| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ziqi Ren, Kelaier Yang, Meng Zhao, Wenxiu Liu, Xin Zhang, Jinyu Chi, Zhiyu Shi, Xiaohui Zhang, Yu Fu, Yue Liu, Xinhua Yi. Calcium-Sensing Receptor on Neutrophil Promotes Myocardial Apoptosis and Fibrosis After Acute Myocardial Infarction via NLRP3 Inflammasome Activation. The Canadian journal of cardiology. vol 36. issue 6. 2021-02-16. PMID:32224080. |
calcium-sensing receptor on neutrophil promotes myocardial apoptosis and fibrosis after acute myocardial infarction via nlrp3 inflammasome activation. |
2021-02-16 |
2023-08-13 |
Not clear |
| Sannula Kesavardhana, Thirumala-Devi Kannegant. ZBP1: A STARGᐰTE to decode the biology of Z-nucleic acids in disease. The Journal of experimental medicine. vol 217. issue 7. 2021-02-12. PMID:32584411. |
zbp1 triggers nlrp3 inflammasome activation/pyroptosis, apoptosis, and necroptosis; the specific ligand for zbp1 activation remains ambiguous. |
2021-02-12 |
2023-08-13 |
Not clear |
| Jiaji Hu, Zhoujie Zhu, Hanglu Ying, Jie Yao, Huabin Ma, Long Li, Yufen Zha. Oleoylethanolamide Protects Against Acute Liver Injury by Regulating Nrf-2/HO-1 and NLRP3 Pathways in Mice. Frontiers in pharmacology. vol 11. 2021-02-06. PMID:33536915. |
together, these findings demonstrated that oea protect against the lps/d-gal-induced acute liver injury in mice through the inhibition of apoptosis, oxidative stress and inflammation, and its mechanisms might be associated with the nrf-2/ho-1 and nlrp3 inflammasome signaling pathways. |
2021-02-06 |
2023-08-13 |
mouse |
| Junna He, Xiangjian Zhan. miR-668 inhibitor attenuates mitochondrial membrane potential and protects against neuronal apoptosis in cerebral ischemic stroke. Folia neuropathologica. vol 58. issue 1. 2021-02-04. PMID:32337954. |
in conclusion, the results of the present study indicated that inhibition of mir-668 prevented neuronal apoptosis in cerebral i/r-induced stroke by modulating mitochondrial function and regulating nlrp3 signalling. |
2021-02-04 |
2023-08-13 |
rat |
| Pankaj Deo, Seong H Chow, Mei-Ling Han, Mary Speir, Cheng Huang, Ralf B Schittenhelm, Subhash Dhital, Jack Emery, Jian Li, Benjamin T Kile, James E Vince, Kate E Lawlor, Thomas Nadere. Mitochondrial dysfunction caused by outer membrane vesicles from Gram-negative bacteria activates intrinsic apoptosis and inflammation. Nature microbiology. vol 5. issue 11. 2021-02-02. PMID:32807891. |
here, we show that macrophages exposed to omvs from neisseria gonorrhoeae, uropathogenic escherichia coli and pseudomonas aeruginosa induce mitochondrial apoptosis and nlrp3 inflammasome activation. |
2021-02-02 |
2023-08-13 |
Not clear |
| Pankaj Deo, Seong H Chow, Mei-Ling Han, Mary Speir, Cheng Huang, Ralf B Schittenhelm, Subhash Dhital, Jack Emery, Jian Li, Benjamin T Kile, James E Vince, Kate E Lawlor, Thomas Nadere. Mitochondrial dysfunction caused by outer membrane vesicles from Gram-negative bacteria activates intrinsic apoptosis and inflammation. Nature microbiology. vol 5. issue 11. 2021-02-02. PMID:32807891. |
in parallel with caspase-11-mediated pyroptosis, mitochondrial apoptosis and potassium ion efflux activate the nlrp3 inflammasome after omv exposure in vitro. |
2021-02-02 |
2023-08-13 |
Not clear |
| Shanshan Wei, Wanjun Ma, Xiaohui Li, Chuanhao Jiang, Taoli Sun, Yuanjian Li, Bikui Zhang, Wenqun L. Involvement of ROS/NLRP3 Inflammasome Signaling Pathway in Doxorubicin-Induced Cardiotoxicity. Cardiovascular toxicology. vol 20. issue 5. 2021-01-25. PMID:32607760. |
dox (1 μm for 48 h) induced the apoptosis of h9c2 cells and primary cardiomyocytes concomitantly with up-regulation of nlrp3, asc and caspase-1 p20 expressions, as well as the increased il-1β secretion, suggesting the activation of nlrp3 inflammasome. |
