| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lu Wang, Xiaohui Wang, Lina Kong, Shuyuan Wang, Kai Huang, Jingjing Wu, Changyuan Wang, Huijun Sun, Kexin Liu, Qiang Men. Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response. International immunopharmacology. vol 100. 2021-10-27. PMID:34555641. |
in conclusion, isl improves the ability of anti-oxidative stress, alleviates inflammatory reaction, apoptosis, and inhibits nlrp3 inflammasome to protect lipopolysaccharide/d-galactosamine (lps/d-galn)-induced alf through activating the pgc-1α/nrf2 pathway, which provides the possibility for the treatment of alf. |
2021-10-27 |
2023-08-13 |
Not clear |
| Jiaye Liu, Zhanjun Jia, Wei Gon. Circulating Mitochondrial DNA Stimulates Innate Immune Signaling Pathways to Mediate Acute Kidney Injury. Frontiers in immunology. vol 12. 2021-10-26. PMID:34248963. |
mitochondrial dna (mtdna) released from damaged mitochondria could serve as a danger-associated molecular pattern (damp) and activate the innate immune system through sting, tlr9, nlrp3, and some other adaptors, and further mediate tubular cell inflammation and apoptosis. |
2021-10-26 |
2023-08-13 |
Not clear |
| Sarah Adriana Scuderi, Giovanna Casili, Rossella Basilotta, Marika Lanza, Alessia Filippone, Gabriele Raciti, Ivana Puliafito, Lorenzo Colarossi, Emanuela Esposito, Irene Paternit. NLRP3 Inflammasome Inhibitor BAY-117082 Reduces Oral Squamous Cell Carcinoma Progression. International journal of molecular sciences. vol 22. issue 20. 2021-10-26. PMID:34681768. |
it has been proven that excessive nlrp3 inflammasome activation and apoptosis alteration may contribute to oral cancer progression. |
2021-10-26 |
2023-08-13 |
human |
| Sarah Adriana Scuderi, Giovanna Casili, Rossella Basilotta, Marika Lanza, Alessia Filippone, Gabriele Raciti, Ivana Puliafito, Lorenzo Colarossi, Emanuela Esposito, Irene Paternit. NLRP3 Inflammasome Inhibitor BAY-117082 Reduces Oral Squamous Cell Carcinoma Progression. International journal of molecular sciences. vol 22. issue 20. 2021-10-26. PMID:34681768. |
therefore, based on these results, the use of bay-117082 could be considered a promising strategy to counteract oral cancer progression, thanks its ability to modulate the nlrp3 inflammasome and apoptosis pathways. |
2021-10-26 |
2023-08-13 |
human |
| Rupak Dey Sarkar, Samraj Sinha, Nabendu Biswa. Manipulation of Inflammasome: A Promising Approach Towards Immunotherapy of Lung Cancer. International reviews of immunology. vol 40. issue 3. 2021-10-25. PMID:33508984. |
of these, five complexes-nlrp1, nlrp3, nlrc4, pyrin, and aim2 are of importance in the context of cancer for their activities in modulating immune responses, cell proliferation, and apoptosis. |
2021-10-25 |
2023-08-13 |
Not clear |
| Aijiao Gao, Huixin Tang, Qian Zhang, Ruiqing Liu, Lin Wang, Yashan Liu, Zhi Qi, Yanna She. Mst1/2-ALK promotes NLRP3 inflammasome activation and cell apoptosis during Listeria monocytogenes infection. Journal of microbiology (Seoul, Korea). vol 59. issue 7. 2021-10-25. PMID:33877580. |
mst1/2-alk promotes nlrp3 inflammasome activation and cell apoptosis during listeria monocytogenes infection. |
2021-10-25 |
2023-08-13 |
Not clear |
| Yi-Qiang Pang, Jing Yang, Chun-Mei Jia, Rui Zhang, Qi Pan. Hypoxic preconditioning reduces NLRP3 inflammasome expression and protects against cerebral ischemia/reperfusion injury. Neural regeneration research. vol 17. issue 2. 2021-10-22. PMID:34269215. |
