| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun Ge, Juan Chen, Yanting Hu, Xinyi Chen, Man Huan. IL-38 Alleviates Inflammation in Sepsis in Mice by Inhibiting Macrophage Apoptosis and Activation of the NLRP3 Inflammasome. Mediators of inflammation. vol 2021. 2021-12-27. PMID:34955683. |
il-38 alleviates inflammation in sepsis in mice by inhibiting macrophage apoptosis and activation of the nlrp3 inflammasome. |
2021-12-27 |
2023-08-13 |
mouse |
| Yun Ge, Juan Chen, Yanting Hu, Xinyi Chen, Man Huan. IL-38 Alleviates Inflammation in Sepsis in Mice by Inhibiting Macrophage Apoptosis and Activation of the NLRP3 Inflammasome. Mediators of inflammation. vol 2021. 2021-12-27. PMID:34955683. |
moreover, exposure to il-38 alone was sufficient to inhibit macrophage apoptosis and lps-driven activation of the nod-, lrr-, and pyrin domain-containing 3 (nlrp3) inflammasome. |
2021-12-27 |
2023-08-13 |
mouse |
| Yun Ge, Juan Chen, Yanting Hu, Xinyi Chen, Man Huan. IL-38 Alleviates Inflammation in Sepsis in Mice by Inhibiting Macrophage Apoptosis and Activation of the NLRP3 Inflammasome. Mediators of inflammation. vol 2021. 2021-12-27. PMID:34955683. |
collectively, these findings present il-38 as a potent immune modulator that restrains the inflammatory response by suppressing macrophage apoptosis and activation of the nlrp3 inflammasome. |
2021-12-27 |
2023-08-13 |
mouse |
| Yajiao Hu, Pingzhu Wang, Kun Ha. Hydrogen attenuated inflammation response and oxidative in hypoxic ischemic encephalopathy via Nrf2 mediated the inhibition of NLRP3 and NF-κB. Neuroscience. 2021-12-26. PMID:34953939. |
taken together, our findings showed that hydrogen alleviated cellular injury and apoptosis, neurobehavioural deficits, the inflammatory response and oxidative stress via the nrf2-mediated nlrp3 and nf-κb pathways. |
2021-12-26 |
2023-08-13 |
mouse |
| Rittibet Yapasert, Patompong Khaw-On, Ratana Banjerdpongcha. Coronavirus Infection-Associated Cell Death Signaling and Potential Therapeutic Targets. Molecules (Basel, Switzerland). vol 26. issue 24. 2021-12-24. PMID:34946543. |
there are a variety of compounds proven to play roles in the cell death inhibition, such as pan-caspase inhibitor (z-vad-fmk) for apoptosis, necrostatin-1 for necroptosis, mcc950, a potent and specific inhibitor of the nlrp3 inflammasome in pyroptosis, and chloroquine/hydroxychloroquine, which can mitigate the corresponding cell death pathways. |
2021-12-24 |
2023-08-13 |
Not clear |
| Rongrong Bai, Yue Lang, Jie Shao, Yu Deng, Reyisha Refuhati, Li Cu. The Role of NLRP3 Inflammasome in Cerebrovascular Diseases Pathology and Possible Therapeutic Targets. ASN neuro. vol 13. 2021-11-30. PMID:34053242. |
reactive oxygen species (ros)/nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb), ros/thioredoxin-interacting protein (txnip) and purinergic receptor-7 (p2x7r) signalling pathways can activate the nlrp3 inflammasome; activation of the nlrp3 inflammasome can aggravate cerebrovascular diseases by mediating apoptosis and pyroptosis. |
2021-11-30 |
2023-08-13 |
Not clear |
| Fang Liu, Xinjing Wang, Yuan Cui, Yan Yin, Dong Qiu, Shilan Li, Xinli L. Apple Polyphenols Extract (APE) Alleviated Dextran Sulfate Sodium Induced Acute Ulcerative Colitis and Accompanying Neuroinflammation via Inhibition of Apoptosis and Pyroptosis. Foods (Basel, Switzerland). vol 10. issue 11. 2021-11-30. PMID:34828992. |
the results showed that ape significantly ameliorated dss-induced acute uc through inhibiting intestinal epithelial cell (iec) apoptosis and the caspase-1/caspase-11-dependent pyroptosis pathway, with increased bcl-2 protein expression and decreased protein levels of nlrp3, asc, caspase-1/11, and gsdnd. |
2021-11-30 |
2023-08-13 |
mouse |