2021-01-25 |
2023-08-13 |
mouse |
| Shanshan Wei, Wanjun Ma, Xiaohui Li, Chuanhao Jiang, Taoli Sun, Yuanjian Li, Bikui Zhang, Wenqun L. Involvement of ROS/NLRP3 Inflammasome Signaling Pathway in Doxorubicin-Induced Cardiotoxicity. Cardiovascular toxicology. vol 20. issue 5. 2021-01-25. PMID:32607760. |
decreasing ros level by nac can inhibit the nlrp3 inflammasome activation, secretion of il-1β and apoptosis in dox-treating h9c2 cells and primary cardiomyocytes. |
2021-01-25 |
2023-08-13 |
mouse |
| Yuanyuan Zou, Bingjie Cui, Pei Liang, Xiaoyu Tian, Yiming Ma, Shaozhen Zha. Inhibition of NLRP3 Protects Human Lens Epithelial Cells against Oxidative Stress-Induced Apoptosis by NF-κB Signaling. Ophthalmic research. vol 63. issue 2. 2021-01-07. PMID:31805556. |
inhibition of nlrp3 protects human lens epithelial cells against oxidative stress-induced apoptosis by nf-κb signaling. |
2021-01-07 |
2023-08-13 |
human |
| Yara A Samra, Mohamed F Hamed, Ahmed R El-Sheak. Hepatoprotective effect of allicin against acetaminophen-induced liver injury: Role of inflammasome pathway, apoptosis, and liver regeneration. Journal of biochemical and molecular toxicology. vol 34. issue 5. 2021-01-07. PMID:32040233. |
therefore, we assessed allicin's protective effect on apap-induced hepatotoxicity and studied its effect on nlrp3 inflammasome and apoptosis. |
2021-01-07 |
2023-08-13 |
mouse |
| Yicong Chang, Liang Yuan, Jiarui Liu, Ishfaq Muhammad, Chuanbao Cao, Chenxi Shi, Yuanyuan Zhang, Rui Li, Changwen Li, Fangping Li. Dihydromyricetin attenuates Escherichia coli lipopolysaccharide-induced ileum injury in chickens by inhibiting NLRP3 inflammasome and TLR4/NF-κB signalling pathway. Veterinary research. vol 51. issue 1. 2021-01-05. PMID:32448367. |
in summary, dhm attenuated the ileum mucosal damage, oxidative stress and apoptosis, maintained barrier function, inhibited nlrp3 inflammasome and tlr4/nf-κb signalling pathway activation triggered by escherichia coli lps. |
2021-01-05 |
2023-08-13 |
chicken |
| Sannula Kesavardhana, R K Subbarao Malireddi, Amanda R Burton, Shaina N Porter, Peter Vogel, Shondra M Pruett-Miller, Thirumala-Devi Kannegant. The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development. The Journal of biological chemistry. vol 295. issue 24. 2020-12-30. PMID:32350114. |
zbp1 activation triggers inflammation and pyroptosis, necroptosis, and apoptosis (panoptosis) by activating receptor-interacting ser/thr kinase 3 (ripk3), caspase-8, and the nlrp3 inflammasome. |
2020-12-30 |
2023-08-13 |
Not clear |
| Marisol Fernández-Ortiz, Ramy K A Sayed, José Fernández-Martínez, Antonia Cionfrini, Paula Aranda-Martínez, Germaine Escames, Tomás de Haro, Darío Acuña-Castroviej. Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging. Antioxidants (Basel, Switzerland). vol 9. issue 12. 2020-12-26. PMID:33260800. |
with the aim of investigating the impact of nlrp3 inflammasome and the actions and target of melatonin in aged myocardium, we analyzed the expression of proteins implied in mitochondria dynamics, autophagy, apoptosis, nrf2-dependent antioxidant response and mitochondria ultrastructure in heart of wild-type and nlrp3-knockout mice of 3, 12, and 24 months-old, with and without melatonin treatment. |
2020-12-26 |
2023-08-13 |
mouse |
| Shuai Zhao, Fan Chen, Qiliang Yin, Dunwei Wang, Wei Han, Yuan Zhan. Reactive Oxygen Species Interact With NLRP3 Inflammasomes and Are Involved in the Inflammation of Sepsis: From Mechanism to Treatment of Progression. Frontiers in physiology. vol 11. 2020-12-17. PMID:33324236. |
nlrp3 inflammasomes enlarge the inflammatory response and trigger apoptosis of immune cells to exacerbate sepsis progression. |
