| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhengxiao Ren, Ping Che, Ziwei Li, Mei Mo, Shanshan Zhang, Yingying Zhan. [Progress in the relationship between NLRP3 inflammasome and lung injury in COVID-19]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 37. issue 9. 2021-09-20. PMID:34533131. |
sars-cov-2 enters lung cells via ace2, and the nlr family pyrin domain containing 3 (nlrp3) inflammasome and the pro-caspase-1 are then activated, followed by release of mature il-1β and il-18 and other inflammatory cytokines, thereby leading to inflammation and apoptosis. |
2021-09-20 |
2023-08-13 |
Not clear |
| Xu Wu, Linjing Gong, Liang Xie, Wenyu Gu, Xinyuan Wang, Zilong Liu, Shanqun L. NLRP3 Deficiency Protects Against Intermittent Hypoxia-Induced Neuroinflammation and Mitochondrial ROS by Promoting the PINK1-Parkin Pathway of Mitophagy in a Murine Model of Sleep Apnea. Frontiers in immunology. vol 12. 2021-09-15. PMID:33717152. |
compared with wild-type mice, nlrp3 deficiency protected them from cih-induced neuronal damage, as indicated by the restoration of fear-conditioning test results and amelioration of neuron apoptosis. |
2021-09-15 |
2023-08-13 |
mouse |
| Hongwei Zhou, Cheng Zhang, Changren Huan. Verbascoside Attenuates Acute Inflammatory Injury Caused by an Intracerebral Hemorrhage Through the Suppression of NLRP3. Neurochemical research. vol 46. issue 4. 2021-09-14. PMID:33400023. |
in this study, we investigated whether vb limited inflammation induced by ich through the targeting of nlrp3, which is associated with acute inflammation and apoptosis. |
2021-09-14 |
2023-08-13 |
rat |
| Nada H Eisa, Mohamed El-Sherbiny, Nada F Abo El-Mag. Betulin alleviates cisplatin-induced hepatic injury in rats: Targeting apoptosis and Nek7-independent NLRP3 inflammasome pathways. International immunopharmacology. vol 99. 2021-09-08. PMID:34217992. |
betulin alleviates cisplatin-induced hepatic injury in rats: targeting apoptosis and nek7-independent nlrp3 inflammasome pathways. |
2021-09-08 |
2023-08-13 |
rat |
| Donghua Du, Wenting Lv, Rina Su, Chunwei Yu, Xiaoxia Jing, Nuwenqimuge Bai, Surong Has. Hydrolyzed camel whey protein alleviated heat stress-induced hepatocyte damage by activated Nrf2/HO-1 signaling pathway and inhibited NF-κB/NLRP3 axis. Cell stress & chaperones. vol 26. issue 2. 2021-09-03. PMID:33405053. |
s-cwp suppressed hs-induced inflammatory response by reducing the phosphorylation of nf-κb p65, the expression of nlrp3, and caspase-1 and finally alleviated caspase-3-mediated apoptosis. |
2021-09-03 |
2023-08-13 |
cat |
| Dongdong Li, Luobing Wang, Jiaoying Ou, Chuanxu Wang, Jiabao Zhou, Lili Lu, Yanshneg Wu, Jiandong Ga. Reactive oxygen species induced by uric acid promote NRK‑52E cell apoptosis through the NEK7‑NLRP3 signaling pathway. Molecular medicine reports. vol 24. issue 4. 2021-08-31. PMID:34414459. |
the ros inhibitor, n‑acetyl‑l‑cysteine, exerted a protective effect on the ua‑induced apoptosis of tubular epithelial cells by reducing excess ros production, which significantly inhibited nek7 and nlrp3 inflammasome activation. |
2021-08-31 |
2023-08-13 |
Not clear |
| Tayier Gulifeire, Chunbo Yang, Xiang Li, Yi Wang, Xiangyou Y. [Activation of NOD-like receptor protein 3 inflammasome mediates inflammatory response and apoptosis in septic intestinal injury model]. Zhonghua wei zhong bing ji jiu yi xue. vol 33. issue 7. 2021-08-23. PMID:34412757. |
to investigate the expression of nod-like receptor protein 3 (nlrp3) inflammasome in intestinal injury models with different severity of sepsis and the inflammatory response and apoptosis mediated by nlrp3 inflammasome. |