compared with control mice, mice with cerebral ischemia/reperfusion injury showed increased bederson neurological function scores, significantly increased cerebral infarction volume, obvious pathological damage to the hippocampus, significantly increased apoptosis; upregulated interleukin-1β, interleukin-6, and interleukin-8 levels in brain tissue; and increased expression levels of nod-like receptor family pyrin domain containing 3 (nlrp3), nlrp inflammasome-related protein caspase-1, and gasdermin d. however, hypoxic preconditioning significantly inhibited the above phenomena. |
2021-10-22 |
2023-08-13 |
mouse |
| Tao Liu, Xuegang Wang, Feng Guo, Xiaobo Sun, Kunxiong Yuan, Qingyong Wang, Chunwei La. Lysophosphatidylcholine induces apoptosis and inflammatory damage in brain microvascular endothelial cells via GPR4-mediated NLRP3 inflammasome activation. Toxicology in vitro : an international journal published in association with BIBRA. vol 77. 2021-10-19. PMID:34293432. |
lysophosphatidylcholine induces apoptosis and inflammatory damage in brain microvascular endothelial cells via gpr4-mediated nlrp3 inflammasome activation. |
2021-10-19 |
2023-08-13 |
Not clear |
| Tao Liu, Xuegang Wang, Feng Guo, Xiaobo Sun, Kunxiong Yuan, Qingyong Wang, Chunwei La. Lysophosphatidylcholine induces apoptosis and inflammatory damage in brain microvascular endothelial cells via GPR4-mediated NLRP3 inflammasome activation. Toxicology in vitro : an international journal published in association with BIBRA. vol 77. 2021-10-19. PMID:34293432. |
apoptosis was monitored by flow cytometry and hoechst staining, while caspase 3, asc, nlrp3, and gpr4 protein expression were examined by western blotting. |
2021-10-19 |
2023-08-13 |
Not clear |
| Tao Liu, Xuegang Wang, Feng Guo, Xiaobo Sun, Kunxiong Yuan, Qingyong Wang, Chunwei La. Lysophosphatidylcholine induces apoptosis and inflammatory damage in brain microvascular endothelial cells via GPR4-mediated NLRP3 inflammasome activation. Toxicology in vitro : an international journal published in association with BIBRA. vol 77. 2021-10-19. PMID:34293432. |
our results showed that lpc significantly increased the levels of inflammatory cytokines (il-1β, il-18, and il-33) and markedly induced apoptosis and nlrp3 inflammasome activation in bmecs. |
2021-10-19 |
2023-08-13 |
Not clear |
| Tao Liu, Xuegang Wang, Feng Guo, Xiaobo Sun, Kunxiong Yuan, Qingyong Wang, Chunwei La. Lysophosphatidylcholine induces apoptosis and inflammatory damage in brain microvascular endothelial cells via GPR4-mediated NLRP3 inflammasome activation. Toxicology in vitro : an international journal published in association with BIBRA. vol 77. 2021-10-19. PMID:34293432. |
above all, we also proved that lpc induced apoptosis and inflammatory injury in bmecs by causing gpr4 to activate nlrp3 inflammasomes. |
2021-10-19 |
2023-08-13 |
Not clear |
| Tong Zheng, Yuqin Tan, Jiang Qiu, Zhenwei Xie, Xiao Hu, Jinhua Zhang, Ning N. Alternative polyadenylation trans-factor FIP1 exacerbates UUO/IRI-induced kidney injury and contributes to AKI-CKD transition via ROS-NLRP3 axis. Cell death & disease. vol 12. issue 6. 2021-10-14. PMID:34011928. |
functionally, such nlrp3 3'utr shortening upregulated nlrp3 expression and amplified inflammation, fibrogenesis, ros production and apoptosis, depending on stabilizing nlrp3 mrna. |
2021-10-14 |
2023-08-13 |
Not clear |
| Tong Zheng, Yuqin Tan, Jiang Qiu, Zhenwei Xie, Xiao Hu, Jinhua Zhang, Ning N. Alternative polyadenylation trans-factor FIP1 exacerbates UUO/IRI-induced kidney injury and contributes to AKI-CKD transition via ROS-NLRP3 axis. Cell death & disease. vol 12. issue 6. 2021-10-14. PMID:34011928. |
more importantly, we found fip1 was upregulated by oxidative stress and required for oxidative stress-induced nlrp3 upregulation, inflammation activation, cell damage and apoptosis. |
2021-10-14 |
2023-08-13 |
Not clear |