2020-12-17 |
2023-08-13 |
Not clear |
| Tao Pan, Qiu-Jiao Zhu, Li-Xiao Xu, Xin Ding, Jian-Qin Li, Bin Sun, Jun Hua, Xing Fen. Knocking down TRPM2 expression reduces cell injury and NLRP3 inflammasome activation in PC12 cells subjected to oxygen-glucose deprivation. Neural regeneration research. vol 15. issue 11. 2020-12-11. PMID:32394974. |
taken together, these results suggest that trpm2 knockdown reduces ogd-induced neuronal injury, potentially by inhibiting apoptosis and reducing oxidative stress levels, mitochondrial membrane potentials, intracellular calcium concentrations, and nlrp3 inflammasome activation. |
2020-12-11 |
2023-08-13 |
Not clear |
| Ava Faridi, Yunxiang Sun, Monika Mortimer, Ritchlynn R Aranha, Aparna Nandakumar, Yuhuan Li, Ibrahim Javed, Aleksandr Kakinen, Qingqing Fan, Anthony W Purcell, Thomas P Davis, Feng Ding, Pouya Faridi, Pu Chun K. Graphene quantum dots rescue protein dysregulation of pancreatic β-cells exposed to human islet amyloid polypeptide. Nano research. vol 12. issue 11. 2020-11-01. PMID:31695851. |
while iapp can activate the nlrp3 inflammasome and modulate cellular autophagy, apoptosis and extracellular matrix metabolism, no data is available concerning intracellular protein expression upon exposure to the polypeptide. |
2020-11-01 |
2023-08-13 |
human |
| R K Subbarao Malireddi, Prajwal Gurung, Sannula Kesavardhana, Parimal Samir, Amanda Burton, Harisankeerth Mummareddy, Peter Vogel, Stephane Pelletier, Sandeepta Burgula, Thirumala-Devi Kannegant. Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity-independent pyroptosis, apoptosis, necroptosis, and inflammatory disease. The Journal of experimental medicine. vol 217. issue 3. 2020-10-29. PMID:31869420. |
tlr priming of tak1-deficient macrophages triggered inflammasome activation, including the activation of caspase-8 and gasdermin d, and the recruitment of nlrp3 and asc into a novel ripk1 kinase activity-independent cell death complex to drive pyroptosis and apoptosis. |
2020-10-29 |
2023-08-13 |
Not clear |
| Kendra L Hanslik, Tyler K Ullan. The Role of Microglia and the Nlrp3 Inflammasome in Alzheimer's Disease. Frontiers in neurology. vol 11. 2020-10-22. PMID:33071950. |
several recent reports indicate that the assembly of the multi-protein complex known as the nod, lrr, and pyrin-domain containing 3 (nlrp3) inflammasome by microglia results in apoptosis spec-like protein containing a card (asc) spec formation, which then nucleates new aβ plaques, thus amplifying aβ-associated pathology. |
2020-10-22 |
2023-08-13 |
Not clear |
| Ting Liu, Lantian Tang, Hui Tang, Jieying Pu, Sitang Gong, Danyun Fang, Hui Zhang, Yi-Ping Li, Xun Zhu, Weidong Wang, Minhao Wu, Yuhui Liao, Chunling Li, Haibo Zhou, Xi Huan. Zika Virus Infection Induces Acute Kidney Injury Through Activating NLRP3 Inflammasome Via Suppressing Bcl-2. Frontiers in immunology. vol 10. 2020-10-05. PMID:31474993. |
overexpression of bcl-2 attenuated zikv-induced nlrp3 inflammasome activation in renal cells and down-regulated parp/caspase-3-mediated renal apoptosis. |
2020-10-05 |
2023-08-13 |
mouse |
| Ting Liu, Lantian Tang, Hui Tang, Jieying Pu, Sitang Gong, Danyun Fang, Hui Zhang, Yi-Ping Li, Xun Zhu, Weidong Wang, Minhao Wu, Yuhui Liao, Chunling Li, Haibo Zhou, Xi Huan. Zika Virus Infection Induces Acute Kidney Injury Through Activating NLRP3 Inflammasome Via Suppressing Bcl-2. Frontiers in immunology. vol 10. 2020-10-05. PMID:31474993. |
overall, our findings demonstrated that zikv infection induced aki by activating nlrp3 inflammasome and apoptosis through suppressing bcl-2 expression, which provided potential therapeutic targets for zikv-associated renal diseases. |
2020-10-05 |
2023-08-13 |
mouse |