2021-08-23 |
2023-08-13 |
Not clear |
| Kaiqiang Sun, Xiaofei Sun, Jingchuan Sun, Yan Jiang, Feng Lin, Fanqi Kong, Fudong Li, Jian Zhu, Le Huan, Bing Zheng, Yuan Wang, Weiguo Zou, Lu Gao, Ximing Xu, Jiangang Sh. Tissue Renin-Angiotensin System (tRAS) Induce Intervertebral Disc Degeneration by Activating Oxidative Stress and Inflammatory Reaction. Oxidative medicine and cellular longevity. vol 2021. 2021-08-21. PMID:34413926. |
then, in vitro experiment suggested that ang ii could decrease the cell viability of human np cells and promote np cell apoptosis, senescence, oxidative stress, and nlrp3 activation in human np cells. |
2021-08-21 |
2023-08-13 |
human |
| Lin Xie, Zhiming Zhao, Zhenhao Chen, Xiaosheng Ma, Xinlei Xia, Hongli Wang, Chaojun Zheng, Jianyuan Jian. Melatonin Alleviates Radiculopathy Against Apoptosis and NLRP3 Inflammasomes Via the Parkin-Mediated Mitophagy Pathway. Spine. vol 46. issue 16. 2021-08-18. PMID:34398134. |
melatonin alleviates radiculopathy against apoptosis and nlrp3 inflammasomes via the parkin-mediated mitophagy pathway. |
2021-08-18 |
2023-08-13 |
Not clear |
| Xin Mao, Rong-Mei Yao, Yan-Yan Bao, Jing Sun, Xiao-Lan Cui, Hai-Jiang Zhang, Yu-Jing Sh. [Effect of polysaccharides from seeds of Vaccaria segetalis in alleviating urinary tract infection induced bladder injury by inhibiting NLRP3 inflammasome]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 13. 2021-08-17. PMID:34396759. |
western blot and immunofluorescence staining were used to detect the expressions of sonic hedgehog( shh) and nlrp3 inflammasome [nod-like receptor thermoprotein domain 3( nlrp3),apoptosis associated speck like protein( asc) and pro-caspase-1]. |
2021-08-17 |
2023-08-13 |
rat |
| Jae Ryong Lim, Hyun Jik Lee, Young Hyun Jung, Jun Sung Kim, Chang Woo Chae, Seo Yihl Kim, Ho Jae Ha. Ethanol-activated CaMKII signaling induces neuronal apoptosis through Drp1-mediated excessive mitochondrial fission and JNK1-dependent NLRP3 inflammasome activation. Cell communication and signaling : CCS. vol 18. issue 1. 2021-08-10. PMID:32787872. |
ethanol-activated camkii signaling induces neuronal apoptosis through drp1-mediated excessive mitochondrial fission and jnk1-dependent nlrp3 inflammasome activation. |
2021-08-10 |
2023-08-13 |
Not clear |
| Lijuan A. Exposure to mono (2-ethylhexyl) phthalate facilitates apoptosis and pyroptosis of human endometrial microvascular endothelial cells through NLRP3 inflammasome. Journal of applied toxicology : JAT. vol 41. issue 5. 2021-07-27. PMID:33159713. |
exposure to mono (2-ethylhexyl) phthalate facilitates apoptosis and pyroptosis of human endometrial microvascular endothelial cells through nlrp3 inflammasome. |
2021-07-27 |
2023-08-13 |
human |
| Lijuan A. Exposure to mono (2-ethylhexyl) phthalate facilitates apoptosis and pyroptosis of human endometrial microvascular endothelial cells through NLRP3 inflammasome. Journal of applied toxicology : JAT. vol 41. issue 5. 2021-07-27. PMID:33159713. |
nlrp3 knockdown markedly ameliorated the increase in ldh release and apoptosis induced by mehp exposure in hemecs. |
2021-07-27 |
2023-08-13 |
human |
| Lijuan A. Exposure to mono (2-ethylhexyl) phthalate facilitates apoptosis and pyroptosis of human endometrial microvascular endothelial cells through NLRP3 inflammasome. Journal of applied toxicology : JAT. vol 41. issue 5. 2021-07-27. PMID:33159713. |
our findings suggested that exposure to mehp facilitates apoptosis and pyroptosis of hemecs through nlrp3 inflammasome. |