| Tong Zheng, Yuqin Tan, Jiang Qiu, Zhenwei Xie, Xiao Hu, Jinhua Zhang, Ning N. Alternative polyadenylation trans-factor FIP1 exacerbates UUO/IRI-induced kidney injury and contributes to AKI-CKD transition via ROS-NLRP3 axis. Cell death & disease. vol 12. issue 6. 2021-10-14. PMID:34011928. |
taken together, our results demonstrated that oxidative stress-upregulated fip1 amplified inflammation, fibrogenesis, ros production and apoptosis via inducing 3'utr shortening of nlrp3, highlighting the importance of crosstalk between oxidative stress and alternative polyadenylation in aki-ckd transition, as well as the therapeutic potential of fip1 in kidney injury treatment. |
2021-10-14 |
2023-08-13 |
Not clear |
| Chaoqing Zhong, Ruiqing Wang, Mingqiang Hua, Chen Zhang, Fengjiao Han, Miao Xu, Xinyu Yang, Guosheng Li, Xiang Hu, Tao Sun, Chunyan Ji, Daoxin M. NLRP3 Inflammasome Promotes the Progression of Acute Myeloid Leukemia Frontiers in immunology. vol 12. 2021-10-14. PMID:34211462. |
the activation of nlrp3 inflammasome in aml cells promotes leukemia cells proliferation, inhibits apoptosis and increases resistance to chemotherapy, while inactivation of nlrp3 by caspase-1 or nf-κb inhibitor shows leukemia-suppressing effects. |
2021-10-14 |
2023-08-13 |
Not clear |
| Meng Zhang, Guanhua Hu, Nan Shao, Yunpeng Qin, Qian Chen, Yan Wang, Peng Zhou, Biao Ca. Thioredoxin-interacting protein (TXNIP) as a target for Alzheimer's disease: flavonoids and phenols. Inflammopharmacology. vol 29. issue 5. 2021-10-14. PMID:34350508. |
txnip separates from the txnip-thioredoxin complex, and the txnip-nlrp3 complex assembles asc and pro-caspase-1 to form the nlrp3 inflammasome, which triggers ad inflammation and apoptosis. |
2021-10-14 |
2023-08-13 |
Not clear |
| Maryam Borhani-Haghighi, Yousef Mohamad. The protective effects of neural stem cells and neural stem cells-conditioned medium against inflammation-induced prenatal brain injury. Journal of neuroimmunology. vol 360. 2021-10-11. PMID:34507013. |
inflammation and apoptosis were evaluated postpartum in offspring via measuring the expression of nlrp3 gene and protein, the expression and the activity of caspase-3, and the expression of pro-inflammatory cytokines by real-time pcr, immunohistochemistry, western blotting, elisa, and colorimetric assay kit. |
2021-10-11 |
2023-08-13 |
mouse |
| Elona Gusho, Danika Baskar, Shuvojit Banerje. New advances in our understanding of the "unique" RNase L in host pathogen interaction and immune signaling. Cytokine. vol 133. 2021-10-07. PMID:27595182. |
the catalytic activity of rnase l has been found to lead into the activation of several cellular signaling pathways, including those involved in autophagy, apoptosis, ifn-β production, nlrp3 inflammasome activation leading to il-1β secretion, inhibition of cell migration, and cell adhesion. |
2021-10-07 |
2023-08-13 |
Not clear |
| Dong-Xia Li, Chang-Nan Wang, Yan Wang, Chang-Lin Ye, Lai Jiang, Xiao-Yan Zhu, Yu-Jian Li. NLRP3 inflammasome-dependent pyroptosis and apoptosis in hippocampus neurons mediates depressive-like behavior in diabetic mice. Behavioural brain research. vol 391. 2021-10-05. PMID:32454054. |
nlrp3 inflammasome-dependent pyroptosis and apoptosis in hippocampus neurons mediates depressive-like behavior in diabetic mice. |
2021-10-05 |
2023-08-13 |
mouse |
| Saifudeen Ismael, Wajidunnisa, Kazuko Sakata, Michael P McDonald, Francesca-Fang Liao, Tauheed Ishra. ER stress associated TXNIP-NLRP3 inflammasome activation in hippocampus of human Alzheimer's disease. Neurochemistry international. vol 148. 2021-09-30. PMID:34153352. |
further, elevated expression of effector molecules of nlrp3 inflammasome activation such as apoptosis associated speck-like protein (asc), cleaved caspase-1 and cleaved interleukin-1β were observed in the ad hippocampus. |
2021-09-30 |
2023-08-13 |
human |