the immune systems, apoptosis, growth, and/or the gut microbiome to impact cancer development. |
2022-06-10 |
2023-08-14 |
Not clear |
| Lina Gong, Yaru Han, Ru Chen, Pu Yang, Chen Zhan. LncRNA ZNF883-Mediated NLRP3 Inflammasome Activation and Epilepsy Development Involve USP47 Upregulation. Molecular neurobiology. 2022-06-09. PMID:35678979. |
znf883, usp47, and nlrp3 were increasingly expressed and mir-138-5p was downregulated in epileptic neurons and rats, concurrent with aggravated inflammation and apoptosis. |
2022-06-09 |
2023-08-14 |
rat |
| Lina Gong, Yaru Han, Ru Chen, Pu Yang, Chen Zhan. LncRNA ZNF883-Mediated NLRP3 Inflammasome Activation and Epilepsy Development Involve USP47 Upregulation. Molecular neurobiology. 2022-06-09. PMID:35678979. |
in epileptic neurons, inhibiting mir-138-5p or overexpressing usp47 partially reversed the znf883 silencing-induced inhibition on nlrp3 inflammasome activation, neuronal apoptosis, and epileptiform activity. |
2022-06-09 |
2023-08-14 |
rat |
| Lina Gong, Yaru Han, Ru Chen, Pu Yang, Chen Zhan. LncRNA ZNF883-Mediated NLRP3 Inflammasome Activation and Epilepsy Development Involve USP47 Upregulation. Molecular neurobiology. 2022-06-09. PMID:35678979. |
znf883 silencing in ep rats decreased usp47 and nlrp3, increased mir-138-5p, and inhibited inflammation and apoptosis. |
2022-06-09 |
2023-08-14 |
rat |
| Marziyeh Tavalaee, Mohsen Rahmani, Joël R Drevet, Mohammad Hossein Nasr-Esfahan. The NLRP3 inflammasome: molecular activation and regulation in spermatogenesis and male infertility; a systematic review. Basic and clinical andrology. vol 32. issue 1. 2022-05-31. PMID:35637440. |
the most important player in ip activation is the nlrp3 (nod[nuclear oligomerization domain]-, lrr[leucine rich repeat]- and pyrin domain-containing protein 3) which functions as an intracellular sensor of d/m/l-amps resulting in activation of caspase-1, promotion of apoptosis, pyroptosis and generation of inflammatory cytokines. |
2022-05-31 |
2023-08-13 |
Not clear |
| Zhaoqi Zhang, Peiwen Guo, Suna Huang, Zhengcai Jia, Tunan Chen, Xin Liu, Hua Feng, Yujie Che. Inhibiting Microglia-Derived NLRP3 Alleviates Subependymal Edema and Cognitive Dysfunction in Posthemorrhagic Hydrocephalus after Intracerebral Hemorrhage via AMPK/Beclin-1 Pathway. Oxidative medicine and cellular longevity. vol 2022. 2022-05-27. PMID:35620574. |
here, based on the hydrocephalus secondary to ich break into ventricular (ich-ivh) in rats, this study investigated whether microglia/macrophage-derived nlrp3 induced subependymal edema formation and neuron apoptosis in subventricular zones (svz). |
2022-05-27 |
2023-08-13 |
rat |
| Zhaoqi Zhang, Peiwen Guo, Suna Huang, Zhengcai Jia, Tunan Chen, Xin Liu, Hua Feng, Yujie Che. Inhibiting Microglia-Derived NLRP3 Alleviates Subependymal Edema and Cognitive Dysfunction in Posthemorrhagic Hydrocephalus after Intracerebral Hemorrhage via AMPK/Beclin-1 Pathway. Oxidative medicine and cellular longevity. vol 2022. 2022-05-27. PMID:35620574. |
the activated nlrp3 in microglia/macrophages promoted the release of il-1beta to extracellular, which contributed to excessive autophagy, leading to neurons apoptosis both in vivo and in vitro through the ampk/beclin-1 pathway combined with transcriptomics. |
2022-05-27 |
2023-08-13 |
rat |
| Rui Li, Min Si, Hui-Yu Jia, Zheng Ma, Xin-Wei Li, Xiao-Yi Li, Xiang-Rong Dai, Peng Gong, Sheng-Yong Lu. Anfibatide alleviates inflammation and apoptosis via inhibiting NF-kappaB/NLRP3 axis in ischemic stroke. European journal of pharmacology. 2022-05-18. PMID:35584710. |