2021-07-27 |
2023-08-13 |
human |
| Pengfei Liu, Quansheng Gao, Lei Guan, Yanting Hu, Jingwen Jiang, Teng Gao, Weixuan Sheng, Xinying Xue, Hui Qiao, Tianzuo L. Atorvastatin attenuates surgery-induced BBB disruption and cognitive impairment partly by suppressing NF-κB pathway and NLRP3 inflammasome activation in aged mice. Acta biochimica et biophysica Sinica. vol 53. issue 5. 2021-07-16. PMID:33674828. |
atorvastatin could also reverse the surgery-induced increase of systemic and hippocampal cytokines, including il-1β, tnf-α, and il-6, accompanied by inhibiting the nuclear factor kappa-b (nf-κb) pathway and nucleotide-binding oligomerization domain, or leucine rich repeat and pyrin domain containing 3 (nlrp3) inflammasome activation, as well as hippocampal neuronal apoptosis. |
2021-07-16 |
2023-08-13 |
mouse |
| Xiaoqing Zhang, Dandan Zhao, Jiling Feng, Xiaoli Yang, Zhenzhen Lan, Tao Yang, Xiaoni Kong, Huiyan Qu, Hua Zho. LuQi Formula Regulates NLRP3 Inflammasome to Relieve Myocardial-Infarction-Induced Cardiac Remodeling in Mice. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-07-15. PMID:34257682. |
this study aimed to evaluate whether lqf could alleviate cardiac injury and apoptosis by regulating the nlrp3 inflammasome and the caspase-3/bax pathway. |
2021-07-15 |
2023-08-13 |
mouse |
| Wenyu Dai, Manyi Wang, Peiqi Wang, Ji Wen, Jiangyue Wang, Sa Cha, Xueling Xiao, Yiruo He, Rui Shu, Ding Ba. lncRNA NEAT1 ameliorates LPS‑induced inflammation in MG63 cells by activating autophagy and suppressing the NLRP3 inflammasome. International journal of molecular medicine. vol 47. issue 2. 2021-07-12. PMID:33416115. |
lps upregulated the expression of inflammatory cytokines and nlrp3, inhibited the expression of autophagy‑related and osteogenesis‑related proteins, promoted apoptosis and altered the cell cycle, which was partially inhibited by neat1 overexpression and promoted by bexarotene. |
2021-07-12 |
2023-08-13 |
human |
| Wenjun Zou, Shasha Luo, Zhengwei Zhang, Libo Cheng, Xiaoli Huang, Nannan Ding, Ying Pan, Zhifeng W. ASK1/p38‑mediated NLRP3 inflammasome signaling pathway contributes to aberrant retinal angiogenesis in diabetic retinopathy. International journal of molecular medicine. vol 47. issue 2. 2021-07-12. PMID:33416127. |
in the present study, an animal model of dr and a cell model using primary human retinal microvascular endothelial cells exposed to high glucose were constructed to examine the association between apoptosis signal‑regulating kinase 1 (ask1)/p38 and nlr family pyrin domain containing 3 (nlrp3) in dr. |
2021-07-12 |
2023-08-13 |
human |
| Rui Xiong, Wenyang Jiang, Ning Li, Bohao Liu, Ruyuan He, Bo Wang, Qing Gen. PM2.5-induced lung injury is attenuated in macrophage-specific NLRP3 deficient mice. Ecotoxicology and environmental safety. vol 221. 2021-07-12. PMID:34146983. |
we constructed macrophage-specific nlrp3 knockout mice to explore the mechanism of pm2.5-induced lung injury in terms of inflammatory response, oxidative stress, and apoptosis levels, including the relationship between these effects and pyroptosis. |
2021-07-12 |
2023-08-13 |
mouse |
| Man Luo, Dongsheng Yan, Qingsong Sun, Jiali Tao, Liang Xu, Hong Sun, Hongmei Zha. Ginsenoside Rg1 attenuates cardiomyocyte apoptosis and inflammation via the TLR4/NF-kB/NLRP3 pathway. Journal of cellular biochemistry. vol 121. issue 4. 2021-07-09. PMID:31709615. |
in addition, treatment with tlr4 small interfering rna (sirna), a p-nf-κb inhibitor, or nlrp3 sirna suppressed lps-induced apoptosis and inflammation. |
2021-07-09 |
2023-08-13 |
mouse |