| Renjun Gao, Hongye Zhao, Xianyan Wang, Bo Tang, Yu Cai, Xinrui Zhang, Hao Zong, Yitong Li, Yanli Wan. Mild Hypothermia Therapy Lowers the Inflammatory Level and Apoptosis Rate of Myocardial Cells of Rats with Myocardial Ischemia-Reperfusion Injury via the NLRP3 Inflammasome Pathway. Computational and mathematical methods in medicine. vol 2021. 2021-11-29. PMID:34422094. |
mild hypothermia therapy lowers the inflammatory level and apoptosis rate of myocardial cells of rats with myocardial ischemia-reperfusion injury via the nlrp3 inflammasome pathway. |
2021-11-29 |
2023-08-13 |
rat |
| Yixuan Wan, Bo He, Dongyong Zhu, Lei Wang, Ruijue Huang, Jing Zhu, Chunhua Wang, Fabao Ga. Nicotinamide mononucleotide attenuates doxorubicin-induced cardiotoxicity by reducing oxidative stress, inflammation and apoptosis in rats. Archives of biochemistry and biophysics. vol 712. 2021-11-29. PMID:34610336. |
in conclusion, the results indicated that nmn protects against dic in rats by inhibiting nlrp3 inflammasome activation, oxidative stress, and apoptosis. |
2021-11-29 |
2023-08-13 |
rat |
| Narayanappa Amruta, Gregory Bi. ATN-161 Ameliorates Ischemia/Reperfusion-induced Oxidative Stress, Fibro-inflammation, Mitochondrial damage, and Apoptosis-mediated Tight Junction Disruption in bEnd.3 Cells. Inflammation. vol 44. issue 6. 2021-11-26. PMID:34420157. |
in continuation with our previous findings, we have further evaluated the mechanistic role of atn-161 in vitro and found that oxygen and glucose deprivation and reperfusion (ogd/r)-induced inflammation, oxidative stress, apoptosis, mitochondrial depolarization, and fibrosis attenuate tight junction integrity via induction of α5, nlrp3, p-fak, and p-akt signaling in mouse brain endothelial cells. |
2021-11-26 |
2023-08-13 |
mouse |
| Narayanappa Amruta, Gregory Bi. ATN-161 Ameliorates Ischemia/Reperfusion-induced Oxidative Stress, Fibro-inflammation, Mitochondrial damage, and Apoptosis-mediated Tight Junction Disruption in bEnd.3 Cells. Inflammation. vol 44. issue 6. 2021-11-26. PMID:34420157. |
atn-161 treatment (10 µm) effectively inhibited ogd/r-induced extracellular matrix (ecm) deposition by reducing integrin α5, mmp-9, and fibronectin expression, as well as reducing oxidative stress by reducing mitochondrial superoxide radicals, intracellular ros, inflammation by reducing nlrp3 inflammasome, tight junction loss by reducing claudin-5 and zo-1 expression levels, mitochondrial damage by inhibiting mitochondrial depolarization, and apoptosis via regulation of p-fak and p-akt levels. |
2021-11-26 |
2023-08-13 |
mouse |
| Honggang Wang, Xingzhuo Shi, Mengyuan Qiu, Shuangyu Lv, Hong Zheng, Baohua Niu, Huiyang Li. Hydrogen Sulfide Plays an Important Role by Influencing NLRP3 inflammasome. International journal of biological sciences. vol 16. issue 14. 2021-11-23. PMID:33110394. |
nucleotide-binding oligomerization domain-like receptor protein 3 (nlrp3) inflammasome is composed of nlrp3, apoptosis associated speck like protein (asc) and pro-caspase-1. |
2021-11-23 |
2023-08-13 |
Not clear |
| Feng Wang, Lu Wang, Guanghong Sui, Caixia Yang, Mengtian Guo, Xiangyang Xiong, Zheng Chen, Ping Le. IGF-1 Alleviates Mitochondrial Apoptosis through the GSK3β/NF-κB/NLRP3 Signaling Pathway in LPS-Treated PC-12 Cells. Journal of molecular neuroscience : MN. vol 71. issue 6. 2021-11-23. PMID:33403593. |
p-gsk3β, nf-κb and nlrp3) was measured using western blotting. compared with the control cells, the lps-treated cells showed evidence of mitochondrial dysfunction, increased apoptosis and upregulation of apoptosis proteins, which were significantly alleviated by mdivi-1. |
2021-11-23 |
2023-08-13 |
Not clear |
| Yingwen Mu, Jiayin Sun, Ziyuan Li, Wanxin Zhang, Zuodong Liu, Chao Li, Cheng Peng, Guanqun Cui, Hua Shao, Zhongjun D. Activation of pyroptosis and ferroptosis is involved in the hepatotoxicity induced by polystyrene microplastics in mice. Chemosphere. 2021-11-21. PMID:34793849. |