recent evidence suggests that nod-like receptor protein-3 (nlrp3) inflammasome is a key mediator of inflammatory response and can induce the activation of apoptosis signaling pathways in ischemic stroke. |
2022-05-18 |
2023-08-13 |
rat |
| Xiaoju Ding, Haijuan Xie, Wuqiang Shan, Ligang L. Agonism of GPR120 Prevented High Glucose-Induced Apoptosis of Retinal Endothelial Cells through Inhibiting NLRP3 Inflammasome. Klinische Monatsblatter fur Augenheilkunde. 2022-05-18. PMID:35584771. |
agonism of gpr120 prevented high glucose-induced apoptosis of retinal endothelial cells through inhibiting nlrp3 inflammasome. |
2022-05-18 |
2023-08-13 |
human |
| Xiaoju Ding, Haijuan Xie, Wuqiang Shan, Ligang L. Agonism of GPR120 Prevented High Glucose-Induced Apoptosis of Retinal Endothelial Cells through Inhibiting NLRP3 Inflammasome. Klinische Monatsblatter fur Augenheilkunde. 2022-05-18. PMID:35584771. |
in this study, gw9508, the gpr120 agonist, was utilized in human retinal microvascular endothelial cells (hrmecs) exposed to high glucose (hg) to investigate the involvement of gpr120 in cellular viability and apoptosis as well as the association with the nlrp3 inflammasome. |
2022-05-18 |
2023-08-13 |
human |
| Yu Zhang, Cheng-Jun Xing, Xiao Liu, Ya-Hong Li, Jing Jia, Jian-Guo Feng, Cheng-Jie Yang, Ye Chen, Jun Zho. Thioredoxin-Interacting Protein (TXNIP) Knockdown Protects against Sepsis-Induced Brain Injury and Cognitive Decline in Mice by Suppressing Oxidative Stress and Neuroinflammation. Oxidative medicine and cellular longevity. vol 2022. 2022-05-16. PMID:35571246. |
furthermore, the alterations in microglial activity, oxidative response, proinflammatory factors, apoptosis, protein levels (txnip and nlrp3 inflammasome), and apoptosis were examined in the hippocampal tissues. |
2022-05-16 |
2023-08-13 |
mouse |
| Lin Liu, Tingting Zhou, Tao Li, Zhanhua Liang, Xiaoguang Lu. LncRNA DLX6-AS1 promotes microglial inflammatory response in Parkinson's disease by regulating the miR-223-3p/NRP1 axis. Behavioural brain research. 2022-05-13. PMID:35550840. |
meanwhile, the cell number of th+/caspase3+/iba1+ in substantia nigra, cell viability, and apoptosis rate of bv2 microglia, inflammatory levels, and nlr family pyrin domain containing 3 (nlrp3) inflammasome were determined using immunohistochemistry, mtt assay, flow cytometry, elisa assay, and western blot. |
2022-05-13 |
2023-08-13 |
mouse |
| Xin-Hua Guo, Yang Zheng, Jia-Hui Wang, Hong-Hong Wang, Shu-Juan Luo, Na Huang, Tie-Jian Zhao, Bo-Wen Zheng, Xin-Yun Liang, Ri-Zhou Wu, Qiu-Yi Re. [Research progress on role of traditional Chinese medicine in hepatic fibrosis based on miRNA-mediated activation of NLRP3 inflammasome]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 9. 2022-05-09. PMID:35531688. |
different mirna molecules regulated liver fibrosis by mediating nlrp3 inflammasome activation, including mirna-350-3 p(mir-350-3 p)/interleukin-6(il-6)-mediated signal transducer and activator of transcription 3(stat3)/c-myc signaling pathway, mir-148 a-induced autophagy and apoptosis of hepatic stellate cells via hedgehog signaling pathway, mir-155-mediated nlrp3 inflammasome by the negative feedback of the suppressor of cytokine signaling-1(socs-1), mir-181 a-mediated downstream nlrp3 inflammatory pathway activation through mitogen-activated protein kinase kinase(mek)/extracellular signal-regulated kinase(erk)/nuclear transcription factor κb(nf-κb) inflammatory pathway, mir-21-promoted expression of nf-κb and nlrp3 of raw264.7 cells in mice by inhibiting tumor necrosis factor-α inducible protein 3(a20), and mir-20 b-promoted expression of il-1β and il-18 by activating nlrp3 signaling pathway. |
2022-05-09 |
2023-08-13 |
mouse |
| Ahmed M Kabel, Samir A Salama, Hany M Borg, Dina A Ali, Maaly A Abd Elmaabou. Targeting p-AKT/mTOR/MAP kinase signaling, NLRP3 inflammasome and apoptosis by fluvastatin with or without taxifolin mitigates gonadal dysfunction induced by bisphenol-A in male rats. Human & experimental toxicology. vol 41. 2022-04-25. PMID:35465754. |
targeting p-akt/mtor/map kinase signaling, nlrp3 inflammasome and apoptosis by fluvastatin with or without taxifolin mitigates gonadal dysfunction induced by bisphenol-a in male rats. |
2022-04-25 |
2023-08-13 |
human |
| Shih-Che Hung, Lu-Chu Ke, Te-Sheng Lien, Hsuan-Shun Huang, Der-Shan Sun, Chia-Liang Cheng, Hsin-Hou Chan. Nanodiamond-Induced Thrombocytopenia in Mice Involve P-Selectin-Dependent Nlrp3 Inflammasome-Mediated Platelet Aggregation, Pyroptosis and Apoptosis. Frontiers in immunology. vol 13. 2022-04-21. PMID:35444640. |
nanodiamond-induced thrombocytopenia in mice involve p-selectin-dependent nlrp3 inflammasome-mediated platelet aggregation, pyroptosis and apoptosis. |
2022-04-21 |
2023-08-13 |
mouse |
| Wei Zhang, Qi Zh. Punicalagin suppresses inflammation in ventilator-induced lung injury through PAR2 inhibition-induced inhibition of NLRP3 inflammasome activation. Chemical biology & drug design. 2022-04-18. PMID:35434894. |
the levels of inflammatory cytokines (tumor necrosis factor (tnf)-α, interleukin (il)-1β, and il-6), par2, nlr family pyrin domain containing-3 (nlrp3) and apoptosis associated speck-like protein containing a card (asc) in the balf lungs or cells were analyzed by enzyme-linked immune-sorbent assay (elisa), qrt-pcr or/and western blot. |
2022-04-18 |
2023-08-13 |
mouse |
| Hui Kong, Hongran Zhao, Tianran Chen, Yanling Song, Yan Cu. Targeted P2X7/NLRP3 signaling pathway against inflammation, apoptosis, and pyroptosis of retinal endothelial cells in diabetic retinopathy. Cell death & disease. vol 13. issue 4. 2022-04-12. PMID:35410316. |
the expression of inflammasome-related proteins p2x7 and nlrp3, and apoptosis in the retinas of 3tc-treated diabetic mice were compared to those of untreated diabetic mice. |
2022-04-12 |
2023-08-13 |
mouse |
| Zi-Tan Peng, Hui Li. Puerarin attenuates LPS-induced inflammatory injury in gastric epithelial cells by repressing NLRP3 inflammasome-mediated apoptosis. Toxicology in vitro : an international journal published in association with BIBRA. 2022-03-25. PMID:35331853. |
puerarin attenuates lps-induced inflammatory injury in gastric epithelial cells by repressing nlrp3 inflammasome-mediated apoptosis. |
2022-03-25 |
2023-08-13 |
Not clear |
| Zi-Tan Peng, Hui Li. Puerarin attenuates LPS-induced inflammatory injury in gastric epithelial cells by repressing NLRP3 inflammasome-mediated apoptosis. Toxicology in vitro : an international journal published in association with BIBRA. 2022-03-25. PMID:35331853. |
puerarin ameliorated lps-induced cytotoxicity and apoptosis, while repressing lps-stimulated nlrp3 inflammasome-mediated pyroptosis in ges-1 cells, as evidenced by significantly decreased expression of nlrp3, asc, cleaved caspase-1, il-1β and il-18. |
2022-03-25 |
2023-08-13 |
Not clear |
| Zi-Tan Peng, Hui Li. Puerarin attenuates LPS-induced inflammatory injury in gastric epithelial cells by repressing NLRP3 inflammasome-mediated apoptosis. Toxicology in vitro : an international journal published in association with BIBRA. 2022-03-25. PMID:35331853. |
our findings suggest that puerarin may ameliorate lps-induced inflammatory injury in ges-1 cells by activating the ampk/sirt1 signaling pathway and thereby repressing nlrp3 inflammasome-mediated apoptosis. |
2022-03-25 |
2023-08-13 |
Not clear |