additionally, mps were shown to induce the nod-like receptor protein 3 (nlrp3) inflammasomes and apoptosis associated speck-like protein (asc) containing a caspase recruitment domain activation in liver tissue, enabling activation of caspase-1-dependent signaling pathway induced by inflammatory stimuli resulting from oxidative stress. |
2021-11-21 |
2023-08-13 |
mouse |
| QuanYun Zhang, Li Zhou, Hong Xie, HongJin Zhang, XuZhu Ga. HAGLR aggravates neuropathic pain and promotes inflammatory response and apoptosis of lipopolysaccharide-treated SH-SY5Y cells by sequestering miR-182-5p from ATAT1 and activating NLRP3 inflammasome. Neurochemistry international. vol 145. 2021-11-18. PMID:33626373. |
haglr aggravates neuropathic pain and promotes inflammatory response and apoptosis of lipopolysaccharide-treated sh-sy5y cells by sequestering mir-182-5p from atat1 and activating nlrp3 inflammasome. |
2021-11-18 |
2023-08-13 |
Not clear |
| Ines Diaz-Del-Olmo, Jonathan Worboys, Fatima Martin-Sanchez, Anna Gritsenko, Ashley R Ambrose, Gillian M Tannahill, Eva-Maria Nichols, Gloria Lopez-Castejon, Daniel M Davi. Internalization of the Membrane Attack Complex Triggers NLRP3 Inflammasome Activation and IL-1β Secretion in Human Macrophages. Frontiers in immunology. vol 12. 2021-11-18. PMID:34650553. |
the mac is first internalized into endosomes and then colocalizes with inflammasome components; adapter protein apoptosis associated speck-like protein containing a card (asc) and nlrp3. |
2021-11-18 |
2023-08-13 |
human |
| Qing Wang, Lujing Ying, Bing Wei, Yikui Ji, Yi X. Effects of quercetin on apoptosis and extracellular matrix degradation of chondrocytes induced by oxidative stress-mediated pyroptosis. Journal of biochemical and molecular toxicology. 2021-11-18. PMID:34791735. |
results showed that quercetin could reduce lps-induced c28/i2 cell apoptosis, extracellular matrix (ecm) degradation, and cell pyroptosis, and overexpression of nucleotide-binding domain and leucine-rich-repeat-containing (nlr) family, pyrin domain-containing 3 (nlrp3) revealed that quercetin reduced chondrocyte apoptosis and ecm degradation by inhibiting nlrp3-mediated pyroptosis. |
2021-11-18 |
2023-08-13 |
rat |
| Xiaohe Li, Ling Ma, Yuli Wei, Jinying Gu, Jingjing Liang, Shimeng Li, Yunyao Cui, Rui Liu, Hui Huang, Cheng Yang, Honggang Zho. Cabozantinib ameliorates lipopolysaccharide-induced lung inflammation and bleomycin--induced early pulmonary fibrosis in mice. International immunopharmacology. vol 101. issue Pt B. 2021-11-17. PMID:34741997. |
the results of in vitro studies showed that cabozantinib could inhibit the inflammatory response and apoptosis of alveolar epithelial cells by inhibiting the activation of tlr4/nf-κb and nlrp3 inflammasome pathways. |
2021-11-17 |
2023-08-13 |
mouse |
| Qisheng Lin, Shu Li, Na Jiang, Haijiao Jin, Xinghua Shao, Xuying Zhu, Jingkui Wu, Minfang Zhang, Zhen Zhang, Jianxiao Shen, Wenyan Zhou, Leyi Gu, Renhua Lu, Zhaohui N. Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagy. Autophagy. vol 17. issue 10. 2021-11-16. PMID:33345685. |
inhibiting nlrp3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of hif1a and bnip3-mediated mitophagy. |
2021-11-16 |
2023-08-13 |
Not clear |
| Qian Li, Mingming Zhang, Ying Zhao, Maolong Don. Irisin Protects Against LPS-Stressed Cardiac Damage Through Inhibiting Inflammation, Apoptosis, and Pyroptosis. Shock (Augusta, Ga.). vol 56. issue 6. 2021-11-16. PMID:34779800. |
after stimuli of lps, the function of myocardium was distinctly impaired, which was closely related to increased level of apoptosis (decreased expression of bcl-2 and elevated expression of caspase-3 and bax), pyroptosis (increased expression of caspase1, nlr family pyrin domain containing 3 (nlrp3), and gasdermin d) and inflammatory mediators (increased level of il-1β, tnf-α, and il-6). |
2021-11-16 |
2023-08-13 |
mouse |